By Professor Andrew John Brown

Journal articles

Luu W; Sharpe LJ; Brown AJ, 2013, 'Protein tyrosine phosphatase inhibition down-regulates ligand-induced ABCA1 expression', Atherosclerosis, 228, pp. 362 - 369, http://dx.doi.org/10.1016/j.atherosclerosis.2013.03.016

Du X; Kazim AS; Dawes IW; Brown AJ; Yang H, 2013, 'The AAA ATPase VPS4/SKD1 regulates endosomal cholesterol trafficking independently of ESCRT-III.', Traffic, 14, pp. 107 - 119, http://dx.doi.org/10.1111/tra.12015

Luu W; Sharpe LJ; Gelissen IC; Brown AJ, 2013, 'The role of signalling in cellular cholesterol homeostasis', IUBMB Life, 65, pp. 675 - 684, http://dx.doi.org/10.1002/iub.1182

Krycer JR; Phan L; Brown AJ, 2012, 'A key regulator of cholesterol homoeostasis, SREBP-2, can be targeted in prostate cancer cells with natural products', Biochemical Journal, 446, pp. 191 - 201, http://dx.doi.org/10.1042/BJ20120545

Ta MT; Kapterian T; Fei W; Du X; Brown AJ; Dawes IW; Yang H, 2012, 'Accumulation of squalene is associated with the clustering of lipid droplets.', FEBS Journal, 279, pp. 4231 - 4244, http://dx.doi.org/10.1111/febs.12015

Luu W; Sharpe LJ; Stevenson J; Brown AJ, 2012, 'Akt acutely activates the cholesterogenic transcription factor SREBP-2.', Biochimica et Biophysica ACTA - Molecular Cell Research, 1823, pp. 458 - 464, http://dx.doi.org/10.1016/j.bbamcr.2011.09.017

Du X; Kazim A; Brown AJ; Yang H, 2012, 'An essential role of Hrs/Vps27 in endosomal cholesterol trafficking', Cell Reports, 1, pp. 29 - 35

Kockx M; Dinnes DL; Huang K; Sharpe LJ; Jessup W; Brown AJ; Kritharides L, 2012, 'Cholesterol accumulation inhibits ER to Golgi transport and protein secretion: Studies of apolipoprotein E and VSVGt', Biochemical Journal, 447, pp. 51 - 60, http://dx.doi.org/10.1042/BJ20111891

Kristiana I; Luu W; Stevenson J; Cartland SP; Jessup W; Belani JD; Rychnovsky SD; Brown AJP, 2012, 'Cholesterol through the looking glass: ability of its enantiomer also to elicit homeostatic responses', The Journal of Biological Chemistry, 287, pp. 33897 - 33904, http://dx.doi.org/10.1074/jbc.M112.360537

Brown AJ, 2012, 'Cholesterol versus other sterols: How do they compare as physiological regulators of cholesterol homeostasis?', European Journal of Lipid Science and Technology, 114, pp. 617 - 623

Krycer JR; Brown AJ, 2012, 'Does changing androgen receptor status during prostate cancer development impact upon cholesterol homeostasis?', PLoS One, 8, pp. e54007, http://dx.doi.org/10.1371/journal.pone.0054007

Gelissen IC; Brown AJ, 2012, 'Highlights from the latest articles in statin pharmacogenomics: Predicting response to statins by pharmacogenetic testing.', Pharmacogenomics, 13, pp. 1223 - 1225, http://dx.doi.org/10.2217/pgs.12.107

Sharpe LJ; Wong J; Garner B; Halliday GM; Brown AJ, 2012, 'Is seladin-1 really a selective Alzheimer's disease indicator?', Journal of Alzheimer's Disease, 30, pp. 35 - 39, http://dx.doi.org/10.3233/JAD-2012-111955

Gelissen IC; Sharpe LJ; Sandoval C; Rao G; Kockx M; Kritharides L; Jessup WK; Brown AJP, 2012, 'Protein kinase A modulates the activity of a major human isoform of ABCG1', Journal of Lipid Research, 53, pp. 2133 - 2140, http://dx.doi.org/10.1194/jlr.M028795

Burns V; Sharpe LJ; Gelissen IC; Brown AJ, 2012, 'Species variation in ABCG1 isoform expression: Implications for the use of animal models in elucidating ABCG1 function', Atherosclerosis, 226, pp. 408 - 411, http://dx.doi.org/10.1016/j.atherosclerosis.2012.12.009

Zerenturk EJ; Sharpe LJ; Brown AJ, 2012, 'Sterols regulate 3β-hydroxysterol Δ24-reductase (DHCR24) via dual sterol regulatory elements: Cooperative induction of key enzymes in lipid synthesis by sterol regulatory element binding proteins.', Biochimica et Biophysica ACTA - Molecular and Cell Biology of Lipids, 1821, pp. 1350 - 1360, http://dx.doi.org/10.1016/j.bbalip.2012.07.006

