By Professor David Thomas

Journal articles

Gaston CL; Grimer RJ; Parry M; Stacchiotti S; Dei Tos AP; Gelderblom H; Ferrari S; Baldi GG; Jones RL; Chawla S; Casali P; LeCesne A; Blay J-Y; Dijkstra SPD; Thomas DM; Rutkowski P, 2016, 'Current status and unanswered questions on the use of Denosumab in giant cell tumor of bone', Clinical Sarcoma Research, 6, pp. 15, http://dx.doi.org/10.1186/s13569-016-0056-0

Thomas D, 2016, 'International survey of awareness of genetic risk in the clinical sarcoma community', Asia Pac J Clin Oncol, 12, pp. 133 - 142, http://dx.doi.org/10.1111/ajco.12457

Sampson JN; Wheeler WA; Yeager M; Panagiotou O; Wang Z; Berndt SI; Lan Q; Abnet CC; Amundadottir LT; Figueroa JD; Landi MT; Mirabello L; Savage SA; Taylor PR; De Vivo I; McGlynn KA; Purdue MP; Rajaraman P; Adami HO; Ahlbom A; Albanes D; Amary MF; An SJ; Andersson U; Andriole G; Andrulis IL; Angelucci E; Ansell SM; Arici C; Armstrong BK; Arslan AA; Austin MA; Baris D; Barkauskas DA; Bassig BA; Becker N; Benavente Y; Benhamou S; Berg C; Van Den Berg D; Bernstein L; Bertrand KA; Birmann BM; Black A; Boeing H; Boffetta P; Boutron-Ruault MC; Bracci PM; Brinton L; Brooks-Wilson AR; Bueno-De-Mesquita HB; Burdett L; Buring J; Butler MA; Cai Q; Cancel-Tassin G; Canzian F; Carrato A; Carreon T; Carta A; Chan JKC; Chang ET; Chang GC; Chang IS; Chang J; Chang-Claude J; Chen CJ; Chen CY; Chen C; Chen CH; Chen C; Chen H; Chen K; Chen KY; Chen KC; Chen Y; Chen YH; Chen YS; Chen YM; Chien LH; Chirlaque MD; Choi JE; Choi YY; Chow WH; Chung CC; Clavel J; Clavel-Chapelon F; Cocco P; Colt JS; Comperat E; Conde L; Connors JM; Conti D; Cortessis VK; Cotterchio M; Cozen W; Crouch S; Crous-Bou M; Cussenot O; Davis FG, 2015, 'Analysis of heritability and shared heritability based on genome-wide association studies for thirteen cancer types', Journal of the National Cancer Institute, 107, http://dx.doi.org/10.1093/jnci/djv279

Thomas DM; Fox S; Lorgelly PK; Ashley D; Richardson G; Lipton L; Parisot JP; Lucas M; McNeil J, 2015, 'Cancer 2015: A longitudinal whole-of-system study of genomic cancer medicine', Drug Discovery Today, 20, pp. 1429 - 1432, http://dx.doi.org/10.1016/j.drudis.2015.10.009

Martin JH; Phillips E; Thomas D; Somogyi AA, 2015, 'Adding the 'medicines' back into personalized medicine to improve cancer treatment outcomes', British Journal of Clinical Pharmacology, 80, pp. 929 - 931, http://dx.doi.org/10.1111/bcp.12690

Parisot JP; Thorne H; Fellowes A; Doig K; Lucas M; McNeil JJ; Doble B; Dobrovic A; John T; James PA; Lipton L; Ashley D; Hayes T; McMurrick P; Richardson G; Lorgelly P; Fox SB; Thomas DM, 2015, '“Cancer 2015”: A prospective, population-based cancer cohort—phase 1: Feasibility of genomics-guided precision medicine in the clinic', Journal of Personalized Medicine, 5, pp. 354 - 369, http://dx.doi.org/10.3390/jpm5040354

Papenfuss AT; Thomas DM, 2015, 'The life history of neochromosomes revealed', Molecular and Cellular Oncology, 2, http://dx.doi.org/10.1080/23723556.2014.1000698

