Select Publications

Books

Gelissen IC; Brown AJ, (ed.), 2017, Cholesterol Homeostasis Methods and Protocols Preface, Methods in Molecular Biology, HUMANA PRESS INC, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000409258000001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Book Chapters

Brown AJ; Sharpe LJ, 2016, 'Cholesterol Synthesis', in Biochemistry of Lipids, Lipoproteins and Membranes: Sixth Edition, pp. 327 - 358, http://dx.doi.org/10.1016/B978-0-444-63438-2.00011-0

Sharpe LJ; Brown AJ, 2015, 'Investigating signaling processes in membrane trafficking.', in Membrane Trafficking, Springer, New York, pp. 81 - 90, http://dx.doi.org/10.1007/978-1-4939-2309-0_6

Sharpe LJ; Du XR; Brown AJ, 2008, 'Approaches to investigate the role of signaling in ER-to-Golgi transport', in Sheehan D; Tyther R (ed.), Methods in Molecular Biology, Two Dimensional Electrophoresis Protocols, Humana Press, Inc., United States, pp. 215 - 227

Journal articles

Chua NK; Coates HW; Brown AJ, 2020, 'Squalene monooxygenase: a journey to the heart of cholesterol synthesis', Progress in Lipid Research, vol. 79, pp. 101033, http://dx.doi.org/10.1016/j.plipres.2020.101033

Chua NK; Brown AJ, 2020, 'Lipid sensing tips the balance for a key cholesterol synthesis enzyme.', J Lipid Res, pp. jlr.ILR120000801 - jlr.ILR120000801, http://dx.doi.org/10.1194/jlr.ILR120000801

Yoshioka H; Coates HW; Chua NK; Hashimoto Y; Brown AJ; Ohgane K, 2020, 'A key mammalian cholesterol synthesis enzyme, squalene monooxygenase, is allosterically stabilized by its substrate', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, pp. 7150 - 7158, http://dx.doi.org/10.1073/pnas.1915923117

Capell-Hattam IM; Sharpe LJ; Qian L; Hart-Smith G; Prabhu AV; Brown AJ, 2020, 'Twin enzymes, divergent control: The cholesterogenic enzymes DHCR14 and LBR are differentially regulated transcriptionally and post-translationally', Journal of Biological Chemistry, vol. 295, pp. 2850 - 2865, http://dx.doi.org/10.1074/jbc.RA119.011323

Scott NA; Sharpe LJ; Capell-Hattam IM; Gullo SJ; Luu W; Brown AJ, 2020, 'The cholesterol synthesis enzyme lanosterol 14α-demethylase is post-translationally regulated by the E3 ubiquitin ligase MARCH6', Biochemical Journal, vol. 477, pp. 541 - 555, http://dx.doi.org/10.1042/BCJ20190647

Simonen P; Li S; Chua NK; Lampi AM; Piironen V; Lommi J; Sinisalo J; Brown AJ; Ikonen E; Gylling H, 2020, 'Amiodarone disrupts cholesterol biosynthesis pathway and causes accumulation of circulating desmosterol by inhibiting 24-dehydrocholesterol reductase', Journal of Internal Medicine, http://dx.doi.org/10.1111/joim.13095

Brown AJ; Sharpe LJ; Rogers MJ, 2020, 'Oxysterols: From physiological tuners to pharmacological opportunities', British Journal of Pharmacology, http://dx.doi.org/10.1111/bph.15073

Xu Y; Du X; Turner N; Brown AJ; Yang H, 2019, 'Enhanced acyl-CoA:cholesterol acyltransferase activity increases cholesterol levels on the lipid droplet surface and impairs adipocyte function', Journal of Biological Chemistry, vol. 294, pp. 19306 - 19321, http://dx.doi.org/10.1074/jbc.RA119.011160