Zerenturk EJ; Kristiana I; Gill S; Brown AJ, 2012, 'The endogenous regulator 24(S),25-epoxycholesterol inhibits cholesterol synthesis at DHCR24 (Seladin-1)', Biochimica et Biophysica ACTA - Molecular and Cell Biology of Lipids, 1821, pp. 1269 - 1277, http://dx.doi.org/10.1016/j.bbalip.2011.11.009

Jansen M; Wang W; Greco D; Bellenchi GC; Di Porzio U; Brown AJ; Ikonen E, 2012, 'What dictates the accumulation of desmosterol in the developing brain?', The FASEB Journal, 27, pp. 865 - 870, http://dx.doi.org/10.1096/fj.12-211235

Du XR; Kumar J; Ferguson C; Schulz TA; Ong YS; Hong W; Prinz WA; Parton RG; Brown AJ; Yang H, 2011, 'A role for oxysterol-binding protein-related protein 5 in endosomal cholesterol trafficking', Journal of Cell Biology, 192, pp. 121 - 135, http://dx.doi.org/10.1083/jcb.201004142

Fei W; Shui G; Zhang Y; Krahmer N; Ferguson C; Kapterian T; Lin RCY; Dawes IW; Brown AJ; Li P; Huang X; Parton R; Wenk M; Walther TC; Yang H, 2011, 'A role for phosphatidic acid in the formation of “supersized” lipid droplets', PLOS Genetics, 7, pp. e1002201 1 - e1002201 11, http://dx.doi.org/10.1371/journal.pgen.1002201

Sharpe LJ; Luu W; Brown AJ, 2011, 'Akt phosphorylates Sec24: New clues into the regulation of ER-to-Golgi trafficking', Traffic (Malden), 12, pp. 19 - 27, http://dx.doi.org/10.1111/j.1600-0854.2010.01133.x

Appelqvist H; Nilsson C; Garner B; Brown AJ; Kagedal K; Ollinger KM, 2011, 'Attenuation of the lysosomal death pathway by lysosomal cholesterol accumulation', American Journal of Pathology, 178, pp. 629 - 639, http://dx.doi.org/10.1016/j.ajpath.2010.10.030

Gill S; Stevenson J; Kristiana I; Brown AJ, 2011, 'Cholesterol-dependent degradation of squalene monooxygenase, a control point in cholesterol synthesis beyond HMG-CoA reductase', Cell Metabolism, 13, pp. 260 - 273, http://dx.doi.org/10.1016/j.cmet.2011.01.015

Krycer JR; Brown AJ, 2011, 'Cross-talk between the androgen receptor and the liver X receptor: Implications for cholesterol homeostasis', The Journal of Biological Chemistry, 286, pp. 20637 - 20647, http://dx.doi.org/10.1074/jbc.M111.227082

Gelissen IC; Brown AJ, 2011, 'Drug targets beyond HMG-CoA reductase: Why venture beyond the statins?', Frontiers in Biology, 6, pp. 197 - 205, http://www.springerlink.com/content/f128456281471166/

Gill S; Brown AJ, 2011, 'Exploiting a physiological regulator to improve the efficacy and safety of statins', Cardiovascular Drugs and Therapy, 25, pp. 183 - 185, http://www.springerlink.com/content/l645l6431462m908/

Brown AJ, 2011, 'Isoprenoid is a perfect fit for fat factor', Biochemical Journal, 438, pp. e1 - e3, http://www.biochemj.org/bj/438/e001/bj438e001.htm

Fei W; Li H; Shui G; Kapterian TS; Bielby C; Du X; Brown AJ; Li P; Wenk M; Liu P; Yang H, 2011, 'Molecular characterization of seipin and its mutants: implications for seipin in triacylglycerol synthesis.', Journal of Lipid Research, 52, pp. 2136 - 2147, http://www.ncbi.nlm.nih.gov/pubmed/21957196

Sharpe LJ; Eden J-S; White PA; Brown AJ, 2011, 'Norovirus RNA-dependent RNA polymerase is phosphorylated by an important survival kinase, Akt', Journal of Virology, 85, pp. 10894 - 10898, http://dx.doi.org/10.1128/JVI.05562-11

Gill S; Stevenson J; Kristiana I; Brown AJ, 2010, 'A Novel Control Point in Cholesterol Biosynthesis', FASEB JOURNAL, 24, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000208675506284&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Kristiana I; Sharpe LJ; Catts VS; Lutze-mann LH; Brown AJ, 2010, 'Antipsychotic drugs upregulate lipogenic gene expression by disrupting intracellular trafficking of lipoprotein-derived cholesterol.', Journal of Pharmacogenomics, 10, pp. 396 - 407

