By Professor Andrew John Brown

Journal articles

Fenton NM; Qian L; Paine EG; Sharpe LJ; Brown AJ, 2024, 'A paREDOX in the control of cholesterol biosynthesis: Does the NADPH sensor and E3 ubiquitin ligase MARCHF6 protect mammalian cells during oxidative stress by controlling sterol biosynthesis?', BioEssays, 46, http://dx.doi.org/10.1002/bies.202400073

Fenton NM; Qian L; Scott NA; Paine EG; Sharpe LJ; Brown AJ, 2024, 'SC5D is the sixth enzyme in cholesterol biosynthesis targeted by the E3 ubiquitin ligase MARCHF6', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1869, http://dx.doi.org/10.1016/j.bbalip.2024.159482

Coates HW; Nguyen TB; Du X; Olzomer EM; Farrell R; Byrne FL; Yang H; Brown AJ, 2024, 'The constitutively active form of a key cholesterol synthesis enzyme is lipid droplet-localized and upregulated in endometrial cancer tissues', Journal of Biological Chemistry, 300, http://dx.doi.org/10.1016/j.jbc.2024.107232

Fenton NM; Brown AJ, 2023, 'A tale of 2 gasses, 1 regulator, and cholesterol homeostasis', PLoS Biology, 21, http://dx.doi.org/10.1371/journal.pbio.3002401

Qian L; Scott NA; Capell-Hattam IM; Draper EA; Fenton NM; Luu W; Sharpe LJ; Brown AJ, 2023, 'Cholesterol synthesis enzyme SC4MOL is fine-tuned by sterols and targeted for degradation by the E3 ligase MARCHF6', Journal of Lipid Research, 64, http://dx.doi.org/10.1016/j.jlr.2023.100362

Fenton NM; Nguyen TB; Sharpe LJ; Brown AJ, 2023, 'Refining sugar's involvement in cholesterol synthesis', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1868, http://dx.doi.org/10.1016/j.bbalip.2022.159266

Coates HW; Capell-Hattam IM; Olzomer EM; Du X; Farrell R; Yang H; Byrne FL; Brown AJ, 2023, 'Hypoxia truncates and constitutively activates the key cholesterol synthesis enzyme squalene monooxygenase', eLife, 12, http://dx.doi.org/10.7554/eLife.82843

Coates HW; Brown AJ, 2023, 'Asters: rising stars in the cholesterol universe', Nature Metabolism, 5, pp. 16 - 18, http://dx.doi.org/10.1038/s42255-022-00717-3

Qian L; Sharpe LJ; Gokool A; Voineagu I; Brown AJ, 2023, 'Controlling an E3 ligase and its substrate: A function for MARCHF6 circRNA', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1868, http://dx.doi.org/10.1016/j.bbalip.2022.159237

Capell-Hattam IM; Fenton NM; Coates HW; Sharpe LJ; Brown AJ, 2022, 'The Non Catalytic Protein ERG28 has a Functional Role in Cholesterol Synthesis and is Coregulated Transcriptionally', Journal of Lipid Research, 63, http://dx.doi.org/10.1016/j.jlr.2022.100295

Yang A; Alrosan AZ; Sharpe LJ; Brown AJ; Callaghan R; Gelissen IC, 2022, 'Corrigendum to “Regulation of ABCG4 transporter expression by sterols and LXR ligands” [PMID: 33141061, DOI: 10.1016/j.bbagen.2020.129769] (BBA - General Subjects (2021) 1865(1), (S0304416520302804), (10.1016/j.bbagen.2020.129769))', Biochimica et Biophysica Acta - General Subjects, 1866, http://dx.doi.org/10.1016/j.bbagen.2022.130169

Qian L; Chai AB; Gelissen IC; Brown AJ, 2022, 'Balancing cholesterol in the brain: from synthesis to disposal', Exploration of Neuroprotective Therapy, 2, pp. 1 - 27, http://dx.doi.org/10.37349/ent.2022.00015

