Researcher

My Expertise

Genetics and molecular biology

CRISPR gene editing

Epigenetics

Human genetic disease

Gene therapy

Keywords

Fields of Research (FoR)

Biochemistry and cell biology, Gene expression (incl. microarray and other genome-wide approaches), Gene Expression (incl. Microarray and other genome-wide approaches), Epigenetics (incl. Genome Methylation and Epigenomics), Genome Structure and Regulation

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Biography

ABOUT ME

 

Biography

Merlin Crossley is Deputy Vice-Chancellor (Academic Quality) at UNSW and Professor of Molecular Biology. He has also worked or studied at the Universities of Melbourne, Oxford, Harvard and Sydney. He has been recognized by numerous awards, including a Rhodes Scholarship and the Australian Academy of Science's Gottschalk Medal. He has made significant contributions to academic administration, serving as Dean at UNSW since...view more

ABOUT ME

 

Biography

Merlin Crossley is Deputy Vice-Chancellor (Academic Quality) at UNSW and Professor of Molecular Biology. He has also worked or studied at the Universities of Melbourne, Oxford, Harvard and Sydney. He has been recognized by numerous awards, including a Rhodes Scholarship and the Australian Academy of Science's Gottschalk Medal. He has made significant contributions to academic administration, serving as Dean at UNSW since 2010, and previously having been Acting Deputy Vice-Chancellor Research at the University of Sydney from 2006 to 2008.

Education

  • BSc Hons (Melb) 1986
  • DPhil (Oxon) 1990

 

RESEARCH

 

Research Goals

  • Fundamental mechanisms of gene regulation
  • Epigenetics
  • Artificial DNA-binding proteins
  • Blood development
  • Haemophilia
  • Sickle cell anaemia and thalassaemia
  • Gene therapy via CRISPR gene editing

Research in Detail

We are interested in understanding the fundamental molecular mechanisms by which genes are controlled. Ultimately we hope to treat chronic diseases, such as sickle cell anaemia or diabetes, by turning on beneficial genes or repressing harmful genes.

Supervision Opportunities/Areas

Please contact my collaborator Kate.Quinlan@unsw.edu.au

 

TEACHING & OUTREACH

 

Courses I contribute to teaching

BIOC2201 Principles of Molecular Biology (Advanced)

BABS3121 Molecular Biology of Nucleic Acids

BABS3281 Molecular Genomics

 

Current professional affiliations and service positions

Board Member, Australian Science Media Centre (AusSMC) 2013–present

Trust Member, Australian Museum 2012–present

Board Member, New South Innovations 2011–present

Council Member, European Molecular Biology Laboratory Australia Council 2011–2015

Board Member, Sydney Institute of Marine Science 2010-17

Advisory Committee, Australian Astronomical Observatory, 2017-present

Board Member, The Conversation (Chair of Editorial Board) 2019-present

Board Member, UNSW Press (NewSouth Publishing) 2015-present (Chair from 2019-present)

 


My Grants

  • National Health and Medical Research Council Ideas Grant GNT2020861 New approaches to treating hemologinopathies M. Crossley and Kate Quinlan, 2023-27 $1,508,780
  • National Health and Medical Research Council Project APP1164920 Silencing silencers to boost fetal globin production and treat beta-hemoglobinopathies M.Crossley, Kate Quinlan, and Mitch Weiss, 2019-2022, $560,394
  • National Health and Medical Research Council Project APP1098391 Editing beneficial single nucleotide polymorphisms into the genome: A new approach to genetic disease M.Crossley, 2016-8, $646,979
  • National Health and Medical Research Council Project APP1025877 Transcriptional regulation of globin genes M. Crossley and R. Pearson, 2012-14, $636,325
  • National Health and Medical Research Council Project APP1025873 Transcriptional control of megakaryopoiesis M. Crossley, K. Ravid, T. Gonda and R. Pearson, 2012-14, $651,010
  • National Health and Medical Research Council Project APP1009172 Identifying regulators of the DNA damage response and tumourigenesis using C.elegans H. Nicholas and M. Crossley, 2011-13, $496,706
  • National Health and Medical Research Council Project Grant ID632877 The transcriptional control of adipogenesis M.Crossley and K. Bell-Anderson, 2010-12, $535,125
  • Australian Research Council Linkage Grant LP210200125 with industry partner CSL Limited Improving the efficiency of CRISPR gene editing in cells 2022-4 $412,919
  • Australian Research Council Discovery Projet DP220101489 Transcription factors find their target genes by reading the epigenetic code Kate Quinlan, Jacqui Matthews, and M. Crossley, 2021-3, $530, 579
  • Australian Research Council Discovery Project DP180103785 One code to rule them all: synthesis of the transcription factor and histone code J.P.Mackay, M. Crossley, K.K.J. Low and K.G.R. Quinlan, 2018-20, $598,198
  • Australian Research Council Discovery Project DP 170101786 Designer DNA-binding proteins M. Crossley and K. Quinlan, 2017-9, $428,000
  • Australian Research Council Discovery Project DP150103503 Role of methylation in transcription factor activity M. Crossley and J.P. Mackay, 2015-7, $428,100
  • Australian Research Council Discovery Project DP120103798 Functional analysis of a nucleic acid binding protein essential for mammalian development J.P. Mackay and M. Crossley, 2012-14, $458,000

My Qualifications

BSc Hons (Melb)

DPhil (Oxon)


My Awards

Rhodes Scholarship 1987

Australian Society for Biochemistry and Molecular Biology Roche Medal 1999

Royal Society of NSW Sir Edgeworth David Medal 2000

Australian Academy of Science Gottschalk Medal 2002

Julian Wells Medal, Lorne Genome Conference 2010

Fellow Queen’s College, Melbourne 2014

Fellow Royal Society of New South Wales 2014

NSW Premier's Prize for Medical Biological Sciences 2020

Australia Society of Biochemistry and Molecular Biology Lemberg Medal 2021


My Research Activities

Fundamental mechanisms of gene regulation with a view to using the information to treat human genetic diseases


My Research Supervision


Areas of supervision

Molecular and cellular biology

CRISPR gene editing

Gene regulation

Globin gene expression

Genetic diseases of blood


Currently supervising

Vala Nejad Safari

Mahdi Haddad

Michael O'Dea

Anthea On-Fai Lee

Sonia Goozee

Ramyashree Prasanna Kumar

Annalise Psaila

Henry Bell

Emily Vohralik

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Location

University of New South Wales
Sydney NSW 2052
Dalton Building
Room 201

Contact

+61 2 9385 2800
51385