By Professor David Simon Ziegler

Conference Abstracts

Lau L; Khoung-Quang DA; Chelsea M; Wong M; Barahona P; Ajuyah P; Senapati A; Nagabushan S; Sherstyuk A; Altekoester AK; Fuentes-Bolanos N; Sullivan A; Mateos M; Tyrrell N; Haber M; Trahair T; Cowley M; Marshall G; Ekert P; Ziegler D, 2024, 'Precision-guided treatment improves outcomes for children with high-risk cancers', in EUROPEAN JOURNAL OF CANCER, ELSEVIER SCI LTD, SPAIN, Barcelona, Vol. 211, pp. S162 - S163, presented at 36th European-Organisation-for-Research-and-Treatment-of-Cancer / National-Cancer-Institute / American-Association-for-Cancer-Research Symposium on Molecular Targets and Cancer Therapeutics (EORTC/NCI/AACR), SPAIN, Barcelona, 23 October 2024 - 25 October 2024, http://dx.doi.org/10.1016/j.ejca.2024.114946

Lau LMS; Khuong-Quang D-A; Staunton J; Sanders N; Sriharan S; Trinder S; Manoharan N; Barahona P; Altekoester A-K; Dias K; Rumford M; Sylvester D; Parhar J; Mateos MK; Wong M; Mayoh C; Cowley MJ; Ekert PG; Haber M; Tyrrell V; Ziegler DS, 2024, 'Clinical utility of real-time comprehensive molecular profiling in childhood brain tumors', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, CANADA, Toronto, Vol. 84, presented at AACR Special Conference in Cancer Research: Advances in Pediatric Cancer Research, CANADA, Toronto, 05 September 2024 - 08 September 2024, http://dx.doi.org/10.1158/1538-7445.PEDIATRIC24-B012

Salomon R; Li W; Toumari M; Lowe A; Mayoh C; Barahona P; Lau LMS; Staunton J; Jacobson E; Nagabushan S; Manoharan N; Mitchell R; Ong F; Haber M; Ziegler DS; Cowley MJ; Mateos MK, 2024, 'Enhanced disease detection using single cell RNAseq in children with brain cancer', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, CANADA, Toronto, Vol. 84, presented at AACR Special Conference in Cancer Research: Advances in Pediatric Cancer Research, CANADA, Toronto, 05 September 2024 - 08 September 2024, http://dx.doi.org/10.1158/1538-7445.PEDIATRIC24-A044

Tax G; Mao J; Cadiz R; Barhen T; Xie J; Harris J; Bae M; Brown LM; Pazaky K; Gifford AJ; Mayoh C; Mateos MK; Peterziel H; Oehme I; Ziegler DS; Tsoli M; Rayner B; Ekert PG; Dolman MEM, 2024, 'Expanding therapeutic horizons: Unleashing the untapped potential of MEK inhibitor treatment in pediatric cancers', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, CANADA, Toronto, Vol. 84, presented at AACR Special Conference in Cancer Research: Advances in Pediatric Cancer Research, CANADA, Toronto, 05 September 2024 - 08 September 2024, http://dx.doi.org/10.1158/1538-7445.PEDIATRIC24-B003

Salomon R; Chen W; Shale C; Toumari M; Lowe A; Li W; Chen J; Bazaz SR; Barahona P; Cui L; Mayoh C; El-Kamand S; Tryell V; Wong-Erasmus M; Lau LMS; Bolanos NF; Cuppen E; Dong AKQ; Staunton J; Mateos MK; Trahair T; Haber M; Ziegler DS; Ekert PG; Priestley P; Cowley MJ, 2024, 'Implementing ultra-sensitive, ctDNA-based liquid biopsy for disease monitoring in paediatric tumours', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, CANADA, Toronto, Vol. 84, presented at AACR Special Conference in Cancer Research: Advances in Pediatric Cancer Research, CANADA, Toronto, 05 September 2024 - 08 September 2024, http://dx.doi.org/10.1158/1538-7445.PEDIATRIC24-A045

