By Professor Megan Lord

Journal articles

Lord MS; Jung MS; Whitelock JM, 2017, 'Optimization of bioengineered heparin/heparan sulfate production for therapeutic applications', Bioengineered, 8, pp. 661 - 664, http://dx.doi.org/10.1080/21655979.2017.1301328

Kim HN; Whitelock JM; Lord MS, 2017, 'Structure-activity relationships of bioengineered heparin/heparan sulfates produced in different bioreactors', Molecules, 22, pp. 806, http://dx.doi.org/10.3390/molecules22050806

Lord MS; Ellis AL; Farrugia BL; Whitelock JM; Grenett H; Li C; O'Grady RL; DeCarlo AA, 2017, 'Perlecan and vascular endothelial growth factor-encoding DNA-loaded chitosan scaffolds promote angiogenesis and wound healing', Journal of Controlled Release, 250, pp. 48 - 61, http://dx.doi.org/10.1016/j.jconrel.2017.02.009

Lord MS; Cheng B; Farrugia BL; McCarthy S; Whitelock JM, 2017, 'Platelet factor 4 binds to vascular proteoglycans and controls both growth factor activities and platelet activation', Journal of Biological Chemistry, 292, pp. 4054 - 4063, http://dx.doi.org/10.1074/jbc.M116.760660

Vassie JA; Whitelock JM; Lord MS, 2017, 'Endocytosis of cerium oxide nanoparticles and modulation of reactive oxygen species in human ovarian and colon cancer cells', Acta Biomaterialia, 50, pp. 127 - 141, http://dx.doi.org/10.1016/j.actbio.2016.12.010

Rnjak-Kovacina J; Tang F; Whitelock JM; Lord MS, 2016, 'Silk biomaterials functionalized with recombinant domain V of human perlecan modulate endothelial cell and platelet interactions for vascular applications', Colloids and Surfaces B: Biointerfaces, 148, pp. 130 - 138, http://dx.doi.org/10.1016/j.colsurfb.2016.08.039

Lord MS; Cheng B; Tang F; Lyons JG; Rnjak-Kovacina J; Whitelock JM, 2016, 'Bioengineered human heparin with anticoagulant activity', Metabolic Engineering, 38, pp. 105 - 114, http://dx.doi.org/10.1016/j.ymben.2016.07.006

Chang T; Gosain P; Stenzel MH; Lord MS, 2016, 'Drug-loading of poly(ethylene glycol methyl ether methacrylate) (PEGMEMA)-based micelles and mechanisms of uptake in colon carcinoma cells', Colloids and Surfaces B: Biointerfaces, 144, pp. 257 - 264, http://dx.doi.org/10.1016/j.colsurfb.2016.04.019

Lord MS; Farrugia BL; Yan CMY; Vassie JA; Whitelock JM, 2016, 'Hyaluronan coated cerium oxide nanoparticles modulate CD44 and reactive oxygen species expression in human fibroblasts', Journal of Biomedical Materials Research - Part A, 104, pp. 1736 - 1746, http://dx.doi.org/10.1002/jbm.a.35704

Hayes AJ; Shu CC; Lord MS; Little CB; Whitelock JM; Melrose J, 2016, 'Pericellular colocalisation and interactive properties of type VI collagen and perlecan in the intervertebral disc', European Cells and Materials, 32, pp. 40 - 57, http://dx.doi.org/10.22203/eCM.v032a03

Farrugia BL; Chandrasekar K; Johnson L; Whitelock JM; Marks D; Irving D; Lord M, 2016, 'Perspectives on the use of biomaterials to store platelets for transfusion', Biointerphases: an open access journal for the biomaterials interface community, 11, pp. 029701 - 029701, http://dx.doi.org/10.1116/1.4952450

Melrose J; Shu C; Whitelock JM; Lord MS, 2016, 'The cartilage extracellular matrix as a transient developmental scaffold for growth plate maturation', Matrix Biology, 52-54, pp. 363 - 383, http://dx.doi.org/10.1016/j.matbio.2016.01.008

