By Professor Jake Baum

Preprints

Duffey M; Zakutansky SE; Gumpp C; Delves MJ; Sala KA; Sherrard-Smith E; Baum J; Leroy D; Rottmann M; Blagborough AM, 2026, Comparing the transmission blocking efficacy of Primaquine and Tafenoquine with in vivo pre-clinical models, http://dx.doi.org/10.64898/2026.03.03.709295

Weate F; Li Y; Novotny D; Meijering E; Baum J, 2025, PlasmoCount 2.0: Rapid Multi-Species Malaria Parasite Detection Using Deep Learning, http://dx.doi.org/10.1101/2025.05.05.25326942

Andradi-Brown C; Wichers-Misterek JS; von Thien H; Höppner YD; Scholz JAM; Hansson HS; Hocke EF; Gilberger TW; Duffy MF; Lavstsen T; Baum J; Otto TD; Cunnington AJ; Bachmann A, 2023, A novel computational pipeline for var gene expression augments the discovery of changes in the Plasmodium falciparum transcriptome during transition from in vivo to short-term in vitro culture, http://dx.doi.org/10.7554/eLife.87726.1

Blight J; Sala KA; Atcheson E; Kramer H; El-Turabi A; Real E; Dahalan FA; Bettencourt P; Dickinson E; Alves E; Salman AM; Janse CJ; Ashcroft F; Hill AVS; Reyes-Sandoval A; Blagborough AM; Baum J, 2020, Dissection-independent production of a protective whole-sporozoite malaria vaccine, http://dx.doi.org/10.1101/2020.06.22.164756

Moussaoui D; Robblee J; Auguin D; Krementsova E; Haase S; Blake T; Baum J; Robert-Paganin J; Trybus K; Houdusse A, 2020, Structure of Full Length Plasmodium Myosin A and its light chain PfELC, dual targets against malaria parasite pathogenesis, http://dx.doi.org/10.1101/2020.06.30.179788

Wang X; Wilkinson M; Lin X; Ren R; Willison K; Ivanov A; Baum J; Edel J, 2019, Single-molecule nanopore sensing of actin dynamics and drug binding, http://dx.doi.org/10.1101/829150

Bookwalter CS; Tay CL; McCrorie R; Previs MJ; Krementsova EB; Fagnant PM; Baum J; Trybus KM, 2017, Binding of a Newly Identified Essential Light Chain to Expressed Plasmodium falciparum Class XIV Myosin Enhances Actin Motility, http://dx.doi.org/10.1101/127118

Yahiya S; Jordan S; Smith HX; Gaboriau DCA; Famodimu MT; Dahalan FA; Churchyard A; Ashdown GW; Baum J, 4D live-cell imaging of microgametogenesis in the human malaria parasite Plasmodium falciparum, http://dx.doi.org/10.1101/2021.07.28.454129

Wilkinson MD; Lai H-E; Freemont PS; Baum J, A biosynthetic platform for antimalarial drug discovery, http://dx.doi.org/10.1101/814715

Imlay LS; Lawong AK; Gahalawat S; Kumar A; Xing C; Mittal N; Wittlin S; Churchyard A; Niederstrasser H; Crespo-Fernandez B; Posner B; Gamo FJ; Baum J; Winzeler EA; Laleu B; Ready JM; Phillips MA, A fast-killing tyrosine amide ((S)-SW228703) with blood and liver-stage antimalarial activity associated with the Cyclic Amine Resistance Locus (PfCARL), http://dx.doi.org/10.1101/2022.10.16.512381

Baumann H; Matthews H; Li M; Hu JJ; Willison KR; Baum J, A high-throughput in vitro translation screen towards discovery of novel antimalarial protein translation inhibitors, http://dx.doi.org/10.1101/248740

Ashdown GW; Dimon M; Fan M; Terán FS-R; Witmer K; Gaboriau DCA; Armstrong Z; Hazard J; Ando DM; Baum J, A machine learning approach to define antimalarial drug action from heterogeneous cell-based screens, http://dx.doi.org/10.1101/2019.12.19.882480

Andradi-Brown C; Wichers-Misterek JS; von Thien H; Höppner YD; Scholz JAM; Hansson H; Hocke EF; Gilberger T-W; Duffy MF; Lavstsen T; Baum J; Otto TD; Cunnington AJ; Bachmann A, A novel computational pipeline for var gene expression augments the discovery of changes in the Plasmodium falciparum transcriptome during transition from in vivo to short-term in vitro culture, http://dx.doi.org/10.1101/2023.03.21.533599

Andradi-Brown C; Wichers-Misterek JS; von Thien H; Höppner YD; Scholz JAM; Hansson H; Hocke EF; Gilberger T-W; Duffy MF; Lavstsen T; Baum J; Otto TD; Cunnington AJ; Bachmann A, A novel computational pipeline for var gene expression augments the discovery of changes in the Plasmodium falciparum transcriptome during transition from in vivo to short-term in vitro culture, http://dx.doi.org/10.7554/elife.87726.2

Real E; Howick VM; Dahalan F; Witmer K; Cudini J; Andradi-Brown C; Blight J; Davidson MS; Dogga SK; Reid AJ; Baum J; Lawniczak MKN, A single-cell atlas of Plasmodium falciparum transmission through the mosquito, http://dx.doi.org/10.1101/2020.10.11.333179