Manoharan N; Cooney T; Dewire-Schottmiller M; Lane A; Nellan A; Leary S; Partap S; Kilburn L; Wright KD; Hummel T; Ziegler DS; Fouladi M; Hoffman LM; Warren KE, 2024, 'CEREBROSPINAL FLUID DIVERSION DOES NOT PROLONG OVERALL SURVIVAL IN CHILDREN WITH DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG): A REPORT FROM THE INTERNATIONAL DIPG REGISTRY', in NEURO-ONCOLOGY, OXFORD UNIV PRESS INC, PA, Philadelphia, Vol. 26, presented at International Symposium on Pediatric Neuro-Oncology (ISPNO), PA, Philadelphia, 29 June 2024 - 02 July 2024, http://dx.doi.org/10.1093/neuonc/noae064.105

Holliday H; Khan A; Jayatilleke N; Mayoh C; Ross SE; Guo X; Sanguino YC; Gopalakrishnan A; Ehteda A; Tsoli M; Ziegler DS, 2024, 'COMBINED EPIGENETIC THERAPY WITH FACT AND BET INHIBITORS REMODELS CHROMATIN AND DISRUPTS ONCOGENIC TRANSCRIPTION IN DIFFUSE MIDLINE GLIOMA', in NEURO-ONCOLOGY, OXFORD UNIV PRESS INC, PA, Philadelphia, Vol. 26, presented at International Symposium on Pediatric Neuro-Oncology (ISPNO), PA, Philadelphia, 29 June 2024 - 02 July 2024, http://dx.doi.org/10.1093/neuonc/noae064.077

Desai K; Rosenberg T; Power P; Manoharan N; Nagabushan S; Green-Murphy A; Ziegler DS; Li Y; Fisher MJ; Chi S, 2024, 'IRS-III: LONG-TERM FOLLOW-UP SHOWS FAVORABLE OUTCOMES AND DURABLE RESPONSES FOR LOCALIZED ATYPICAL TERATOID RHABDOID TUMOR (ATRT)', in NEURO-ONCOLOGY, OXFORD UNIV PRESS INC, PA, Philadelphia, Vol. 26, presented at International Symposium on Pediatric Neuro-Oncology (ISPNO), PA, Philadelphia, 29 June 2024 - 02 July 2024, http://dx.doi.org/10.1093/neuonc/noae064.011

Nagabushan S; Fuentes-Bolanos N; Lau LMS; Rumford M; Warby M; Courtney E; Grant A; Rodriguez M; Solinas A; Ziegler DS; Kellie SJ; Heath J; Ballinger M; Tucker K, 2024, 'LOW GRADE GLIOMA CAUGHT IN TRANSFORMATION: UTILITY OF COMPREHENSIVE GENOMIC PROFILING IN PEDIATRIC LI FRAUMENI SYNDROME ASSOCIATED HIGH-GRADE GLIOMA', in NEURO-ONCOLOGY, OXFORD UNIV PRESS INC, PA, Philadelphia, Vol. 26, presented at International Symposium on Pediatric Neuro-Oncology (ISPNO), PA, Philadelphia, 29 June 2024 - 02 July 2024, http://dx.doi.org/10.1093/neuonc/noae064.334

Tsoli M; Ung C; Upton DH; Venkat P; Salerno A; Pandher R; Mayoh C; Vittorio O; Ziegler DS, 2024, 'OVERCOMING THE BLOOD-BRAIN BARRIER CHALLENGE IN DIFFUSE MIDLINE GLIOMA', in NEURO-ONCOLOGY, OXFORD UNIV PRESS INC, PA, Philadelphia, Vol. 26, presented at International Symposium on Pediatric Neuro-Oncology (ISPNO), PA, Philadelphia, 29 June 2024 - 02 July 2024, http://dx.doi.org/10.1093/neuonc/noae064.088

Mateos MK; Ajuyah P; Fuentes-Bolanos N; El Kamand S; Barahona P; Altekoester A; Mayoh C; Holiday H; Liu J; Cui L; Pfaff E; Mackay A; Resnick A; Pinese M; Lau LMS; Khuong-Quang D-A; Dias K; Goudie C; Salkeld A; Rokita JL; Jones DTW; Juretic N; Hayden E; Pfister SM; Kramm CM; Blattner-Johnson M; Jabado N; Tsoli M; Vittorio O; Mueller S; Guo Y; Tucker K; Waszak SM; Perreault S; Jones C; Wong-Erasmus M; Cowley MJ; Ziegler DS, 2024, 'PEDIATRIC PATIENTS WITH DIFFUSE MIDLINE GLIOMA DEMONSTRATE AN UNEXPECTED PREVALENCE OF GERMLINE VARIANTS IN HOMOLOGOUS RECOMBINATION GENES', in NEURO-ONCOLOGY, OXFORD UNIV PRESS INC, PA, Philadelphia, Vol. 26, presented at International Symposium on Pediatric Neuro-Oncology (ISPNO), PA, Philadelphia, 29 June 2024 - 02 July 2024, http://dx.doi.org/10.1093/neuonc/noae064.129