Shu CC; Jackson MT; Smith MM; Smith SM; Penm S; Lord MS; Whitelock JM; Little CB; Melrose J, 2016, 'Ablation of Perlecan Domain 1 Heparan Sulfate Reduces Progressive Cartilage Degradation, Synovitis, and Osteophyte Size in a Preclinical Model of Posttraumatic Osteoarthritis', Arthritis and Rheumatology, 68, pp. 868 - 879, http://dx.doi.org/10.1002/art.39529

Nandakumar D; Bendavid A; Martin PJ; Harris KD; Ruys AJ; Lord MS, 2016, 'Fabrication of Semiordered Nanopatterned Diamond-like Carbon and Titania Films for Blood Contacting Applications', ACS Applied Materials and Interfaces, 8, pp. 6802 - 6810, http://dx.doi.org/10.1021/acsami.5b11614

Chang T; Trench D; Putnam J; Stenzel MH; Lord MS, 2016, 'Curcumin-Loading-Dependent Stability of PEGMEMA-Based Micelles Affects Endocytosis and Exocytosis in Colon Carcinoma Cells', Molecular Pharmaceutics, 13, pp. 924 - 932, http://dx.doi.org/10.1021/acs.molpharmaceut.5b00820

Farrugia BL; Whitelock JM; O'Grady R; Caterson B; Lord MS, 2016, 'Mast Cells Produce a Unique Chondroitin Sulfate Epitope', Journal of Histochemistry and Cytochemistry: imaging the spectrum of cell biology, 64, pp. 85 - 98, http://dx.doi.org/10.1369/0022155415620649

An H; Brettle M; Lee T; Heng B; Lim CK; Guillemin GJ; Lord MS; Klotzsch E; Geczy CL; Bryant K; Fath T; Tedla N, 2016, 'Soluble LILRA3 promotes neurite outgrowth and synapses formation through a high-affinity interaction with Nogo 66', Journal of Cell Science, 129, pp. 1198 - 1209, http://dx.doi.org/10.1242/jcs.182006

Lord M; Chuang C; Rnjak‐Kovacina J; Cheng B; Lyons G; Whitelock J, 2016, 'Bioengineering Proteoglycan‐based Matrices For Blood Contacting Applications', The FASEB Journal, 30, http://dx.doi.org/10.1096/fasebj.30.1_supplement.622.2

Shawky MS; Ricciardelli C; Lord M; Whitelock J; Ferro V; Britt K; Thompson EW, 2015, 'Proteoglycans: Potential Agents in Mammographic Density and the Associated Breast Cancer Risk', Journal of Mammary Gland Biology and Neoplasia, 20, pp. 121 - 131, http://dx.doi.org/10.1007/s10911-015-9346-z

Farrugia BL; Lord MS; Melrose J; Whitelock JM, 2015, 'Can we produce heparin/heparan sulfate biomimetics using "mother-nature" as the gold standard?', Molecules, 20, pp. 4254 - 4276, http://dx.doi.org/10.3390/molecules20034254

Chen Y; Lord MS; Piloni A; Stenzel MH, 2015, 'Correlation between molecular weight and branch structure of glycopolymers stars and their binding to lectins', Macromolecules, 48, pp. 346 - 357, http://dx.doi.org/10.1021/ma501742v

Lord MS; Farrugia BL; Rnjak-Kovacina J; Whitelock JM, 2015, 'Current serological possibilities for the diagnosis of arthritis with special focus on proteins and proteoglycans from the extracellular matrix', Expert Review of Molecular Diagnostics, 15, pp. 77 - 95, http://dx.doi.org/10.1586/14737159.2015.979158

Chrzanowski W; Lee JH; Kondyurin A; Lord MS; Jang JH; Kim HW; Bilek MMM, 2015, 'Nano-Bio-Chemical Braille for Cells: The Regulation of Stem Cell Responses using Bi-Functional Surfaces', Advanced Functional Materials, 25, pp. 193 - 205, http://dx.doi.org/10.1002/adfm.201401696

Chrzanowski W; Lee JH; Kondyurin A; Lord MS; Jang J; Kim H; Bilek MMM, 2015, 'Biointerfaces: Nano‐Bio‐Chemical Braille for Cells: The Regulation of Stem Cell Responses using Bi‐Functional Surfaces (Adv. Funct. Mater. 2/2015)', Advanced Functional Materials, 25, pp. 339 - 339, http://dx.doi.org/10.1002/adfm.201570014

