Select Publications
Journal articles
2024, 'BloodChIP Xtra: an expanded database of comparative genome-wide transcription factor binding and gene-expression profiles in healthy human stem/progenitor subsets and leukemic cells', Nucleic Acids Research, 52, pp. D1131 - D1137, http://dx.doi.org/10.1093/nar/gkad918
,2023, 'The NCOR-HDAC3 co-repressive complex modulates the leukemogenic potential of the transcription factor ERG', Nature Communications, 14, http://dx.doi.org/10.1038/s41467-023-41067-2
,2023, 'Genome-wide transcription factor–binding maps reveal cell-specific changes in the regulatory architecture of human HSPCs', Blood, 142, pp. 1448 - 1462, http://dx.doi.org/10.1182/blood.2023021120
,2023, 'Delivery of PEGylated liposomal doxorubicin by bispecific antibodies improves treatment in models of high-risk childhood leukemia', Science translational medicine, 15, pp. eabm1262 - eabm1262, http://dx.doi.org/10.1126/scitranslmed.abm1262
,2023, 'Contribution of mutant HSC clones to immature and mature cells in MDS and CMML, and variations with AZA therapy', Blood, 141, pp. 1316 - 1321, http://dx.doi.org/10.1182/blood.2022018602
,2023, 'Defined Microenvironments Trigger In Vitro Gastrulation in Human Pluripotent Stem Cells', Advanced Science, 10, http://dx.doi.org/10.1002/advs.202203614
,2023, 'DDX41: the poster child for familial MDS/AML grows up', Blood, 141, pp. 447 - 449, http://dx.doi.org/10.1182/blood.2022018787
,2022, 'Clinical Response to Azacytidine (AZA) Is Associated with Increased Contribution from Mutated Blood Progenitors: Insights from Single Cell Genotyping of Matched Stem/Progenitor and Mature Blood Cells from MDS/CMML Patients Pre- and Post-AZA Treatment', Blood, 140, pp. 9751 - 9752, http://dx.doi.org/10.1182/blood-2022-163158
,2022, 'Comparative Analysis of Genome-Scale Gene Regulatory Networks in Human Hematopoietic Stem and Myeloid Progenitor Fractions', BLOOD, 140, pp. 2846 - 2848, http://dx.doi.org/10.1182/blood-2022-165620
,2022, 'Genome-Wide CRISPR-Cas9 Screening Identifies a Synergy between Hypomethylating Agents and Sumoylation Blockade in Myelodysplastic Syndromes and Acute Myeloid Leukemia', BLOOD, 140, http://dx.doi.org/10.1182/blood-2022-165713
,2022, 'In Vivo Drug Incorporation and Intracellular Dynamics of Injectable Versus Oral Azacytidine: A Phase II Open Label Multicentre Trial', Blood, 140, pp. 6927 - 6929, http://dx.doi.org/10.1182/blood-2022-157634
,2022, 'Neoantigen reactive T cells correlate with the low mutational burden in hematological malignancies', Leukemia, 36, pp. 2734 - 2738, http://dx.doi.org/10.1038/s41375-022-01705-y
,2022, 'AML-131 ERG: From a Fortuitous Discovery to Potential Treatment for AML', Clinical Lymphoma, Myeloma and Leukemia, 22, pp. S215 - S216, http://dx.doi.org/10.1016/S2152-2650(22)01225-3
,2022, 'p57Kip2 regulates embryonic blood stem cells by controlling sympathoadrenal progenitor expansion', Blood, 140, pp. 464 - 477, http://dx.doi.org/10.1182/blood.2021014853
,2022, 'Mesoderm-derived PDGFRA+ cells regulate the emergence of hematopoietic stem cells in the dorsal aorta', Nature Cell Biology, 24, pp. 1211 - 1225, http://dx.doi.org/10.1038/s41556-022-00955-3
