Select Publications

Journal articles

Ghai R; Du X; Wang H; Dong J; Ferguson C; Brown AJ; Parton RG; Wu JW; Yang H, 2017, 'ORP5 and ORP8 bind phosphatidylinositol-4, 5-biphosphate (PtdIns(4,5)P 2) and regulate its level at the plasma membrane', Nature Communications, 8, http://dx.doi.org/10.1038/s41467-017-00861-5

Qi Y; Sun L; Yang H, 2017, 'Lipid droplet growth and adipocyte development: mechanistically distinct processes connected by phospholipids', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1862, pp. 1273 - 1283, http://dx.doi.org/10.1016/j.bbalip.2017.06.016

Bai Z; Chai XR; Yoon MJ; Kim HJ; Lo KA; Zhang ZC; Xu D; Siang DTC; Walet ACE; Xu SH; Chia SY; Chen P; Yang H; Ghosh S; Sun L, 2017, 'Dynamic transcriptome changes during adipose tissue energy expenditure reveal critical roles for long noncoding RNA regulators', PLoS Biology, 15, pp. e2002176, http://dx.doi.org/10.1371/journal.pbio.2002176

Luo J; Jiang L; Yang H; Song BL, 2017, 'Routes and mechanisms of post-endosomal cholesterol trafficking: A story that never ends', Traffic, 18, pp. 209 - 217, http://dx.doi.org/10.1111/tra.12471

Du X; Lukmantara I; Yang H, 2017, 'CRISPR/Cas9-mediated generation of niemann–pick C1 knockout cell line', , 1583, pp. 73 - 83, http://dx.doi.org/10.1007/978-1-4939-6875-6_7

Pagac M; Cooper DE; Qi Y; Lukmantara IE; Mak HY; Wu Z; Tian Y; Liu Z; Lei M; Du X; Ferguson C; Kotevski D; Sadowski P; Chen W; Boroda S; Harris TE; Liu G; Parton RG; Huang X; Coleman RA; Yang H, 2016, 'SEIPIN Regulates Lipid Droplet Expansion and Adipocyte Development by Modulating the Activity of Glycerol-3-phosphate Acyltransferase', Cell Reports, 17, pp. 1546 - 1559, http://dx.doi.org/10.1016/j.celrep.2016.10.037

Liu X; Xie B; Qi Y; Du X; Wang S; Zhang Y; Paxinos G; Yang H; Liang H, 2016, 'The expression of SEIPIN in the mouse central nervous system', Brain Structure and Function, 221, pp. 4111 - 4127, http://dx.doi.org/10.1007/s00429-015-1151-3

Wang M; Gao M; Liao J; Qi Y; Du X; Wang Y; Li L; Liu G; Yang H, 2016, 'Adipose tissue deficiency results in severe hyperlipidemia and atherosclerosis in the low-density lipoprotein receptor knockout mice', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1861, pp. 410 - 418, http://dx.doi.org/10.1016/j.bbalip.2016.02.018

Qi Y; Kapterian TS; Du X; Ma Q; Fei W; Zhang Y; Huang X; Dawes IW; Yang H, 2016, 'CDP-diacylglycerol synthases regulate the growth of lipid droplets and adipocyte development', Journal of Lipid Research, 57, pp. 767 - 780, http://dx.doi.org/10.1194/jlr.M060574

Du X; Zhang Y; Jo SR; Liu X; Qi Y; Osborne B; Byrne FL; Smith GC; Turner N; Hoehn KL; Brown AJ; Yang H, 2015, 'Akt activation increases cellular cholesterol by promoting the proteasomal degradation of Niemann-Pick C1', Biochemical Journal, 471, pp. 243 - 253, http://dx.doi.org/10.1042/BJ20150602

He X; Leow KY; Yang H; Heng CK, 2015, 'Functional characterization of two single nucleotide polymorphisms of acyl-coenzyme A: Cholesterol acyltransferase 2', Gene, 566, pp. 236 - 241, http://dx.doi.org/10.1016/j.gene.2015.04.061