Lord MS; Whitelock JM; Simmons A; Williams RL; Milthorpe BK, 2014, 'Fibrinogen adsorption and platelet adhesion to silica surfaces with stochastic nanotopography', Biointerphases, 9, pp. 041002, http://dx.doi.org/10.1116/1.4900993

Chang T; Lord MS; Bergmann B; MacMillan A; Stenzel MH, 2014, 'Size effects of self-assembled block copolymer spherical micelles and vesicles on cellular uptake in human colon carcinoma cells', Journal of Materials Chemistry B, 2, pp. 2883 - 2891, http://dx.doi.org/10.1039/c3tb21751e

Farrugia BL; Whitelock JM; Jung M; O'Grady RL; McGrath B; McCarthy SJ; Lord MS, 2014, 'The localisation of inflammatory cells and expression of associated proteoglycans in response to implanted chitosan', Biomaterials, 35, pp. 1462 - 1477, http://dx.doi.org/10.1016/j.biomaterials.2013.10.068

, 2014, 'Bioengineered heparin: Is there a future for this form of the successful therapeutic?', Bioengineered, 5, pp. 222 - 226, http://dx.doi.org/10.4161/bioe.29388

Lord MS; Tsoi BM; Farrugia BL; Simon Ting SR; Baker S; Wiesmann WP; Whitelock JM, 2014, 'Synthesis and characterization of water soluble biomimetic chitosans for bone and cartilage tissue regeneration', Journal of Materials Chemistry B, 20, pp. 6517 - 6526, http://dx.doi.org/10.1039/c4tb00531g

Lord MS; Chuang CY; Melrose J; Davies MJ; Iozzo RV; Whitelock JM, 2014, 'The role of vascular-derived perlecan in modulating cell adhesion, proliferation and growth factor signaling', Matrix Biology, 35, pp. 112 - 122, http://dx.doi.org/10.1016/j.matbio.2014.01.016

Lord MS; Jung MS; Cheng B; Whitelock JM, 2014, 'Transcriptional complexity of the HSPG2 gene in the human mast cell line, HMC-1', Matrix Biology, 35, pp. 123 - 131, http://dx.doi.org/10.1016/j.matbio.2013.12.005

Zhao Y; Lord MS; Stenzel MH, 2013, 'A polyion complex micelle with heparin for growth factor delivery and uptake into cells', Journal of Materials Chemistry, 1, pp. 1635 - 1643

Lord MS; Tsoi BM; Gunawan C; Teoh WY; Amal R; Whitelock J, 2013, 'Anti-Angiogenic Activity of Heparin Functionalised Cerium Oxide Nanoparticles', Biomaterials, 34, pp. 8808 - 8818, http://dx.doi.org/10.1016/j.biomaterials.2013.07.083

Ting SRS; Whitelock J; Tomic R; Gunawan C; Teoh WY; Amal R; Lord MS, 2013, 'Cellular uptake and activity of heparin functionalised cerium oxide nanoparticles in monocytes', Biomaterials, 34, pp. 4377 - 4386, http://dx.doi.org/10.1016/j.biomaterials.2013.02.042

Reyes-ortega F; Rodriguez G; Aguilar MR; Lord MS; Whitelock J; Stenzel MH; San Roman J, 2013, 'Encapsulation of low molecular weight heparin (bemiparin) into polymeric nanoparticles obtained from cationic block copolymers: Properties and cell activity', Journal of Materials Chemistry, 1, pp. 850 - 860

Jung M; Lord MS; Cheng B; Lyons JG; Alkouri H; Hughes M; McCarthy S; Iozzo R; Whitelock J, 2013, 'Mast cells produce novel shorter forms of perlecan that contain functional endorepellin: A role in angiogenesis and wound healing', The Journal of Biological Chemistry, 288, pp. 3289 - 3304, http://dx.doi.org/10.1074/jbc.M112.387811

Lord MS; Whitelock J, 2013, 'Recombinant production of proteoglycans and their bioactive domains', FEBS Journal, 280, pp. 2490 - 2510, http://dx.doi.org/10.1111/febs.12197

