By Professor Levon Michael Khachigian

Journal articles

Zhang C; Kavurma MM; Lai A; Khachigian LM, 2003, 'Ets-1 protects vascular smooth muscle cells from undergoing apoptosis by activating p21^WAF1/Cip1: ETS-1 regulates basal and inducible p21^WAF1/Cip1 transcription via distinct cis-acting elements in the p21^WAF1/Cip1 promoter', Journal of Biological Chemistry, 278, pp. 27903 - 27909, http://dx.doi.org/10.1074/jbc.M304328200

Lowe HC; Jang IK; Khachigian LM, 2003, 'Animal models of vulnerable plaque', Thrombosis and Haemostasis, 90, pp. 774 - 780

Francis DJ; Parish CR; McGarry M; Santiago FS; Lowe HC; Brown KJ; Bingley JA; Hayward IP; Cowden WB; Campbell JH; Campbell GR; Chesterman CN; Khachigian LM, 2003, 'Blockade of Vascular Smooth Muscle Cell Proliferation and Intimal Thickening After Balloon Injury by the Sulfated Oligosaccharide PI-88', Circulation Research, 92, pp. 70 - 77

Khachigian L, 2003, 'DNAzymes targeting immediate-early genes: potential therapeutic tools in in-stent restenosis and angiogenesis', Journal of Thrombosis and Haemostasis, 1, pp. OC231 - OC231, http://dx.doi.org/10.1111/j.1538-7836.2003.tb04637.x

Burkhart CA; Cheng AJ; Madafiglio J; Kavallaris M; Mili M; Marshall GM; Weiss WA; Khachigian LM; Norris MD; Haber M, 2003, 'Effects of MYCN antisense oligonucleotide administration on tumorigenesis in a murine model of neuroblastoma', Journal of National Cancer Institute, 95, pp. 1394 - 1403

Kavurma MM; Khachigian LM, 2003, 'ERK, JNK, and p38 MAP Kinases Differentially Regulate Proliferation and Migration of Phenotypically Distinct Smooth Muscle Cell Subtypes', Journal of Cellular Biochemistry, 89, pp. 289 - 300

Ward MR; Hanratty CG; Murrell M; Khachigian L; Tsao PS, 2003, 'Low flow increases stent restenosis. Comparison with flow-dependent lumen loss after angioplasty and effects of the antioxidant PDTC', Heart, Lung and Circulation, 12, pp. A73 - A74, http://dx.doi.org/10.1046/j.1443-9506.2003.02873.x

Pimanda JE; Lowe HC; Hogg PJ; Chesterman CN; Khachigian LM, 2003, 'Novel and Emerging Therapies in Cardiology and Haematology', Current Drug Targets, 3, pp. 101 - 103

Eisbacher M; Holmes ML; Newton A; Hogg PJ; Crossley M; Chong BH; Khachigian LM, 2003, 'Protein-protein interaction between Fli-1 and GATA 1 mediates synergistic expression of megakaryocyte-specific genes through cooperative DNA binding', Molecular and Cellular Biology, 23, pp. 3427 - 3441, http://dx.doi.org/10.1128/MCB.23.10.3427-3441.2003

Kavurma MM; Khachigian LM, 2003, 'Signaling and transcriptional control of Fas ligand gene expresion', Cell death and differentiation, 10, pp. 36 - 44

Fahmy R; Dass CR; Sun L; Chesterman CN; Khachigian LM, 2003, 'Transcription factor Egr-1 supports FGF-dependent angiogenesis during neovascularization and tumour growth', Nature Medicine, 9, pp. 1026 - 1032

MacNeill BD; James B; Chesterman CN; Khachigian LM, 2002, 'Overstretch stent injury to the rat aorta leads to in-stent restenosis', American Journal of Cardiology, 89, pp. 1010, http://dx.doi.org/10.1016/S0002-9149(02)02264-6

Lowe HC; Khachigian LM, 2002, 'Coating stents with antirestenotic drugs: the blunderbuss or the magic bullet?', Circulation, 105, http://dx.doi.org/10.1161/circ.105.4.e29

Fahmy R; Khachigian LM, 2002, 'Antisense Egr-1 RNA driven by the CMV promoter is an inhibitor of vascular smooth muscle cell proliferation and regrowth after injury', Journal of Cellular Biochemistry, 84, pp. 575 - 582

Lowe HC; Burkoff D; Khachigian LM; MacNeill BD; Hayase M; Oesterle SN, 2002, 'Beyond angioplasty: novel developments in interventional cardiology', Internal Medicine Journal, 32, pp. 470 - 474

