By Dr Yoshiro Okubo

Journal articles

Yahata N; Takahashi H; Okubo Y, 2005, 'Pharmacological modulations on the human cognitive processes: An fMRI study', Journal of Nippon Medical School, 72, pp. 2 - 3, http://dx.doi.org/10.1272/jnms.72.2

Oda K; Matsushima E; Okubo Y; Ohta K; Murata Y; Koike R; Miyasaka N; Kato M, 2005, 'Abnormal regional cerebral blood flow in systemic lupus erythematosus patients with psychiatric symptoms', Journal of Clinical Psychiatry, 66, pp. 907 - 913, http://dx.doi.org/10.4088/JCP.v66n0714

Okubo Y; Ito I; Oda K, 2004, 'Brain imaging of patients with psychiatric diseases', Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica, 106, pp. 900 - 905

Sakamoto A; Ogawa R; Suzuki H; Kimura M; Okubo Y; Fujiya T, 2004, 'Landiolol attenuates acute hemodynamic responses but does not reduce seizure duration during maintenance electroconvulsive therapy', Psychiatry and Clinical Neurosciences, 58, pp. 630 - 635, http://dx.doi.org/10.1111/j.1440-1819.2004.01322.x

Takahashi H; Yahata N; Koeda M; Matsuda T; Asai K; Okubo Y, 2004, 'Brain activation associated with evaluative processes of guilt and embarrassment: An fMRI study', NeuroImage, 23, pp. 967 - 974, http://dx.doi.org/10.1016/j.neuroimage.2004.07.054

Matsuura M; Adachi N; Oana Y; Okubo Y; Kato M; Nakano T; Takei N, 2004, 'A polydiagnostic and dimensional comparison of epileptic psychoses and schizophrenia spectrum disorders', Schizophrenia Research, 69, pp. 189 - 201, http://dx.doi.org/10.1016/S0920-9964(02)00492-9

Aritake S; Uchiyama M; Tagaya H; Suzuki H; Kuriyama K; Ozaki A; Tan X; Shibui K; Kamei Y; Okubo Y; Takahashi K, 2004, 'Time estimation during nocturnal sleep in human subjects', Neuroscience Research, 49, pp. 387 - 393, http://dx.doi.org/10.1016/j.neures.2004.04.006

Watanabe H; Murata Y; Ohashi I; Oda K; Matsushima E; Okubo Y; Shibuya H, 2004, 'Long-term change in size of cerebral infarction: Predictive value of brain perfusion SPECT using statistical parametric mapping', Cerebrovascular Diseases, 18, pp. 22 - 29, http://dx.doi.org/10.1159/000078604

Takahashi H; Koeda M; Oda K; Matsuda T; Matsushima E; Matsuura M; Asai K; Okubo Y, 2004, 'An fMRI study of differential neural response to affective pictures in schizophrenia', NeuroImage, 22, pp. 1247 - 1254, http://dx.doi.org/10.1016/j.neuroimage.2004.03.028

Yasuno F; Suhara T; Okubo Y; Sudo Y; Inoue M; Ichimiya T; Takano A; Nakayama K; Halldin C; Farde L, 2004, 'Low dopamine D2 receptor binding in subregions of the thalamus in schizophrenia', American Journal of Psychiatry, 161, pp. 1016 - 1022, http://dx.doi.org/10.1176/appi.ajp.161.6.1016

Shirahama Y; Ohta K; Takashima A; Matsushima E; Okubo Y, 2004, 'Magnetic brain activity elicited by visually presented symbols and Japanese characters', NeuroReport, 15, pp. 771 - 775, http://dx.doi.org/10.1097/00001756-200404090-00006

Yasuno F; Suhara T; Ichimiya T; Takano A; Ando T; Okubo Y, 2004, 'Decreased 5-HT1A receptor binding in amygdala of schizophrenia', Biological Psychiatry, 55, pp. 439 - 444, http://dx.doi.org/10.1016/j.biopsych.2003.11.016

Takano A; Suhara T; Ikoma Y; Yasuno F; Maeda J; Ichimiya T; Sudo Y; Inoue M; Okubo Y, 2004, 'Estimation of the time-course of dopamine D2 receptor occupancy in living human brain from plasma pharmacokinetics of antipsychotics', International Journal of Neuropsychopharmacology, 7, pp. 19 - 26, http://dx.doi.org/10.1017/S1461145703003912