Brown AJ; Galea AM, 2010, 'Cholesterol as an evolutionary response to living with oxygen.', Evolution, 64, pp. 2179 - 2183

Wiklund ED; Catts VS; Catts SV; Ng TF; Whitaker NJ; Brown AJ; Lutze-Mann L, 2010, 'Cytotoxic effects of antipsychotic drugs implicate cholesterol homeostasis as a novel chemotherapeutic target.', International Journal of Cancer, 126, pp. 28 - 40

Brown AJ, 2010, 'Does upsizing statins have a downside?', Drug Safety, 33, pp. 435 - 436

Gelissen I; Cartland SP; Brown AJ; Sandoval C; Lee Y; Dinnes DL; Hsieh V; Kritharides L; Jessup W; Gaus K, 2010, 'Expression and stability of two isoforms of ABCG1 in human vascular cells.', Atherosclerosis, 208, pp. 75 - 82

Appelqvist H; Nilsson C; Garner B; Brown A; Kågedal K; Karin Öllinger , 2010, 'P2‐211: Attenuation of the lysosomal death pathway by lysosomal cholesterol accumulation', Alzheimer's & Dementia, 6, http://dx.doi.org/10.1016/j.jalz.2010.05.1260

Krycer JR; Sharpe LJ; Luu W; Brown AJ, 2010, 'The Akt-SREBP nexus: cell signaling meets lipid metabolism.', Trends in Endocrinology and Metabolism, 21, pp. 268 - 278

Brown AJ, 2009, '24(S),25-Epoxycholesterol: A messenger for cholesterol homeostasis', International Journal of Biochemistry and Cell Biology, 41, pp. 744 - 747

Brown AJ; Kristiana I; Krycer JR, 2009, 'Cholesterol homeostasis in two commonly used human prostate cancer cell-lines, LNCap and PC-3.', PLoS One, 4, pp. e8496

Stevenson J; Brown AJ, 2009, 'How essential is cholesterol?', Biochemical Journal, 420

Brown AJ; Jessup W, 2009, 'Oxysterols: Sources, cellular storage and metabolism, and new insights into their roles in cholesterol homeostasis', Molecular Aspects of Medicine, 30, pp. 111 - 122

Krycer JR; Brown AJ, 2009, 'Putative Fat Fighter Hits the Middle Man', Chemistry and biology, 16, pp. 798 - 800

Galea AM; Brown AJ, 2009, 'Special relationship between sterols and oxygen: Were sterols an adaptation to aerobic life?', Free Radical Biology and Medicine, 47, pp. 880 - 889

Sharpe LJ; Du X; Brown AJ, 2008, 'Approaches to investigate the role of signaling in ER-to-golgi transport', Methods in Molecular Biology, 457, pp. 215 - 225, http://dx.doi.org/10.1007/978-1-59745-261-8_16

McCarthy F; Brown AJ, 2008, 'Autonomous Hedgehog signalling is undetectable in PC-3 prostate cancer cells', Biochemical and Biophysical Research Communications, 373, pp. 109 - 112

Kristiana I; Yang H; Brown AJ, 2008, 'Different kinetics of cholesterol delivery to components of the cholesterol homeostatic machinery: Implications for cholesterol trafficking to the endoplasmic reticulum', Biochimica et Biophysica ACTA - Molecular and Cell Biology of Lipids, 1781, pp. 724 - 730

Wong J; Quinn CM; Gelissen I; Brown AJ, 2008, 'Endogenous 24(S),25-epoxycholesterol fine-tunes acute control of cellular cholesterol homeostasis', The Journal of Biological Chemistry, 283, pp. 700 - 707, http://dx.doi.org/10.1074/jbc.M706416200

Fei W; Shui G; Gaeta BA; Du XR; Kuerschner L; Liu P; Brown AJ; Wenk M; Parton R; Yang H, 2008, 'Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast', Journal of Cell Biology, 180, pp. 473 - 482, http://dx.doi.org/10.1083/icb.200711136

Yan DB; Mayranpaa M; Wong J; Perttila J; Lehto M; Jauhiainen M; Kovanen P; Ehnholm C; Brown AJ; Olkkonen V, 2008, 'OSBP-related protein 8 (ORP8) suppresses ABCA1 expression and cholesterol efflux from macrophages', The Journal of Biological Chemistry, 283, pp. 332 - 340, http://dx.doi.org/10.1074/jbc.M705313200

Sharpe LJ; Brown AJ, 2008, 'Rapamycin down-regulates LDL-receptor expression independently of SREBP-2', Biochemical and Biophysical Research Communications, 373, pp. 670 - 674

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