Khachigian LM; Fahmy R; Zhang GS; Bobryshev YV; Kaniaros A, 2002, 'c-Jun regulates vascular smooth muscle cell growth and neointima formation after arterial injury. Inhibition by a novel DNA enzyme targeting c-Jun', The Journal of Biological Chemistry, 277, pp. 22985 - 22991

Lowe HC; Chesterman CN; Khachigian LM, 2002, 'Catalytic Antisense DNA Molecules Targeting Egr-1 Inhibit Neointima Formation following Permanent Ligation of Rat Common Carotid Arteries', Thrombosis and Haemostasis, 87, pp. 134 - 140

Lowe HC; Oesterle SN; Khachigian LM, 2002, 'Coronary In-Stent Restenosis: Current Status and Future Strategies', Journal of the American College of Cardiology, 39, pp. 183 - 193

Khachigian LM, 2002, 'DNAzymes: cutting a path to a new class of therapeutics', Current Opinion in Molecular Therapeutics, 4, pp. 119 - 121

Kavurma MM; Bobryshev YV; Khachigian LM, 2002, 'Ets-1 positively regulates Fas ligand transcription via cooperative interactions with Sp1', The Journal of Biological Chemistry, 277, pp. 36244 - 36252

Rafty LA; Santiago FS; Khachigian LM, 2002, 'NF1/X represses PDGF A-chain transcription by interacting with Sp1 and antagonizing Sp1 occupancy of the promoter', European Molecular Biology Organization, 21, pp. 334 - 343

Rafty LA; Khachigian LM, 2002, 'von Hippel-Lindau tumor suppressor protein represses platelet-derived growth factor B-chain gene expression via the Sp1 binding element in the proximal PDGF-B promoter', Journal of Cellular Biochemistry, 85, pp. 490 - 495

Eisbacher M; Newton A; Holmes ML; Khachigian LM; Crossley M; Chong BH, 2001, 'The protein-protein interaction between FLI-1 and GATA-1 is crucial for expression of the megakaryocyte-specific gene Glycoprotein IX.', BLOOD, 98, pp. 286A - 286A, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000172134101211&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Lowe HC; Fahmy R; Chesterman CN; Khachigian LM, 2001, 'Catalytic oligodeoxynucleotides targeting the human transcription factor EGR-1 as inhibitors of restenosis', CIRCULATION, 104, pp. 265 - 265, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000171895001261&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Rafty LA; Khachigian LM, 2001, 'Sp1 phosphorylation mediates inducible platelet-derived growth factor B-chain gene expression: Phosphorylation mediated by atypical protein kinase C-zeta', FASEB JOURNAL, 15, pp. A1185 - A1185, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000167454202722&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Khachigian LM, 2001, 'Catalytic oligonucleotides targeting Egr-1 as potential inhibitors of in-stent restenosis', Annals of the New York Academy of Sciences, 947, pp. 412 - 415, http://dx.doi.org/10.1111/j.1749-6632.2001.tb03975.x

Khachigian LM, 2001, 'Single-stranded catalytic dna as potential therapeutic agents in vascular disease', Today's Life Science, 13, pp. 30 - 31

Lowe HC; Chesterman CN; Hopkins AP; Juergens CP; Khachigian LM, 2001, 'Acute Local Release of Fibroblast Growth Factor 2 but not Transforming Growth Factor B1 following Coronary Stenting', Journal of Thrombosis and Thrombolysis, pp. 574 - 576

Lowe HC; Fahmy R; Kavurma MM; Baker A; Chesterman CN; Khachigian LM, 2001, 'Catalytic Oligodeoxynucleotides Define a Key Regulatory Role for Early Growth Response Factor-1 in the Porcine Model of Coronary In-Stent Restenosis', Circulation Research, pp. 670 - 677

Lowe HC; Kumar RK; Chesterman CN; Fahmy R; Khachigian LM, 2001, 'Coronary Stent Thrombosis: Insights from the Porcine Coronary Stent Model', Journal of Thrombosis and Thrombolysis, pp. 937 - 938

Lowe HC; Chesterman CN; Khachigian LM, 2001, 'Does Thrombus Contribute to In-stent Restenosis in the Porcine Coronary Stent Model?', Journal of Thrombosis and Thrombolysis, pp. 1117 - 1118

Gousseva N; Kugathasan K; Chesterman CN; Khachigian LM, 2001, 'Early Growth Response Factor-1 Mediates Insulin-Inducible Vascular Endothelial Cell Proliferation and Regrowth After Injury', Journal of Cellular Biochemistry, pp. 523 - 534