Obata T; Someya Y; Suhara T; Ota Y; Hirakawa K; Ikehira H; Tanada S; Okubo Y, 2004, 'Neural damage due to temporal lobe epilepsy: Dual-nuclei (proton and phosphorus) magnetic resonance spectroscopy study', Psychiatry and Clinical Neurosciences, 58, pp. 48 - 53, http://dx.doi.org/10.1111/j.1440-1819.2004.01192.x

Sumiyoshi T; Meltzer HY; Yasuno F; Suhara T; Nakayama T; Ichimiya T; Takano A; Ando T; Inoue M; Maeda J; Suzuki K; Okubo Y, 2004, 'Serotonin 1A receptors in memory function [11] (multiple letters)', American Journal of Psychiatry, 161, pp. 1505 - 1506, http://dx.doi.org/10.1176/appi.ajp.161.8.1505

Halldin C; Erixon-Lindroth N; Pauli S; Chou YH; Okubo Y; Karlsson P; Lundkvist C; Olsson H; Guilloteau D; Emond P; Farde L, 2003, '[¹¹C]PE21: A highly selective radioligand for PET examination of the dopamine transporter in monkey and human brain', European Journal of Nuclear Medicine and Molecular Imaging, 30, pp. 1220 - 1230, http://dx.doi.org/10.1007/s00259-003-1212-3

Shioe K; Ichimiya T; Suhara T; Takano A; Sudo Y; Yasuno F; Hirano M; Shinohara M; Kagami M; Okubo Y; Nankai M; Kanba S, 2003, 'No association between genotype of the promoter region of serotonin transporter gene and serotonin transporter binding in human brain measured by pet', Synapse, 48, pp. 184 - 188, http://dx.doi.org/10.1002/syn.10204

Hossain AKMM; Murata Y; Zhang L; Taura SI; Saitoh Y; Mizusawa H; Oda K; Matsushima E; Okubo Y; Shibuya H, 2003, 'Brain perfusion SPECT in patients with corticobasal degeneration: Analysis using statistical parametric mapping', Movement Disorders, 18, pp. 697 - 703, http://dx.doi.org/10.1002/mds.10415

Suhara T; Takano A; Sudo Y; Ichimiya T; Inoue M; Yasuno F; Ikoma Y; Okubo Y, 2003, 'High levels of serotonin transporter occupancy with low-dose clomipramine in comparative occupancy study with fluvoxamine using positron emission tomography', Archives of General Psychiatry, 60, pp. 386 - 391, http://dx.doi.org/10.1001/archpsyc.60.4.386

Nakamura M; Uchida S; Maehara T; Kawai K; Hirai N; Nakabayashi T; Arakaki H; Okubo Y; Nishikawa T; Shimizu H, 2003, 'Sleep spindles in human prefrontal cortex: An electrocorticographic study', Neuroscience Research, 45, pp. 419 - 427, http://dx.doi.org/10.1016/S0168-0102(03)00007-5

Ako M; Kawara T; Uchida S; Miyazaki S; Nishihara K; Mukai J; Hirao K; Ako J; Okubo Y, 2003, 'Correlation between electroencephalography and heart rate variability during sleep', Psychiatry and Clinical Neurosciences, 57, pp. 59 - 65, http://dx.doi.org/10.1046/j.1440-1819.2003.01080.x

Yasuno F; Suhara T; Nakayama T; Ichimiya T; Okubo Y; Takano A; Ando T; Inoue M; Maeda J; Suzuki K, 2003, 'Inhibitory effect of hippocampal 5-HT1A receptors on human explicit memory', American Journal of Psychiatry, 160, pp. 334 - 340, http://dx.doi.org/10.1176/appi.ajp.160.2.334

Oda K; Okubo Y; Ishida R; Murata Y; Ohta K; Matsuda T; Matsushima E; Ichimiya T; Suhara T; Shibuya H; Nishikawa T, 2003, 'Regional cerebral blood flow in depressed patients with white matter magnetic resonance hyperintensity', Biological Psychiatry, 53, pp. 150 - 156, http://dx.doi.org/10.1016/S0006-3223(02)01548-2

Nakayama T; Suhara T; Okubo Y; Ichimiya T; Yasuno F; Maeda J; Takano A; Saijo T; Suzuki K, 2002, 'In vivo drug action of tandospirone at 5-HT1A receptor examined using positron emission tomography and neuroendocrine response', Psychopharmacology, 165, pp. 37 - 42, http://dx.doi.org/10.1007/s00213-002-1234-8

Adachi N; Matsuura M; Hara T; Oana Y; Okubo Y; Kato M; Onuma T, 2002, 'Psychoses and epilepsy: Are interictal and postictal psychoses distinct clinical entities?', Epilepsia, 43, pp. 1574 - 1582, http://dx.doi.org/10.1046/j.1528-1157.2002.22402.x

