By Professor Kate Louise Seib

Journal articles

Veggi D; Gentile MA; Cantini F; Lo Surdo P; Nardi-Dei V; Seib KL; Pizza M; Rappuoli R; Banci L; Savino S; Scarselli M, 2012, 'The factor h binding protein of neisseria meningitidis interacts with xenosiderophores in vitro', Biochemistry, 51, pp. 9384 - 9393, http://dx.doi.org/10.1021/bi301161w

Seib KL; Zhao X; Rappuoli R, 2012, 'Developing vaccines in the era of genomics: A decade of reverse vaccinology', Clinical Microbiology and Infection, 18, pp. 109 - 116, http://dx.doi.org/10.1111/j.1469-0691.2012.03939.x

Moriel DG; Rosini R; Seib KL; Serino L; Pizza M; Rappuoli R, 2012, 'Escherichia coli: Great diversity around a common core', Mbio, 3, http://dx.doi.org/10.1128/mBio.00118-12

Seib KL; Pigozzi E; Muzzi A; Gawthorne JA; Delany I; Jennings MP; Rappuoli R, 2011, 'A novel epigenetic regulator associated with the hypervirulent Neisseria meningitidis clonal complex 41/44', FASEB Journal, 25, pp. 3622 - 3633, http://dx.doi.org/10.1096/fj.11-183590

Echenique-Rivera H; Muzzi A; Del Tordello E; Seib KL; Francois P; Rappuoli R; Pizza M; Serruto D, 2011, 'Transcriptome analysis of Neisseria meningitidis in human whole blood and mutagenesis studies identify virulence factors involved in blood survival', Plos Pathogens, 7, http://dx.doi.org/10.1371/journal.ppat.1002027

Budroni S; Siena E; Dunning Hotopp JC; Seib KL; Serruto D; Nofroni C; Comanducci M; Riley DR; Daugherty SC; Angiuoli SV; Covacci A; Pizza M; Rappuoli R; Moxon ER; Tettelin H; Medini D, 2011, 'Neisseria meningitidis is structured in clades associated with restriction modification systems that modulate homologous recombination', Proceedings of the National Academy of Sciences of the United States of America, 108, pp. 4494 - 4499, http://dx.doi.org/10.1073/pnas.1019751108

Seib KL; Brunelli B; Brogioni B; Palumbo E; Bambini S; Muzzi A; DiMarcello F; Marchi S; Van Der Ende A; Aricó B; Savino S; Scarselli M; Comanducci M; Rappuoli R; Giuliani MM; Pizza M, 2011, 'Characterization of diverse subvariants of the meningococcal factor H (fH) binding protein for their ability to bind fH, to mediate serum resistance, and to induce bactericidal antibodies', Infection and Immunity, 79, pp. 970 - 981, http://dx.doi.org/10.1128/IAI.00891-10

Seib KL; Oriente F; Adu-Bobie J; Montanari P; Ferlicca F; Giuliani MM; Rappuoli R; Pizza M; Delany I, 2010, 'Influence of serogroup B meningococcal vaccine antigens on growth and survival of the meningococcus in vitro and in ex vivo and in vivo models of infection', Vaccine, 28, pp. 2416 - 2427, http://dx.doi.org/10.1016/j.vaccine.2009.12.082

Wu HJ; Seib KL; Srikhanta YN; Edwards J; Kidd SP; Maguire TL; Hamilton A; Pan KT; Hsiao HH; Yao CW; Grimmond SM; Apicella MA; McEwan AG; Wang AHJ; Jennings MP, 2010, 'Manganese regulation of virulence factors and oxidative stress resistance in Neisseria gonorrhoeae', Journal of Proteomics, 73, pp. 899 - 916, http://dx.doi.org/10.1016/j.jprot.2009.12.001

