By Professor Levon Michael Khachigian

Journal articles

Khachigian LM, 2024, 'Early growth response-1, a dynamic conduit in cardiovascular disease', Frontiers in Cardiovascular Medicine, 11, http://dx.doi.org/10.3389/fcvm.2024.1487668

Zhang J; Joshua AM; Li Y; O'Meara CH; Morris MJ; Khachigian LM, 2024, 'Targeted therapy, immunotherapy, and small molecules and peptidomimetics as emerging immunoregulatory agents for melanoma', Cancer Letters, 586, http://dx.doi.org/10.1016/j.canlet.2024.216633

Khoo A; Boyer M; Jafri Z; Makeham T; Pham T; Khachigian LM; Floros P; Dowling E; Fedder K; Shonka D; Garneau J; O’Meara CH, 2024, 'Human Papilloma Virus Positive Oropharyngeal Squamous Cell Carcinoma and the Immune System: Pathogenesis, Immunotherapy and Future Perspectives', International Journal of Molecular Sciences, 25, http://dx.doi.org/10.3390/ijms25052798

O’Meara CH; Nguyen TV; Jafri Z; Boyer M; Shonka DC; Khachigian LM, 2024, 'Personalised Medicine and the Potential Role of Electrospinning for Targeted Immunotherapeutics in Head and Neck Cancer', Nanomaterials, 14, http://dx.doi.org/10.3390/nano14010006

Khachigian LM; Liew G; Teo KYC; Wong TY; Mitchell P, 2023, 'Emerging therapeutic strategies for unmet need in neovascular age-related macular degeneration', Journal of Translational Medicine, 21, http://dx.doi.org/10.1186/s12967-023-03937-7

Li Y; Wu B; Hossain MJ; Quagliata L; O’Meara C; Wilkins MR; Corley S; Khachigian LM, 2023, 'Flubendazole inhibits PD-1 and suppresses melanoma growth in immunocompetent mice', Journal of Translational Medicine, 21, http://dx.doi.org/10.1186/s12967-023-04289-y

Khachigian LM, 2023, 'The MEK-ERK-Egr-1 axis and its regulation in cardiovascular disease', Vascular Pharmacology, 153, http://dx.doi.org/10.1016/j.vph.2023.107232

Broadhead GK; Khachigian LM, 2023, 'Translating discoveries as novel biomarkers and interventions in ophthalmology', Journal of Translational Medicine, 21, http://dx.doi.org/10.1186/s12967-023-04216-1

O’Meara CH; Jafri Z; Khachigian LM, 2023, 'Immune Checkpoint Inhibitors, Small-Molecule Immunotherapies and the Emerging Role of Neutrophil Extracellular Traps in Therapeutic Strategies for Head and Neck Cancer', International Journal of Molecular Sciences, 24, http://dx.doi.org/10.3390/ijms241411695

Khachigian LM; Varcoe RL; Suoranta T; Laham-Karam N; Ylä-Herttuala S, 2023, 'Gene Therapeutic Strategies for Peripheral Artery Disease and New Opportunities Provided by Adeno-Associated Virus Vectors', Arteriosclerosis, Thrombosis, and Vascular Biology, 43, pp. 836 - 851, http://dx.doi.org/10.1161/ATVBAHA.122.318902

Billah M; Naz A; Noor R; Bhindi R; Khachigian LM, 2023, 'Early Growth Response-1: Friend or Foe in the Heart?', Heart Lung and Circulation, 32, pp. e23 - e35, http://dx.doi.org/10.1016/j.hlc.2023.02.005

Liew G; Tsang T; Marshall B; Saw M; Khachigian LM; Ong S; Ho IV; Wong V, 2023, 'Proportion of people with diabetic retinopathy and macular oedema varies by ethnicity in a tertiary retinal clinic in Australia: findings from the Liverpool Eye and Diabetes Study (LEADS)', BMJ Open, 13, http://dx.doi.org/10.1136/bmjopen-2021-055404