Ziegler DS; Hassall T; Valvi S; Cai D, 2024, 'PHASE 1 DOSE-ESCALATION STUDY OF ACT001 IN PEDIATRIC PATIENTS WITH ADVANCED BRAIN AND SOLID TUMORS SHOWS ACTIVITY IN DIFFUSE MIDLINE GLIOMA (DMG)', in NEURO-ONCOLOGY, OXFORD UNIV PRESS INC, PA, Philadelphia, Vol. 26, presented at International Symposium on Pediatric Neuro-Oncology (ISPNO), PA, Philadelphia, 29 June 2024 - 02 July 2024, http://dx.doi.org/10.1093/neuonc/noae064.137

Khan A; Gopalakrishnan A; Liu J; Burns MR; Tsoli M; Ziegler DS, 2024, 'STARVING TUMORS OF POLYAMINES: A NOVEL APPROACH IN TREATING AGGRESSIVE PEDIATRIC MEDULLOBLASTOMA', in NEURO-ONCOLOGY, OXFORD UNIV PRESS INC, PA, Philadelphia, Vol. 26, presented at International Symposium on Pediatric Neuro-Oncology (ISPNO), PA, Philadelphia, 29 June 2024 - 02 July 2024, http://dx.doi.org/10.1093/neuonc/noae064.510

Hayden E; Dolman EM; Upton DH; Franshaw L; Liu J; Nguyen H; Tsoli M; Guo X; Mayoh C; Rayner BS; Ziegler DS, 2024, 'TARGETING VULNERABILITIES IN PAEDIATRIC DIFFUSE MIDLINE GLIOMAS: LEVERAGING PLK1 INHIBITION TO EXPLOIT RAS/PI3K PATHWAY DEPENDENCY', in NEURO-ONCOLOGY, OXFORD UNIV PRESS INC, PA, Philadelphia, Vol. 26, presented at International Symposium on Pediatric Neuro-Oncology (ISPNO), PA, Philadelphia, 29 June 2024 - 02 July 2024, http://dx.doi.org/10.1093/neuonc/noae064.103

Rayner BS; Samadder A; Holliday H; Chen Y; Nguyen H; Lee A; Liu J; Hayden E; Ogunmodede OS; Rye K-A; Tsoli M; Bertoldo JB; Ziegler DS, 2024, 'THE BIG AND SMALL OF PROTEIN POST-TRANSLATIONAL MODIFICATIONS: TARGETING SUMOYLATION AND CITRULLINATION IN DIFFUSE MIDLINE GLIOMA', in NEURO-ONCOLOGY, OXFORD UNIV PRESS INC, PA, Philadelphia, Vol. 26, presented at International Symposium on Pediatric Neuro-Oncology (ISPNO), PA, Philadelphia, 29 June 2024 - 02 July 2024, http://dx.doi.org/10.1093/neuonc/noae064.069

Khan A; Upton D; Gopalakrishnan A; Chen Y; Tsoli M; Ziegler DS, 2024, 'TOTAL THERAPY FOR DIFFUSE MIDLINE GLIOMAS: A SEQUENTIAL, INTENSIVE, MULTI-AGENT COMBINATION PLATFORM IS A POTENT TREATMENT STRATEGY', in NEURO-ONCOLOGY, OXFORD UNIV PRESS INC, PA, Philadelphia, Vol. 26, presented at International Symposium on Pediatric Neuro-Oncology (ISPNO), PA, Philadelphia, 29 June 2024 - 02 July 2024, http://dx.doi.org/10.1093/neuonc/noae064.099

