By Professor Kate Gemma Quinlan

Journal articles

Martyn GE; Doerfler PA; Yao Y; Quinlan KGR; Weiss MJ; Crossley M, 2024, 'Hydroxyurea reduces the levels of the fetal globin gene repressors ZBTB7A/LRF and BCL11A in erythroid cells in vitro', Journal of Sickle Cell Disease, 1, http://dx.doi.org/10.1093/jscdis/yoae008

Sikder S; Pierce D; Sarkar ER; McHugh C; Quinlan KGR; Giacomin P; Loukas A, 2024, 'Regulation of host metabolic health by parasitic helminths', Trends in Parasitology, 40, pp. 386 - 400, http://dx.doi.org/10.1016/j.pt.2024.03.006

Shah M; Knights AJ; Vohralik EJ; Psaila AM; Quinlan KGR, 2023, 'Blood and adipose-resident eosinophils are defined by distinct transcriptional profiles', Journal of Leukocyte Biology, 113, pp. 191 - 202, http://dx.doi.org/10.1093/jleuko/qiac009

Ly LC; Yang Y; Li F; Crossley M; Shi Y; Quinlan KGR, 2022, 'Protocols for protein-DNA binding analysis of a zinc finger transcription factor bound to its cognate promoter', STAR protocols, 3, pp. 101598, http://dx.doi.org/10.1016/j.xpro.2022.101598

Topfer SK; Feng R; Huang P; Ly LC; Martyn GE; Blobel GA; Weiss MJ; Quinlan KGR; Crossley M, 2022, 'Disrupting the adult globin promoter alleviates promoter competition and reactivates fetal globin gene expression', Blood, 139, pp. 2107 - 2118, http://dx.doi.org/10.1182/blood.2021014205

Psaila AM; Vohralik EJ; Quinlan KGR, 2022, 'Shades of white: new insights into tissue-resident leukocyte heterogeneity', FEBS Journal, 289, pp. 308 - 318, http://dx.doi.org/10.1111/febs.15737

Yang Y; Ren R; Ly LC; Horton JR; Li F; Quinlan KGR; Crossley M; Shi Y; Cheng X, 2021, 'Structural basis for human ZBTB7A action at the fetal globin promoter', Cell Reports, 36, http://dx.doi.org/10.1016/j.celrep.2021.109759

Seto JT; Roeszler KN; Meehan LR; Wood HD; Tiong C; Bek L; Lee SF; Shah M; Quinlan KGR; Gregorevic P; Houweling PJ; North KN, 2021, 'ACTN3 genotype influences skeletal muscle mass regulation and response to dexamethasone', Science Advances, 7, http://dx.doi.org/10.1126/sciadv.abg0088

Chen SY; Beretta M; Alexopoulos SJ; Shah DP; Olzomer EM; Hargett SR; Childress ES; Salamoun JM; Aleksovska I; Roseblade A; Cranfield C; Rawling T; Quinlan KGR; Morris MJ; Tucker SP; Santos WL; Hoehn KL, 2021, 'Mitochondrial uncoupler SHC517 reverses obesity in mice without affecting food intake', Metabolism: Clinical and Experimental, 117, http://dx.doi.org/10.1016/j.metabol.2021.154724

Knights AJ; Vohralik EJ; Houweling PJ; Stout ES; Norton LJ; Alexopoulos SJ; Yik JJ; Mat Jusoh H; Olzomer EM; Bell-Anderson KS; North KN; Hoehn KL; Crossley M; Quinlan KGR, 2020, 'Eosinophil function in adipose tissue is regulated by Krüppel-like factor 3 (KLF3)', Nature Communications, 11, http://dx.doi.org/10.1038/s41467-020-16758-9

Yang L; Chen Z; Stout ES; Delerue F; Ittner LM; Wilkins MR; Quinlan KGR; Crossley M, 2020, 'Methylation of a CGATA element inhibits binding and regulation by GATA-1', Nature Communications, 11, http://dx.doi.org/10.1038/s41467-020-16388-1

Vohralik EJ; Psaila AM; Knights AJ; Quinlan KGR, 2020, 'EoTHINophils: Eosinophils as key players in adipose tissue homeostasis', Clinical and Experimental Pharmacology and Physiology, 47, pp. 1495 - 1505, http://dx.doi.org/10.1111/1440-1681.13304

