By Professor Andrew John Brown

Journal articles

Meerman R; Brown A, 2018, 'Why diets fail: Eating more, moving less', Postgraduate Medical Journal, 94, pp. 65, http://dx.doi.org/10.1136/postgradmedj-2017-135153

Chua NK; Howe V; Jatana N; Thukral L; Brown AJ, 2018, 'A Conserved Degron Containing an Amphipathic Helix Regulates the Cholesterol‐Mediated Turnover of Human Squalene Monooxygenase, a Rate‐Limiting Enzyme in Cholesterol Synthesis', The FASEB Journal, 32, http://dx.doi.org/10.1096/fasebj.2018.32.1_supplement.539.4

Chua NK; Howe V; Jatana N; Thukral L; Brown AJ, 2017, 'A conserved degron containing an amphipathic helix regulates the cholesterol-mediated turnover of human squalene monooxygenase, a rate-limiting enzyme in cholesterol synthesis', Journal of Biological Chemistry, 292, pp. 19959 - 19973, http://dx.doi.org/10.1074/jbc.M117.794230

Ghai R; Du X; Wang H; Dong J; Ferguson C; Brown AJ; Parton RG; Wu JW; Yang H, 2017, 'ORP5 and ORP8 bind phosphatidylinositol-4, 5-biphosphate (PtdIns(4,5)P 2) and regulate its level at the plasma membrane', Nature Communications, 8, http://dx.doi.org/10.1038/s41467-017-00861-5

Caruana BT; Skoric A; Brown AJ; Lutze-Mann LH, 2017, 'Site-1 protease, a novel metabolic target for glioblastoma', Biochemical and Biophysical Research Communications, 490, pp. 760 - 766, http://dx.doi.org/10.1016/j.bbrc.2017.06.114

Howe V; Sharpe LJ; Prabhu AV; Brown AJ, 2017, 'New insights into cellular cholesterol acquisition: promoter analysis of human HMGCR and SQLE, two key control enzymes in cholesterol synthesis', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1862, pp. 647 - 657, http://dx.doi.org/10.1016/j.bbalip.2017.03.009

Gelissen IC; Brown AJ, 2017, 'An overview of cholesterol homeostasis', , 1583, pp. 1 - 6, http://dx.doi.org/10.1007/978-1-4939-6875-6_1

Howe V; Brown AJ, 2017, 'Determining the topology of membrane-bound proteins using PEGylation', , 1583, pp. 201 - 210, http://dx.doi.org/10.1007/978-1-4939-6875-6_15

Sharpe LJ; Brown AJ, 2017, 'Identifying sterol response elements within promoters of genes', , 1583, pp. 185 - 191, http://dx.doi.org/10.1007/978-1-4939-6875-6_13

Luu W; Gelissen IC; Brown AJ, 2017, 'Manipulating cholesterol status within cells', , 1583, pp. 41 - 52, http://dx.doi.org/10.1007/978-1-4939-6875-6_4

Prabhu AV; Luu W; Brown AJ, 2017, 'Measuring activity of cholesterol synthesis enzymes using gas chromatography/mass spectrometry', , 1583, pp. 211 - 219, http://dx.doi.org/10.1007/978-1-4939-6875-6_16

Prabhu AV; Luu W; Sharpe LJ; Brown AJ, 2017, 'Phosphorylation regulates activity of 7-dehydrocholesterol reductase (DHCR7), a terminal enzyme of cholesterol synthesis', Journal of Steroid Biochemistry and Molecular Biology, 165, pp. 363 - 368, http://dx.doi.org/10.1016/j.jsbmb.2016.08.003

Jurczyluk J; Munoz MA; Skinner OP; Chai RC; Ali N; Palendira U; Quinn JMW; Preston A; Tangye SG; Brown AJ; Argent E; Ziegler JB; Mehr S; Rogers MJ, 2016, 'Mevalonate kinase deficiency leads to decreased prenylation of Rab GTPases', Immunology and Cell Biology, 94, pp. 994 - 999, http://dx.doi.org/10.1038/icb.2016.58