Mirabello L; Koster R; Moriarity BS; Spector LG; Meltzer PS; Gary J; Machiela MJ; Pankratz N; Panagiotou OA; Largaespada D; Wang Z; Gastier-Foster JM; Gorlick R; Khanna C; de Toledo SRC; Petrilli AS; Patiño-Garcia A; Sierrasesúmaga L; Lecanda F; Andrulis IL; Wunder JS; Gokgoz N; Serra M; Hattinger C; Picci P; Scotlandi K; Flanagan AM; Tirabosco R; Amary MF; Halai D; Ballinger ML; Thomas DM; Davis S; Barkauskas DA; Marina N; Helman L; Otto GM; Becklin KL; Wolf NK; Weg MT; Tucker M; Wacholder S; Fraumeni JF; Caporaso NE; Boland JF; Hicks BD; Vogt A; Burdett L; Yeager M; Hoover RN; Chanock SJ; Savage SA, 2015, 'A genome-wide scan identifies variants in NFIB associated with metastasis in patients with osteosarcoma', Cancer Discovery, 5, pp. 920 - 931, http://dx.doi.org/10.1158/2159-8290.CD-15-0125

Thomas DM, 2015, 'The growing problem of benign connective tissue tumours', Lancet Oncology, 16, pp. 879 - 880, http://dx.doi.org/10.1016/S1470-2045(15)00147-3

Ballinger ML; Mitchell G; Thomas DM, 2015, 'Surveillance recommendations for patients with germline TP53 mutations', Current Opinion in Oncology, 27, pp. 332 - 337, http://dx.doi.org/10.1097/CCO.0000000000000200

Thomas DM; James PA; Ballinger ML, 2015, 'Clinical implications of genomics for cancer risk genetics', Lancet Oncology, 16, pp. e303 - e308, http://dx.doi.org/10.1016/S1470-2045(15)70026-4

Cassier PA; Maki RG; Wagner AJ; Bompas E; Gelderblom H; Kroep JR; Thomas DM; Italiano A; Seddon BM; Van Der Graaf WTA; Domont J; Blay J-Y; Stacchiotti S, 2015, 'Imatinib mesylate (IM) activity in patients (pts) with locally advanced tenosynovial giant cell tumor/pigmented villonodular synovitis (TGCT).', Journal of Clinical Oncology, 33, pp. 10561 - 10561, http://dx.doi.org/10.1200/jco.2015.33.15_suppl.10561

Chantrill LA; Nagrial AM; Watson C; Johns AL; Martyn-Smith M; Simpson S; Mead S; Jones MD; Samra JS; Gill AJ; Watson N; Chin VT; Humphris JL; Chou A; Brown B; Morey A; Pajic M; Grimmond SM; Chang DK; Thomas D; Sebastian L; Sjoquist K; Yip S; Pavlakis N; Asghari R; Harvey S; Grimison P; Simes J; Biankin AV, 2015, 'Precision medicine for advanced pancreas cancer: The individualized molecular pancreatic cancer therapy (IMPaCT) Trial', Clinical Cancer Research, 21, pp. 2029 - 2037, http://dx.doi.org/10.1158/1078-0432.CCR-15-0426

Thomas DM; Wood MA, 2015, 'THE EMERGENCE OF NEGATIVE SUPERHUMPS IN CATACLYSMIC VARIABLES: SMOOTHED PARTICLE HYDRODYNAMICS SIMULATIONS', ASTROPHYSICAL JOURNAL, 803, http://dx.doi.org/10.1088/0004-637X/803/2/55

Wong SQ; Fellowes A; Doig K; Ellul J; Bosma TJ; Irwin D; Vedururu R; Tan AYC; Weiss J; Chan KS; Lucas M; Thomas DM; Dobrovic A; Parisot JP; Fox SB, 2015, 'Assessing the clinical value of targeted massively parallel sequencing in a longitudinal, prospective population-based study of cancer patients', British Journal of Cancer, 112, pp. 1411 - 1420, http://dx.doi.org/10.1038/bjc.2015.80