Dong J; Du X; Wang H; Wang J; Lu C; Chen X; Zhu Z; Luo Z; Yu L; Brown AJ; Yang H; Wu JW, 2019, 'Allosteric enhancement of ORP1-mediated cholesterol transport by PI(4,5)P 2 /PI(3,4)P 2', Nature Communications, vol. 10, pp. 829, http://dx.doi.org/10.1038/s41467-019-08791-0

Brown AJ; Chua NK; Yan N, 2019, 'The shape of human squalene epoxidase expands the arsenal against cancer', Nat Commun, vol. 10, pp. 888 - 888, http://dx.doi.org/10.1038/s41467-019-08866-y

Coates HW; Chua NK; Brown AJ, 2019, 'Consulting prostate cancer cohort data uncovers transcriptional control: Regulation of the MARCH6 gene', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, vol. 1864, pp. 1656 - 1668, http://dx.doi.org/10.1016/j.bbalip.2019.08.006

Chua NK; Scott NA; Brown AJ, 2019, 'Valosin-containing protein mediates the ERAD of squalene monooxygenase and its cholesterol-responsive degron', Biochemical Journal, vol. 476, pp. 2545 - 2560, http://dx.doi.org/10.1042/BCJ20190418

Brown A; Sharpe L, 2019, 'Oxysterols', Encyclopedia of Molecular Pharmacology, vol. 3rd Edition, pp. 1 - 6, http://dx.doi.org/10.1007/978-3-030-21573-6_10016-1

Alrosan A; Aleidi SM; Yang A; Brown AJ; Gelissen IC, 2019, 'The adaptor protein alix is involved in the interaction between the ubiquitin ligase NEDD4-1 and its targets, ABCG1 and ABCG4', International Journal of Molecular Sciences, vol. 20, http://dx.doi.org/10.3390/ijms20112714

Chua NK; Hart-Smith G; Brown AJ, 2019, 'Non-canonical ubiquitination of the cholesterol-regulated degron of squalene monooxygenase', Journal of Biological Chemistry, vol. 294, pp. 8134 - 8147, http://dx.doi.org/10.1074/jbc.RA119.007798

Sharpe LJ; Howe V; Scott NA; Luu W; Phan L; Berk JM; Hochstrasser M; Brown AJ, 2019, 'Cholesterol increases protein levels of the E3 ligase MARCH6 and thereby stimulates protein degradation', Journal of Biological Chemistry, vol. 294, pp. 2436 - 2448, http://dx.doi.org/10.1074/jbc.RA118.005069

Wang H; Ma Q; Qi Y; Dong J; Du X; Rae J; Wang J; Wu WF; Brown AJ; Parton RG; Wu JW; Yang H, 2019, 'ORP2 Delivers Cholesterol to the Plasma Membrane in Exchange for Phosphatidylinositol 4, 5-Bisphosphate (PI(4,5)P 2 )', Molecular Cell, vol. 73, pp. 458 - 473.e7, http://dx.doi.org/10.1016/j.molcel.2018.11.014

Baker MAB; Brown AJ, 2019, 'A detour to sterol synthesis', Nature Microbiology, vol. 4, pp. 214 - 215, http://dx.doi.org/10.1038/s41564-018-0347-8

Coates HW; Brown AJ, 2019, 'A Wolf in sheep’s clothing: Unmasking the lanosterol-induced degradation of HMG-CoA reductase1', Journal of Lipid Research, vol. 60, pp. 1643 - 1645, http://dx.doi.org/10.1194/jlr.C119000358

Chua NK; Brown AJ, 2018, 'Correction: Mallostery: Filling a niche between quality and metabolic control.', Journal of Biological Chemistry, vol. 293, pp. 16176, http://dx.doi.org/10.1074/jbc.AAC118.006017

Chua NK; Brown AJ, 2018, 'Mallostery: Filling a niche between quality and metabolic control', Journal of Biological Chemistry, vol. 293, pp. 14951 - 14952, http://dx.doi.org/10.1074/jbc.H118.005031

Chua NK; Coates HW; Brown AJ, 2018, 'Cholesterol, cancer, and rebooting a treatment for athlete’s foot', Science Translational Medicine, vol. 10, http://dx.doi.org/10.1126/scitranslmed.aat3741