Jurczyluk J; Munoz MA; Skinner OP; Chai RC; Ali N; Palendira U; Quinn JMW; Preston A; Tangye SG; Brown AJ; Argent E; Ziegler JB; Mehr S; Rogers MJ, 2016, 'Mevalonate kinase deficiency leads to decreased prenylation of Rab GTPases', IMMUNOLOGY AND CELL BIOLOGY, 94, pp. 994 - 999, http://dx.doi.org/10.1038/icb.2016.58

Prabhu AV; Luu W; Li D; Sharpe LJ; Brown AJ, 2016, 'DHCR7: A vital enzyme switch between cholesterol and vitamin D production', Progress in Lipid Research, 64, pp. 138 - 151, http://dx.doi.org/10.1016/j.plipres.2016.09.003

Howe V; Sharpe LJ; Alexopoulos SJ; Kunze SV; Chua NK; Li D; Brown AJ, 2016, 'Cholesterol homeostasis: How do cells sense sterol excess?', Chemistry and Physics of Lipids, 199, pp. 170 - 178, http://dx.doi.org/10.1016/j.chemphyslip.2016.02.011

Luu W; Sharpe LJ; Capell-Hattam I; Gelissen IC; Brown AJ, 2016, 'Oxysterols: Old Tale, New Twists', Annual Review of Pharmacology and Toxicology, 56, pp. 447 - 467, http://dx.doi.org/10.1146/annurev-pharmtox-010715-103233

Loregger A; Cook ECL; Nelson JK; Moeton M; Sharpe LJ; Engberg S; Karimova M; Lambert G; Brown AJ; Zelcer N, 2016, 'A MARCH6 and IDOL E3 ubiquitin ligase circuit uncouples cholesterol synthesis from lipoprotein uptake in hepatocytes', Molecular and Cellular Biology, 36, pp. 285 - 294, http://dx.doi.org/10.1128/MCB.00890-15

Brown AJ; Hsieh J, 2016, 'Foiling IDOL to help control cholesterol', Circulation Research, 118, pp. 371 - 373, http://dx.doi.org/10.1161/CIRCRESAHA.116.308191

Prabhu AV; Luu W; Sharpe LJ; Brown AJ, 2016, 'Cholesterol-Mediated Degradation of 7-Dehydrocholesterol Reductase Switches the Balance from Cholesterol to Vitamin D Synthesis', Journal of Biological Chemistry, http://dx.doi.org/10.1074/jbc.M115.699546

Rye KA; Barter PJ; Brown AJ, 2015, 'Speed kills in more ways than one: Methamphetamine and atherosclerosis', Atherosclerosis, 243, pp. 654 - 655, http://dx.doi.org/10.1016/j.atherosclerosis.2015.09.034

Sharpe LJ; Howe V; Prabhu AV; Luu W; Brown AJ, 2015, 'Navigating the shallows and rapids of cholesterol synthesis downstream of HMGCR', Journal of Nutritional Science and Vitaminology, 61, pp. S154 - S156, http://dx.doi.org/10.3177/jnsv.61.S154

Howe V; Chua NK; Stevenson J; Brown AJ, 2015, 'The regulatory domain of squalene monooxygenase contains a re-entrant loop and senses cholesterol via a conformational change', Journal of Biological Chemistry, 290, pp. 27533 - 27544, http://dx.doi.org/10.1074/jbc.M115.675181

Du X; Zhang Y; Jo SR; Liu X; Qi Y; Osborne B; Byrne FL; Smith GC; Turner N; Hoehn KL; Brown AJ; Yang H, 2015, 'Akt activation increases cellular cholesterol by promoting the proteasomal degradation of Niemann-Pick C1', Biochemical Journal, 471, pp. 243 - 253, http://dx.doi.org/10.1042/BJ20150602