Khachigian LM; Black BL, 2023, 'TCF7L1 Exacerbates Abdominal Aortic Aneurysm Prevalence and Severity', JACC: Basic to Translational Science, 8, pp. 171 - 173, http://dx.doi.org/10.1016/j.jacbts.2022.09.006

Grapotte M; Saraswat M; Bessière C; Menichelli C; Ramilowski JA; Severin J; Hayashizaki Y; Itoh M; Tagami M; Murata M; Kojima-Ishiyama M; Noma S; Noguchi S; Kasukawa T; Hasegawa A; Suzuki H; Nishiyori-Sueki H; Frith MC; Abugessaisa I; Aitken S; Aken BL; Alam I; Alam T; Alasiri R; Alhendi AMN; Alinejad-Rokny H; Alvarez MJ; Andersson R; Arakawa T; Araki M; Arbel T; Archer J; Archibald AL; Arner E; Arner P; Asai K; Ashoor H; Astrom G; Babina M; Baillie JK; Bajic VB; Bajpai A; Baker S; Baldarelli RM; Balic A; Bansal M; Batagov AO; Batzoglou S; Beckhouse AG; Beltrami AP; Beltrami CA; Bertin N; Bhattacharya S; Bickel PJ; Blake JA; Blanchette M; Bodega B; Bonetti A; Bono H; Bornholdt J; Bttcher M; Bougouffa S; Boyd M; Breda J; Brombacher F; Brown JB; Bult CJ; Burroughs AM; Burt DW; Busch A; Caglio G; Califano A; Cameron CJ; Cannistraci CV; Carbone A; Carlisle AJ; Carninci P; Carter KW; Cesselli D; Chang JC; Chen JC; Chen Y; Chierici M; Christodoulou J; Ciani Y; Clark EL; Coskun M; Dalby M; Dalla E; Daub CO; Davis CA; de Hoon MJL; de Rie D; Denisenko E; Deplancke B; Detmar M; Deviatiiarov R; Di Bernardo D; Diehl AD; Dieterich LC, 2022, 'Author Correction: Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network (Nature Communications, (2021), 12, 1, (3297), 10.1038/s41467-021-23143-7)', Nature Communications, 13, http://dx.doi.org/10.1038/s41467-022-28758-y

Khachigian LM; Black BL; Ferdinandy P; De Caterina R; Madonna R; Geng YJ, 2022, 'Transcriptional regulation of vascular smooth muscle cell proliferation, differentiation and senescence: Novel targets for therapy', Vascular Pharmacology, 146, http://dx.doi.org/10.1016/j.vph.2022.107091

Deshpande N; Wilkins MR; Khachigian LM, 2022, 'RNA sequencing identifies genes reliant upon Ser26 in the zinc finger transcription factor, early growth response-1', Vascular Pharmacology, 143, http://dx.doi.org/10.1016/j.vph.2022.106952

Grapotte M; Saraswat M; Bessière C; Menichelli C; Ramilowski JA; Severin J; Hayashizaki Y; Itoh M; Tagami M; Murata M; Kojima-Ishiyama M; Noma S; Noguchi S; Kasukawa T; Hasegawa A; Suzuki H; Nishiyori-Sueki H; Frith MC; Abugessaisa I; Aitken S; Aken BL; Alam I; Alam T; Alasiri R; Alhendi AMN; Alinejad-Rokny H; Alvarez MJ; Andersson R; Arakawa T; Araki M; Arbel T; Archer J; Archibald AL; Arner E; Arner P; Asai K; Ashoor H; Astrom G; Babina M; Baillie JK; Bajic VB; Bajpai A; Baker S; Baldarelli RM; Balic A; Bansal M; Batagov AO; Batzoglou S; Beckhouse AG; Beltrami AP; Beltrami CA; Bertin N; Bhattacharya S; Bickel PJ; Blake JA; Blanchette M; Bodega B; Bonetti A; Bono H; Bornholdt J; Bttcher M; Bougouffa S; Boyd M; Breda J; Brombacher F; Brown JB; Bult CJ; Burroughs AM; Burt DW; Busch A; Caglio G; Califano A; Cameron CJ; Cannistraci CV; Carbone A; Carlisle AJ; Carninci P; Carter KW; Cesselli D; Chang JC; Chen JC; Chen Y; Chierici M; Christodoulou J; Ciani Y; Clark EL; Coskun M; Dalby M; Dalla E; Daub CO; Davis CA; de Hoon MJL; de Rie D; Denisenko E; Deplancke B; Detmar M; Deviatiiarov R; Di Bernardo D; Diehl AD; Dieterich LC, 2021, 'Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network', Nature Communications, 12, http://dx.doi.org/10.1038/s41467-021-23143-7