Thomas DM; Ballinger ML, 2015, 'Etiologic, environmental and inherited risk factors in sarcomas', Journal of Surgical Oncology, 111, pp. 490 - 495, http://dx.doi.org/10.1002/jso.23809

Ashley D; Thomas D; Gore L; Carter R; Zalcberg JR; Otmar R; Savulescu J, 2015, 'Accepting risk in the acceleration of drug development for rare cancers', Lancet Oncology, 16, pp. e190 - e194, http://dx.doi.org/10.1016/S1470-2045(14)71153-2

Tattersall MHN; Thomas DM, 2015, 'Distinguishing activity from progress', Lancet Oncology, 16, pp. 1586 - 1588, http://dx.doi.org/10.1016/S1470-2045(15)00466-0

Neuhaus SJ; Thomas D; Desai J; Vuletich C; Von Dincklage J; Olver I, 2015, 'Wiki-based clinical practice guidelines for the management of adult onset sarcoma: A new paradigm in sarcoma evidence', Sarcoma, 2015, http://dx.doi.org/10.1155/2015/614179

Glover M; Kira A; Johnston V; Walker N; Thomas D; Chang AB; Bullen C; Segan CJ; Brown N, 2015, 'A systematic review of barriers and facilitators to participation in randomized controlled trials by Indigenous people from New Zealand, Australia, Canada and the United States', GLOBAL HEALTH PROMOTION, 22, pp. 21 - 31, http://dx.doi.org/10.1177/1757975914528961

Glover M; Kira A; Johnston V; Walker N; Brown N; Thomas D, 2015, 'Australian and New Zealand Indigenous mothers' report respect for smoking bans in homes', WOMEN AND BIRTH, 28, pp. 1 - 7, http://dx.doi.org/10.1016/j.wombi.2014.09.004

Walker N; Johnston V; Glover M; Bullen C; Trenholme A; Chang A; Morris P; Segan C; Brown N; Fenton D; Hawthorne E; Borland R; Parag V; Von Blaramberg T; Westphal D; Thomas D, 2015, 'Effect of a Family-Centered, Secondhand Smoke Intervention to Reduce Respiratory Illness in Indigenous Infants in Australia and New Zealand: A Randomized Controlled Trial', NICOTINE & TOBACCO RESEARCH, 17, pp. 48 - 57, http://dx.doi.org/10.1093/ntr/ntu128

Lewin J; Khamly KK; Young RJ; Mitchell C; Hicks RJ; Toner GC; Ngan SYK; Chander S; Powell GJ; Herschtal A; Te Marvelde L; Desai J; Choong PFM; Stacker SA; Achen MG; Ferris N; Fox S; Slavin J; Thomas DM, 2014, 'A phase Ib/II translational study of sunitinib with neoadjuvant radiotherapy in soft-tissue sarcoma', British Journal of Cancer, 111, pp. 2254 - 2261, http://dx.doi.org/10.1038/bjc.2014.537

Wang Z; Zhu B; Zhang M; Parikh H; Jia J; Chung CC; Sampson JN; Hoskins JW; Hutchinson A; Burdette L; Ibrahim A; Hautman C; Raj PS; Abnet CC; Adjei AA; Ahlbom A; Albanes D; Allen NE; Ambrosone CB; Aldrich M; Amiano P; Amos C; Andersson U; Gerald Andriole GA; Andrulis IL; Arici C; Arslan AA; Austin MA; Baris D; Barkauskas DA; Bassig BA; Freeman LEB; Berg CD; Berndt SI; Bertazzi PA; Biritwum RB; Black A; Blot W; Boeing H; Boffetta P; Bolton K; Boutron-Ruault MC; Bracci PM; Brennan P; Brinton LA; Brotzman M; Bueno-de-Mesquita HB; Buring JE; Butler MA; Cai Q; Cancel-Tassin G; Canzian F; Cao G; Caporaso NE; Carrato A; Carreon T; Carta A; Chang GC; Chang IS; Chang-Claude J; Che X; Chen CJ; Chen CY; Chen CH; Chen C; Chen KY; Chen YM; Chokkalingam AP; Chu LW; Clavel-Chapelon F; Colditz GA; Colt JS; Conti D; Cook MB; Cortessis VK; Crawford ED; Cussenot O; Davis FG; De Vivo I; Deng X; Ding T; Dinney CP; Di Stefano AL; Diver WR; Duell EJ; Elena JW; Fan JH; Feigelson HS; Feychting M; Figueroa JD; Flanagan AM; Fraumeni JF; Freedman ND; Fridley BL; Fuchs CS; Gago-Dominguez M; Gallinger S; Gao YT; Gapstur SM; Garcia-Closas M, 2014, 'Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33', Human Molecular Genetics, 23, pp. 6616 - 6633, http://dx.doi.org/10.1093/hmg/ddu363