Aleidi SM; Howe V; Sharpe LJ; Yang A; Rao G; Brown AJ; Gelissen IC, 2015, 'The E3 ubiquitin ligases, HUWE1 and NEDD4-1, are involved in the post-translational regulation of the ABCG1 and ABCG4 lipid transporters', Journal of Biological Chemistry, 290, pp. 24604 - 24613, http://dx.doi.org/10.1074/jbc.M115.675579

Sharpe LJ; Rao G; Jones PM; Glancey E; Aleidi SM; George AM; Brown AJ; Gelissen IC, 2015, 'Cholesterol sensing by the ABCG1 lipid transporter: Requirement of a CRAC motif in the final transmembrane domain', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1851, pp. 956 - 964, http://dx.doi.org/10.1016/j.bbalip.2015.02.016

Luu W; Hart-Smith G; Sharpe LJ; Brown AJ, 2015, 'The terminal enzymes of cholesterol synthesis, DHCR24 and DHCR7, interact physically and functionally', Journal of Lipid Research, 56, pp. 888 - 897, http://dx.doi.org/10.1194/jlr.M056986

Stevenson J; Brown AJ, 2015, 'Universal CG cloning of polymerase chain reaction products', Analytical Biochemistry, 471, pp. 80 - 82, http://dx.doi.org/10.1016/j.ab.2014.10.018

Moon H; Ruelcke JE; Choi E; Sharpe LJ; Nassar ZD; Bielefeldt-Ohmann H; Parat MO; Shah A; Francois M; Inder KL; Brown AJ; Russell PJ; Parton RG; Hill MM, 2015, 'Diet-induced hypercholesterolemia promotes androgen-independent prostate cancer metastasis via IQGAP1 and caveolin-1', Oncotarget, 6, pp. 7438 - 7453, http://dx.doi.org/10.18632/oncotarget.3476

Du X; Brown AJ; Yang H, 2015, 'Novel mechanisms of intracellular cholesterol transport: oxysterol-binding proteins and membrane contact sites', Current Opinion in Cell Biology, 35, pp. 37 - 42, http://dx.doi.org/10.1016/j.ceb.2015.04.002

Meerman R; Brown A, 2014, 'When somebody loses weight, where does the fat go? (vol 349, pg g7257, 2014)', BMJ-BRITISH MEDICAL JOURNAL, 349, http://dx.doi.org/10.1136/bmj.g7782

Meerman R; Brown AJ, 2014, 'When somebody loses weight, where does the fat go?', BMJ (Online), 349, http://dx.doi.org/10.1136/bmj.g7257

Stevenson J; Luu W; Kristiana I; Brown AJ, 2014, 'Squalene mono-oxygenase, a key enzyme in cholesterol synthesis, is stabilized by unsaturated fatty acids', Biochemical Journal, 461, pp. 435 - 442, http://dx.doi.org/10.1042/BJ20131404

Hsieh V; Kim MJ; Gelissen IC; Brown AJ; Sandoval C; Hallab JC; Kockx M; Traini M; Jessup W; Kritharides L, 2014, 'Cellular cholesterol regulates ubiquitination and degradation of the cholesterol export proteins ABCA1 and ABCG1', Journal of Biological Chemistry, 289, pp. 7524 - 7536, http://dx.doi.org/10.1074/jbc.M113.515890

Brown AJ; Ikonen E; Olkkonen VM, 2014, 'Cholesterol precursors: More than mere markers of biosynthesis', Current Opinion in Lipidology, 25, pp. 133 - 139, http://dx.doi.org/10.1097/MOL.0000000000000038

Tint GS; Pan L; Shang Q; Sharpe LJ; Brown AJ; Li M; Yu H, 2014, 'Desmosterol in brain is elevated because DHCR24 Needs REST for robust expression but REST is poorly expressed', Developmental Neuroscience, 36, pp. 132 - 142, http://dx.doi.org/10.1159/000362363

Zerenturk EJ; Sharpe LJ; Brown AJ, 2014, 'DHCR24 associates strongly with the endoplasmic reticulum beyond predicted membrane domains: Implications for the activities of this multi-functional enzyme', Bioscience Reports, 34, pp. 107 - 117, http://dx.doi.org/10.1042/BSR20130127