Khachigian LM, 2021, 'Emerging insights on functions of the anthelmintic flubendazole as a repurposed anticancer agent', Cancer Letters, 522, pp. 57 - 62, http://dx.doi.org/10.1016/j.canlet.2021.09.013

Khachigian LM, 2021, 'Early growth response-1, an integrative sensor in cardiovascular and inflammatory disease', Journal of the American Heart Association, 10, http://dx.doi.org/10.1161/JAHA.121.023539

Santiago FS; Li Y; Zhong L; Raftery MJ; Lins L; Khachigian LM, 2021, 'Truncated YY1 interacts with BASP1 through a ³³⁹KLK³⁴¹motif in YY1 and suppresses vascular smooth muscle cell growth and intimal hyperplasia after vascular injury', Cardiovascular Research, 117, pp. 2395 - 2406, http://dx.doi.org/10.1093/cvr/cvab021

Yeh MC; Wu BJ; Li Y; Elahy M; Prado-Lourenco L; Sockler J; Lau H; Day RO; Khachigian LM, 2021, 'BT2 suppresses human monocytic-endothelial cell adhesion, bone erosion and inflammation', Journal of Inflammation Research, 14, pp. 1019 - 1028, http://dx.doi.org/10.2147/JIR.S296676

Santiago FS; Li Y; Khachigian LM, 2021, 'Serine 26 in early growth response-1 is critical for endothelial proliferation, migration, and network formation', Journal of the American Heart Association, 10, pp. e020521, http://dx.doi.org/10.1161/JAHA.120.020521

Meara CHO; Coupland LA; Kordbacheh F; Quah BJC; Chang CW; Simon Davis DA; Bezos A; Browne AM; Freeman C; Hammill DJ; Chopra P; Pipa G; Madge PD; Gallant E; Segovis C; Dulhunty AF; Arnolda LF; Mitchell I; Khachigian LM; Stephens RW; von Itzstein M; Parish CR, 2020, 'Neutralizing the pathological effects of extracellular histones with small polyanions', Nature Communications, 11, http://dx.doi.org/10.1038/s41467-020-20231-y

Allahwala UK; Khachigian LM; Nour D; Ridiandres A; Billah M; Ward M; Weaver J; Bhindi R, 2020, 'Recruitment and maturation of the coronary collateral circulation: Current understanding and perspectives in arteriogenesis', Microvascular Research, 132, http://dx.doi.org/10.1016/j.mvr.2020.104058

Alam T; Agrawal S; Severin J; Young RS; Andersson R; Arner E; Hasegawa A; Lizio M; Ramilowski JA; Abugessaisa I; Ishizu Y; Noma S; Tarui H; Taylor MS; Lassmann T; Itoh M; Kasukawa T; Kawaji H; Marchionni L; Sheng G; Forrest ARR; Khachigian LM; Hayashizaki Y; Carninci P; De Hoon MJL, 2020, 'Comparative transcriptomics of primary cells in vertebrates', Genome Research, 30, pp. 951 - 961, http://dx.doi.org/10.1101/gr.255679.119

Khachigian LM, 2020, 'Pharmaceutical patents: reconciling the human right to health with the incentive to invent', Drug Discovery Today, 25, pp. 1135 - 1141, http://dx.doi.org/10.1016/j.drudis.2020.04.009

