Select Publications
Journal articles
, 2026, 'Precision-guided therapy in H3K27-altered diffuse midline glioma', Nature Communications, 17, http://dx.doi.org/10.1038/s41467-026-73304-9
, 2026, 'RNA N6-methyladenosine (m6A) regulates cell cycle progression in diffuse midline glioma (DMG) and confers sensitivity to FTO inhibition', Cell Death and Disease, 17, http://dx.doi.org/10.1038/s41419-026-08647-8
, 2026, 'Family experiences of receiving treatment recommendations in a precision medicine trial for poor-prognosis childhood cancer', npj Genomic Medicine, http://dx.doi.org/10.1038/s41525-026-00591-y
, 2026, 'Comprehensive Multiplatform Tyrosine Kinase Profiling Reveals Novel Actionable FGFR Aberrations across Sarcomas Affecting the Young', Molecular Cancer Therapeutics, 25, pp. 1077 - 1094, http://dx.doi.org/10.1158/1535-7163.mct-25-0736
, 2026, 'ID #107 Family experiences of precision-guided treatment recommendations for poor prognosis paediatric Central Nervous System (CNS) cancer', Neuro-Oncology Pediatrics, 2, pp. wuag026.020, http://dx.doi.org/10.1093/neuped/wuag026.020
, 2026, 'ID #1113 Low dose intravenous autologous third generation GD2-CAR-T cell therapy in diffuse midline glioma patients: anti-tumour activity with minimal toxicity', Neuro-Oncology Pediatrics, 2, http://dx.doi.org/10.1093/neuped/wuag026.501
, 2026, 'ID #112 PAEDNEOVAX - Multicentre, investigator-initiated phase I/II study to assess safety and efficacy of personalised mRNA vaccine targetting tumour-associated neoantigens in children and young adults with high-risk brain tumours.', Neuro-Oncology Pediatrics, 2, pp. wuag026.021, http://dx.doi.org/10.1093/neuped/wuag026.021
, 2026, 'ID #1122 Preliminary feasibility of an international, multidisciplinary central screening platform for the CONNECT TarGeT molecularly-guided phase 2 umbrella trial for children and young adults with newly-diagnosed high-grade glioma (HGG) including diffuse intrinsic pontine glioma (DIPG)', Neuro-Oncology Pediatrics, 2, http://dx.doi.org/10.1093/neuped/wuag026.507
, 2026, 'ID #1128 Lynch syndrome-associated high-grade glioma in adolescence: implications of integrated molecular profiling for diagnosis and therapy', Neuro-Oncology Pediatrics, 2, http://dx.doi.org/10.1093/neuped/wuag026.511
, 2026, 'ID #140 Clinical, Radiological and Molecular Characteristics of H3K27M-mutant Pediatric Primary Spinal Diffuse Midline Glioma: An International Multi-registry and Institutional Study', Neuro-Oncology Pediatrics, 2, http://dx.doi.org/10.1093/neuped/wuag026.031
, 2026, 'ID #311 Targeting MYC-driven vulnerabilities in lethal childhood brain tumours using a first-in-class brain-penetrant MYC degrader', Neuro-Oncology Pediatrics, 2, http://dx.doi.org/10.1093/neuped/wuag026.091
, 2026, 'ID #421 Copper deprivation disrupts epigenetic, kinase, and metabolic signaling to induce DNA damage and mitotic failure in Diffuse Midline Glioma', Neuro-Oncology Pediatrics, 2, pp. wuag026.142, http://dx.doi.org/10.1093/neuped/wuag026.142
, 2026, 'ID #429 Therapeutic development of the clinically active compound ACT001 with Mcl-1 inhibitors for the treatment of paediatric diffuse midline glioma', Neuro-Oncology Pediatrics, 2, http://dx.doi.org/10.1093/neuped/wuag026.148
, 2026, 'ID #500 Novel therapeutic targets in drug-resistant BRAFV600E paediatric high-grade glioma', Neuro-Oncology Pediatrics, 2, http://dx.doi.org/10.1093/neuped/wuag026.183
, 2026, 'ID #598 Unravelling the Role of Neural Progenitor Cells in the Development of Paediatric High-Grade Glioma', Neuro-Oncology Pediatrics, 2, http://dx.doi.org/10.1093/neuped/wuag026.228
, 2026, 'ID #661 Psychological distress in parents of children with poor prognosis central nervous system (CNS) cancers participating in the PRISM precision medicine trial', Neuro-Oncology Pediatrics, 2, pp. wuag026.264, http://dx.doi.org/10.1093/neuped/wuag026.264