Blake TCA; Haase S; Baum J, Actomyosin forces and the energetics of red blood cell invasion by the malaria parasite Plasmodium falciparum, http://dx.doi.org/10.1101/2020.06.25.171900

Del Rosario M; Periz J; Pavlou G; Lyth O; Latorre-Barragan F; Das S; Pall GS; Stortz JF; Lemgruber L; Baum J; Tardieux I; Meissner M, Apicomplexan F-actin is required for efficient nuclear entry during host cell invasion, http://dx.doi.org/10.1101/646463

Witmer K; Dahalan FA; Delves MJ; Yahiya S; Watson OJ; Straschil U; Chiwcharoen D; Sornboon B; Pukrittayakamee S; Pearson RD; Howick VM; Lawniczak MKN; White NJ; Dondorp AM; Okell LC; Ruecker A; Chotivanich K; Baum J, Artemisinin-resistant malaria parasites show enhanced transmission to mosquitoes under drug pressure, http://dx.doi.org/10.1101/2020.02.04.933572

Davidson MS; Yahiya S; Chmielewski J; O’Donnell AJ; Gurung P; Jeninga M; Prommana P; Andrew D; Petter M; Uthaipibull C; Boyle M; Ashdown GW; Dvorin JD; Reece SE; Wilson DW; Ando DM; Dimon M; Baum J, Automated detection and staging of malaria parasites from cytological smears using convolutional neural networks, http://dx.doi.org/10.1101/2021.01.26.21250284

Malpartida-Cardenas K; Baum J; Cunnington A; Georgiou P; Rodriguez-Manzano J, Electricity-free nucleic acid extraction method from dried blood spots on filter paper for point-of-care diagnostics, http://dx.doi.org/10.1101/2022.07.28.501845

Delves MJ; Marques SR; Ruecker A; Straschil U; Miguel-Blanco C; López-Barragá MJ; Lelièvre J; Molina I; Wree M; Okitsu SL; Winzeler E; Li F; Vinetz J; Sheppard S; Guedes J; Guerra N; Herreros E; Sinden RE; Baum J, Failure of in vitro differentiation of Plasmodium falciparum gametocytes into ookinetes arises because of poor gamete fertilisation, http://dx.doi.org/10.1101/216721

Haase S; Condron M; Miller D; Cherkaoui D; Jordan S; Gulbis JM; Baum J, Identification and characterisation of a phospholipid scramblase in the malaria parasite Plasmodium falciparum, http://dx.doi.org/10.1101/2020.06.22.165258

Moussaoui D; Robblee JP; Auguin D; Fisher F; Fagnant PM; Macfarlane JE; Schaletzky J; Wehri E; Mueller-Dieckmann C; Baum J; Robert-Paganin J; Trybus KM; Houdusse A, Mechanism of small molecule inhibition of Plasmodium falciparum myosin A informs antimalarial drug design, http://dx.doi.org/10.1101/2022.09.09.507123

Yahiya S; Saunders CN; Straschil U; Fischer OJ; Rueda-Zubiaurre A; Haase S; Vizcay-Barrena G; Jordan S; Hassan S; Delves MJ; Tate EW; Barnard A; Fuchter MJ; Baum J, Plasmodium falciparum protein Pfs16 is a target for transmission-blocking antimalarial drug development, http://dx.doi.org/10.1101/2021.06.14.448287

de Vries LE; Jansen PAM; Barcelo C; Munro J; Verhoef JMJ; Pasaje CFA; Rubiano K; Striepen J; Bolscher JM; Henderson R; Huijs T; Koolen KMJ; Tumwebaze PK; Yeo T; Aguiar ACC; Angulo-Barturen I; Churchyard A; Baum J; Fernández BC; Gamo F-J; Guido RVC; Jiménez-Diaz MB; Pereira DB; Rochford R; Sanz LM; Trevitt G; Wittlin S; Cooper RA; Rosenthal PJ; Sauerwein RW; Schalkwijk J; Hermkens PHH; Bonnert R; Campo B; Fidock DA; Llinás M; Niles JC; Kooij TWA; Dechering KJ, Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183, http://dx.doi.org/10.1101/2021.05.12.443866

Benns H; Storch M; Falco J; Fisher ; Alves E; Wincott C; Baum J; Baldwin G; Weerapana E; Tate E; Child M, Prioritization of antimicrobial targets by CRISPR-based oligo recombineering, http://dx.doi.org/10.1101/2021.02.04.429737

Malpartida-Cardenas K; Miscourides N; Rodriguez-Manzano J; Yu LS; Baum J; Georgiou P, Quantitative and rapid Plasmodium falciparum malaria diagnosis and artemisinin-resistance detection using a CMOS Lab-on-Chip platform, http://dx.doi.org/10.1101/638221

Satchwell TJ; Wright KE; Haydn-Smith KL; Terán FS-R; Hawksworth J; Frayne J; Toye AM; Baum J, Stable knockout and complementation of receptor expression using in vitro cell line derived reticulocytes for dissection of host malaria invasion requirements, http://dx.doi.org/10.1101/495853

Koch M; Cegla J; Jones B; Lu Y; Mallat Z; Blagborough A; Angrisano F; Baum J, The effects of dyslipidaemia and cholesterol modulation on erythrocyte susceptibility to malaria parasite infection, http://dx.doi.org/10.1101/630251

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