Garsed DW; Marshall OJ; Corbin VDA; Hsu A; DiStefano L; Schröder J; Li J; Feng ZP; Kim BW; Kowarsky M; Lansdell B; Brookwell R; Myklebost O; Meza-Zepeda L; Holloway AJ; Pedeutour F; Choo KHA; Damore MA; Deans AJ; Papenfuss AT; Thomas DM, 2014, 'The Architecture and Evolution of Cancer Neochromosomes', Cancer Cell, 26, pp. 653 - 667, http://dx.doi.org/10.1016/j.ccell.2014.09.010

Kansara M; Teng MW; Smyth MJ; Thomas DM, 2014, 'Translational biology of osteosarcoma', Nature Reviews Cancer, 14, pp. 722 - 735, http://dx.doi.org/10.1038/nrc3838

Gallagher* L; Li W; Ray R; Romano M; Wernli K; Gao D; Thomas D; Checkoway H, 2014, 'Occupational Exposures and Risk of Stomach and Esophageal Cancer among a Cohort of Female Textile Workers in Shanghai, China', ISEE Conference Abstracts, 2014, http://dx.doi.org/10.1289/isee.2014.p3-735

Wong SQ; Li J; Tan AYC; Vedururu R; Pang JMB; Do H; Ellul J; Doig K; Bell A; Macarthur GA; Fox SB; Thomas DM; Fellowes A; Parisot JP; Dobrovic A, 2014, 'Sequence artefacts in a prospective series of formalin-fixed tumours tested for mutations in hotspot regions by massively parallel sequencing', BMC Medical Genomics, 7, http://dx.doi.org/10.1186/1755-8794-7-23

Pishas KI; Neuhaus SJ; Clayer MT; Schreiber AW; Lawrence DM; Perugini M; Whitfield RJ; Farshid G; Manavis J; Chryssidis S; Mayo BJ; Haycox RC; Ho K; Brown MP; D'Andrea RJ; Evdokiou A; Thomas DM; Desai J; Callen DF; Neilsen PM, 2014, 'Nutlin-3a efficacy in sarcoma predicted by transcriptomic and epigenetic profiling', Cancer Research, 74, pp. 921 - 931, http://dx.doi.org/10.1158/0008-5472.CAN-13-2424

Cox BM; Shah MM; Cichon T; Tancer ME; Galloway MP; Thomas DM; Perrine SA, 2014, 'Behavioral and neurochemical effects of repeated MDMA administration during late adolescence in the rat.', Prog Neuropsychopharmacol Biol Psychiatry, 48, pp. 229 - 235, http://dx.doi.org/10.1016/j.pnpbp.2013.09.021

McBride KA; Ballinger ML; Killick E; Kirk J; Tattersall MHN; Eeles RA; Thomas DM; Mitchell G, 2014, 'Li-Fraumeni syndrome: Cancer risk assessment and clinical management', Nature Reviews Clinical Oncology, 11, pp. 260 - 271, http://dx.doi.org/10.1038/nrclinonc.2014.41

Kansara M; Thomas DM, 2014, 'RB1-mediated cell-autonomous and hostdependent oncosuppressor mechanisms in radiation-induced osteosarcoma', Oncoimmunology, 3, http://dx.doi.org/10.4161/onci.27569

Cipponi A; Thomas DM, 2014, 'Stress-induced cellular adaptive strategies: Ancient evolutionarily conserved programs as new anticancer therapeutic targets', Bioessays, 36, pp. 552 - 560, http://dx.doi.org/10.1002/bies.201300170