, 2026, 'ID #672 A phase II study of continuous low dose panobinostat in paediatric patients with atypical teratoid rhabdoid tumours (ATRT).', Neuro-Oncology Pediatrics, 2, http://dx.doi.org/10.1093/neuped/wuag026.271
, 2026, 'ID #673 Bereaved Parents’ Reflections on PRISM Precision Medicine Trial Participation for Poor-Prognosis Paediatric CNS Cancer', Neuro-Oncology Pediatrics, 2, http://dx.doi.org/10.1093/neuped/wuag026.272
, 2026, 'ID #674 Unmasking Epigenomic Vulnerabilities in Diffuse Midline Glioma to Guide Epigenetic Therapy', Neuro-Oncology Pediatrics, 2, http://dx.doi.org/10.1093/neuped/wuag026.273
, 2026, 'ID #676 Precision-Guided Oncology for Pediatric Brain Tumors Using Functional Ex Vivo Drug Sensitivity Profiling', Neuro-Oncology Pediatrics, 2, http://dx.doi.org/10.1093/neuped/wuag026.275
, 2026, 'ID #736 Ultra-sensitive plasma ctDNA assay enables detection of brain tumour DNA in peripheral blood and is prognostic in childhood brain cancer', Neuro-Oncology Pediatrics, 2, pp. wuag026.309, http://dx.doi.org/10.1093/neuped/wuag026.309
, 2026, 'ID #771 Inhibition of MCL-1-mediated anti-apoptotic signalling as a potential therapeutic strategy for paediatric high-grade gliomas', Neuro-Oncology Pediatrics, 2, http://dx.doi.org/10.1093/neuped/wuag026.326
, 2026, 'ID #811 Modelling the human blood-brain barrier in 3D to accelerate nanoparticle delivery strategies for brain cancer', Neuro-Oncology Pediatrics, 2, http://dx.doi.org/10.1093/neuped/wuag026.339
, 2026, 'ID #832 FIREFLY-1 3-Year Results: Impact of Prior Therapy on Tovorafenib Activity in BRAF-Altered Pediatric Low-Grade Glioma', Neuro-Oncology Pediatrics, 2, http://dx.doi.org/10.1093/neuped/wuag026.351
, 2026, 'ID #867 Targeting lactate production pathways as a novel therapy against DIPG', Neuro-Oncology Pediatrics, 2, http://dx.doi.org/10.1093/neuped/wuag026.368
, 2026, 'ID #95 Dual polyamine pathway blockade synergises with irinotecan to eradicate MYC-driven medulloblastoma', Neuro-Oncology Pediatrics, 2, http://dx.doi.org/10.1093/neuped/wuag026.017
, 2026, 'Targeted therapies plus radiotherapy for diffuse intrinsic pontine glioma: the randomized phase 2 BIOMEDE trial', Nature Medicine, 32, pp. 2201 - 2215, http://dx.doi.org/10.1038/s41591-026-04354-1
, 2026, 'Integrated Germline and Somatic Molecular Profiling to Detect Cancer Predisposition Has a High Clinical Impact in Poor-Prognosis Pediatric Cancer', Clinical Cancer Research, 32, pp. 2047 - 2059, http://dx.doi.org/10.1158/1078-0432.CCR-25-3806
, 2026, 'A new hope: Clinical advances in targeted therapies for pediatric diffuse midline glioma', Neuro Oncology Advances, 8, pp. ii41 - ii58, http://dx.doi.org/10.1093/noajnl/vdaf008
, 2026, 'Clinical stability after tovorafenib treatment in patients with relapsed/refractory pediatric low-grade glioma: Updated results from the phase 2 FIREFLY-1 trial', Neuro-Oncology Pediatrics, 2, pp. wuag022, http://dx.doi.org/10.1093/neuped/wuag022
, 2026, 'Metabolic dependencies and neural progenitor dysregulation: driving forces in paediatric high-grade glioma development', Cancer and Metastasis Reviews, 45, http://dx.doi.org/10.1007/s10555-026-10325-2
, 2026, 'Combined inhibition of FACT and BET disrupts transcription to suppress tumor growth in mouse models of diffuse midline glioma', Science Translational Medicine, 18, http://dx.doi.org/10.1126/scitranslmed.adr1557
, 2026, 'A single logic model capturing clinical, service, and implementation interventions using a practical example in pediatric precision medicine', Jbi Evidence Implementation, http://dx.doi.org/10.1097/XEB.0000000000000600
, 2025, 'Animated videos for childhood cancer precision medicine: development and evaluation with parents and patients', Supportive Care in Cancer, 33, http://dx.doi.org/10.1007/s00520-025-10191-8