Zhou L; Park SY; Xu L; Xia X; Ye J; Su L; Jeong KH; Hur JH; Oh H; Tamori Y; Zingaretti CM; Cinti S; Argente J; Yu M; Wu L; Ju S; Guan F; Yang H; Choi CS; Savage DB; Li P, 2015, 'Insulin resistance and white adipose tissue inflammation are uncoupled in energetically challenged Fsp27-deficient mice', Nature Communications, 6, http://dx.doi.org/10.1038/ncomms6949

Chu B-B; Liao Y-C; Qi W; Xie C; Du X; Wang J; Yang H; Miao H-H; Li B-L; Song B-L, 2015, 'Cholesterol Transport through Lysosome-Peroxisome Membrane Contacts', Cell, 161, pp. 291 - 306, http://dx.doi.org/10.1016/j.cell.2015.02.019

Du X; Brown AJ; Yang H, 2015, 'Novel mechanisms of intracellular cholesterol transport: oxysterol-binding proteins and membrane contact sites', Current Opinion in Cell Biology, 35, pp. 37 - 42, http://dx.doi.org/10.1016/j.ceb.2015.04.002

Wu L; Xu D; Zhou L; Xie B; Yu L; Yang H; Huang L; Ye J; Deng H; Yuan YA; Chen S; Li P, 2014, 'Rab8a-AS160-MSS4 regulatory circuit controls lipid droplet fusion and growth', Developmental Cell, 30, pp. 378 - 393, http://dx.doi.org/10.1016/j.devcel.2014.07.005

Jiang M; Gao M; Wu C; He H; Guo X; Zhou Z; Yang H; Xiao X; Liu G; Sha J, 2014, 'Lack of testicular seipin causes teratozoospermia syndrome in men', Proceedings of the National Academy of Sciences of the United States of America, 111, pp. 7054 - 7059, http://dx.doi.org/10.1073/pnas.1324025111

Liu L; Jiang Q; Wang X; Zhang Y; Lin RCY; Lam SM; Shui G; Zhou L; Li P; Wang Y; Cui X; Gao M; Zhang L; Lv Y; Xu G; Liu G; Zhao D; Yang H, 2014, 'Adipose-specific knockout of Seipin/Bscl2 results in progressive lipodystrophy', Diabetes, 63, pp. 2320 - 2331, http://dx.doi.org/10.2337/db13-0729

Sun Z; Gong J; Wu H; Xu W; Wu L; Xu D; Gao J; Wu JW; Yang H; Yang M; Li P, 2014, 'Erratum: Perilipin1 promotes unilocular lipid droplet formation through the activation of Fsp27 in adipocytes (Nature Communications (2013) 4 (1594) 10.1038/ncomms2581))', Nature Communications, 5, http://dx.doi.org/10.1038/ncomms5985

Tong J; Yang H; Yang H; Eom SH; Im YJ, 2013, 'Structure of Osh3 reveals a conserved mode of phosphoinositide binding in oxysterol-binding proteins', Structure, 21, pp. 1203 - 1213, http://dx.doi.org/10.1016/j.str.2013.05.007

Lu Y; Tayebi N; Li H; Saha N; Yang H; Heng CK, 2013, 'Association of CETP Taq1B and -629C > A polymorphisms with coronary artery disease and lipid levels in the multi-ethnic Singaporean population', Lipids in Health and Disease, 12, http://dx.doi.org/10.1186/1476-511X-12-85

Du X; Yang H, 2013, 'Endosomal cholesterol trafficking: protein factors at a glance.', ACTA Biochimica et Biophysica Sinica, 45, pp. 11 - 17, http://dx.doi.org/10.1093/abbs/gms095&#65279

Aung-Htut MT; Lam YT; Lim YL; Rinnerthaler M; Gelling CL; Breitenbach M; Yang H; Dawes IW, 2013, 'Maintenance of mitochondrial morphology by autophagy and its role in high glucose effects on chronological lifespan of Saccharomyces cerevisiae', Oxidative Medicine and Cellular Longevity, 2013, pp. 1 - 13, http://dx.doi.org/10.1155/2013/636287

Yang H; Li P; Gong J; Sun Z, 2013, 'Perilipin1 promotes unilocular lipid droplet formation through the activation of Fsp27 in adipocytes.', Nature communications, 4, pp. 1594, http://www.ncbi.nlm.nih.gov/pubmed/23481402