Knights AJ; Yang L; Shah M; Norton LJ; Green GS; Stout ES; Vohralik EJ; Crossley M; Quinlan KGR, 2020, 'Krüppel-like factor 3 (klf3) suppresses nf-b-driven inflammation in mice', Journal of Biological Chemistry, 295, pp. 608 - 6091, http://dx.doi.org/10.1074/jbc.RA120.013114

Byrne FL; Olzomer EM; Marriott GR; Quek LE; Katen A; Su J; Nelson ME; Hart-Smith G; Larance M; Sebesfi VF; Cuff J; Martyn GE; Childress E; Alexopoulos SJ; Poon IK; Faux MC; Burgess AW; Reid G; McCarroll JA; Santos WL; Quinlan KG; Turner N; Fazakerley DJ; Kumar N; Hoehn KL, 2020, 'Phenotypic screen for oxygen consumption rate identifies an anti-cancer naphthoquinone that induces mitochondrial oxidative stress', Redox Biology, 28, pp. 101374, http://dx.doi.org/10.1016/j.redox.2019.101374

Seto JT; Roeszler KN; Meehan LR; Wood HD; Tiong C; Bek L; Lee SF; Shah M; Quinlan KGR; Gregorevic P; Houweling PJ; North KN, 2020, 'ACTN3genotype influences skeletal muscle mass regulation and response to dexamethasone', , http://dx.doi.org/10.1101/2020.11.20.392282

Shah M; Funnell APW; Quinlan KGR; Crossley M, 2019, 'Hit and Run Transcriptional Repressors Are Difficult to Catch in the Act', BioEssays, 41, pp. e1900041, http://dx.doi.org/10.1002/bies.201900041

Martyn GE; Wienert B; Kurita R; Nakamura Y; Quinlan KGR; Crossley M, 2019, 'A natural regulatory mutation in the proximal promoter elevates fetal globin expression by creating a de novo GATA1 site', Blood, 133, pp. 852 - 856, http://dx.doi.org/10.1182/blood-2018-07-863951

Caruana BT; Byrne FL; Knights AJ; Quinlan KGR; Hoehn KL, 2019, 'Characterization of glucose transporter 6 in lipopolysaccharide-induced bone marrow-derived macrophage function', Journal of Immunology, 202, pp. 1826 - 1832, http://dx.doi.org/10.4049/jimmunol.1801063

Artuz CM; Knights AJ; Funnell APW; Gonda TJ; Ravid K; Pearson RCM; Quinlan KGR; Crossley M, 2018, 'Partial reprogramming of heterologous cells by defined factors to generate megakaryocyte lineage-restricted biomolecules', Biotechnology Reports, 20, http://dx.doi.org/10.1016/j.btre.2018.e00285

Wienert B; Martyn GE; Funnell APW; Quinlan KGR; Crossley M, 2018, 'Wake-up Sleepy Gene: Reactivating Fetal Globin for β-Hemoglobinopathies', Trends in Genetics, 34, pp. 927 - 940, http://dx.doi.org/10.1016/j.tig.2018.09.004

Knights AJ; Vohralik EJ; Hoehn KL; Crossley M; Quinlan KGR, 2018, 'Defining Eosinophil Function in Adiposity and Weight Loss', BioEssays, 40, http://dx.doi.org/10.1002/bies.201800098

Martyn GE; Wienert B; Yang L; Shah M; Norton LJ; Burdach J; Kurita R; Nakamura Y; Pearson RCM; Funnell APW; Quinlan KGR; Crossley M, 2018, 'Natural regulatory mutations elevate the fetal globin gene via disruption of BCL11A or ZBTB7A binding', Nature Genetics, 50, pp. 498 - 503, http://dx.doi.org/10.1038/s41588-018-0085-0

Summers MA; Rupasinghe T; Vasiljevski ER; Evesson FJ; Mikulec K; Peacock L; Quinlan KGR; Cooper ST; Roessner U; Stevenson DA; Little DG; Schindeler A, 2018, 'Dietary intervention rescues myopathy associated with neurofibromatosis type 1', Human Molecular Genetics, 27, pp. 577 - 588, http://dx.doi.org/10.1093/hmg/ddx423

