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Conference Abstracts
, 2024, 'Identifying and targeting FOLFIRINOX resistance mechanisms to improve outcomes in pancreatic cancer', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, MA, Boston, Vol. 84, presented at AACR Special Conference in Cancer Research: Advances in Pancreatic Cancer Research, MA, Boston, 15 September 2024 - 18 September 2024, http://dx.doi.org/10.1158/1538-7445.PANCREATIC24-A067
, 2024, 'Selective targeting of integrins αVβ8 and αVβ1 within the dynamic ecosystem of pancreatic cancer to improve the overall anti-tumor response', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, CA, San Diego, Vol. 84, presented at Annual Meeting of the American-Association-for-Cancer-Research (AACR), CA, San Diego, 05 April 2024 - 10 April 2024, http://dx.doi.org/10.1158/1538-7445.AM2024-6575
, 2024, 'Abstract 720: Combining zelasudil, a small molecule ROCK2 inhibitor, with chemotherapy or immunotherapy improves response in preclinical models of pancreatic cancer', in Cancer Research, American Association for Cancer Research (AACR), Vol. 84, pp. 720 - 720, http://dx.doi.org/10.1158/1538-7445.am2024-720
, 2024, 'Abstract A029: Re-purposing non-oncology agent itraconazole to target the dynamic cellular ecosystem of pancreatic cancer', in Cancer Research, American Association for Cancer Research (AACR), Vol. 84, pp. a029 - a029, http://dx.doi.org/10.1158/1538-7445.panca2023-a029
, 2024, 'Abstract C017: The anti-fungal itraconazole improves immunotherapy efficacy in pancreatic ductal adenocarcinoma by reversing the immune-suppressive tumor microenvironment', in Cancer Research, American Association for Cancer Research (AACR), Vol. 84, pp. c017 - c017, http://dx.doi.org/10.1158/1538-7445.panca2023-c017
, 2024, '1513P Impact of symptom and functional burden on survival in pancreatic ductal adenocarcinoma (PDAC)', in Annals of Oncology, Elsevier, Vol. 35, pp. s925, http://dx.doi.org/10.1016/j.annonc.2024.08.1576
, 2023, 'Anti-fibrotic FAK 'priming' to improve contemporary chemotherapy in pancreatic cancer', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, MA, Boston, Vol. 84, presented at AACR Special Conference - Pancreatic Cancer, MA, Boston, 27 September 2023 - 30 September 2023, http://dx.doi.org/10.1158/1538-7445.PANCA2023-B037
, 2022, 'EFFECTIVE CO-TARGETING OF FIBROTIC AND IMMUNE MICROENVIRONMENTS TO IMPROVE THE OVERALL ANTI-TUMOUR RESPONSE IN MODELS OF ADVANCED PANCREATIC CANCER', in JOURNAL FOR IMMUNOTHERAPY OF CANCER, BMJ PUBLISHING GROUP, Vol. 10, pp. A1514 - A1514, http://dx.doi.org/10.1136/jitc-2022-SITC2022.1455
, 2017, 'Effect of Rho/ROCK pathway inhibition on metastasis-free and overall survival in biomarker selected, orthotopic, patient-derived models of pancreatic cancer.', in Journal of Clinical Oncology, American Society of Clinical Oncology (ASCO), Vol. 35, pp. e15759 - e15759, http://dx.doi.org/10.1200/jco.2017.35.15_suppl.e15759
, 2015, 'Targeting the Rho-ROCK pathway to treat pancreatic cancer: The use of unique preclinical models to ascertain the effects on cancer growth and metastasis', in JOURNAL OF CLINICAL ONCOLOGY, AMER SOC CLINICAL ONCOLOGY, CA, San Francisco, Vol. 33, presented at Gastrointestinal Cancers Symposium, CA, San Francisco, 15 January 2015 - 17 January 2015, http://dx.doi.org/10.1200/jco.2015.33.3_suppl.312
, 2013, 'From functional genomics to precision medicine: The therapeutic potential of targeting ROCK signaling in pancreatic cancer.', in JOURNAL OF CLINICAL ONCOLOGY, LIPPINCOTT WILLIAMS & WILKINS, IL, Chicago, Vol. 31, presented at 49th Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), IL, Chicago, 31 May 2013 - 04 June 2013, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000335419603693&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