Mak HY; Ouyang Q; Tumanov S; Xu J; Rong P; Dong F; Lam SM; Wang X; Lukmantara I; Du X; Gao M; Brown AJ; Gong X; Shui G; Stocker R; Huang X; Chen S; Yang H, 2021, 'AGPAT2 interaction with CDP-diacylglycerol synthases promotes the flux of fatty acids through the CDP-diacylglycerol pathway', Nature Communications, 12, http://dx.doi.org/10.1038/s41467-021-27279-4

Brown AJ; Sharpe LJ; Rogers MJ, 2021, 'Oxysterols: From physiological tuners to pharmacological opportunities', British Journal of Pharmacology, 178, pp. 3089 - 3103, http://dx.doi.org/10.1111/bph.15073

Xiang J; Zhang S; Xu R; Chu H; Biswas S; Yu S; Miao D; Li W; Li S; Brown AJ; Yang H; Xu Y; Li B; Liu H, 2021, 'Elevated HB-EGF expression in neural stem cells causes middle age obesity by suppressing Hypocretin/Orexin expression', FASEB Journal, 35, http://dx.doi.org/10.1096/fj.202001945R

Yan R; Cao P; Song W; Qian H; Du X; Coates HW; Zhao X; Li Y; Gao S; Gong X; Liu X; Sui J; Lei J; Yang H; Brown AJ; Zhou Q; Yan C; Yan N, 2021, 'A structure of human scap bound to insig-2 suggests how their interaction is regulated by sterols', Science, 371, pp. 1012 - +, http://dx.doi.org/10.1126/science.abb2224

Jun SY; Brown AJ; Chua NK; Yoon JY; Lee JJ; Yang JO; Jang IS; Jeon SJ; Choi TIK; Kim CH; Kim NS, 2021, 'Reduction of Squalene Epoxidase by Cholesterol Accumulation Accelerates Colorectal Cancer Progression and Metastasis', Gastroenterology, 160, pp. 1194 - 1207.e28, http://dx.doi.org/10.1053/j.gastro.2020.09.009

Yang A; Alrosan AZ; Sharpe LJ; Brown AJ; Callaghan R; Gelissen IC, 2021, 'Regulation of ABCG4 transporter expression by sterols and LXR ligands', Biochimica et Biophysica Acta - General Subjects, 1865, http://dx.doi.org/10.1016/j.bbagen.2020.129769

Chua NK; Brown AJ, 2021, 'The Degron Architecture of Squalene Monooxygenase and How Specific Lipids Calibrate Levels of This Key Cholesterol Synthesis Enzyme', , 21, pp. 1 - 12, http://dx.doi.org/10.1007/5584_2020_583

Scott NA; Sharpe LJ; Brown AJ, 2021, 'The E3 ubiquitin ligase MARCHF6 as a metabolic integrator in cholesterol synthesis and beyond', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1866, http://dx.doi.org/10.1016/j.bbalip.2020.158837

Coates HW; Capell-Hattam IM; Brown AJ, 2021, 'The mammalian cholesterol synthesis enzyme squalene monooxygenase is proteasomally truncated to a constitutively active form', Journal of Biological Chemistry, 296, http://dx.doi.org/10.1016/j.jbc.2021.100731

, 2021, 'Encyclopedia of Molecular Pharmacology', , http://dx.doi.org/10.1007/978-3-030-57401-7

Sharpe LJ; Coates HW; Brown AJ, 2020, 'Post-translational control of the long and winding road to cholesterol', Journal of Biological Chemistry, 295, pp. 17549 - 17559, http://dx.doi.org/10.1074/jbc.REV120.010723

Sharpe LJ; Coates HW; Brown AJ, 2020, 'Post-translational control of the long and winding road to cholesterol.', J Biol Chem, 295, pp. 17549 - 17559, http://dx.doi.org/10.1074/jbc.REV120.010723