Li Y; Alhendi AMN; Yeh MC; Elahy M; Santiago FS; Deshpande NP; Wu B; Chan E; Inam S; Prado-Lourenco L; Marchand J; Joyce RD; Wilkinson-White LE; Raftery MJ; Zhu M; Adamson SJ; Barnat F; Viaud-Quentric K; Sockler J; Mackay JP; Chang A; Mitchell P; Marcuccio SM; Khachigian LM, 2020, 'Thermostable small-molecule inhibitor of angiogenesis and vascular permeability that suppresses a pERK-FosB/ΔFosB-VCAM-1 axis', Science Advances, 6, pp. eaaz7815, http://dx.doi.org/10.1126/sciadv.aaz7815

Billah M; Ridiandries A; Allahwala UK; Mudaliar H; Dona A; Hunyor S; Khachigian LM; Bhindi R, 2020, 'Remote ischemic preconditioning induces cardioprotective autophagy and signals through the IL-6-dependent JAK-STAT pathway', International Journal of Molecular Sciences, 21, http://dx.doi.org/10.3390/ijms21051692

Billah M; Ridiandries A; Rayner BS; Allahwala UK; Dona A; Khachigian LM; Bhindi R, 2020, 'Egr-1 functions as a master switch regulator of remote ischemic preconditioning-induced cardioprotection', Basic Research in Cardiology, 115, http://dx.doi.org/10.1007/s00395-019-0763-9

Khachigian LM, 2020, 'Repurposing drugs for skin cancer', Current Medicinal Chemistry, 27, pp. 7214 - 7221, http://dx.doi.org/10.2174/0929867327666191220103901

Khachigian LM, 2019, 'Transcription factors targeted by miRNAs regulating smooth muscle cell growth and intimal thickening after vascular injury', International Journal of Molecular Sciences, 20, http://dx.doi.org/10.3390/ijms20215445

Li Y; Acharya G; Elahy M; Xin H; Khachigian LM, 2019, 'The anthelmintic flubendazole blocks human melanoma growth and metastasis and suppresses programmed cell death protein-1 and myeloid-derived suppressor cell accumulation', Cancer Letters, 459, pp. 268 - 276, http://dx.doi.org/10.1016/j.canlet.2019.05.026

Santiago FS; Sanchez-Guerrero E; Zhang G; Zhong L; Raftery MJ; Khachigian LM, 2019, 'Extracellular signal-regulated kinase-1 phosphorylates early growth response-1 at serine 26', Biochemical and Biophysical Research Communications, 510, pp. 345 - 351, http://dx.doi.org/10.1016/j.bbrc.2019.01.019

Khachigian LM, 2019, 'Deoxyribozymes as catalytic nanotherapeutic agents', Cancer Research, 79, pp. 879 - 888, http://dx.doi.org/10.1158/0008-5472.CAN-18-2474

Billah M; Ridiandries A; Allahwala U; Mudaliar H; Dona A; Hunyor S; Khachigian LM; Bhindi R, 2019, 'Circulating mediators of remote ischemic preconditioning: Search for the missing link between non-lethal ischemia and cardioprotection', Oncotarget, 10, pp. 216 - 244, http://dx.doi.org/10.18632/oncotarget.26537

Alhendi AMN; Patrikakis M; Daub CO; Kawaji H; Itoh M; de Hoon M; Carninci P; Hayashizaki Y; Arner E; Khachigian LM, 2018, 'Promoter Usage and Dynamics in Vascular Smooth Muscle Cells Exposed to Fibroblast Growth Factor-2 or Interleukin-1β', Scientific Reports, 8, http://dx.doi.org/10.1038/s41598-018-30702-4

Cai H; Cho EA; Li Y; Sockler J; Parish CR; Chong BH; Edwards J; Dodds TJ; Ferguson PM; Wilmott JS; Scolyer RA; Halliday GM; Khachigian LM, 2018, 'Melanoma protective antitumor immunity activated by catalytic DNA', Oncogene, 37, pp. 5115 - 5126, http://dx.doi.org/10.1038/s41388-018-0306-0