Santiago FS; Lowe HC; Bobryshev YV; Khachigian LM, 2001, 'Induction of the transcriptional repressor Yin Yang-1 by vascular cell injury. Autocrine/paracrine role of endogenous fibroblast growth factor-2.', The Journal of Biological Chemistry, pp. 41143 - 41149

Santiago FS; Khachigian LM, 2001, 'Nucleic acid based strategies as potential therapeutic tools: mechanistic considerations and implications to restenosis.', Molecular Medicine, pp. 695 - 706

Lowe HC; Chesterman CN; Khachigian LM, 2001, 'Rat Aortic Stenting: Toward a Simple Model of In-Stent Restenosis', American Journal of Cardiology, pp. 720 - 721

Kavurma MM; Santiago FS; Bonfoco E; Khachigian LM, 2001, 'Sp1 Phosphorylation Regulates Apoptosis via Extracellular FasL-Fas Engagement', The Journal of Biological Chemistry, pp. 4964 - 4971

Rafty LA; Khachigian LM, 2001, 'Sp1 phosphorylation regulates inducible expression of platelet-derived growth factor B-chain gene via atypical proten kinase C-', Nucleic Acids Research, pp. 1027 - 1033

Chong BH; Eisbacher M; Khin TH; Khachigian LM, 2000, 'Inducible expression of GPIX by PMA and TPO in megakaryocytic cells requires an intact Ets site and upstream activation of ERK.', BLOOD, 96, pp. 672A - 672A, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000165256102891&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Lowe HC; Chesterman CN; Hopkins AP; Juergens CP; Khachigian LM, 2000, 'Acute local release of fibroblast growth factor-2, but not transforming growth factor-beta(1), following coronary stenting', CIRCULATION, 102, pp. 732 - 732, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000090072303532&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Lowe HC; Santiago FS; Chesterman CN; Khachigian LM, 2000, 'A novel catalytic DNA molecule targeting the transcription factor Egr-1 inhibits neointimal formation following rat carotid angioplasty', JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 35, pp. 15A - 15A, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000085209700059&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Lowe HC; Santiago FS; Chesterman CN; Khachigian LM, 2000, 'Immobilized hyaluronic acid as a thromboresistant coating for cardiovascular devices', JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 35, pp. 15A - 15A, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000085209700057&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Khachigian LM, 2000, 'Catalytic DNAs as potential therapeutic agents and sequent-specific molecular tools to dissect biological function', Journal of Clinical Investigation, 106, pp. 1189 - 1195

Lowe HC; Costandi M; Chesterman CN; Khachigian LM, 2000, 'Human vascular injury triggers fibroblast growth factor 2 (FGF 2) release. Neointima formation in vitro is inhibited by novel catalytic DNA molecules targeting human EGR-1', Heart, Lung and Circulation, 9, pp. A95 - A95, http://dx.doi.org/10.1046/j.1443-9506.2000.0622x.x

Tapsall JW; Khachigian LM, 2000, 'Induction of platelet-derived growth factor B-chain expression by transforming growth factor-b involves transactivation by smads', The Journal of Biological Chemistry, pp. 16709 - 16716

Lowe HC; Murray BJ; Chong BH; Chesterman CN; Khachigian LM, 2000, 'Intracoronary blood sampling using the multifunction probing catheter does not cause platelet activation', Journal of Invasive Cardiology, 12, pp. 144 - 146

Khachigian LM; Takuwa Y; Collins TF, 2000, 'Mechanisms of angiotensin II-induced platelet-derived growth factor gene expression', Molecular and Cellular Biochemistry, pp. 183 - 186

Lowe HC; Chesterman CN; Khachigian LM, 2000, 'Neointimal formation following rat carotid angioplasty is inhibited by a novel catalytic DNA molecule targeting the transcription factor EGR-1', Heart, Lung and Circulation, 9, pp. A90 - A90, http://dx.doi.org/10.1046/j.1443-9506.2000.06012.x

Rafty LA; Khachigian LM, 2000, 'Novel negative regulatory element in the platelet-derived growth factor B chain promoter that mediates ERK-dependent transcriptional repression', The Journal of Biological Chemistry, pp. 11478 - 11483

Larkin L; Khachigian LM; Jessup W, 2000, 'Regulation of apolipoprotein E production in macrophages', International Journal of Molecular Medicine, pp. 253 - 258

Sungaran R; Chisholm OT; Markovic B; Khachigian LM; Tanaka Y; Chong BH, 2000, 'The role of platelet ?-granular proteins in the regulation of thrombopoietin messenger RNA expression in human bone marrow stromal cells.', Blood, pp. 3094 - 3101

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