Select Publications
Journal articles
2018, 'Lymphocyte-Specific Chromatin Accessibility Pre-determines Glucocorticoid Resistance in Acute Lymphoblastic Leukemia', Cancer Cell, 34, pp. 906 - 921.e8, http://dx.doi.org/10.1016/j.ccell.2018.11.002
,2018, 'A novel role for Lyl1 in primitive erythropoiesis', Development (Cambridge), 145, http://dx.doi.org/10.1242/dev.162990
,2018, 'Disruption of a 35 KB enhancer impairs CTCF binding and MLH1 expression in colorectal cells', Clinical Cancer Research, 24, pp. 4602 - 4611, http://dx.doi.org/10.1158/1078-0432.CCR-17-3678
,2018, 'Srsf2P95H initiates myeloid bias and myelodysplastic/ myeloproliferative syndrome from hemopoietic stem cells', Blood, 132, pp. 608 - 621, http://dx.doi.org/10.1182/blood-2018-04-845602
,2018, 'GENERATING MULTIPOTENT STEM CELLS FROM PRIMARY HUMAN ADIPOCYTES FOR TISSUE REPAIR', EXPERIMENTAL HEMATOLOGY, 64, pp. S94 - S94, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000975534800199&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
,2018, 'Granulomonocytic progenitors are key target cells of azacytidine in higher risk myelodysplastic syndromes and acute myeloid leukemia', Leukemia, 32, pp. 1856 - 1860, http://dx.doi.org/10.1038/s41375-018-0076-2
,2018, 'MESODERM-DERIVED PDGFRA plus CELLS REGULATE EMERGENCE OF HEMATOPOIETIC STEM CELLS IN THE DORSALAORTA', EXPERIMENTAL HEMATOLOGY, 64, pp. S45 - S45, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000975534800043&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
,2018, 'AZA-MS: A novel multiparameter mass spectrometry method to determine the intracellular dynamics of azacitidine therapy in vivo', Leukemia, 32, pp. 900 - 910, http://dx.doi.org/10.1038/leu.2017.340
,2018, 'A four-gene LincRNA expression signature predicts risk in multiple cohorts of acute myeloid leukemia patients', Leukemia, 32, pp. 263 - 272, http://dx.doi.org/10.1038/leu.2017.210
,2017, 'The non-coding RNA landscape of human hematopoiesis and leukemia', Nature Communications, 8, http://dx.doi.org/10.1038/s41467-017-00212-4
,2017, 'Annotating function to differentially expressed LincRNAs in myelodysplastic syndrome using a network-based method', Bioinformatics, 33, pp. 2622 - 2630, http://dx.doi.org/10.1093/bioinformatics/btx280
,2017, 'DECLINED PRESENTATION CHARACTERISATION OF STROMAL CELL POPULATIONS IN THE FOETAL LIVER AND THEIR CONTRIBUTIONS TO EMBRYONIC HAEMATOPOIETIC AND VASCULAR DEVELOPMENT', EXPERIMENTAL HEMATOLOGY, 53, pp. S118 - S118, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000972742900273&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
,2017, 'IN VIVO CRISPR EDITING OF DNMT3A IN JAK2V617F HEMATOPOIETIC STEM CELLS INDUCES MYELOFIBROSIS', EXPERIMENTAL HEMATOLOGY, 53, pp. S95 - S95, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000972742900206&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
,2017, 'Integrative Genomics Identifies the Molecular Basis of Resistance to Azacitidine Therapy in Myelodysplastic Syndromes', Cell Reports, 20, pp. 572 - 585, http://dx.doi.org/10.1016/j.celrep.2017.06.067
,2017, 'Maintenance of primitive haematopoiesis is shared by SCL and LYL1', Experimental Hematology, 53, pp. S115 - S115, http://dx.doi.org/10.1016/j.exphem.2017.06.288
,2016, 'Functional Mutations Form at CTCF-Cohesin Binding Sites in Melanoma Due to Uneven Nucleotide Excision Repair across the Motif', Cell Reports, 17, pp. 2865 - 2872, http://dx.doi.org/10.1016/j.celrep.2016.11.055
