Select Publications
Journal articles
2024, 'Exploration and characterization of the antimalarial activity of cyclopropyl carboxamides that target the mitochondrial protein, cytochrome b', European Journal of Medicinal Chemistry, 280, http://dx.doi.org/10.1016/j.ejmech.2024.116921
,2024, 'Enhanced Antimalarial and Antisequestration Activity of Methoxybenzenesulfonate-Modified Biopolymers and Nanoparticles for Tackling Severe Malaria', ACS Infectious Diseases, 10, pp. 732 - 745, http://dx.doi.org/10.1021/acsinfecdis.3c00564
,2024, 'A novel computational pipeline for var gene expression augments the discovery of changes in the Plasmodium falciparum transcriptome during transition from in vivo to short-term in vitro culture', eLife, 12, http://dx.doi.org/10.7554/eLife.87726
,2024, 'A novel computational pipeline for var gene expression augments the discovery of changes in the Plasmodium falciparum transcriptome during transition from in vivo to short-term in vitro culture', eLife, 12, http://dx.doi.org/10.7554/elife.87726.3
,2024, 'Tambjamines as Fast-Acting Multistage Antimalarials', ACS Infectious Diseases, http://dx.doi.org/10.1021/acsinfecdis.4c00659
,2024, 'Dissecting the plasmodium actomyosin system, a new perspective against malaria', Biophysical Journal, 123, pp. 2a - 3a, http://dx.doi.org/10.1016/j.bpj.2023.11.148
,2023, 'Bottoms up! Malaria parasite invasion the right way around', Trends in Parasitology, 39, pp. 1004 - 1013, http://dx.doi.org/10.1016/j.pt.2023.09.010
,2023, 'Mechanism of small molecule inhibition of Plasmodium falciparum myosin A informs antimalarial drug design', Nature Communications, 14, http://dx.doi.org/10.1038/s41467-023-38976-7
,2023, 'A sting in the tail—are antibodies against the C-terminus of Plasmodium falciparum circumsporozoite protein protective?', EMBO Molecular Medicine, 15, http://dx.doi.org/10.15252/emmm.202317556
,2023, 'A dual paper-based nucleic acid extraction method from blood in under ten minutes for point-of-care diagnostics', Analyst, 148, pp. 3036 - 3044, http://dx.doi.org/10.1039/d3an00296a
,2023, 'Radial spoke protein 9 is necessary for axoneme assembly in Plasmodium but not in trypanosomatid parasites', Journal of cell science, 136, http://dx.doi.org/10.1242/jcs.260655
,2023, 'Sensitive Detection of Asymptomatic and Symptomatic Malaria with Seven Novel Parasite-Specific LAMP Assays and Translation for Use at Point-of-Care', Microbiology Spectrum, 11, http://dx.doi.org/10.1128/spectrum.05222-22
,2023, '7-N-Substituted-3-oxadiazole Quinolones with Potent Antimalarial Activity Target the Cytochrome bc
2023, 'Fast-Killing Tyrosine Amide ((S)-SW228703) with Blood- and Liver-Stage Antimalarial Activity Associated with the Cyclic Amine Resistance Locus (PfCARL)', ACS Infectious Diseases, 9, pp. 527 - 539, http://dx.doi.org/10.1021/acsinfecdis.2c00527
,2023, 'Optimization of 2,3-Dihydroquinazolinone-3-carboxamides as Antimalarials Targeting PfATP4', Journal of Medicinal Chemistry, 66, pp. 3540 - 3565, http://dx.doi.org/10.1021/acs.jmedchem.2c02092
,2023, 'A novel class of sulphonamides potently block malaria transmission by targeting a Plasmodium vacuole membrane protein', DMM Disease Models and Mechanisms, 16, pp. dmm049950, http://dx.doi.org/10.1242/dmm.049950
,2023, 'EVALUATION OF SYMPTOMATIC AND ASYMPTOMATIC P. FALCIPARUM WITH SPECIES-SPECIFIC LAMP ASSAY AND TRANSLATION TO THE POINT- OF-CARE', International Journal of Infectious Diseases, 130, pp. S133 - S133, http://dx.doi.org/10.1016/j.ijid.2023.04.328
,2022, 'The malaria parasite chaperonin containing TCP-1 (CCT) complex: Data integration with other CCT proteomes', Frontiers in Molecular Biosciences, 9, http://dx.doi.org/10.3389/fmolb.2022.1057232
,2022, 'Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183', Nature Communications, 13, http://dx.doi.org/10.1038/s41467-022-29688-5
,2022, 'CRISPR-based oligo recombineering prioritizes apicomplexan cysteines for drug discovery', Nature Microbiology, 7, pp. 1891 - 1905, http://dx.doi.org/10.1038/s41564-022-01249-y
,2022, 'Potent Virustatic Polymer-Lipid Nanomimics Block Viral Entry and Inhibit Malaria Parasites in Vivo', ACS Central Science, 8, pp. 1238 - 1257, http://dx.doi.org/10.1021/acscentsci.1c01368
,2022, 'Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy', Science, 376, pp. 1074 - 1079, http://dx.doi.org/10.1126/science.abn0611
,2022, 'High-Throughput Screening Platform To Identify Inhibitors of Protein Synthesis with Potential for the Treatment of Malaria', Antimicrobial Agents and Chemotherapy, 66, http://dx.doi.org/10.1128/aac.00237-22
,2022, 'The Plasmodium falciparum parasitophorous vacuole protein P113 interacts with the parasite protein export machinery and maintains normal vacuole architecture', Molecular Microbiology, 117, pp. 1245 - 1262, http://dx.doi.org/10.1111/mmi.14904