Michniewicz F; Cazzoli R; Bell J; Saletta F; Poursani E; Rouaen JR; Shai-Hee T; Vu P; Jue TR; Biery M; Bramberger L; Lim T; Khan A; Giorgi FM; Mercatelli D; Mayoh C; Cirillo G; Macmillan A; Whan R; Barlow CT; Tsoli M; Vitanza N; Berry S; Faridi P; Ziegler D; Vittorio O, 2024, 'A comprehensive approach: Copper chelation therapy modulates epigenetic, kinase signaling and metabolic pathways in diffuse midline gliomas (DMG)', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, CA, San Diego, Vol. 84, presented at Annual Meeting of the American-Association-for-Cancer-Research (AACR), CA, San Diego, 05 April 2024 - 10 April 2024, http://dx.doi.org/10.1158/1538-7445.AM2024-525

Ung C; Upton D; Venkat P; Pandher R; Mayoh C; Tsoli M; Ziegler D, 2023, 'BARRIER TO PROGRESS: DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG) INDUCES A TIGHTENED BLOOD-BRAIN BARRIER PHENOTYPE.', in NEURO-ONCOLOGY, OXFORD UNIV PRESS INC, CANADA, Vancouver, Vol. 25, presented at 28th Annual Scientific Meeting of the Society-for-Neuro-Oncology (SNO), CANADA, Vancouver, 15 November 2023 - 19 November 2023

Holliday H; Khan A; Jayatilleke N; Mayoh C; Ross SE; Sanguino YC; Gopalakrishnan A; Ehteda A; Rayner B; Tsoli M; Ziegler DS, 2023, 'Targeting the epigenome through combined Facilitates Chromatin Transcription (FACT) and Bromodomain and Extra-Terminal Domain (BET) inhibition in Diffuse Midline Glioma (DMG)', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, MN, Minneapolis, Vol. 84, presented at AACR Special Conference on Brain Cancer, MN, Minneapolis, 19 October 2023 - 22 October 2023, http://dx.doi.org/10.1158/1538-7445.BRAIN23-B016

Nagabushan S; Hamayun M; Fardell JE; Donoghoe M; Bland E; Bye A; Jacobson E; Manoharan N; Ziegler DS; McLoone JK; Johnson AM; Cohn RJ, 2023, 'COGNITIVE, ACADEMIC, AND QUALITY OF LIFE OUTCOMES IN SURVIVORS OF PEDIATRIC LOW-GRADE GLIOMA: CHALLENGING THE 'BENIGN TUMOR' PERCEPTION.', in NEURO-ONCOLOGY, OXFORD UNIV PRESS INC, DC, Washington, Vol. 25, presented at 7th Pediatric Neuro-Oncology Research Conference, DC, Washington, 22 June 2023 - 24 June 2023, http://dx.doi.org/10.1093/neuonc/noad073.221

Courtney E; Hetherington K; Ajuyah P; Altekoester A-K; Rumford M; Dias K; Sylvester D; Fuentes-Bolanos N; Warby M; Mayoh C; Kirk J; Sullivan A; Wong M; Lau L; Dong AKQ; Ekert P; Cowley M; Wakefield C; Tyrrell V; Haber M; Ziegler D; Tucker K; Barahona P; Pinese M, 2023, 'Tumour profiling frequently informs the interpretation of germline variants arising from paired analysis in children and young people', in EUROPEAN JOURNAL OF HUMAN GENETICS, SPRINGERNATURE, SCOTLAND, Glasgow, Vol. 32, pp. 572 - 572, presented at 56th Annual Conference of the European-Society-of-Human-Genetics (ESHG), SCOTLAND, Glasgow, 10 June 2023 - 13 June 2023

Upton D; George S; Liu J; Misevska K; Nguyen H; Cai DD; Su SY-C; Rayner B; Tsoli M; Ziegler D, 2023, 'ACT001 AND CBL0137: A VIABLE COMBINATION THERAPEUTIC FOR DIFFUSE INTRINSIC PONTINE GLIOMAS', in PEDIATRIC BLOOD & CANCER, WILEY, Vol. 70, pp. S153 - S153