Lord MS; Day AJ; Youssef P; Zhuo L; Watanabe H; Caterson B; Whitelock J, 2013, 'Sulfation of the bikunin chondroitin sulfate chain determines heavy chain-hyaluronan complex formation', The Journal of Biological Chemistry, 288, pp. 11941 - 22930, http://dx.doi.org/10.1074/jbc.M112.404186

Chrzanowski W; Kondyurin A; Lee JH; Lord MS; Bilek MMM; Kim H-W, 2012, 'Biointerface: protein enhanced stem cells binding to implant surface', Journal of Materials Science - Materials in Medicine, 23, pp. 2203 - 2215, http://dx.doi.org/10.1007/s10856-012-4687-2

Lord MS; Jung M; Teoh WY; Gunawan C; Vassie JA; Amal R; Whitelock J, 2012, 'Cellular uptake and reactive oxygen species modulation of cerium oxide nanoparticles in human monocyte cell line U937', Biomaterials, 33, pp. 7915 - 7924, http://dx.doi.org/10.1016/j.biomaterials.2012.07.024

Lord MS; Estrella RP; Chuang CY; Youssef P; Karlsson NG; Flannery CR; Whitelock J, 2012, 'Not all lubricin isoforms are substituted with a glycosaminoglycan chain', Connective Tissue Research, 53, pp. 132 - 141, http://dx.doi.org/10.3109/03008207.2011.614364

Decarlo AA; Belousova A; Ellis AL; Petersen D; Grenett H; Hardigan P; O''Grady R; Lord MS; Whitelock J, 2012, 'Perlecan domain 1 recombinant proteoglycan augments BMP-2 activity and osteogenesis', BMC Biotechnology, 12, pp. 60 - 60, http://dx.doi.org/10.1186/1472-6750-12-60

Chuang CY; Shahin K; Lord MS; Melrose J; Doran PM; Whitelock J, 2012, 'The cartilage matrix molecule components produced by human foetal cartilage rudiment cells within scaffolds and the role of exogenous growth factors', Biomaterials, 33, pp. 4078 - 4088, http://dx.doi.org/10.1016/j.biomaterials.2012.02.032

Hayes AJ; Lord MS; Smith SM; Smith MM; Whitelock JM; Weiss AS; Melrose J, 2011, 'Colocalization in vivo and association in vitro of perlecan and elastin', Histochemistry and Cell Biology, 136, pp. 437 - 454, http://dx.doi.org/10.1007/s00418-011-0854-7

Inglis D; Lord MS; Nordon R, 2011, 'Scaling deterministic lateral displacement arrays for high throughput and dilution-free enrichment of leukocytes', Journal of Micromechanics and Microengineering, 21, pp. 054024, http://dx.doi.org/10.1088/0960-1317/21/5/054024

Lord MS; Cheng B; McCarthy S; Jung M; Whitelock J, 2011, 'The modulation of platelet adhesion and activation by chitosan through plasma and extracellular matrix proteins', Biomaterials, 32, pp. 6655 - 6662, http://dx.doi.org/10.1016/j.biomaterials.2011.05.062

Chuang CY; Lord MS; Melrose J; Rees MD; Knox SM; Freeman C; Iozzo R; Whitelock J, 2010, 'Heparan sulfate-dependent signaling of fibroblast growth factor 18 by chondrocyte-derived perlecan', Biochemistry, 49, pp. 5524 - 5532, http://dx.doi.org/10.1021/bi1005199

Lord MS; Foss M; Besenbacher F, 2010, 'Influence of nanoscale surface topography on protein adsorption and cellular response', Nano Today, 5, pp. 66 - 78, http://dx.doi.org/10.1016/j.nantod.2010.01.001

Holst J; Watson S; Lord MS; Eamegdool SS; Bax DV; Nivison-Smith LB; Kondyurin A; Ma L; Overhauser AF; Weiss AS; Rasko JEJ, 2010, 'Substrate elasticity provides mechanical signals for the expansion of hemopoietic stem and progenitor cells', Nature Biotechnology, 28, pp. 1123 - 1130, http://dx.doi.org/10.1038/nbt.1687

Lord MS; Pasqui D; Barbucci R; Milthorpe BK, 2009, 'Protein adsorption on derivatives of hyaluronic acid and subsequent cellular response', Journal of Biomedical Materials Research Part A, 91, pp. 635 - 646, http://dx.doi.org/10.1002/jbm.a.32219

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