Khachigian LM, 2018, 'The Yin and Yang of YY1 in tumor growth and suppression', International Journal of Cancer, 143, pp. 460 - 465, http://dx.doi.org/10.1002/ijc.31255

Sheahan AV; Biankin AV; Parish CR; Khachigian LM, 2018, 'Targeted therapies in the management of locally advanced and metastatic pancreatic cancer: A systematic review', Oncotarget, 9, pp. 21613 - 21627, http://dx.doi.org/10.18632/oncotarget.25085

Cannistraci CV; Nieminen T; Nishi M; Khachigian LM; Viikilä J; Laine M; Cianflone D; Maseri A; Yeo KK; Bhindi R; Ammirati E, 2018, '"Summer Shift": A potential effect of sunshine on the time onset of ST-elevation acute myocardial infarction', Journal of the American Heart Association, 7, http://dx.doi.org/10.1161/JAHA.117.006878

Buckler JN; Banwell MG; Kordbacheh F; Parish CR; Santiago FS; Khachigian LM, 2017, 'Developing neolignans as proangiogenic agents: Stereoselective total syntheses and preliminary biological evaluations of the four guaiacylglycerol 8-O-4'-coniferyl ethers', ACS Omega, 2, pp. 7375 - 7388, http://dx.doi.org/10.1021/acsomega.7b01459

Noguchi S; Arakawa T; Fukuda S; Furuno M; Hasegawa A; Hori F; Ishikawa-Kato S; Kaida K; Kaiho A; Kanamori-Katayama M; Kawashima T; Kojima M; Kubosaki A; Manabe RI; Murata M; Nagao-Sato S; Nakazato K; Ninomiya N; Nishiyori-Sueki H; Noma S; Saijyo E; Saka A; Sakai M; Simon C; Suzuki N; Tagami M; Watanabe S; Yoshida S; Arner P; Axton RA; Babina M; Kenneth Baillie J; Barnett TC; Beckhouse AG; Blumenthal A; Bodega B; Bonetti A; Briggs J; Brombacher F; Carlisle AJ; Clevers HC; Davis CA; Detmar M; Dohi T; Edge BAS; Edinger M; Ehrlund A; Ekwall K; Endoh M; Enomoto H; Eslami A; Fagiolini M; Fairbairn L; Farach-Carson MC; Faulkner GJ; Ferrai C; Fisher ME; Forrester LM; Fujita R; Furusawa JI; Geijtenbeek TB; Gingeras T; Goldowitz D; Guhl S; Guler R; Gustincich S; Ha TJ; Hamaguchi M; Hara M; Hasegawa Y; Herlyn M; Heutink P; Hitchens KJ; Hume DA; Ikawa T; Ishizu Y; Kai C; Kawamoto H; Kawamura YI; Kempfle JS; Kenna TJ; Kere J; Khachigian LM; Kitamura T; Klein S; Peter Klinken S; Knox AJ; Kojima S; Koseki H; Koyasu S; Lee W; Lennartsson A; MacKay-Sim A; Mejhert N; Mizuno Y; Morikawa H; Morimoto M; Moro K; Morris KJ; Motohashi H, 2017, 'FANTOM5 CAGE profiles of human and mouse samples', Scientific Data, 4, http://dx.doi.org/10.1038/sdata.2017.112

Billah M; Ridiandries A; Khachigian L; Dona A; Bhindi R, 2017, 'Abstract 445: Autophagy is Essential for Remote Preconditioning Induced Cardioprotection and May Involve JAK-STAT Pathway for Autophagy Activation', Circulation Research, 121, http://dx.doi.org/10.1161/res.121.suppl_1.445

Murrell M; Khachigian L; Ward MR, 2017, 'Corrigendum to “The role of c-jun in PDTC-sensitive flow-dependent restenosis after angioplasty and stenting” [Atherosclerosis 194 (2) (2007) 364–371] (S0021915006006836) (10.1016/j.atherosclerosis.2006.11.016)', Atherosclerosis, 261, pp. 172, http://dx.doi.org/10.1016/j.atherosclerosis.2016.05.011

