Select Publications
Book Chapters
2018, 'Genome editing of erythroid cell culture model systems', in Lloyd JA (ed.), Erythropoiesis methods and protocols, Springer, pp. 245 - 257, http://dx.doi.org/10.1007/978-1-4939-7428-3_15
,Journal articles
2024, 'Hydroxyurea reduces the levels of the fetal globin gene repressors ZBTB7A/LRF and BCL11A in erythroid cells in vitro', Journal of Sickle Cell Disease, 1, http://dx.doi.org/10.1093/jscdis/yoae008
,2024, 'Regulation of host metabolic health by parasitic helminths', Trends in Parasitology, 40, pp. 386 - 400, http://dx.doi.org/10.1016/j.pt.2024.03.006
,2023, 'Blood and adipose-resident eosinophils are defined by distinct transcriptional profiles', Journal of Leukocyte Biology, 113, pp. 191 - 202, http://dx.doi.org/10.1093/jleuko/qiac009
,2022, 'Protocols for protein-DNA binding analysis of a zinc finger transcription factor bound to its cognate promoter', STAR protocols, 3, pp. 101598, http://dx.doi.org/10.1016/j.xpro.2022.101598
,2022, 'Disrupting the adult globin promoter alleviates promoter competition and reactivates fetal globin gene expression', Blood, 139, pp. 2107 - 2118, http://dx.doi.org/10.1182/blood.2021014205
,2022, 'Shades of white: new insights into tissue-resident leukocyte heterogeneity', FEBS Journal, 289, pp. 308 - 318, http://dx.doi.org/10.1111/febs.15737
,2021, 'Structural basis for human ZBTB7A action at the fetal globin promoter', Cell Reports, 36, http://dx.doi.org/10.1016/j.celrep.2021.109759
,2021, 'ACTN3 genotype influences skeletal muscle mass regulation and response to dexamethasone', Science Advances, 7, http://dx.doi.org/10.1126/sciadv.abg0088
,2021, 'Mitochondrial uncoupler SHC517 reverses obesity in mice without affecting food intake', Metabolism: Clinical and Experimental, 117, http://dx.doi.org/10.1016/j.metabol.2021.154724
,2020, 'Eosinophil function in adipose tissue is regulated by Krüppel-like factor 3 (KLF3)', Nature Communications, 11, http://dx.doi.org/10.1038/s41467-020-16758-9
,2020, 'Methylation of a CGATA element inhibits binding and regulation by GATA-1', Nature Communications, 11, http://dx.doi.org/10.1038/s41467-020-16388-1
,2020, 'EoTHINophils: Eosinophils as key players in adipose tissue homeostasis', Clinical and Experimental Pharmacology and Physiology, 47, pp. 1495 - 1505, http://dx.doi.org/10.1111/1440-1681.13304
,2020, 'Krüppel-like factor 3 (klf3) suppresses nf-b-driven inflammation in mice', Journal of Biological Chemistry, 295, pp. 608 - 6091, http://dx.doi.org/10.1074/jbc.RA120.013114
,2020, 'Phenotypic screen for oxygen consumption rate identifies an anti-cancer naphthoquinone that induces mitochondrial oxidative stress', Redox Biology, 28, pp. 101374, http://dx.doi.org/10.1016/j.redox.2019.101374
,2020, 'ACTN3genotype influences skeletal muscle mass regulation and response to dexamethasone', , http://dx.doi.org/10.1101/2020.11.20.392282
,2019, 'Hit and Run Transcriptional Repressors Are Difficult to Catch in the Act', BioEssays, 41, pp. e1900041, http://dx.doi.org/10.1002/bies.201900041
,2019, 'A natural regulatory mutation in the proximal promoter elevates fetal globin expression by creating a de novo GATA1 site', Blood, 133, pp. 852 - 856, http://dx.doi.org/10.1182/blood-2018-07-863951
,2019, 'Characterization of glucose transporter 6 in lipopolysaccharide-induced bone marrow-derived macrophage function', Journal of Immunology, 202, pp. 1826 - 1832, http://dx.doi.org/10.4049/jimmunol.1801063
,2018, 'Partial reprogramming of heterologous cells by defined factors to generate megakaryocyte lineage-restricted biomolecules', Biotechnology Reports, 20, http://dx.doi.org/10.1016/j.btre.2018.e00285
,2018, 'Wake-up Sleepy Gene: Reactivating Fetal Globin for β-Hemoglobinopathies', Trends in Genetics, 34, pp. 927 - 940, http://dx.doi.org/10.1016/j.tig.2018.09.004
,2018, 'Defining Eosinophil Function in Adiposity and Weight Loss', BioEssays, 40, http://dx.doi.org/10.1002/bies.201800098
,2018, 'Natural regulatory mutations elevate the fetal globin gene via disruption of BCL11A or ZBTB7A binding', Nature Genetics, 50, pp. 498 - 503, http://dx.doi.org/10.1038/s41588-018-0085-0
,2018, 'Dietary intervention rescues myopathy associated with neurofibromatosis type 1', Human Molecular Genetics, 27, pp. 577 - 588, http://dx.doi.org/10.1093/hmg/ddx423
,2017, 'Direct competition between DNA binding factors highlights the role of Krüppel-like Factor 1 in the erythroid/megakaryocyte switch', Scientific Reports, 7, pp. 3137, http://dx.doi.org/10.1038/s41598-017-03289-5
,2017, 'METTL21B Is a Novel Human lysine methyltransferase of translation elongation factor 1A: Discovery by CRISPR/Cas9 Knockout', Molecular and Cellular Proteomics, 16, pp. 2229 - 2242, http://dx.doi.org/10.1074/mcp.M116.066308