Yamamoto M; Suhara T; Okubo Y; Ichimiya T; Sudo Y; Inoue M; Takano A; Yasuno F; Yoshikawa K; Tanada S, 2002, 'Age-related decline of serotonin transporters in living human brain of healthy males', Life Sciences, 71, pp. 751 - 757, http://dx.doi.org/10.1016/S0024-3205(02)01745-9

Ichimiya T; Suhara T; Sudo Y; Okubo Y; Nakayama K; Nankai M; Inoue M; Yasuno F; Takano A; Maeda J; Shibuya H, 2002, 'Serotonin transporter binding in patients with mood disorders: A PET study with [¹¹C](+)McN5652', Biological Psychiatry, 51, pp. 715 - 722, http://dx.doi.org/10.1016/S0006-3223(01)01351-8

Adachi N; Onuma T; Hara T; Matsuura M; Okubo Y; Kato M; Oana Y, 2002, 'Frequency and age-related variables in interictal psychoses in localization-related epilepsies', Epilepsy Research, 48, pp. 25 - 31, http://dx.doi.org/10.1016/S0920-1211(01)00329-1

Ishiguro H; Okubo Y; Ohtsuki T; Yamakawa-Kobayashi K; Arinami T, 2002, 'Mutation analysis of the retinoid X receptor beta, nuclear-related receptor 1, and peroxisome proliferator-activated receptor alpha genes in schizophrenia and alcohol dependence: Possible haplotype association of nuclear-related receptor 1 gene to alcohol dependence', American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 114, pp. 15 - 23, http://dx.doi.org/10.1002/ajmg.1620

Sassa T; Suhara T; Ikehira H; Obata T; Girard F; Tanada S; Okubo Y, 2002, '¹⁹F-magnetic resonance spectroscopy and chemical shift imaging for schizophrenic patients using haloperidol decanoate', Psychiatry and Clinical Neurosciences, 56, pp. 637 - 642, http://dx.doi.org/10.1046/j.1440-1819.2002.01068.x

Suhara T; Okubo Y; Yasuno F; Sudo Y; Inoue M; Ichimiya T; Nakashima Y; Nakayama K; Tanada S; Suzuki K; Halldin C; Farde L, 2002, 'Decreased dopamine D2 receptor binding in the anterior cingulate cortex in schizophrenia', Archives of General Psychiatry, 59, pp. 25 - 30, http://dx.doi.org/10.1001/archpsyc.59.1.25

Okubo Y; Saijo T; Oda K, 2001, 'A review of MRI studies of progressive brain changes in schizophrenia', Journal of Medical and Dental Sciences, 48, pp. 61 - 67

Obayashi S; Matsushima E; Okubo Y; Ohkura T; Kojima T; Kakuma T, 2001, 'Relationship between exploratory eye movements and clinical course in schizophrenic patients', European Archives of Psychiatry and Clinical Neuroscience, 251, pp. 211 - 216, http://dx.doi.org/10.1007/s004060170029

Inoue M; Suhara T; Sudo Y; Okubo Y; Yasuno F; Kishimoto T; Yoshikawa K; Tanada S, 2001, 'Age-related reduction of extrastriatal dopamine D2 receptor measured by PET', Life Sciences, 69, pp. 1079 - 1084, http://dx.doi.org/10.1016/S0024-3205(01)01205-X

Girard F; Suhara T; Sassa T; Okubo Y; Obata T; Ikehira H; Sudo Y; Koga M; Yoshioka H; Yoshida K, 2001, '⁷Li 2D CSI of human brain on a clinical scanner', Magnetic Resonance Materials in Physics, Biology and Medicine, 13, pp. 1 - 7, http://dx.doi.org/10.1016/S1352-8661(01)00117-X

Yoshikawa T; Kikuchi M; Saito K; Watanabe A; Yamada K; Shibuya H; Nankai M; Kurumaji A; Hattori E; Ishiguro H; Shimizu H; Okubo Y; Toru M; Detera-Wadleigh SD, 2001, 'Evidence for association of the myo-inositol monophosphatase 2 (IMPA2) gene with schizophrenia in Japanese samples', Molecular Psychiatry, 6, pp. 202 - 210, http://dx.doi.org/10.1038/sj.mp.4000835

Nakabayashi T; Uchida S; Maehara T; Hirai N; Nakamura M; Arakaki H; Shimisu H; Okubo Y, 2001, 'Absence of sleep spindles in human medial and basal temporal lobes', Psychiatry and Clinical Neurosciences, 55, pp. 57 - 65, http://dx.doi.org/10.1046/j.1440-1819.2001.00785.x