Aleidi SM; Yang A; Sharpe LJ; Rao G; Cochran BJ; Rye KA; Kockx M; Brown AJ; Gelissen IC, 2018, 'The E3 ubiquitin ligase, HECTD1, is involved in ABCA1-mediated cholesterol export from macrophages', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, vol. 1863, pp. 359 - 368, http://dx.doi.org/10.1016/j.bbalip.2017.12.011

Du X; Zadoorian A; Lukmantara IE; Qi Y; Brown AJ; Yang H, 2018, 'Oxysterol-binding protein–related protein 5 (ORP5) promotes cell proliferation by activation of MTORC1 signaling', Journal of Biological Chemistry, vol. 293, pp. 3806 - 3818, http://dx.doi.org/10.1074/jbc.RA117.001558

Brown AJ; Gelissen IC, 2018, 'Cholesterol and desmosterol dancing to the beat of a different drug', Journal of Internal Medicine, vol. 283, pp. 102 - 105, http://dx.doi.org/10.1111/joim.12710

Meerman R; Brown A, 2018, 'Why diets fail: Eating more, moving less', Postgraduate Medical Journal, vol. 94, pp. 65, http://dx.doi.org/10.1136/postgradmedj-2017-135153

Chua NK; Howe V; Jatana N; Thukral L; Brown AJ, 2017, 'A conserved degron containing an amphipathic helix regulates the cholesterol-mediated turnover of human squalene monooxygenase, a rate-limiting enzyme in cholesterol synthesis', Journal of Biological Chemistry, vol. 292, pp. 19959 - 19973, http://dx.doi.org/10.1074/jbc.M117.794230

Ghai R; Du X; Wang H; Dong J; Ferguson C; Brown AJ; Parton RG; Wu JW; Yang H, 2017, 'ORP5 and ORP8 bind phosphatidylinositol-4, 5-biphosphate (PtdIns(4,5)P 2) and regulate its level at the plasma membrane', Nature Communications, vol. 8, http://dx.doi.org/10.1038/s41467-017-00861-5

Caruana BT; Skoric A; Brown AJ; Lutze-Mann LH, 2017, 'Site-1 protease, a novel metabolic target for glioblastoma', Biochemical and Biophysical Research Communications, vol. 490, pp. 760 - 766, http://dx.doi.org/10.1016/j.bbrc.2017.06.114

Howe V; Sharpe LJ; Prabhu AV; Brown AJ, 2017, 'New insights into cellular cholesterol acquisition: promoter analysis of human HMGCR and SQLE, two key control enzymes in cholesterol synthesis', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, vol. 1862, pp. 647 - 657, http://dx.doi.org/10.1016/j.bbalip.2017.03.009

Gelissen IC; Brown AJ, 2017, 'An overview of cholesterol homeostasis', Methods in Molecular Biology, vol. 1583, pp. 1 - 6, http://dx.doi.org/10.1007/978-1-4939-6875-6_1

Howe V; Brown AJ, 2017, 'Determining the topology of membrane-bound proteins using PEGylation', Methods in Molecular Biology, vol. 1583, pp. 201 - 210, http://dx.doi.org/10.1007/978-1-4939-6875-6_15

Sharpe LJ; Brown AJ, 2017, 'Identifying sterol response elements within promoters of genes', Methods in Molecular Biology, vol. 1583, pp. 185 - 191, http://dx.doi.org/10.1007/978-1-4939-6875-6_13

Luu W; Gelissen IC; Brown AJ, 2017, 'Manipulating cholesterol status within cells', Methods in Molecular Biology, vol. 1583, pp. 41 - 52, http://dx.doi.org/10.1007/978-1-4939-6875-6_4

Prabhu AV; Luu W; Brown AJ, 2017, 'Measuring activity of cholesterol synthesis enzymes using gas chromatography/mass spectrometry', Methods in Molecular Biology, vol. 1583, pp. 211 - 219, http://dx.doi.org/10.1007/978-1-4939-6875-6_16