,2022, 'P417: A SINGLE AMINO ACID AT THE PNT DOMAIN OF ERG MEDIATES ITS LEUKEMOGENIC ACTIVITY THROUGH INTERACTION WITH THE NCOR-HDAC3 CO-REPRESSOR COMPLEX.', HemaSphere, 6, pp. 317 - 318, http://dx.doi.org/10.1097/01.hs9.0000844556.94296.43
,2022, 'P748: SINGLE CELL GENOTYPING OF MATCHED BONE MARROW AND PERIPHERAL BLOOD CELLS IN TREATMENT NAIVE AND AZA-TREATED MDS AND CMML', HemaSphere, 6, pp. 643 - 644, http://dx.doi.org/10.1097/01.hs9.0000845876.01682.15
,2022, 'Demethylation and Up-Regulation of an Oncogene after Hypomethylating Therapy', New England Journal of Medicine, 386, pp. 1998 - 2010, http://dx.doi.org/10.1056/nejmoa2119771
,2022, 'Analysing high-throughput sequencing data in Python with HTSeq 2.0', Bioinformatics, 38, pp. 2943 - 2945, http://dx.doi.org/10.1093/bioinformatics/btac166
,2022, 'Analysing high-throughput sequencing data in Python with HTSeq 2.0.', Bioinformatics, 38, pp. 2943 - 2945, http://dx.doi.org/10.1093/bioinformatics/btac166
,2022, 'Poster: AML-131 ERG: From a Fortuitous Discovery to Potential Treatment for AML', Clinical Lymphoma Myeloma and Leukemia, 22, pp. S129 - S129, http://dx.doi.org/10.1016/s2152-2650(22)00769-8
,2021, 'Targeting an Inducible SALL4-Mediated Cancer Vulnerability with Sequential Therapy', Cancer Research, 81, pp. 6018 - 6028, http://dx.doi.org/10.1158/0008-5472.CAN-21-0030
,2021, 'Disruption of a GATA2-TAL1-ERG regulatory circuit promotes erythroid transition in healthy and leukemic stem cells', Blood, 138, pp. 1441 - 1455, http://dx.doi.org/10.1182/blood.2020009707
,2021, 'To switch or not to switch: PU.1 expression is the question', Blood, 138, pp. 1289 - 1291, http://dx.doi.org/10.1182/blood.2021012112
,2021, 'Label-Free Isolation and Single Cell Biophysical Phenotyping Analysis of Primary Cardiomyocytes Using Inertial Microfluidics', Small, 17, http://dx.doi.org/10.1002/smll.202006176
,2021, 'Induction of muscle-regenerative multipotent stem cells from human adipocytes by PDGF-AB and 5-azacytidine', Science Advances, 7, pp. eabd1929, http://dx.doi.org/10.1126/sciadv.abd1929
,2021, '3034 – DISRUPTION OF A GATA2, TAL1, ERG REGULATORY CIRCUIT PROMOTES ERYTHROID TRANSITION IN HEALTHY AND LEUKEMIC STEM CELLS', Experimental Hematology, 100, pp. S59 - S59, http://dx.doi.org/10.1016/j.exphem.2021.12.255
,2021, 'Heart on A Chip: Label‐Free Isolation and Single Cell Biophysical Phenotyping Analysis of Primary Cardiomyocytes Using Inertial Microfluidics (Small 8/2021)', Small, 17, http://dx.doi.org/10.1002/smll.202170034
,2021, 'Induction of Muscle Regenerative Multipotent Stem Cells from Human Adipocytes by PDGF-AB and 5-Azacytidine', Science Advances, pp. 2020.06.04.130872 - 2020.06.04.130872, http://dx.doi.org/10.1126/sciadv.abd1929
,2021, 'Mesoderm-Derived PDGFRA+Cells Regulate the Emergence of Hematopoietic Stem Cells in the Dorsal Aorta', , http://dx.doi.org/10.1101/2021.08.08.455592
,2020, 'Human endogenous retroviruses form a reservoir of T cell targets in hematological cancers', Nature Communications, 11, pp. 5660, http://dx.doi.org/10.1038/s41467-020-19464-8
,2020, 'Label-free Isolation and Single Cell Biophysical Phenotyping Analysis of Primary Cardiomyocytes Using Inertial Microfluidics', , http://dx.doi.org/10.1101/2020.08.31.243592