,2016, 'A quantitative proteomics approach identifies ETV6 and IKZF1 as new regulators of an ERG-driven transcriptional network', Nucleic Acids Research, 44, pp. 10644 - 10661, http://dx.doi.org/10.1093/nar/gkw804
,2016, 'Integrated genetic, epigenetic, and transcriptional profiling identifies molecular pathways in the development of laterally spreading tumors', Molecular Cancer Research, 14, pp. 1217 - 1228, http://dx.doi.org/10.1158/1541-7786.MCR-16-0175
,2016, 'Identification of novel regulators of developmental hematopoiesis using Endoglin regulatory elements as molecular probes', Blood, 128, pp. 1928 - 1939, http://dx.doi.org/10.1182/blood-2016-02-697870
,2016, 'Acute sensitivity of Ph-like acute lymphoblastic leukemia to the SMAC-mimetic birinapant', Cancer Research, 76, pp. 4579 - 4591, http://dx.doi.org/10.1158/0008-5472.CAN-16-0523
,2016, 'GFI136N as a therapeutic and prognostic marker for myelodysplastic syndrome', Experimental Hematology, 44, pp. 590 - 595.e1, http://dx.doi.org/10.1016/j.exphem.2016.04.001
,2016, 'MAPK/ERK2 phosphorylates ERG at serine 283 in leukemic cells and promotes stem cell signatures and cell proliferation', Leukemia, 30, pp. 1552 - 1561, http://dx.doi.org/10.1038/leu.2016.55
,2016, 'Pdgf-ab and 5-Azacytidine induce conversion of somatic cells into tissue-regenerative multipotent stem cells', Proceedings of the National Academy of Sciences of the United States of America, 113, pp. E2306 - E2315, http://dx.doi.org/10.1073/pnas.1518244113
,2016, 'Differential DNA repair underlies mutation hotspots at active promoters in cancer genomes', Nature, 532, pp. 259 - 263, http://dx.doi.org/10.1038/nature17437
,2016, 'Clinical significance of cancerous inhibitor of protein phosphatase 2A in human cancers', International Journal of Cancer, 138, pp. 525 - 532, http://dx.doi.org/10.1002/ijc.29431
,2016, 'Acute myeloid leukemia requires Hhex to enable PRC2-mediated epigenetic repression of Cdkn2a', Genes and Development, 30, pp. 78 - 91, http://dx.doi.org/10.1101/gad.268425.115
,2016, 'An autonomous CEBPA enhancer specific for myeloid-lineage priming and neutrophilic differentiation', Blood, 127, pp. 2991 - 3003, http://dx.doi.org/10.1182/blood-2016-01-695759
,2016, 'Arrested hematopoiesis and vascular relaxation defects in mice with a mutation in Dhfr', Molecular and Cellular Biology, 36, pp. 1222 - 1236, http://dx.doi.org/10.1128/MCB.01035-15
,2015, 'A novel mouse model identifies cooperating mutations and therapeutic targets critical for chronic myeloid leukemia progression', Journal of Experimental Medicine, 212, pp. 1551 - 1569, http://dx.doi.org/10.1084/jem.20141661
,2015, 'Systematic screening of promoter regions pinpoints functional cis-regulatory mutations in a cutaneous melanoma genome', Molecular Cancer Research, 13, pp. 1218 - 1226, http://dx.doi.org/10.1158/1541-7786.MCR-15-0146
,2015, 'Endoglin potentiates nitric oxide synthesis to enhance definitive hematopoiesis', Biology Open, 4, pp. 819 - 829, http://dx.doi.org/10.1242/bio.011494
,2015, 'High-level Gpr56 expression is dispensable for the maintenance and function of hematopoietic stem and progenitor cells in mice', Stem Cell Research, 14, pp. 307 - 322, http://dx.doi.org/10.1016/j.scr.2015.02.001
,2015, 'Overexpression of ERG in cord blood progenitors promotes expansion and recapitulates molecular signatures of high ERG leukemias', Leukemia, 29, pp. 819 - 827, http://dx.doi.org/10.1038/leu.2014.299