Prabhu AV; Luu W; Sharpe LJ; Brown AJ, 2017, 'Phosphorylation regulates activity of 7-dehydrocholesterol reductase (DHCR7), a terminal enzyme of cholesterol synthesis', Journal of Steroid Biochemistry and Molecular Biology, vol. 165, pp. 363 - 368, http://dx.doi.org/10.1016/j.jsbmb.2016.08.003

Jurczyluk J; Munoz MA; Skinner OP; Chai RC; Ali N; Palendira U; Quinn JMW; Preston A; Tangye SG; Brown AJ; Argent E; Ziegler JB; Mehr S; Rogers MJ, 2016, 'Mevalonate kinase deficiency leads to decreased prenylation of Rab GTPases', IMMUNOLOGY AND CELL BIOLOGY, vol. 94, pp. 994 - 999, http://dx.doi.org/10.1038/icb.2016.58

Prabhu AV; Luu W; Li D; Sharpe LJ; Brown AJ, 2016, 'DHCR7: A vital enzyme switch between cholesterol and vitamin D production', Progress in Lipid Research, vol. 64, pp. 138 - 151, http://dx.doi.org/10.1016/j.plipres.2016.09.003

Howe V; Sharpe LJ; Alexopoulos SJ; Kunze SV; Chua NK; Li D; Brown AJ, 2016, 'Cholesterol homeostasis: How do cells sense sterol excess?', Chemistry and Physics of Lipids, vol. 199, pp. 170 - 178, http://dx.doi.org/10.1016/j.chemphyslip.2016.02.011

Luu W; Sharpe LJ; Capell-Hattam I; Gelissen IC; Brown AJ, 2016, 'Oxysterols: Old Tale, New Twists', Annual Review of Pharmacology and Toxicology, vol. 56, pp. 447 - 467, http://dx.doi.org/10.1146/annurev-pharmtox-010715-103233

Loregger A; Cook ECL; Nelson JK; Moeton M; Sharpe LJ; Engberg S; Karimova M; Lambert G; Brown AJ; Zelcer N, 2016, 'A MARCH6 and IDOL E3 ubiquitin ligase circuit uncouples cholesterol synthesis from lipoprotein uptake in hepatocytes', Molecular and Cellular Biology, vol. 36, pp. 285 - 294, http://dx.doi.org/10.1128/MCB.00890-15

Brown AJ; Hsieh J, 2016, 'Foiling IDOL to help control cholesterol', Circulation Research, vol. 118, pp. 371 - 373, http://dx.doi.org/10.1161/CIRCRESAHA.116.308191

Prabhu AV; Luu W; Sharpe LJ; Brown AJ, 2016, 'Cholesterol-Mediated Degradation of 7-Dehydrocholesterol Reductase Switches the Balance from Cholesterol to Vitamin D Synthesis', Journal of Biological Chemistry, vol. 291, pp. 8363 - 8376, http://dx.doi.org/10.1074/jbc.M115.699546

Rye KA; Barter PJ; Brown AJ, 2015, 'Speed kills in more ways than one: Methamphetamine and atherosclerosis', Atherosclerosis, vol. 243, pp. 654 - 655, http://dx.doi.org/10.1016/j.atherosclerosis.2015.09.034

Sharpe LJ; Howe V; Prabhu AV; Luu W; Brown AJ, 2015, 'Navigating the shallows and rapids of cholesterol synthesis downstream of HMGCR', Journal of Nutritional Science and Vitaminology, vol. 61, pp. S154 - S156, http://dx.doi.org/10.3177/jnsv.61.S154

Howe V; Chua NK; Stevenson J; Brown AJ, 2015, 'The regulatory domain of squalene monooxygenase contains a re-entrant loop and senses cholesterol via a conformational change', Journal of Biological Chemistry, vol. 290, pp. 27533 - 27544, http://dx.doi.org/10.1074/jbc.M115.675181


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