,2020, 'The EMT modulator SNAI1 contributes to AML pathogenesis via its interaction with LSD1', Blood, 136, pp. 957 - 973, http://dx.doi.org/10.1182/blood.2019002548
,2020, 'Titans awake: HMAs for virus-driven ATL', Blood, 136, pp. 777 - 779, http://dx.doi.org/10.1182/blood.2020006488
,2020, 'Capturing Neonatal Cardiomyocyte – Endothelial interactions on-a-Chip', , http://dx.doi.org/10.1101/2020.08.10.243600
,2020, 'RNA Splicing Alterations Induce a Cellular Stress Response Associated with Poor Prognosis in Acute Myeloid Leukemia', Clinical Cancer Research, 26, pp. 3597 - 3607, http://dx.doi.org/10.1158/1078-0432.CCR-20-0184
,2020, 'DKC1 is a transcriptional target of GATA1 and drives upregulation of telomerase activity in normal human erythroblasts', Haematologica, 105, pp. 1517 - 1526, http://dx.doi.org/10.3324/haematol.2018.215699
,2020, 'Constitutive CHK1 Expression Drives a pSTAT3–CIP2A Circuit that Promotes Glioblastoma Cell Survival and Growth', Molecular Cancer Research, 18, pp. 709 - 722, http://dx.doi.org/10.1158/1541-7786.MCR-19-0934
,2020, 'Human endogenous retroviruses form a reservoir of T cell targets in hematological cancers with low mutational burden', The Journal of Immunology, 204, pp. 242.14 - 242.14, http://dx.doi.org/10.4049/jimmunol.204.supp.242.14
,2020, 'Murine and related chapparvoviruses are nephro-tropic and produce novel accessory proteins in infected kidneys', PLoS Pathogens, 16, pp. e1008262, http://dx.doi.org/10.1371/journal.ppat.1008262
,2020, 'Disruption of a GATA2, TAL1, ERG regulatory circuit promotes erythroid transition in healthy and leukemic stem cells', , http://dx.doi.org/10.1101/2020.10.26.353797
,2020, 'RNA splicing alterations induce a cellular stress response associated with poor prognosis in AML', , http://dx.doi.org/10.1101/2020.01.10.895714
,2019, 'A Menin-MLL Inhibitor Induces Specific Chromatin Changes and Eradicates Disease in Models of MLL-Rearranged Leukemia', Cancer Cell, 36, pp. 660 - 673.e11, http://dx.doi.org/10.1016/j.ccell.2019.11.001
,2019, 'Transcriptional networks in acute myeloid leukemia', Genes Chromosomes and Cancer, 58, pp. 859 - 874, http://dx.doi.org/10.1002/gcc.22794
,2019, 'Shared roles for Scl and Lyl1 in murine platelet production and function', Blood, 134, pp. 826 - 835, http://dx.doi.org/10.1182/blood.2019896175
,2019, 'Scarcity of Recurrent Regulatory Driver Mutations in Colorectal Cancer Revealed by Targeted Deep Sequencing', JNCI CANCER SPECTRUM, 3, http://dx.doi.org/10.1093/jncics/pkz012
,2019, 'HMGA2 promotes long-term engraftment and myeloerythroid differentiation of human hematopoietic stem and progenitor cells', Blood Advances, 3, pp. 681 - 691, http://dx.doi.org/10.1182/bloodadvances.2018023986
,2018, 'Jak2V617F and Dnmt3a loss cooperate to induce myelofibrosis through activated enhancer-driven inflammation', Blood, 132, pp. 2707 - 2721, http://dx.doi.org/10.1182/blood-2018-04-846220
,2018, 'Lymphocyte-Specific Chromatin Accessibility Pre-determines Glucocorticoid Resistance in Acute Lymphoblastic Leukemia', Cancer Cell, 34, pp. 906 - 921.e8, http://dx.doi.org/10.1016/j.ccell.2018.11.002
,2018, 'A novel role for Lyl1 in primitive erythropoiesis', Development (Cambridge), 145, http://dx.doi.org/10.1242/dev.162990
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