,2022, 'Live-cell fluorescence imaging of microgametogenesis in the human malaria parasite Plasmodium falciparum', PLoS Pathogens, 18, http://dx.doi.org/10.1371/journal.ppat.1010276
,2021, 'A single-cell atlas of Plasmodium falciparum transmission through the mosquito', Nature Communications, 12, http://dx.doi.org/10.1038/s41467-021-23434-z
,2021, 'The antimalarial efficacy and mechanism of resistance of the novel chemotype DDD01034957', Scientific Reports, 11, http://dx.doi.org/10.1038/s41598-021-81343-z
,2021, 'The novel bis-1,2,4-Triazine MIPS-0004373 demonstrates rapid and potent activity against all blood stages of the malaria parasite', Antimicrobial Agents and Chemotherapy, 65, http://dx.doi.org/10.1128/AAC.00311-21
,2021, 'Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome', Proceedings of the National Academy of Sciences of the United States of America, 118, http://dx.doi.org/10.1073/pnas.2107213118
,2021, 'Dissection-independent production of Plasmodium sporozoites from whole mosquitoes', Life Science Alliance, 4, http://dx.doi.org/10.26508/lsa.202101094
,2021, 'Repositioning and Characterization of 1-(Pyridin-4-yl)pyrrolidin-2-one Derivatives as Plasmodium Cytoplasmic Prolyl-tRNA Synthetase Inhibitors', ACS Infectious Diseases, 7, pp. 1680 - 1689, http://dx.doi.org/10.1021/acsinfecdis.1c00020
,2021, 'Identification and characterisation of a phospholipid scramblase in the malaria parasite Plasmodium falciparum', Molecular and Biochemical Parasitology, 243, http://dx.doi.org/10.1016/j.molbiopara.2021.111374
,2021, 'Novel Antimalarial Tetrazoles and Amides Active against the Hemoglobin Degradation Pathway in Plasmodium falciparum', Journal of Medicinal Chemistry, 64, pp. 2739 - 2761, http://dx.doi.org/10.1021/acs.jmedchem.0c02022
,2021, 'Structure-Activity Studies of Truncated Latrunculin Analogues with Antimalarial Activity', ChemMedChem, 16, pp. 679 - 693, http://dx.doi.org/10.1002/cmdc.202000399
,2021, 'Transmission of artemisinin-resistant malaria parasites to mosquitoes under antimalarial drug pressure', Antimicrobial Agents and Chemotherapy, 65, http://dx.doi.org/10.1128/AAC.00898-20
,2021, 'Automated detection and staging of malaria parasites from cytological smears using convolutional neural networks.', Biol Imaging, 1, pp. e2, http://dx.doi.org/10.1017/S2633903X21000015
,2021, 'Deciphering the Function and the Regulation of Plasmodium falciparum Myosin A', Biophysical Journal, 120, pp. 344a - 344a, http://dx.doi.org/10.1016/j.bpj.2020.11.2143
,2020, 'Batch equalization with a generative adversarial network', Bioinformatics, 36, pp. I875 - I883, http://dx.doi.org/10.1093/bioinformatics/btaa819
,2020, 'Actomyosin forces and the energetics of red blood cell invasion by the malaria parasite Plasmodium falciparum', PLoS Pathogens, 16, http://dx.doi.org/10.1371/journal.ppat.1009007
,2020, 'Synthesis and Structure-Activity Relationship of Dual-Stage Antimalarial Pyrazolo[3,4- b]pyridines', Journal of Medicinal Chemistry, 63, pp. 11902 - 11919, http://dx.doi.org/10.1021/acs.jmedchem.0c01152
,2020, 'Full-length plasmodium falciparum myosin a and essential light chain pfelc structures provide new anti-malarial targets', eLife, 9, pp. 1 - 24, http://dx.doi.org/10.7554/eLife.60581
,2020, 'A machine learning approach to define antimalarial drug action from heterogeneous cell-based screens', Science Advances, 6, http://dx.doi.org/10.1126/sciadv.aba9338
,2020, 'Erratum: Single-molecule nanopore sensing of actin dynamics and drug binding (Chemical Science (2020) 11 (970-979) DOI: 10.1039/C9SC05710B)', Chemical Science, 11, pp. 8036 - 8038, http://dx.doi.org/10.1039/d0sc90132f
,2020, 'Peptide Probes for Plasmodium falciparum MyoA Tail Interacting Protein (MTIP): Exploring the Druggability of the Malaria Parasite Motor Complex', ACS Chemical Biology, 15, pp. 1313 - 1320, http://dx.doi.org/10.1021/acschembio.0c00328
,2020, 'Conditional expression of PfAP2-G for controlled massive sexual conversion in Plasmodium falciparum', Science Advances, 6, http://dx.doi.org/10.1126/sciadv.aaz5057
,2020, 'The R
2020, 'A biosynthetic platform for antimalarial drug discovery', Antimicrobial Agents and Chemotherapy, 64, http://dx.doi.org/10.1128/AAC.02129-19
,2020, 'Structure-Activity Relationship Studies of a Novel Class of Transmission Blocking Antimalarials Targeting Male Gametes', Journal of Medicinal Chemistry, 63, pp. 2240 - 2262, http://dx.doi.org/10.1021/acs.jmedchem.9b00898
,2020, 'Design of a basigin-mimicking inhibitor targeting the malaria invasion protein RH5', Proteins: Structure, Function and Bioinformatics, 88, pp. 187 - 195, http://dx.doi.org/10.1002/prot.25786
,2020, 'Single-molecule nanopore sensing of actin dynamics and drug binding', Chemical Science, 11, pp. 970 - 979, http://dx.doi.org/10.1039/c9sc05710b
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