Serruto D; Spadafina T; Ciucchi L; Lewis LA; Ram S; Tontini M; Santini L; Biolchi A; Seib KL; Giuliani MM; Donnelly JJ; Berti F; Savino S; Scarselli M; Costantino P; Simon Kroll J; O'Dwyer C; Qiu J; Plaut AG; Moxon R; Rappuoli R; Pizza M; Aricò B, 2010, 'Neisseria meningitidis GNA2132, a heparin-binding protein that induces protective immunity in humans', Proceedings of the National Academy of Sciences of the United States of America, 107, pp. 3770 - 3775, http://dx.doi.org/10.1073/pnas.0915162107

Seib KL; Dougan G; Rappuoli R, 2009, 'The key role of genomics in modern vaccine and drug design for emerging infectious diseases', Plos Genetics, 5, http://dx.doi.org/10.1371/journal.pgen.1000612

Rinaudo CD; Telford JL; Rappuoli R; Seib KL, 2009, 'Vaccinology in the genome era', Journal of Clinical Investigation, 119, pp. 2515 - 2525, http://dx.doi.org/10.1172/JCI38330

Fantappiè L; Metruccio MME; Seib KL; Oriente F; Cartocci E; Ferlicca F; Giuliani MM; Scarlato V; Delany I, 2009, 'The RNA chaperone Hfq is involved in stress response and virulence in Neisseria meningitidis and is a pleiotropic regulator of protein expression', Infection and Immunity, 77, pp. 1842 - 1853, http://dx.doi.org/10.1128/IAI.01216-08

Srikhanta YN; Dowideit SJ; Edwards JL; Falsetta ML; Wu HJ; Harrison OB; Fox KL; Seib KL; Maguire TL; Wang AHJ; Maiden MC; Grimmond SM; Apicella MA; Jennings MP, 2009, 'Phasevarions mediate random switching of gene expression in pathogenic Neisseria', Plos Pathogens, 5, http://dx.doi.org/10.1371/journal.ppat.1000400

Seib KL; Serruto D; Oriente F; Delany I; Adu-Bobie J; Veggi D; Aricò B; Rappuoli R; Pizza M, 2009, 'Factor H-binding protein is important for meningococcal survival in human whole blood and serum and in the presence of the antimicrobial peptide LL-37', Infection and Immunity, 77, pp. 292 - 299, http://dx.doi.org/10.1128/IAI.01071-08

Ieva R; Roncarati D; Metruccio MME; Seib KL; Scarlato V; Delany I, 2008, 'OxyR tightly regulates catalase expression in Neisseria meningitidis through both repression and activation mechanisms', Molecular Microbiology, 70, pp. 1152 - 1165, http://dx.doi.org/10.1111/j.1365-2958.2008.06468.x

Seib KL; Wu HJ; Srikhanta YN; Edwards JL; Falsetta ML; Hamilton AJ; Maguire TL; Grimmond SM; Apicella MA; McEwan AG; Jennings MP, 2007, 'Characterization of the OxyR regulon of Neisseria gonorrhoeae', Molecular Microbiology, 63, pp. 54 - 68, http://dx.doi.org/10.1111/j.1365-2958.2006.05478.x

Power PM; Seib KL; Jennings MP, 2006, 'Pilin glycosylation in Neisseria meningitidis occurs by a similar pathway to wzy-dependent O-antigen biosynthesis in Escherichia coli', Biochemical and Biophysical Research Communications, 347, pp. 904 - 908, http://dx.doi.org/10.1016/j.bbrc.2006.06.182

Seib KL; Wu HJ; Kidd SP; Apicella MA; Jennings MP; McEwan AG, 2006, 'Defenses against oxidative stress in Neisseria gonorrhoeae: A system tailored for a challenging environment', Microbiology and Molecular Biology Reviews, 70, pp. 344 - 361, http://dx.doi.org/10.1128/MMBR.00044-05

Wu HJ; Seib KL; Srikhanta YN; Kidd SP; Edwards JL; Maguire TL; Grimmond SM; Apicella MA; McEwan AG; Jennings MP, 2006, 'PerR controls Mn-dependent resistance to oxidative stress in Neisseria gonorrhoeae', Molecular Microbiology, 60, pp. 401 - 416, http://dx.doi.org/10.1111/j.1365-2958.2006.05079.x