, 2012, 'Risk factors for pancreatic cancer in patients with and without a family history of pancreatic cancer', in JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, WILEY-BLACKWELL, Vol. 27, pp. 127 - 127, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000308642600262&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
, 2012, 'Proffered Paper: Testing Individualised Treatment Strategies in Preclinical Models of Pancreatic Cancer', in EUROPEAN JOURNAL OF CANCER, ELSEVIER SCI LTD, SPAIN, Barcelona, Vol. 48, pp. S22 - S22, presented at 22nd Biennial Congress of the European-Association-for-Cancer-Research, SPAIN, Barcelona, 07 July 2012 - 10 July 2012, http://dx.doi.org/10.1016/S0959-8049(12)70795-5
, 2006, '169 POSTER Sensitisation of neuroblastoma tumours to chemotherapy by use of a novel class of MRP1 small molecule inhibitor', in European Journal of Cancer Supplements, Elsevier, Vol. 4, pp. 54, http://dx.doi.org/10.1016/s1359-6349(06)70175-6
Working Papers
, PGRMC1 phosphorylation affects cell shape, motility, glycolysis, mitochondrial form and function, and tumor growth, Research Square Platform, http://dx.doi.org10.21203/rs.2.22342/v3
, PGRMC1 phosphorylation and cell plasticity 1: glycolysis, mitochondria, tumor growth, Cold Spring Harbor Laboratory, http://dx.doi.org10.1101/737718
Preprints
, 2019, HNF4A and GATA6 Loss Reveals Therapeutically Actionable Subtypes in Pancreatic Cancer, http://dx.doi.org/10.2139/ssrn.3430714
, 2018, The PAK Inhibitor PF-3758309 Promotes the Inhibitory Effects of Multiple Chemotherapeutic Reagents on Patient-Derived Pancreatic Cancer Cell Lines, http://dx.doi.org/10.20944/preprints201809.0322.v1
, Performance comparison of high throughput single-cell RNA-Seq platforms in complex tissues, http://dx.doi.org/10.1101/2023.04.04.535585
, PGRMC1 phosphorylation affects cell shape, motility, glycolysis, mitochondrial form and function, and tumor growth, http://dx.doi.org/10.21203/rs.2.22342/v1
, PGRMC1 phosphorylation affects cell shape, motility, glycolysis, mitochondrial form and function, and tumor growth, http://dx.doi.org/10.21203/rs.2.22342/v2
, Pulsed priming with the FAK inhibitor narmafotinib enhances both gemcitabine/Abraxane and FOLFIRINOX chemotherapy response in pancreatic cancer, http://dx.doi.org/10.64898/2026.07.23.740234
, Substrate-biased activity-based probes identify the urokinase-plasminogen axis as a master regulator of metastatic signaling by orphan membrane receptor CDCP1, http://dx.doi.org/10.21203/rs.3.rs-92391/v1
, Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer, http://dx.doi.org/10.1101/713545
, βIII-Tubulin is a Brake on Extrinsic Cell-Death in Pancreatic Cancer, http://dx.doi.org/10.1101/2022.09.29.510034
Other
, 2025, Data from Integration of Whole-Genome Sequencing Analysis with Unique Patient-Derived Models Reveals Clinically Relevant Drug Targets in <i>TFCP2</i> Fusion–Defined Rhabdomyosarcoma, http://dx.doi.org/10.1158/1535-7163.c.8179124
, 2025, Supplementary Fig. S1 from Integration of Whole-Genome Sequencing Analysis with Unique Patient-Derived Models Reveals Clinically Relevant Drug Targets in <i>TFCP2</i> Fusion–Defined Rhabdomyosarcoma, http://dx.doi.org/10.1158/1535-7163.30761555
, 2025, Supplementary Fig. S2 from Integration of Whole-Genome Sequencing Analysis with Unique Patient-Derived Models Reveals Clinically Relevant Drug Targets in <i>TFCP2</i> Fusion–Defined Rhabdomyosarcoma, http://dx.doi.org/10.1158/1535-7163.30761552