Anninga JK; Cleton-Jansen A-M; Hassan B; Amary MF; Baumhoer D; Blay J-Y; Brugieres L; Ferrari S; Jurgens H; Kempf-Bielack B; Kovar H; Myklebost O; Nathrath M; Picci P; Riegman P; Schilham MW; Soliman R; Stark DP; Strauss S; Sydes M; Tarpey P; Thomas D; Whelan J; Wilhelm M; Zamzam M; Gelderblom H; Bielack SS, 2014, 'Workshop report on the 2nd Joint ENCCA/EuroSARC European bone sarcoma network meeting: integration of clinical trials with tumour biology', CLINICAL SARCOMA RESEARCH, 4, http://dx.doi.org/10.1186/2045-3329-4-4

Checkoway H; Lundin J; Costello S; Ray R; Li W; Eisen E; Astrakianakis G; Seixas N; Applebaum K; Li Gao D; Thomas D, 2014, '0347 Possible pro-carcinogenic effect of endotoxin on lung cancer in an extended follow-up of Shanghai women textile workers', Occupational and Environmental Medicine, 71, pp. A42.3 - A43, http://dx.doi.org/10.1136/oemed-2014-102362.131

Bandopadhayay P; Jabbour AM; Riffkin C; Salmanidis M; Gordon L; Popovski D; Rigby L; Ashley DM; Watkins DN; Thomas DM; Algar E; Ekert PG, 2013, 'The oncogenic properties of EWS/WT1 of desmoplastic small round cell tumors are unmasked by loss of p53 in murine embryonic fibroblasts', BMC Cancer, 13, http://dx.doi.org/10.1186/1471-2407-13-585

Kansara M; Leong HS; Lin DM; Popkiss S; Pang P; Garsed DW; Walkley CR; Cullinane C; Ellul J; Haynes NM; Hicks R; Kuijjer ML; Cleton-Jansen AM; Hinds PW; Smyth MJ; Thomas DM, 2013, 'Immune response to rb1-Regulated senescence limits radiation-Induced osteosarcoma formation', Journal of Clinical Investigation, 123, pp. 5351 - 5360, http://dx.doi.org/10.1172/JCI70559

Tothill RW; Li J; Mileshkin L; Doig K; Siganakis T; Cowin P; Fellowes A; Semple T; Fox S; Byron K; Kowalczyk A; Thomas D; Schofield P; Bowtell DD, 2013, 'Massively-parallel sequencing assists the diagnosis and guided treatment of cancers of unknown primary', Journal of Pathology, 231, pp. 413 - 423, http://dx.doi.org/10.1002/path.4251

Rossello FJ; Tothill RW; Britt K; Marini KD; Falzon J; Thomas DM; Peacock CD; Marchionni L; Li J; Bennett S; Tantoso E; Brown T; Chan P; Martelotto LG; Watkins DN, 2013, 'Next-Generation Sequence Analysis of Cancer Xenograft Models', Plos One, 8, http://dx.doi.org/10.1371/journal.pone.0074432

Doble B; Harris A; Thomas DM; Fox S; Lorgelly P, 2013, 'Multiomics medicine in oncology: Assessing effectiveness, cost-effectiveness and future research priorities for the molecularly unique individual', Pharmacogenomics, 14, pp. 1405 - 1417, http://dx.doi.org/10.2217/pgs.13.142

Chawla S; Henshaw R; Seeger L; Choy E; Blay JY; Ferrari S; Kroep J; Grimer R; Reichardt P; Rutkowski P; Schuetze S; Skubitz K; Staddon A; Thomas D; Qian Y; Jacobs I, 2013, 'Safety and efficacy of denosumab for adults and skeletally mature adolescents with giant cell tumour of bone: Interim analysis of an open-label, parallel-group, phase 2 study', Lancet Oncology, 14, pp. 901 - 908, http://dx.doi.org/10.1016/S1470-2045(13)70277-8