Simonen P; Li S; Chua NK; Lampi AM; Piironen V; Lommi J; Sinisalo J; Brown AJ; Ikonen E; Gylling H, 2020, 'Amiodarone disrupts cholesterol biosynthesis pathway and causes accumulation of circulating desmosterol by inhibiting 24-dehydrocholesterol reductase', Journal of Internal Medicine, 288, pp. 560 - 569, http://dx.doi.org/10.1111/joim.13095

Chua NK; Brown AJ, 2020, 'Lipid sensing tips the balance for a key cholesterol synthesis enzyme', Journal of Lipid Research, 61, pp. 1363, http://dx.doi.org/10.1194/jlr.ILR120000801

Capell-Hattam IM; Brown AJ, 2020, 'Sterol Evolution: Cholesterol Synthesis in Animals Is Less a Required Trait Than an Acquired Taste', Current Biology, 30, pp. R886 - R888, http://dx.doi.org/10.1016/j.cub.2020.06.007

Chua NK; Coates HW; Brown AJ, 2020, 'Squalene monooxygenase: a journey to the heart of cholesterol synthesis', Progress in Lipid Research, 79, http://dx.doi.org/10.1016/j.plipres.2020.101033

Yoshioka H; Coates HW; Chua NK; Hashimoto Y; Brown AJ; Ohgane K, 2020, 'A key mammalian cholesterol synthesis enzyme, squalene monooxygenase, is allosterically stabilized by its substrate', Proceedings of the National Academy of Sciences of the United States of America, 117, pp. 7150 - 7158, http://dx.doi.org/10.1073/pnas.1915923117

Capell-Hattam IM; Sharpe LJ; Qian L; Hart-Smith G; Prabhu AV; Brown AJ, 2020, 'Twin enzymes, divergent control: The cholesterogenic enzymes DHCR14 and LBR are differentially regulated transcriptionally and post-translationally', Journal of Biological Chemistry, 295, pp. 2850 - 2865, http://dx.doi.org/10.1074/jbc.RA119.011323

Scott NA; Sharpe LJ; Capell-Hattam IM; Gullo SJ; Luu W; Brown AJ, 2020, 'The cholesterol synthesis enzyme lanosterol 14α-demethylase is post-translationally regulated by the E3 ubiquitin ligase MARCH6', Biochemical Journal, 477, pp. 541 - 555, http://dx.doi.org/10.1042/BCJ20190647

Aw YC; Brown AJ; Wu JW; Yang H, 2020, 'ORP1L, ORP1S, and ORP2: Lipid Sensors and Transporters', Contact, 3, http://dx.doi.org/10.1177/2515256420956818

Xu Y; Du X; Turner N; Brown AJ; Yang H, 2019, 'Enhanced acyl-CoA:cholesterol acyltransferase activity increases cholesterol levels on the lipid droplet surface and impairs adipocyte function', Journal of Biological Chemistry, 294, pp. 19306 - 19321, http://dx.doi.org/10.1074/jbc.RA119.011160

Dong J; Du X; Wang H; Wang J; Lu C; Chen X; Zhu Z; Luo Z; Yu L; Brown AJ; Yang H; Wu JW, 2019, 'Allosteric enhancement of ORP1-mediated cholesterol transport by PI(4,5)P 2 /PI(3,4)P 2', Nature Communications, 10, http://dx.doi.org/10.1038/s41467-019-08791-0

Brown AJ; Chua NK; Yan N, 2019, 'The shape of human squalene epoxidase expands the arsenal against cancer', Nat Commun, 10, pp. 888 - 888, http://dx.doi.org/10.1038/s41467-019-08866-y

Coates HW; Chua NK; Brown AJ, 2019, 'Consulting prostate cancer cohort data uncovers transcriptional control: Regulation of the MARCH6 gene', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1864, pp. 1656 - 1668, http://dx.doi.org/10.1016/j.bbalip.2019.08.006

Chua NK; Scott NA; Brown AJ, 2019, 'Valosin-containing protein mediates the ERAD of squalene monooxygenase and its cholesterol-responsive degron', Biochemical Journal, 476, pp. 2545 - 2560, http://dx.doi.org/10.1042/BCJ20190418