Du X; Kazim AS; Dawes IW; Brown AJ; Yang H, 2013, 'The AAA ATPase VPS4/SKD1 regulates endosomal cholesterol trafficking independently of ESCRT-III.', Traffic, 14, pp. 107 - 119, http://dx.doi.org/10.1111/tra.12015

Ta MT; Kapterian T; Fei W; Du X; Brown AJ; Dawes IW; Yang H, 2012, 'Accumulation of squalene is associated with the clustering of lipid droplets.', FEBS Journal, 279, pp. 4231 - 4244, http://dx.doi.org/10.1111/febs.12015

Du X; Kazim A; Brown AJ; Yang H, 2012, 'An essential role of Hrs/Vps27 in endosomal cholesterol trafficking', Cell Reports, 1, pp. 29 - 35

Yang H; Sytnyk V; Crossley M; Galea AM, 2012, 'Controlling the size of lipid droplets: Lipid and protein factors', Current Opinion in Cell Biology, 24, pp. 509 - 516, http://dx.doi.org/10.1016/j.ceb.2012.05.012

Yang H; Fei W, 2012, 'Genome-wide screens for gene products regulating lipid droplet dynamics', Methods in Cell Biology, 108, pp. 303 - 316, http://www.ncbi.nlm.nih.gov/pubmed/22325608

Yang H; Liu P; Ding Y, 2012, 'Identification of the major functional proteins of prokaryotic lipid droplets', Journal of Lipid Research, 53, pp. 399 - 411, http://www.ncbi.nlm.nih.gov/pubmed/22180631

Tian N; Leshchyns'ka I; Welch J; Diakowski W; Yang H; Schachner M; Sytnyk V, 2012, 'Lipid raft-dependent endocytosis of close homolog of adhesion molecule L1 (CHL1) promotes neuritogenesis.', The Journal of Biological Chemistry, 287, pp. 44447 - 44463, http://dx.doi.org/10.1074/jbc.M112.394973

Cui X; Wang Y; Meng L; Fei W; Deng J; Xu G; Peng X; Ju SH; Zhang L; Liu G; Zhao L; Yang H, 2012, 'Overexpression of a short human seipin/bscl2 isoform in mouse adipose tissue results in mild lipodystrophy', American Journal of Physiology - Endocrinology and Metabolism, 302, pp. 705 - 713

Du XR; Kumar J; Ferguson C; Schulz TA; Ong YS; Hong W; Prinz WA; Parton RG; Brown AJ; Yang H, 2011, 'A role for oxysterol-binding protein-related protein 5 in endosomal cholesterol trafficking', Journal of Cell Biology, 192, pp. 121 - 135, http://dx.doi.org/10.1083/jcb.201004142

Fei W; Shui G; Zhang Y; Krahmer N; Ferguson C; Kapterian T; Lin RCY; Dawes IW; Brown AJ; Li P; Huang X; Parton R; Wenk M; Walther TC; Yang H, 2011, 'A role for phosphatidic acid in the formation of “supersized” lipid droplets', PLOS Genetics, 7, pp. e1002201 1 - e1002201 11, http://dx.doi.org/10.1371/journal.pgen.1002201

Lam YT; Aung MT; Lim YL; Yang H; Dawes IW, 2011, 'Changes in reactive oxygen species begin early during replicative aging of Saccharomyces cerevisiae cells', Free Radical Biology and Medicine, 50, pp. 963 - 970, http://dx.doi.org/10.1016/j.freeradbiomed.2011.01.013

Yang H; Parton RG; Li P; Shui G; Gong J, 2011, 'Fsp27 promotes lipid droplet growth by lipid exchange and transfer at lipid droplet contact sites', Journal of Cell Biology, 195, pp. 953 - 963, http://www.ncbi.nlm.nih.gov/pubmed/22144693

Fei W; Li H; Shui G; Kapterian TS; Bielby C; Du X; Brown AJ; Li P; Wenk M; Liu P; Yang H, 2011, 'Molecular characterization of seipin and its mutants: implications for seipin in triacylglycerol synthesis.', Journal of Lipid Research, 52, pp. 2136 - 2147, http://www.ncbi.nlm.nih.gov/pubmed/21957196