Luu W; Zerenturk EJ; Kristiana I; Bucknal MP; Sharpe LJ; Brown AJ, 2014, 'Signaling regulates activity of DHCR24, the final enzyme in cholesterol synthesi[s]', Journal of Lipid Research, 55, pp. 410 - 420, http://dx.doi.org/10.1194/jlr.M043257

Zelcer N; Sharpe LJ; Loregger A; Kristiana I; Cook ECL; Phan L; Stevenson J; Brown AJ, 2014, 'The E3 ubiquitin ligase MARCH6 degrades squalene monooxygenase and affects 3-hydroxy-3-methyl-glutaryl coenzyme a reductase and the cholesterol synthesis pathway', Molecular and Cellular Biology, 34, pp. 1262 - 1270, http://dx.doi.org/10.1128/MCB.01140-13

Prabhu AV; Sharpe LJ; Brown AJ, 2014, 'The sterol-based transcriptional control of human 7-dehydrocholesterol reductase (DHCR7): Evidence of a cooperative regulatory program in cholesterol synthesis', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1841, pp. 1431 - 1439, http://dx.doi.org/10.1016/j.bbalip.2014.07.006

Sharpe LJ; Cook ECL; Zelcer N; Brown AJ, 2014, 'The UPS and downs of cholesterol homeostasis', Trends in Biochemical Sciences, 39, pp. 527 - 535, http://dx.doi.org/10.1016/j.tibs.2014.08.008

Sharpe LJ; Burns V; Brown AJ, 2014, 'A Lipidomic Perspective on Intermediates in Cholesterol Synthesis as Indicators of Disease Status', Journal of Genetics and Genomics, 41, pp. 275 - 282, http://dx.doi.org/10.1016/j.jgg.2014.03.001

Brown A; Sharpe L; Loregger A; Cook E; Phan L; Stevenson J; Zelcer N, 2014, 'One E3 ligase targets two key control points in cholesterol synthesis (605.5)', The FASEB Journal, 28, http://dx.doi.org/10.1096/fasebj.28.1_supplement.605.5

Moon H; Hill MM; Roberts MJ; Gardiner RA; Brown AJ, 2014, 'Statins: protectors or pretenders in prostate cancer?', Trends in Endocrinology & Metabolism, 25, pp. 188 - 196, http://dx.doi.org/10.1016/j.tem.2013.12.007

Stevenson J; Krycer JR; Phan L; Brown AJ, 2013, 'A practical comparison of ligation-independent cloning techniques', PLoS ONE, 8, http://dx.doi.org/10.1371/journal.pone.0083888

Zerenturk EJ; Sharpe LJ; Ikonen E; Brown AJ, 2013, 'Desmosterol and DHCR24: Unexpected new directions for a terminal step in cholesterol synthesis', Progress in Lipid Research, 52, pp. 666 - 680, http://dx.doi.org/10.1016/j.plipres.2013.09.002

Sharpe LJ; Brown AJ, 2013, 'Controlling cholesterol synthesis beyond 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR)', Journal of Biological Chemistry, 288, pp. 18707 - 18715, http://dx.doi.org/10.1074/jbc.R113.479808

Krycer JR; Brown AJ, 2013, 'Cholesterol accumulation in prostate cancer: A classic observation from a modern perspective', Biochimica et Biophysica ACTA - Reviews on Cancer, 1835, pp. 219 - 229, http://dx.doi.org/10.1016/j.bbcan.2013.01.002

Thukral L; Brown AJ, 2013, 'Lipid-protein interactions in membranes: implications for health and disease', Journal of Clinical Lipidology, 8, pp. 43 - 45, http://dx.doi.org/10.2217/clp.12.85

Prabhu AV; Krycer JR; Brown AJ, 2013, 'Overexpression of a key regulator of lipid homeostasis, Scap, promotes respiration in prostate cancer cells', FEBS Letters, 587, pp. 983 - 988, http://dx.doi.org/10.1016/j.febslet.2013.02.040

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