Norton LJ; Hallal S; Stout ES; Funnell APW; Pearson RCM; Crossley M; Quinlan KGR, 2017, 'Direct competition between DNA binding factors highlights the role of Krüppel-like Factor 1 in the erythroid/megakaryocyte switch', Scientific Reports, 7, pp. 3137, http://dx.doi.org/10.1038/s41598-017-03289-5

Hamey JJ; Wienert B; Quinlan KGR; Wilkins MR, 2017, 'METTL21B Is a Novel Human lysine methyltransferase of translation elongation factor 1A: Discovery by CRISPR/Cas9 Knockout', Molecular and Cellular Proteomics, 16, pp. 2229 - 2242, http://dx.doi.org/10.1074/mcp.M116.066308

Wienert B; Martyn GE; Kurita R; Nakamura Y; Quinlan KGR; Crossley M, 2017, 'KLF1 drives the expression of fetal hemoglobin in British HPFH', Blood, 130, pp. 803 - 807, http://dx.doi.org/10.1182/blood-2017-02-767400

Baldwin JN; McKay MJ; Simic M; Hiller CE; Moloney N; Nightngale EJ; Burns J; 1000 Norms Project Consortium ; Huebscher M, 2017, 'Self-reported knee pain and disability among healthy individuals: reference data and factors associated with the Knee injury and Osteoarthritis Outcome Score (KOOS) and KOOS-Child', Osteoarthritis and Cartilage, pp. 1282 - 1290, http://dx.doi.org/10.1016/j.joca.2017.03.007

Houweling PJ; Berman YD; Turner N; Quinlan KGR; Seto JT; Yang N; Lek M; MacArthur DG; Cooney G; North KN, 2017, 'Exploring the relationship between α-actinin-3 deficiency and obesity in mice and humans', International Journal of Obesity, 41, pp. 1154 - 1157, http://dx.doi.org/10.1038/ijo.2017.72

Martyn GE; Quinlan KGR; Crossley M, 2017, 'The regulation of human globin promoters by CCAAT box elements and the recruitment of NF-Y', Biochimica et Biophysica Acta - Gene Regulatory Mechanisms, 1860, pp. 525 - 536, http://dx.doi.org/10.1016/j.bbagrm.2016.10.002

Norton LJ; Funnell APW; Burdach J; Wienert B; Kurita R; Nakamura Y; Philipsen S; Pearson RCM; Quinlan KGR; Crossley M, 2017, 'KLF1 directly activates expression of the novel fetal globin repressor ZBTB7A/LRF in erythroid cells', Blood Advances, 1, pp. 685 - 692, http://dx.doi.org/10.1182/bloodadvances.2016002303

McKay MJ; Baldwin JN; Ferreira P; Simic M; Vanicek N; Burns J; Nightingale E; Pourkazemi F; Sman A; Hiller C; Mousavi S; Nicholson L; Rose K; Chard A; Mackey M; Moloney N; Raymond J; Yan AF; Hübscher M; Refshauge K; Wegener C; Lee F; North K; Quinlan K, 2017, 'Reference values for developing responsive functional outcome measures across the lifespan', Neurology, 88, pp. 1512 - 1519, http://dx.doi.org/10.1212/WNL.0000000000003847

McKay MJ; Baldwin JN; Ferreira P; Simic M; Vanicek N; Burns J; Nightingale E; Pourkazemi F; Sman A; Hiller C; Mousavi S; Nicholson L; Rose K; Chard A; Mackey M; Moloney N; Raymond J; Yan AF; Hübscher M; Refshauge K; Wegener C; Lee F; North K; Quinlan K, 2017, 'Normative reference values for strength and flexibility of 1,000 children and adults', Neurology, 88, pp. 36 - 43, http://dx.doi.org/10.1212/WNL.0000000000003466