,2015, 'Erratum to Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo, [Cancer Cell, 25, 2014, 794-808]', Cancer Cell, 27, pp. 603 - 605, http://dx.doi.org/10.1016/j.ccell.2015.03.003
,2015, 'Myelodysplastic Syndromes Are Propagated by Rare and Distinct Human Cancer Stem Cells In Vivo (vol 25, pg 794, 2014)', CANCER CELL, 27, pp. 603 - 605, http://dx.doi.org/10.1016/j.ccell.2015.03.003
,2015, 'Whole-transcriptome analysis of endothelial to hematopoietic stem cell transition reveals a requirement for Gpr56 in HSC generation', Journal of Experimental Medicine, 212, pp. 93 - 106, http://dx.doi.org/10.1084/jem.20140767
,2015, 'CIP2A is a candidate therapeutic target in clinically challenging prostate cancer cell populations', Oncotarget, 6, pp. 19661 - 19670, http://dx.doi.org/10.18632/oncotarget.3875
,2015, 'SMAD1 and SMAD5 expression is coordinately regulated by FLI1 and GATA2 during endothelial development', Molecular and Cellular Biology, 35, pp. 2165 - 2172, http://dx.doi.org/10.1128/MCB.00239-15
,2015, '117PD Clinical relevance of DNA damage modulator checkpoint kinase 1 (CHK1) and cancerous inhibitor of protein phosphatase 2A (CIP2A) in human gliomas', Annals of Oncology, 26, pp. ix34 - ix34, http://dx.doi.org/10.1093/annonc/mdv520.01
,2015, '72 PERSONALIZED TREATMENT APPROACH FOR GFI136N HETEROZYGOUS OR HOMOZYGOUS MDS PATIENTS', Leukemia Research, 39, pp. S35 - S35, http://dx.doi.org/10.1016/s0145-2126(15)30073-4
,2015, 'Opposing regulation of BIM and BCL2 controls glucocorticoid-induced apoptosis of pediatric acute lymphoblastic leukemia cells', Blood, 125, pp. 273 - 283, http://dx.doi.org/10.1182/blood-2014-05-576470
,2014, 'Mutations in Histone Modulators and HOXA5 Methylation Levels Affects Survival in Azacitidine Treated MDS Patients', BLOOD, 124, http://www.bloodjournal.org/content/124/21/4613
,2014, 'ENDOGLIN MODULATES STAGE SPECIFIC CELL RESPONSES DURING LINEAGE COMMITMENT FROM EMBRYONIC STEM CELLS TO BLOOD AND ENDOTHELIUM', EXPERIMENTAL HEMATOLOGY, 42, pp. S54 - S54, http://dx.doi.org/10.1016/j.exphem.2014.07.203
,2014, 'Myelodysplastic Syndromes Are Propagated by Rare and Distinct Human Cancer Stem Cells In Vivo (vol 25, pg 794, 2014)', CANCER CELL, 25, pp. 861 - 861, http://dx.doi.org/10.1016/j.ccr.2014.05.027
,2014, 'Keeping GBM in check by targeting CHK1-CIP2A axis.', Journal of Clinical Oncology, 32, pp. 2036 - 2036, http://dx.doi.org/10.1200/jco.2014.32.15_suppl.2036
,2014, 'Epigenetic inactivation of the candidate tumor suppressor USP44 is a frequent and early event in colorectal neoplasia', Epigenetics, 9, pp. 1092 - 1100, http://dx.doi.org/10.4161/epi.29222
,2014, 'Erratum: Activity of a heptad of transcription factors is associated with stem cell programs and clinical outcome in acute myeloid leukemia (Blood (2013) 121:12 (2289-2300))', Blood, 123, pp. 2901, http://dx.doi.org/10.1182/blood-2014-03-564831
,2014, 'BloodChIP: A database of comparative genome-wide transcription factor binding profiles in human blood cells', Nucleic Acids Research, 42, http://dx.doi.org/10.1093/nar/gkt1036
,2014, 'Oncocis: Annotation of cis-regulatory mutations in cancer', Genome Biology, 15, http://dx.doi.org/10.1186/s13059-014-0485-0
,2014, 'Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer', eLife, 3, pp. e02935, http://dx.doi.org/10.7554/eLife.02935
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