,2017, 'KLF1 drives the expression of fetal hemoglobin in British HPFH', Blood, 130, pp. 803 - 807, http://dx.doi.org/10.1182/blood-2017-02-767400
,2017, 'Self-reported knee pain and disability among healthy individuals: reference data and factors associated with the Knee injury and Osteoarthritis Outcome Score (KOOS) and KOOS-Child', Osteoarthritis and Cartilage, pp. 1282 - 1290, http://dx.doi.org/10.1016/j.joca.2017.03.007
,2017, 'Exploring the relationship between α-actinin-3 deficiency and obesity in mice and humans', International Journal of Obesity, 41, pp. 1154 - 1157, http://dx.doi.org/10.1038/ijo.2017.72
,2017, 'The regulation of human globin promoters by CCAAT box elements and the recruitment of NF-Y', Biochimica et Biophysica Acta - Gene Regulatory Mechanisms, 1860, pp. 525 - 536, http://dx.doi.org/10.1016/j.bbagrm.2016.10.002
,2017, 'KLF1 directly activates expression of the novel fetal globin repressor ZBTB7A/LRF in erythroid cells', Blood Advances, 1, pp. 685 - 692, http://dx.doi.org/10.1182/bloodadvances.2016002303
,2017, 'Reference values for developing responsive functional outcome measures across the lifespan', Neurology, 88, pp. 1512 - 1519, http://dx.doi.org/10.1212/WNL.0000000000003847
,2017, 'Normative reference values for strength and flexibility of 1,000 children and adults', Neurology, 88, pp. 36 - 43, http://dx.doi.org/10.1212/WNL.0000000000003466
,2017, 'Correlates of Perceived Ankle Instability in Healthy Individuals Aged 8 to 101 Years', Archives of Physical Medicine and Rehabilitation, 98, pp. 72 - 79, http://dx.doi.org/10.1016/j.apmr.2016.08.474
,2016, 'Krüppel-like factor 3 (KLF3/BKLF) is required for widespread repression of the inflammatory modulator galectin-3 (Lgals3)', Journal of Biological Chemistry, 291, pp. 16048 - 16058, http://dx.doi.org/10.1074/jbc.M116.715748
,2016, 'How does α-actinin-3 deficiency alter muscle function? Mechanistic insights into ACTN3, the 'gene for speed'', Biochimica et Biophysica Acta - Molecular Cell Research, 1863, pp. 686 - 693, http://dx.doi.org/10.1016/j.bbamcr.2016.01.013
,2016, '1000 Norms Project: Protocol of a cross-sectional study cataloging human variation', Physiotherapy (United Kingdom), 102, pp. 50 - 56, http://dx.doi.org/10.1016/j.physio.2014.12.002
,2016, 'Analysis of the ACTN3 heterozygous genotype suggests that α-actinin-3 controls sarcomeric composition and muscle function in a dose-dependent fashion', Human Molecular Genetics, 25, pp. 866 - 877, http://dx.doi.org/10.1093/hmg/ddv613
,2015, 'Directing an artificial zinc finger protein to new targets by fusion to a non-DNA-binding domain', Nucleic Acids Research, 44, pp. 3118 - 3130, http://dx.doi.org/10.1093/nar/gkv1380
,2015, 'A gene for speed: The influence of ACTN3 on muscle performance in health and disease', NEUROMUSCULAR DISORDERS, 25, pp. S185 - S185, http://dx.doi.org/10.1016/j.nmd.2015.06.011
,2015, 'Skeletal muscle and motor deficits in Neurofibromatosis Type 1', J Musculoskelet Neuronal Interact, 15, pp. 161 - 170
,2015, 'Editing the genome to introduce a beneficial naturally occurring mutation associated with increased fetal globin', Nature Communications, 6, pp. 7085, http://dx.doi.org/10.1038/ncomms8085
,2015, 'Phosphorylation of krüppel-like factor 3 (KLF3/BKLF) and C-terminal binding protein 2 (CtBP2) by homeodomaininteracting protein kinase 2 (HIPK2) modulates KLF3 DNA binding and activity', Journal of Biological Chemistry, 290, pp. 8591 - 8605, http://dx.doi.org/10.1074/jbc.M115.638338
,2015, 'Altered Ca2+ Kinetics Associated with α-Actinin-3 Deficiency May Explain Positive Selection for ACTN3 Null Allele in Human Evolution', PLoS Genetics, 11, pp. e1004862, http://dx.doi.org/10.1371/journal.pgen.1004862
,2014, 'Leiomodin-dysfunction results in thin filament disorganization and nemaline myopathy', Journal of Clinical Investigation, 124, pp. 4693 - 4708, http://dx.doi.org/10.1172/JCI75199
,2014, 'The identification and structure of an N-terminal PR domain show that FOG1 is a member of the PRDM family of proteins', PLoS ONE, 9, pp. e106011, http://dx.doi.org/10.1371/journal.pone.0106011
,2014, 'Differential regulation of the α-globin locus by Krüppel-like factor 3 in erythroid and non-erythroid cells', BMC Molecular Biology, 15, pp. 8, http://dx.doi.org/10.1186/1471-2199-15-8
,2014, 'α-Actinin-3 deficiency alters muscle adaptation in response to denervation and immobilization', Human molecular genetics, 23, pp. 1879 - 1893, http://dx.doi.org/10.1093/hmg/ddt580
,2014, 'NF1 is a critical regulator of muscle development and metabolism', Human Molecular Genetics, 23, pp. 1250 - 1259, http://dx.doi.org/10.1093/hmg/ddt515
,2014, 'Evidence based selection of commonly used RT-qPCR reference genes for the analysis of mouse skeletal muscle', PLoS ONE, 9, pp. e88653, http://dx.doi.org/10.1371/journal.pone.0088653
,