Wu HJ; Seib KL; Edwards JL; Apicella MA; McEwan AG; Jennings MP, 2005, 'Azurin of pathogenic Neisseria spp. is involved in defense against hydrogen peroxide and survival within cervical epithelial cells', Infection and Immunity, 73, pp. 8444 - 8448, http://dx.doi.org/10.1128/IAI.73.12.8444-8448.2005

Seib KL; Simons MP; Wu HJ; McEwan AG; Nauseef WM; Apicella MA; Jennings MP, 2005, 'Investigation of oxidative stress defenses of Neisseria gonorrhoeae by using a human polymorphonuclear leukocyte survival assay', Infection and Immunity, 73, pp. 5269 - 5272, http://dx.doi.org/10.1128/IAI.73.8.5269-5272.2005

Seib KL; Tseng HJ; McEwan AG; Apicella MA; Jennings MP, 2004, 'Defenses against oxidative stress in Neisseria gonorrhoeae and Neisseria meningitidis: Distinctive systems for different lifestyles', Journal of Infectious Diseases, 190, pp. 136 - 147, http://dx.doi.org/10.1086/421299

Seib KL; Jennings MP; McEwan AG, 2003, 'A Sco homologue plays a role in defence against oxidative stress in pathogenic Neisseria', FEBS Letters, 546, pp. 411 - 415, http://dx.doi.org/10.1016/S0014-5793(03)00632-X

Seib KL; Peak IRA; Jennings MP, 2002, 'Phase variable restriction-modification systems in Moraxella catarrhalis', FEMS Immunology and Medical Microbiology, 34, pp. 159 - 165, http://dx.doi.org/10.1111/j.1574-695X.2002.tb00548.x

Seib K, 2002, 'Phase variable restriction–modification systems in Moraxella catarrhalis', Pathogens and Disease, 32, pp. 159 - 165, http://dx.doi.org/10.1016/s0928-8244(01)00294-2

Conference Papers

Seib KL; Semchenko E; Eskandari S; Taha ; Slesarenko V; Huges I; O'Sullivan M; Thing C, 2022, 'Characterization of Meningococcal Vaccine--Induced Antibodies to Neisseria gonorrhoeae', in SEXUALLY TRANSMITTED DISEASES, LIPPINCOTT WILLIAMS & WILKINS, MA, Boston, pp. S52 - S53, presented at Annual Meeting of the Infectious-Diseases-Society-for-Obstetrics-and-Gynecology (IDSOG), MA, Boston, 04 August 2022 - 06 August 2022

Seib KL, 2019, 'PROGRESS TOWARDS A GONORRHOEA VACCINE', in SEXUALLY TRANSMITTED INFECTIONS, BMJ PUBLISHING GROUP, pp. A20 - A20, http://dx.doi.org/10.1136/sextrans-2019-sti.57

Seib KL; Semchenko EA, 2017, 'VACCINE DEVELOPMENT TO COMBAT ANTIMICROBIAL RESISTANT GONORRHOEA', in SEXUALLY TRANSMITTED INFECTIONS, BMJ PUBLISHING GROUP, pp. A30 - A30, http://dx.doi.org/10.1136/sextrans-2017-053264.74

Preprints

Thng C; Semchenko EA; Hughes I; O'Sullivan M; Seib KL, An open-label randomised controlled trial evaluating the efficacy of a meningococcal serogroup B (4CMenB) vaccine on Neisseria gonorrhoeae infection in gay and bisexual men: the MenGO study Protocol, http://dx.doi.org/10.21203/rs.3.rs-2252982/v1

Pollock GL; Pasricha S; Azzopardi KI; de Kretser D; Semchenko EA; Seib KL; Osowicki J; Williamson DA; Williams E; McCarthy JS, Characterisation and manufacture of a Neisseria gonorrhoeae challenge agent for use in an oropharyngeal controlled human infection model, http://dx.doi.org/10.64898/2026.08.06.743127

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