Gereis J; Hetherington K; Robertson E; Ziegler D; Wakefield C, 2022, 'PARENTS' AND PATIENTS' UNDERSTANDING OF A PRECISION MEDICINE TRIAL FOR HIGH-RISK CHILDHOOD CANCER', in PEDIATRIC BLOOD & CANCER, WILEY, Vol. 69, pp. S399 - S399, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000859203901450&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Mayoh C; Meyran D; Nguyen T; Darcy C; Ziegler D; Haber M; Trapani J; Ekert P; Neeson P, 2022, 'PRECISION MEDICINE REVEALS A HETEROGENOUS TUMOUR IMMUNE MICROENVIRONMENT IN PAEDIATRIC GLIOMAS', in PEDIATRIC BLOOD & CANCER, WILEY, Vol. 69, pp. S327 - S328, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000859203901292&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Michniewicz F; Bell J; Saletta F; Watkinson T; Mercatelli D; Giorgi FM; Barlow CK; Faridi P; Tsoli M; Ziegler D; Vittorio O, 2022, 'COPPER CHELATION THERAPY TARGETS S-ADENOSYLMETHIONINE (SAM) METABOLISM AND EPIGENETIC REGULATORS IN DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG)', in NEURO-ONCOLOGY, OXFORD UNIV PRESS INC, GERMANY, Hamburg, Vol. 24, pp. 22 - 22, presented at 20th International Symposium on Pediatric Neuro-Oncology (ISPNO) / Annual Meeting of the Brain-Tumor-Group-of-SIOP-Europe (SIOPE-BTG), GERMANY, Hamburg, 11 June 2022 - 15 June 2022

Ung C; Upton DH; Venkat P; Pandher R; Curnis F; Corti A; Nicolazzo J; Mayoh C; Tsoli M; Ziegler DS, 2022, 'DIPG CELLS ALTER THE PERMEABILITY OF THE BLOOD-BRAIN BARRIER IN THE BRAINSTEM LEADING TO TREATMENT FAILURE', in NEURO-ONCOLOGY, OXFORD UNIV PRESS INC, GERMANY, Hamburg, Vol. 24, pp. 22 - 22, presented at 20th International Symposium on Pediatric Neuro-Oncology (ISPNO) / Annual Meeting of the Brain-Tumor-Group-of-SIOP-Europe (SIOPE-BTG), GERMANY, Hamburg, 11 June 2022 - 15 June 2022

Das A; Morgenstern D; Bianchi V; Sudhaman S; Edwards M; Stengs L; Larouche V; Samuel D; Van Damme A; Gass D; Ziegler D; Bielack S; Zelcer S; Yalon M; Constantini S; Sarosiek T; Libionka W; Nichols K; De Mola RL; Bielamowicz K; Sabel M; Frojd C; Wood MD; Sous Migueis JC; Abongwa C; Yen LY; Stearns D; Opocher E; Bhatia K; Sen S; Quiroga Cantero E; Solano Paez P; Crooks B; Magimairajan V; Reddy A; Adamski J; Mason G; Lindhorst S; Aronson M; Ertl-Wagner B; Hawkins C; Bouffet E; Tabori U, 2022, 'DUAL CTLA4/PD-1 BLOCKADE IMPROVES SURVIVAL FOR REPLICATION-REPAIR DEFICIENT HIGH-GRADE GLIOMAS FAILING SINGLE AGENT PD-1 INHIBITION: AN IRRDC STUDY', in NEURO-ONCOLOGY, OXFORD UNIV PRESS INC, GERMANY, Hamburg, Vol. 24, pp. 84 - 84, presented at 20th International Symposium on Pediatric Neuro-Oncology (ISPNO) / Annual Meeting of the Brain-Tumor-Group-of-SIOP-Europe (SIOPE-BTG), GERMANY, Hamburg, 11 June 2022 - 15 June 2022