Brown A; Sharpe L, 2019, 'Oxysterols', Encyclopedia of Molecular Pharmacology, 3rd Edition, pp. 1 - 6, http://dx.doi.org/10.1007/978-3-030-21573-6_10016-1

Alrosan A; Aleidi SM; Yang A; Brown AJ; Gelissen IC, 2019, 'The adaptor protein alix is involved in the interaction between the ubiquitin ligase NEDD4-1 and its targets, ABCG1 and ABCG4', International Journal of Molecular Sciences, 20, http://dx.doi.org/10.3390/ijms20112714

Chua NK; Hart-Smith G; Brown AJ, 2019, 'Non-canonical ubiquitination of the cholesterol-regulated degron of squalene monooxygenase', Journal of Biological Chemistry, 294, pp. 8134 - 8147, http://dx.doi.org/10.1074/jbc.RA119.007798

Sharpe LJ; Howe V; Scott NA; Luu W; Phan L; Berk JM; Hochstrasser M; Brown AJ, 2019, 'Cholesterol increases protein levels of the E3 ligase MARCH6 and thereby stimulates protein degradation', Journal of Biological Chemistry, 294, pp. 2436 - 2448, http://dx.doi.org/10.1074/jbc.RA118.005069

Wang H; Ma Q; Qi Y; Dong J; Du X; Rae J; Wang J; Wu WF; Brown AJ; Parton RG; Wu JW; Yang H, 2019, 'ORP2 Delivers Cholesterol to the Plasma Membrane in Exchange for Phosphatidylinositol 4, 5-Bisphosphate (PI(4,5)P 2 )', Molecular Cell, 73, pp. 458 - 473.e7, http://dx.doi.org/10.1016/j.molcel.2018.11.014

Baker MAB; Brown AJ, 2019, 'A detour to sterol synthesis', Nature Microbiology, 4, pp. 214 - 215, http://dx.doi.org/10.1038/s41564-018-0347-8

Coates HW; Brown AJ, 2019, 'A Wolf in sheep’s clothing: Unmasking the lanosterol-induced degradation of HMG-CoA reductase¹', Journal of Lipid Research, 60, pp. 1643 - 1645, http://dx.doi.org/10.1194/jlr.C119000358

Chua NK; Brown AJ, 2018, 'Correction: Mallostery: Filling a niche between quality and metabolic control.', Journal of Biological Chemistry, 293, pp. 16176, http://dx.doi.org/10.1074/jbc.AAC118.006017

Chua NK; Brown AJ, 2018, 'Mallostery: Filling a niche between quality and metabolic control', Journal of Biological Chemistry, 293, pp. 14951 - 14952, http://dx.doi.org/10.1074/jbc.H118.005031

Chua NK; Coates HW; Brown AJ, 2018, 'Cholesterol, cancer, and rebooting a treatment for athlete’s foot', Science Translational Medicine, 10, http://dx.doi.org/10.1126/scitranslmed.aat3741

Aleidi SM; Yang A; Sharpe LJ; Rao G; Cochran BJ; Rye KA; Kockx M; Brown AJ; Gelissen IC, 2018, 'The E3 ubiquitin ligase, HECTD1, is involved in ABCA1-mediated cholesterol export from macrophages', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1863, pp. 359 - 368, http://dx.doi.org/10.1016/j.bbalip.2017.12.011

Du X; Zadoorian A; Lukmantara IE; Qi Y; Brown AJ; Yang H, 2018, 'Oxysterol-binding protein–related protein 5 (ORP5) promotes cell proliferation by activation of MTORC1 signaling', Journal of Biological Chemistry, 293, pp. 3806 - 3818, http://dx.doi.org/10.1074/jbc.RA117.001558

Brown AJ; Gelissen IC, 2018, 'Cholesterol and desmosterol dancing to the beat of a different drug', Journal of Internal Medicine, 283, pp. 102 - 105, http://dx.doi.org/10.1111/joim.12710

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