Cui X; Wang Y; Tang Y; Liu G; Yang H; Liu Y; Zhao L; Deng J; Xu G; Peng X; Ju SH, 2011, 'Seipin ablation in mice results in severe generalized lipodystrophy', Human Molecular Genetics, 20, pp. 3022 - 3030, http://www.ncbi.nlm.nih.gov/pubmed/21551454

Fei W; Du XR; Yang H, 2011, 'Seipin, adipogenesis and lipid droplets.', Trends in Endocrinology and Metabolism, 22, pp. 204 - 210, http://www.ncbi.nlm.nih.gov/pubmed/21497513

Du X; Yang H, 2011, 'Sterol-binding proteins and endosomal cholesterol transport', Frontiers in Biology, 6, pp. 190 - 196

Fei W; Zhong L; Ta T; Yang H, 2011, 'The size and phospholipid composition of lipid droplets can influence their proteome', Biochemical and Biophysical Research Communications, 415, pp. 455 - 462, http://www.ncbi.nlm.nih.gov/pubmed/22057011

tian Y; Bi J; Shui G; Wenk M; Yang H; Huang X, 2011, 'Tissue-autonomous function of Drosophila seipin in preventing ectopic lipid droplet formation', PLOS Genetics, 7, pp. e1001364, http://www.ncbi.nlm.nih.gov/pubmed/21533227

Shui G; Guan XL; Gopalakrishnan P; Xue Y; Goh JSY; Yang H; Wenk MR, 2010, 'Characterization of substrate preference for Slc1p and Cst26p in saccharomyces cerevisiae using lipidomic approaches and an LPAAT activity assay', PLoS ONE, 5, http://dx.doi.org/10.1371/journal.pone.0011956

Shui G; Guan XL; Gopalakrishnan P; Xue Y; Goh JSY; Yang H; Wenk MR, 2010, 'Characterization of substrate preference for Slc1p and Cst26p in Saccharomyces cerevisiae using lipidomic approaches and an LPAAT activity assay', PLoS One, 4, pp. 11956, http://www.ncbi.nlm.nih.gov/pubmed/20694142

Yang H, 2010, 'Toward one step analysis of cellular lipidomes using liquid', Molecular Biosystems, 6, pp. 1008 - 1017, http://dx.doi.org/10.1039/b913353d

Fei W; Wang H; Fu X; Christopher B; Yang H, 2009, 'Conditions of endoplasmic reticulum stress stimulate lipid droplet formation in saccharomyces cerevisiae', Biochemical Journal, 424, pp. 61 - 67, http://dx.doi.org/10.1042/BJ20090785

Low C; Shui G; Liew L; Buttner S; Madeo F; Dawes IW; Wenk M; Yang H, 2008, 'Caspase-dependent and -independent lipotoxic cell-death pathways in fission yeast', Journal of Cell Science, 121, pp. 2671 - 2684, http://dx.doi.org/10.1242/jcs.028977

Kristiana I; Yang H; Brown AJ, 2008, 'Different kinetics of cholesterol delivery to components of the cholesterol homeostatic machinery: Implications for cholesterol trafficking to the endoplasmic reticulum', Biochimica et Biophysica ACTA - Molecular and Cell Biology of Lipids, 1781, pp. 724 - 730

Fei W; Shui G; Gaeta BA; Du XR; Kuerschner L; Liu P; Brown AJ; Wenk M; Parton R; Yang H, 2008, 'Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast', Journal of Cell Biology, 180, pp. 473 - 482, http://dx.doi.org/10.1083/icb.200711136

Fei W; Alfaro G; Muthusamy B; Klaassen Z; Graham T; Yang H; Beh C, 2008, 'Genome-wide analysis of sterol-lipid storage and trafficking in Saccharomyces cerevisiae', Eukaryotic Cell, pp. 401 - 414

Low C; Yang H, 2008, 'Programmed cell death in fission yeast Schizosaccharomyces pombe', Biochimica et Biophysica ACTA - Molecular Cell Research, 1783, pp. 1335 - 1349


Back to profile page