Saijo T; Abe T; Someya Y; Sassa T; Sudo Y; Suhara T; Shuno T; Asai K; Okubo Y, 2001, 'Ten year progressive ventricular enlargement in schizophrenia: An MRI morphometrical study', Psychiatry and Clinical Neurosciences, 55, pp. 41 - 47, http://dx.doi.org/10.1046/j.1440-1819.2001.00783.x

Uchida S; Maehara T; Hirai N; Okubo Y; Shimizu H, 2001, 'Cortical oscillations in human medial temporal lobe during wakefulness and all-night sleep', Brain Research, 891, pp. 7 - 19, http://dx.doi.org/10.1016/S0006-8993(00)03154-1

Ishiguro H; Ohtsuki T; Okubo Y; Kurumaji A; Arinami T, 2001, 'Association analysis of the pituitary adenyl cyclase activating peptide gene (PACAP) on chromosome 18p11 with schizophrenia and bipolar disorders', Journal of Neural Transmission, 108, pp. 849 - 854, http://dx.doi.org/10.1007/s007020170034

Suhara T; Yasuno F; Sudo Y; Yamamoto M; Inoue M; Okubo Y; Suzuki K, 2001, 'Dopamine D2 receptors in the insular cortex and the personality trait of novelty seeking', NeuroImage, 13, pp. 891 - 895, http://dx.doi.org/10.1006/nimg.2001.0761

Yasuno F; Suhara T; Okubo Y; Sudo Y; Inoue M; Ichimiya T; Tanada S, 2001, 'Dose relationship of limbic-cortical D2-dopamine receptor occupancy with risperidone', Psychopharmacology, 154, pp. 112 - 114, http://dx.doi.org/10.1007/s002130000643

Ito H; Sudo Y; Suhara T; Okubo Y; Halldin C; Farde L, 2001, 'Error analysis for quantification of [¹¹C]FLB 457 binding to extrastriatal D2 dopamine receptors in the human brain', NeuroImage, 13, pp. 531 - 539, http://dx.doi.org/10.1006/nimg.2000.0717

Okubo Y; Suhara T, 2001, 'Receptor occupancy and antipsychotic drug action measured by PET and SPECT', Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica, 103, pp. 329 - 340

Ichimiya T; Okubo Y; Suhara T; Sudo Y, 2001, 'Reduced volume of the cerebellar vermis in neuroleptic-naive schizophrenia', Biological Psychiatry, 49, pp. 20 - 27, http://dx.doi.org/10.1016/S0006-3223(00)01081-7

Yasuno F; Suhara T; Sudo Y; Yamamoto M; Inoue M; Okubo Y; Suzuki K, 2001, 'Relation among dopamine D2 receptor binding, obesity and personality in normal human subjects', Neuroscience Letters, 300, pp. 59 - 61, http://dx.doi.org/10.1016/S0304-3940(01)01552-X

Adachi N; Matsuura M; Okubo Y; Oana Y; Takei N; Kato M; Hara T; Onuma T, 2000, 'Predictive variables of interictal psychosis in epilepsy', Neurology, 55, pp. 1310 - 1314, http://dx.doi.org/10.1212/WNL.55.9.1310

Kikuchi M; Saito K; Watanabe A; Yamada K; Shibuya H; Nankai M; Kurumaji A; Hattori E; Ishiguro H; Shimizu H; Okubo Y; Toru M; Detera-Wadleigh SD; Yoshikawa T, 2000, 'Evidence for association of the myo-inositol monophosphatase 2 (IMPA2) gene with schizophrenia in Japanese samples', American Journal of Medical Genetics - Neuropsychiatric Genetics, 96, pp. 477

Hara K; Terasaki O; Okubo Y, 2000, 'Dipole estimation of alpha EEG during alcohol ingestion in males genotypes for ALDH2', Life Sciences, 67, pp. 1163 - 1173, http://dx.doi.org/10.1016/S0024-3205(00)00707-4

Okubo Y; Suhara T; Suzuki K; Kobayashi K; Inoue O; Terasaki O; Someya Y; Sassa T; Sudo Y; Matsushima E; Iyo M; Tateno Y; Toru M, 2000, 'Serotonin 5-HT2 receptors in schizophrenic patients studied by positron emission tomography', Life Sciences, 66, pp. 2455 - 2464, http://dx.doi.org/10.1016/S0024-3205(00)80005-3

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