Mitchell G; Ballinger ML; Wong S; Hewitt C; James P; Young MA; Cipponi A; Pang T; Goode DL; Dobrovic A; Thomas DM; Porceddu S; Gattas M; Neuhaus S; Suthers G; Tattersall M; Tucker K; Lewis C; Carey-Smith R, 2013, 'High Frequency of Germline TP53 Mutations in a Prospective Adult-Onset Sarcoma Cohort', Plos One, 8, http://dx.doi.org/10.1371/journal.pone.0069026

Collins M; Wilhelm M; Conyers R; Herschtal A; Whelan J; Bielack S; Kager L; Kühne T; Sydes M; Gelderblom H; Ferrari S; Picci P; Smeland S; Eriksson M; Petrilli AS; Bleyer A; Thomas DM, 2013, 'Benefits and adverse events in younger versus older patients receiving neoadjuvant chemotherapy for osteosarcoma: Findings from a meta-analysis', Journal of Clinical Oncology, 31, pp. 2303 - 2312, http://dx.doi.org/10.1200/JCO.2012.43.8598

Lewin J; Khamly K; Mitchell C; Hicks RJ; Toner GC; Ngan S; Powell G; Desai J; Choong P; Stacker S; Slavin J; Thomas DM, 2013, 'Hypoxia, angiogenic markers, and response to neoadjuvant radiotherapy in soft-tissue sarcomas.', Journal of Clinical Oncology, 31, pp. 10567 - 10567, http://dx.doi.org/10.1200/jco.2013.31.15_suppl.10567

Cain JE; McCaw A; Jayasekara WSN; Rossello FJ; Marini KD; Irving AT; Kansara M; Thomas DM; Ashley DM; Watkins DN, 2013, 'Sustained low-dose treatment with the Histone deacetylase inhibitor LBH589 induces terminal differentiation of osteosarcoma cells', Sarcoma, 2013, http://dx.doi.org/10.1155/2013/608964

Harvey KF; Zhang X; Thomas DM, 2013, 'The Hippo pathway and human cancer', Nature Reviews Cancer, 13, pp. 246 - 257, http://dx.doi.org/10.1038/nrc3458

Lewin J; Thomas D, 2013, 'Denosumab: A new treatment option for giant cell tumor of bone', Drugs of Today, 49, pp. 693 - 700, http://dx.doi.org/10.1358/dot.2013.49.11.2064725

Savage SA; Mirabello L; Wang Z; Gastier-Foster JM; Gorlick R; Khanna C; Flanagan AM; Tirabosco R; Andrulis IL; Wunder JS; Gokgoz N; Patiño-Garcia A; Sierrasesúmaga L; Lecanda F; Kurucu N; Ilhan IE; Sari N; Serra M; Hattinger C; Picci P; Spector LG; Barkauskas DA; Marina N; De Toledo SRC; Petrilli AS; Amary MF; Halai D; Thomas DM; Douglass C; Meltzer PS; Jacobs K; Chung CC; Berndt SI; Purdue MP; Caporaso NE; Tucker M; Rothman N; Landi MT; Silverman DT; Kraft P; Hunter DJ; Malats N; Kogevinas M; Wacholder S; Troisi R; Helman L; Fraumeni JF; Yeager M; Hoover RN; Chanock SJ, 2013, 'Genome-wide association study identifies two susceptibility loci for osteosarcoma', Nature Genetics, 45, pp. 799 - 803, http://dx.doi.org/10.1038/ng.2645

Lewin J; Wieringa S; Collins M; Desai J; Orme L; Lingaratnam S; Thomas DM, 2013, 'Intra-patient dose escalation in Ewing's sarcoma treated with vincristine, doxorubicin, cyclophosphamide alternating with ifosfamide and etoposide: a retrospective review', CLINICAL SARCOMA RESEARCH, 3, http://dx.doi.org/10.1186/2045-3329-3-15

Lewin J; Puri A; Quek R; Ngan R; Alcasabas AP; Wood D; Thomas D, 2013, 'Management of sarcoma in the asia-pacific region: Resource-stratified guidelines', Lancet Oncology, 14, pp. e562 - e570, http://dx.doi.org/10.1016/S1470-2045(13)70475-3

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