Li Y; McRobb LS; Khachigian LM, 2016, 'Inhibition of intimal thickening after vascular injury with a cocktail of vascular endothelial growth factor and cyclic Arg-Gly-Asp peptide', International Journal of Cardiology, 220, pp. 185 - 191, http://dx.doi.org/10.1016/j.ijcard.2016.06.300

Khachigian LM, 2016, 'Early growth response-1 in the pathogenesis of cardiovascular disease', Journal of Molecular Medicine, 94, pp. 747 - 753, http://dx.doi.org/10.1007/s00109-016-1428-x

Li Y; McRobb LS; Khachigian LM, 2016, 'MicroRNA miR-191 targets the zinc finger transcription factor Egr-1 and suppresses intimal thickening after carotid injury', International Journal of Cardiology, 212, pp. 299 - 302, http://dx.doi.org/10.1016/j.ijcard.2016.03.037

Tan NY; Li J-M; Stocker R; Khachigian LM, 2016, 'Angiotensin II-Inducible Smooth Muscle Cell Apoptosis Involves the Angiotensin II Type 2 Receptor, GATA-6 Activation, and FasL-Fas Engagement (Retraction of vol 105, pg 422, 2009)', CIRCULATION RESEARCH, 118, pp. E31 - E31, http://dx.doi.org/10.1161/RES.0000000000000090

Hurst LD; Ghanbarian AT; Forrest ARR; Huminiecki L; Rehli M; Kenneth Baillie J; de Hoon MJL; Haberle V; Lassmann T; Kulakovskiy IV; Lizio M; Itoh M; Andersson R; Mungall CJ; Meehan TF; Schmeier S; Bertin N; Jørgensen M; Dimont E; Arner E; Schmidl C; Schaefer U; Medvedeva YA; Plessy C; Vitezic M; Severin J; Semple CA; Ishizu Y; Young RS; Francescatto M; Alam I; Albanese D; Altschuler GM; Arakawa T; Archer JAC; Arner P; Babina M; Baker S; Balwierz PJ; Beckhouse AG; Pradhan SB; Blake JA; Blumenthal A; Bodega B; Bonetti A; Briggs J; Brombacher F; Maxwell Burroughs A; Califano A; Cannistraci CV; Carbajo D; Chen Y; Chierici M; Ciani Y; Clevers HC; Dalla E; Davis CA; Detmar M; Diehl AD; Dohi T; Drabløs F; Edge ASB; Edinger M; Ekwall K; Endoh M; Enomoto H; Fagiolini M; Fairbairn L; Fang H; Farach-Carson MC; Faulkner GJ; Favorov AV; Fisher ME; Frith MC; Fujita R; Fukuda S; Furlanello C; Furuno M; Furusawa JI; Geijtenbeek TB; Gibson A; Gingeras T; Goldowitz D; Gough J; Guhl S; Guler R; Gustincich S; Ha TJ; Hamaguchi M; Hara M; Harbers M; Harshbarger J; Hasegawa A; Hasegawa Y; Hashimoto T; Herlyn M; Hitchens KJ; Ho Sui SJ; Hofmann OM, 2015, 'The Constrained Maximal Expression Level Owing to Haploidy Shapes Gene Content on the Mammalian X Chromosome', PLoS Biology, 13, http://dx.doi.org/10.1371/journal.pbio.1002315

Fahmy RG; Waldman A; Zhang G; Mitchell A; Tedla N; Cai H; Geczy CR; Chesterman CN; Perry M; Khachigian LM, 2015, 'Erratum: Suppression of vascular permeability and inflammation by targeting of the transcription factor c-Jun(Nat.Biotechnol.(2006) 24(856-863))', Nature Biotechnology, 33, pp. 882, http://dx.doi.org/10.1038/nbt0815-882c

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