, 2025, Supplementary Fig. S3 from Integration of Whole-Genome Sequencing Analysis with Unique Patient-Derived Models Reveals Clinically Relevant Drug Targets in <i>TFCP2</i> Fusion–Defined Rhabdomyosarcoma, http://dx.doi.org/10.1158/1535-7163.30761549
, 2025, Supplementary Fig. S4 from Integration of Whole-Genome Sequencing Analysis with Unique Patient-Derived Models Reveals Clinically Relevant Drug Targets in <i>TFCP2</i> Fusion–Defined Rhabdomyosarcoma, http://dx.doi.org/10.1158/1535-7163.30761546
, 2025, Supplementary Fig. S5 from Integration of Whole-Genome Sequencing Analysis with Unique Patient-Derived Models Reveals Clinically Relevant Drug Targets in <i>TFCP2</i> Fusion–Defined Rhabdomyosarcoma, http://dx.doi.org/10.1158/1535-7163.30761543
, 2025, Supplementary Fig. S6 from Integration of Whole-Genome Sequencing Analysis with Unique Patient-Derived Models Reveals Clinically Relevant Drug Targets in <i>TFCP2</i> Fusion–Defined Rhabdomyosarcoma, http://dx.doi.org/10.1158/1535-7163.30761540
, 2025, Supplementary Table S1 from Integration of Whole-Genome Sequencing Analysis with Unique Patient-Derived Models Reveals Clinically Relevant Drug Targets in <i>TFCP2</i> Fusion–Defined Rhabdomyosarcoma, http://dx.doi.org/10.1158/1535-7163.30761537
, 2025, Supplementary Table S10 from Integration of Whole-Genome Sequencing Analysis with Unique Patient-Derived Models Reveals Clinically Relevant Drug Targets in <i>TFCP2</i> Fusion–Defined Rhabdomyosarcoma, http://dx.doi.org/10.1158/1535-7163.30761534
, 2025, Supplementary Table S11 from Integration of Whole-Genome Sequencing Analysis with Unique Patient-Derived Models Reveals Clinically Relevant Drug Targets in <i>TFCP2</i> Fusion–Defined Rhabdomyosarcoma, http://dx.doi.org/10.1158/1535-7163.30761531
, 2025, Supplementary Table S2 from Integration of Whole-Genome Sequencing Analysis with Unique Patient-Derived Models Reveals Clinically Relevant Drug Targets in <i>TFCP2</i> Fusion–Defined Rhabdomyosarcoma, http://dx.doi.org/10.1158/1535-7163.30761528
, 2025, Supplementary Table S3 from Integration of Whole-Genome Sequencing Analysis with Unique Patient-Derived Models Reveals Clinically Relevant Drug Targets in <i>TFCP2</i> Fusion–Defined Rhabdomyosarcoma, http://dx.doi.org/10.1158/1535-7163.30761525
, 2025, Supplementary Table S4 from Integration of Whole-Genome Sequencing Analysis with Unique Patient-Derived Models Reveals Clinically Relevant Drug Targets in <i>TFCP2</i> Fusion–Defined Rhabdomyosarcoma, http://dx.doi.org/10.1158/1535-7163.30761522
, 2025, Supplementary Table S5 from Integration of Whole-Genome Sequencing Analysis with Unique Patient-Derived Models Reveals Clinically Relevant Drug Targets in <i>TFCP2</i> Fusion–Defined Rhabdomyosarcoma, http://dx.doi.org/10.1158/1535-7163.30761519
, 2025, Supplementary Table S6 from Integration of Whole-Genome Sequencing Analysis with Unique Patient-Derived Models Reveals Clinically Relevant Drug Targets in <i>TFCP2</i> Fusion–Defined Rhabdomyosarcoma, http://dx.doi.org/10.1158/1535-7163.30761516
, 2025, Supplementary Table S7 from Integration of Whole-Genome Sequencing Analysis with Unique Patient-Derived Models Reveals Clinically Relevant Drug Targets in <i>TFCP2</i> Fusion–Defined Rhabdomyosarcoma, http://dx.doi.org/10.1158/1535-7163.30761513
, 2025, Supplementary Table S8 from Integration of Whole-Genome Sequencing Analysis with Unique Patient-Derived Models Reveals Clinically Relevant Drug Targets in <i>TFCP2</i> Fusion–Defined Rhabdomyosarcoma, http://dx.doi.org/10.1158/1535-7163.30761510
, 2025, Supplementary Table S9 from Integration of Whole-Genome Sequencing Analysis with Unique Patient-Derived Models Reveals Clinically Relevant Drug Targets in <i>TFCP2</i> Fusion–Defined Rhabdomyosarcoma, http://dx.doi.org/10.1158/1535-7163.30761507