Sanguino YC; de la Fuente LR; Kisswani D; Kearney P; Jackson E; Duchatel R; Holliday H; Jabado N; Tsoli M; Ziegler D; Dun M; Mora FV, 2022, 'EXPLORING THE ROLE OF THE EPIGENETIC FACTOR H2A.Z ACETYLATION IN DIPG', in NEURO-ONCOLOGY, OXFORD UNIV PRESS INC, GERMANY, Hamburg, Vol. 24, pp. 26 - 27, presented at 20th International Symposium on Pediatric Neuro-Oncology (ISPNO) / Annual Meeting of the Brain-Tumor-Group-of-SIOP-Europe (SIOPE-BTG), GERMANY, Hamburg, 11 June 2022 - 15 June 2022, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000840122400096&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Daniel P; Sun C; Koptyra M; Drinkwater C; Chew N; Bradshaw G; Loi M; Shi C; Tourchi M; Parackal S; Chong WC; Fernando D; Adjumain S; Hoang N; Habarakada D; Sooraj D; Crombie D; Zhukova N; Jones C; Rubens J; Raabe E; Vinci M; Dun M; Ludlow L; Nazarian J; Fletcher J; Ekert P; Ziegler D; Loh AHP; Low SYY; Monje M; Neeman N; Williams B; Resnick A; Gough D; Cain J; Firestein R, 2022, 'THE CHILDHOOD BRAIN CANCER CELL LINE ATLAS: A RESOURCE FOR BIOMARKER IDENTIFICATION AND THERAPEUTIC DEVELOPMENT', in NEURO-ONCOLOGY, OXFORD UNIV PRESS INC, GERMANY, Hamburg, Vol. 24, pp. 172 - 172, presented at 20th International Symposium on Pediatric Neuro-Oncology (ISPNO) / Annual Meeting of the Brain-Tumor-Group-of-SIOP-Europe (SIOPE-BTG), GERMANY, Hamburg, 11 June 2022 - 15 June 2022

Wood P; Desai J; Waldeck K; Cain J; Gottardo N; Strong R; Kinross K; Carr M; Jones J; Wong L; Ziegler D; Hansford J; Michael M; Ashley D, 2022, 'ATRT-17. A phase II study of continuous low dose panobinostat in paediatric patients with malignant rhabdoid tumours and atypical teratoid rhabdoid tumours.', in Neuro-Oncology, Oxford University Press (OUP), Vol. 24, pp. i6 - i7, http://dx.doi.org/10.1093/neuonc/noac079.016

Holliday H; Ehteda A; Khan A; Krug B; Rouaen JRC; Jayatilleke N; Mayoh C; Vittorio O; Jabado N; Tsoli M; Ziegler DS, 2022, 'DIPG-06. Uncovering the FACTs in Diffuse Midline Glioma (DMG)', in Neuro-Oncology, Oxford University Press (OUP), Vol. 24, pp. i18 - i18, http://dx.doi.org/10.1093/neuonc/noac079.063

Upton D; George S; Liu J; Cai DD; Su SY-C; Rayner B; Tsoli M; Ziegler D, 2022, 'DIPG-08. The development of ACT001 as a novel therapeutic for diffuse intrinsic pontine gliomas', in Neuro-Oncology, Oxford University Press (OUP), Vol. 24, pp. i19 - i19, http://dx.doi.org/10.1093/neuonc/noac079.065

Michniewicz F; Bell J; Saletta F; Watkinson T; Mercatelli D; Giorgi FM; Barlow CK; Faridi P; Tsoli M; Ziegler D; Vittorio O, 2022, 'DIPG-20. Copper chelation therapy targets S-adenosylmethionine (SAM) metabolism and epigenetic regulators in diffuse intrinsic pontine glioma (DIPG)', in Neuro-Oncology, Oxford University Press (OUP), Vol. 24, pp. i22 - i22, http://dx.doi.org/10.1093/neuonc/noac079.077

Sanguino YC; de la Fuente LR; Kisswani D; Kearney P; Jackson E; Duchatel R; Holliday H; Jabado N; Tsoli M; Ziegler D; Dun M; Mora FV, 2022, 'DIPG-37. Exploring the role of the epigenetic factor H2A.Z acetylation in DIPG', in Neuro-Oncology, Oxford University Press (OUP), Vol. 24, pp. i26 - i27, http://dx.doi.org/10.1093/neuonc/noac079.094

Landi DB; Ziegler DS; Franson AF; Baxter PA; Leary S; Larouche V; Waanders AJ; Van der Lugt J; McCowage GB; Doz F; Jabado N; Schiavello E; Zapotocky M; Cornelio I; Blackman SC; Da Costa D; Cox MC; Witt O; Kilburn LB; Hansford JR, 2022, 'FIREFLY-1 (PNOC 026): A phase 2 study to evaluate the safety and efficacy of tovorafenib (DAY101) in pediatric patients with RAF-altered recurrent or progressive low-grade glioma or advanced solid tumors.', in Journal of Clinical Oncology, American Society of Clinical Oncology (ASCO), Vol. 40, pp. TPS10062 - TPS10062, http://dx.doi.org/10.1200/jco.2022.40.16_suppl.tps10062