, 2025, 'Arginine depletion potentiates standard-of-care chemo-immunotherapy in preclinical models of high-risk neuroblastoma', Journal of Experimental and Clinical Cancer Research, 44, http://dx.doi.org/10.1186/s13046-025-03502-8
, 2025, 'Chemotherapy reprograms miRNA expression profiles in apoptotic extracellular vesicles from medulloblastoma cells, regulating pro- and anti-proliferative effects on recipient drug-naïve cells', Cell Communication and Signaling, 23, http://dx.doi.org/10.1186/s12964-025-02241-9
, 2025, 'Returning raw genomic data to research participants in a pediatric cancer precision medicine trial', Npj Genomic Medicine, 10, http://dx.doi.org/10.1038/s41525-025-00470-y
, 2025, 'CTP-17. Clinical stability following tovorafenib treatment in relapsed/refractory pediatric low-grade glioma: updated results from the phase 2 FIREFLY-1 trial', Neuro-Oncology, 27, pp. v149 - v149, http://dx.doi.org/10.1093/neuonc/noaf201.0589
, 2025, 'Beyond base camp: PI3K/mTOR inhibition for the treatment of pediatric high-grade gliomas', Neuro Oncology, 27, pp. 2789 - 2803, http://dx.doi.org/10.1093/neuonc/noaf163
, 2025, 'Data Sharing, Biopsies and Patient Confidentiality in a Precision Medicine Trial for Childhood Cancer: A Mixed Method Study of Parents, Oncologists, and Scientists’ Perspectives', Journal of Personalized Medicine, 15, http://dx.doi.org/10.3390/jpm15110531
, 2025, 'From Sequencing to Survival: The Growing Role of Precision Medicine in Paediatric Oncology', Targeted Oncology, 20, pp. 907 - 915, http://dx.doi.org/10.1007/s11523-025-01178-w
, 2025, 'OR28-05 Selpercatinib in Pediatric and Adolescent Patients with RET-Altered Solid Tumors: Safety and Efficacy Results from the Phase 1/2 LIBRETTO-121 Study', Journal of the Endocrine Society, 9, http://dx.doi.org/10.1210/jendso/bvaf149.1746
, 2025, 'Abstract A017-PR013: Alectinib in children and adolescents with solid or CNS tumors harboring ALK-fusions: An update from the iMATRIX alectinib phase I/II open-label, multi-center study', Cancer Research, 85, http://dx.doi.org/10.1158/1538-7445.pediatric25-a017-pr013
, 2025, 'Cooperation between germline and somatic drivers in childhood cancer: insights from the ZERO cohort', CANCER RESEARCH, 85, pp. A45 - A45, http://dx.doi.org/10.1158/1538-7445.PEDIATRIC25-A045
, 2025, 'The biology of childhood tumors with germline CHEK2 loss of function variants', CANCER RESEARCH, 85, pp. A44 - A44, http://dx.doi.org/10.1158/1538-7445.PEDIATRIC25-A044
, 2025, 'Whole-genome-based, tumor-informed circulating tumor DNA detection correlates with treatment response and survival of pediatric solid tumor', CANCER RESEARCH, 85, pp. A001PR9 - A001PR9, http://dx.doi.org/10.1158/1538-7445.PEDIATRIC25-A001-PR009
, 2025, 'The Immunization Agenda 2030 Strategy to reach zero-dose children in low-income and middle-income countries: a scoping review', BMJ Global Health, 10, http://dx.doi.org/10.1136/bmjgh-2024-018293
, 2025, 'Multiancestry Transcriptome-Wide Association Study Identifies Candidate Genes Associated with Hepatoblastoma', Cancer Epidemiology Biomarkers and Prevention, 34, pp. 1405 - 1414, http://dx.doi.org/10.1158/1055-9965.EPI-24-1553
, 2025, 'The Spectrum of IDH-and H3-Wildtype High-Grade Glioma Subgroups Occurring across Teenage and Young Adult Patient Populations', Clinical Cancer Research, 31, pp. 3259 - 3275, http://dx.doi.org/10.1158/1078-0432.CCR-24-1256
, 2025, 'Author Correction: The type II RAF inhibitor tovorafenib in relapsed/refractory pediatric low-grade glioma: the phase 2 FIREFLY-1 trial (Nature Medicine, (2024), 30, 1, (207-217), 10.1038/s41591-023-02668-y)', Nature Medicine, 31, pp. 2454, http://dx.doi.org/10.1038/s41591-025-03709-4