Baldwin JN; McKay MJ; Hiller CE; Nightingale EJ; Moloney N; Burns J; Chard A; Ferreira P; Yan AF; Hawke F; Lee (née Zheng) F; Mackey M; Mousavi S; Nicholson L; Pourkazemi F; Raymond J; Rose K; Simic M; Sman A; Wegener C; Refshauge KM; Hübscher M; Vanicek N; Quinlan K; North K, 2017, 'Correlates of Perceived Ankle Instability in Healthy Individuals Aged 8 to 101 Years', Archives of Physical Medicine and Rehabilitation, 98, pp. 72 - 79, http://dx.doi.org/10.1016/j.apmr.2016.08.474

Knights AJ; Yik JJ; Jusoh HM; Norton LJ; Funnell APW; Pearson RCM; Bell-Anderson KS; Crossley M; Quinlan KGR, 2016, 'Krüppel-like factor 3 (KLF3/BKLF) is required for widespread repression of the inflammatory modulator galectin-3 (Lgals3)', Journal of Biological Chemistry, 291, pp. 16048 - 16058, http://dx.doi.org/10.1074/jbc.M116.715748

Lee FXZ; Houweling PJ; North KN; Quinlan KGR, 2016, 'How does α-actinin-3 deficiency alter muscle function? Mechanistic insights into ACTN3, the 'gene for speed'', Biochimica et Biophysica Acta - Molecular Cell Research, 1863, pp. 686 - 693, http://dx.doi.org/10.1016/j.bbamcr.2016.01.013

McKay MJ; Baldwin JN; Ferreira P; Simic M; Vanicek N; Hiller CE; Nightingale EJ; Moloney NA; Quinlan KG; Pourkazemi F; Sman AD; Nicholson LL; Mousavi SJ; Rose K; Raymond J; Mackey MG; Chard A; Hübscher M; Wegener C; Fong Yan A; Refshauge KM; Burns J, 2016, '1000 Norms Project: Protocol of a cross-sectional study cataloging human variation', Physiotherapy (United Kingdom), 102, pp. 50 - 56, http://dx.doi.org/10.1016/j.physio.2014.12.002

Hogarth MW; Garton FC; Houweling PJ; Tukiainen T; Lek M; Macarthur DG; Seto JT; Quinlan KGR; Yang N; Head SI; North KN, 2016, 'Analysis of the ACTN3 heterozygous genotype suggests that α-actinin-3 controls sarcomeric composition and muscle function in a dose-dependent fashion', Human Molecular Genetics, 25, pp. 866 - 877, http://dx.doi.org/10.1093/hmg/ddv613

Lim WF; Burdach J; Funnell APW; Pearson RCM; Quinlan KGR; Crossley M, 2015, 'Directing an artificial zinc finger protein to new targets by fusion to a non-DNA-binding domain', Nucleic Acids Research, 44, pp. 3118 - 3130, http://dx.doi.org/10.1093/nar/gkv1380

Houweling P; Seto J; Garton F; Quinlan K; Head S; North K, 2015, 'A gene for speed: The influence of ACTN3 on muscle performance in health and disease', NEUROMUSCULAR DISORDERS, 25, pp. S185 - S185, http://dx.doi.org/10.1016/j.nmd.2015.06.011

Quinlan KG; Summers MA; Payne JM; Little DG; North KN; Schindeler A, 2015, 'Skeletal muscle and motor deficits in Neurofibromatosis Type 1', J Musculoskelet Neuronal Interact, 15, pp. 161 - 170

Wienert B; Funnell APW; Norton LJ; Pearson RCM; Wilkinson-White LE; Lester K; Vadolas J; Porteus MH; Matthews JM; Quinlan KGR; Crossley M, 2015, 'Editing the genome to introduce a beneficial naturally occurring mutation associated with increased fetal globin', Nature Communications, 6, pp. 7085, http://dx.doi.org/10.1038/ncomms8085

Dewi V; Kwok A; Lee S; Lee MM; Tan YM; Nicholas HR; Isono KI; Wienert B; Mak KS; Knights AJ; Quinlan KGR; Cordwell SJ; Funnell APW; Pearson RCM; Crossley M, 2015, 'Phosphorylation of krüppel-like factor 3 (KLF3/BKLF) and C-terminal binding protein 2 (CtBP2) by homeodomaininteracting protein kinase 2 (HIPK2) modulates KLF3 DNA binding and activity', Journal of Biological Chemistry, 290, pp. 8591 - 8605, http://dx.doi.org/10.1074/jbc.M115.638338