Cooney T; DeWire-Schottmiller M; Lane A; Saab R; Bandopadhayay P; Dorris K; Packer R; Kilburn L; Minturn J; Dodgshun A; Parkin S; Goldman S; Sandler E; Greiner R; Gottardo N; Dholaria H; Coven S; Hassall T; Hansford J; Samson Y; Leary S; Bartels U; Fonseca A; Bouffet E; Tinkle C; Monje M; Fisher P; Ziegler D; Chintagumpala M; Wagner L; Koschmann C; Leach J; Jones B; Benito EC; Bond H; Chaney B; Black K; Asher A; Fouladi M; Hoffman L; Warren K, 2022, 'PATTERNS OF CEREBROSPINAL FLUID DIVERSION AND SURVIVAL IN CHILDREN WITH DIFFUSE INTRINSIC PONTINE GLIOMA: A REPORT FROM THE INTERNATIONAL DIFFUSE INTRINSIC PONTINE GLIOMA REGISTRY', in NEURO-ONCOLOGY, OXFORD UNIV PRESS INC, Vol. 24, pp. 23 - 24, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000840122400084&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Upton D; George S; Liu J; Cai DD; Su SY-C; Rayner B; Tsoli M; Ziegler D, 2022, 'THE DEVELOPMENT OF ACT001 AS A NOVEL THERAPEUTIC FOR DIFFUSE INTRINSIC PONTINE GLIOMAS', in NEURO-ONCOLOGY, OXFORD UNIV PRESS INC, Vol. 24, pp. 19 - 19, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000840122400067&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Holliday H; Ehteda A; Khan A; Krug B; Rouaen JRC; Jayatilleke N; Mayoh C; Vittorio O; Jabado N; Tsoli M; Ziegler DS, 2022, 'UNCOVERING THE FACTS IN DIFFUSE MIDLINE GLIOMA (DMG)', in NEURO-ONCOLOGY, OXFORD UNIV PRESS INC, Vol. 24, pp. 18 - 18, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000840122400065&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Mazariego CG; Dobson M; McKay S; McGill B; Daly R; Wakefield C; Ziegler D; Taylor N, 2022, 'Designing for implementation: co-design of a paediatric oncology medicines database (ProCure) to support complex care provision for children with a hard-to-treat cancer', in ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, WILEY, Vol. 18, pp. 229 - 229

Brown MP; Gargett T; Ebert LM; Truong N; Sedivakova K; Kollis PM; Yu W; Yeo E; Vittorio O; Ziegler DS, 2022, 'Immunotherapy: IN VITRO STUDIES IN SUPPORT OF GD2-SPECIFIC CAR-T CELL THERAPY FOR AGGRESSIVE ADULT AND PEDIATRIC BRAIN TUMORS', in Cytotherapy, Elsevier BV, Vol. 24, pp. S125 - S125, http://dx.doi.org/10.1016/s1465-3249(22)00336-x

Mayoh C; Terry RL; Wong M; Lau LM; Khuong-Quang DA; Mateos MK; Tyrrell V; Haber M; Ziegler DS; Cowley MJ; Trapani JA; Neeson PJ; Ekert PG, 2021, 'Abstract 3044: The unexplored immune landscape of high-risk pediatric cancers', in Cancer Research, American Association for Cancer Research (AACR), Vol. 81, pp. 3044 - 3044, http://dx.doi.org/10.1158/1538-7445.am2021-3044

Upton D; George S; Liu J; Cai D; Su SY-C; Manoharan N; Foresto S; Hassall T; Tsoli M; Ziegler D, 2021, 'ACT001-A PROMISING THERAPEUTIC FOR DIFFUSE INTRINSIC PONTINE GLIOMAS', in NEURO-ONCOLOGY, OXFORD UNIV PRESS INC, Vol. 23, pp. 20 - 20, http://dx.doi.org/10.1093/neuonc/noab090.080

Ung C; Upton D; Tsoli M; Ziegler D, 2021, 'HGG-10. THE BLOOD-BRAIN BARRIER IN DIPG: INVESTIGATING REGION-SPECIFIC DIFFERENCES IN PERMEABILITY', in Neuro-Oncology, Oxford University Press (OUP), Vol. 23, pp. i19 - i19, http://dx.doi.org/10.1093/neuonc/noab090.076

Khan A; Gamble L; Upton D; Yu D; Pandher R; Mayoh C; Burns MR; Norris MD; Haber M; Tsoli M; Ziegler DS, 2021, 'POLYAMINE PATHWAY INHIBITION IS A POTENT NOVEL THERAPEUTIC STRATEGY AGAINST DIFFUSE INTRINSIC PONTINE GLIOMA', in NEURO-ONCOLOGY, OXFORD UNIV PRESS INC, Vol. 23, pp. 40 - 41, http://dx.doi.org/10.1093/neuonc/noab090.163

Upton D; Valvi S; Liu J; Yeung N; George S; Ung C; Khan A; Franshaw L; Ehteda A; Shen H; Orienti I; Farruggia G; Reynolds P; Tsoli M; Ziegler D, 2021, 'POTENTIAL NEW THERAPIES FOR DIFFUSE INTRINSIC PONTINE GLIOMAS IDENTIFIED THROUGH HIGH THROUGHPUT DRUG SCREENING', in NEURO-ONCOLOGY, OXFORD UNIV PRESS INC, Vol. 23, pp. 42 - 42, http://dx.doi.org/10.1093/neuonc/noab090.169

Ehteda A; Simon S; Franshaw L; Giorgi FM; Liu J; Hayden E; Rouaen J; Pang CNI; Pandher R; Mayoh C; Tang Y; Khan A; Ung C; Kankean A; Lehmann R; Shen S; Gopalakrishnan A; Trebilcock P; Gurova K; Gudkov A; Norris MD; Haber M; Vittorio O; Tsoli M; Ziegler DS, 2021, 'TARGETING FACILITATES CHROMATIN TRANSCRIPTION (FACT) AS A NOVEL STRATEGY THAT ENHANCES RESPONSE TO HISTONE DEACETYLASE (HDAC) INHIBITION IN DIPG', in NEURO-ONCOLOGY, OXFORD UNIV PRESS INC, Vol. 23, pp. 18 - 19, http://dx.doi.org/10.1093/neuonc/noab090.075

Mayoh C; Terry RL; Wong M; Lau LM; Khuong-Quang DA; Mateos MK; Tyrrell V; Haber M; Ziegler DS; Cowley MJ; Trapani JA; Neeson PJ; Ekert PG, 2021, 'The unexplored immune landscape of high-risk pediatric cancers.', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, PA, Philadelphia, Vol. 81, presented at Annual Meeting of the American-Association-for-Cancer-Research (AACR), PA, Philadelphia, 10 April 2021 - 21 May 2021

Ung C; Tsoli M; Liu J; Cassano D; Upton D; Ehteda A; Mansfield F; Failes T; Kavallaris M; Arndt G; Vittorio O; Voliani V; Cirilo G; Ziegler DS, 2020, 'DDEL-12. NANOPARTICLE DELIVERY OF DOXORUBICIN FOR THE TREATMENT OF DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG)', in Neuro-Oncology, Oxford University Press (OUP), Vol. 22, pp. iii286 - iii286, http://dx.doi.org/10.1093/neuonc/noaa222.047

Upton D; Valvi S; Liu J; Yeung N; George S; Ung C; Khan A; Franshaw L; Ehteda A; Shen H; Orienti I; Farruggia G; Nath C; Reynolds P; Tsoli M; Ziegler D, 2020, 'DIPG-07. HIGH THROUGHPUT DRUG SCREENING IDENTIFIES POTENTIAL NEW THERAPIES FOR DIFFUSE INTRINSIC PONTINE GLIOMAS (DIPGs)', in Neuro-Oncology, Oxford University Press (OUP), Vol. 22, pp. iii288 - iii288, http://dx.doi.org/10.1093/neuonc/noaa222.058

Franshaw L; Hayden E; Joshi S; Liu J; Ehteda A; Pang CNI; Tsoli M; Ziegler DS, 2020, 'DIPG-14. TARGETING POLO-LIKE KINASE 1 IN COMBINATION WITH KEY ONCOGENIC DRIVERS IN DIPG: FROM SINGLE AGENT TO COMBINATION STRATEGIES', in Neuro-Oncology, Oxford University Press (OUP), Vol. 22, pp. iii289 - iii289, http://dx.doi.org/10.1093/neuonc/noaa222.064

Back to profile page