Head SI; Chan S; Houweling PJ; Quinlan KGR; Murphy R; Wagner S; Friedrich O; North KN, 2015, 'Altered Ca²⁺ Kinetics Associated with α-Actinin-3 Deficiency May Explain Positive Selection for ACTN3 Null Allele in Human Evolution', PLoS Genetics, 11, pp. e1004862, http://dx.doi.org/10.1371/journal.pgen.1004862

Yuen M; Sandaradura SA; Dowling JJ; Kostyukova AS; Moroz N; Quinlan KG; Lehtokari VL; Ravenscroft G; Todd EJ; Ceyhan-Birsoy O; Gokhin DS; Maluenda J; Lek M; Nolent F; Pappas CT; Novak SM; D'Amico A; Malfatti E; Thomas BP; Gabriel SB; Gupta N; Daly MJ; Ilkovski B; Houweling PJ; Davidson AE; Swanson LC; Brownstein CA; Gupta VA; Medne L; Shannon P; Martin N; Bick DP; Flisberg A; Holmberg E; Van Den Bergh P; Lapunzina P; Waddell LB; Sloboda DD; Bertini E; Chitayat D; Telfer WR; Laquerrière A; Gregorio CC; Ottenheijm CAC; Bönnemann CG; Pelin K; Beggs AH; Hayashi YK; Romero NB; Laing NG; Nishino I; Wallgren-Pettersson C; Melki J; Fowler VM; MacArthur DG; North KN; Clarke NF, 2014, 'Leiomodin-dysfunction results in thin filament disorganization and nemaline myopathy', Journal of Clinical Investigation, 124, pp. 4693 - 4708, http://dx.doi.org/10.1172/JCI75199

Clifton MK; Westman BJ; Thong SY; O'Connell MR; Webster MW; Shepherd NE; Quinlan KG; Crossley M; Blobel GA; Mackay JP, 2014, 'The identification and structure of an N-terminal PR domain show that FOG1 is a member of the PRDM family of proteins', PLoS ONE, 9, pp. e106011, http://dx.doi.org/10.1371/journal.pone.0106011

Funnell APW; Vernimmen D; Lim WF; Mak KS; Wienert B; Martyn GE; Artuz CM; Burdach J; Quinlan KGR; Higgs DR; Whitelaw E; Pearson RCM; Crossley M, 2014, 'Differential regulation of the α-globin locus by Krüppel-like factor 3 in erythroid and non-erythroid cells', BMC Molecular Biology, 15, pp. 8, http://dx.doi.org/10.1186/1471-2199-15-8

Garton FC; Seto JT; Quinlan KGR; Yang N; Houweling PJ; North KN, 2014, 'α-Actinin-3 deficiency alters muscle adaptation in response to denervation and immobilization', Human molecular genetics, 23, pp. 1879 - 1893, http://dx.doi.org/10.1093/hmg/ddt580

Sullivan K; El-hoss J; Quinlan KGR; Deo N; Garton F; Seto JTC; Gdalevitch M; Turner N; Cooney GJ; Kolanczyk M; North KN; Little DG; Schindeler A, 2014, 'NF1 is a critical regulator of muscle development and metabolism', Human Molecular Genetics, 23, pp. 1250 - 1259, http://dx.doi.org/10.1093/hmg/ddt515

Thomas KC; Zheng XF; Suarez FG; Raftery JM; Quinlan KGR; Yang N; North KN; Houweling PJ, 2014, 'Evidence based selection of commonly used RT-qPCR reference genes for the analysis of mouse skeletal muscle', PLoS ONE, 9, pp. e88653, http://dx.doi.org/10.1371/journal.pone.0088653

Seto JT; Quinlan KGR; Lek M; Zheng XF; Garton F; Macarthur DG; Hogarth MW; Houweling PJ; Gregorevic P; Turner N; Cooney GJ; Yang N; North KN, 2013, 'ACTN3 genotype infuences muscle performance through the regulation of calcineurin signaling', Journal of Clinical Investigation, 123, pp. 4255 - 4263, http://dx.doi.org/10.1172/JCI67691

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