Select Publications

Journal articles

Martyn GE;Wienert B;Kurita R;Nakamura Y;Quinlan KG R;Crossley M, 2019, 'A natural regulatory mutation in the proximal promoter elevates fetal globin expression by creating a de novo GATA1 site', Blood, vol. 133, pp. 852 - 856,

Blobel GA;Crossley M, 2018, 'Charting a noncoding gene for γ-globin activation', Blood, vol. 132, pp. 1865 - 1867,

Artuz CM;Knights AJ;Funnell AP W;Gonda TJ;Ravid K;Pearson RC M;Quinlan KG R;Crossley M, 2018, 'Partial reprogramming of heterologous cells by defined factors to generate megakaryocyte lineage-restricted biomolecules', Biotechnology Reports, vol. 20,

Wienert B;Martyn GE;Funnell AP W;Quinlan KG R;Crossley M, 2018, 'Wake-up Sleepy Gene: Reactivating Fetal Globin for β-Hemoglobinopathies', Trends in Genetics, vol. 34, pp. 927 - 940,

Knights AJ;Vohralik EJ;Hoehn KL;Crossley M;Quinlan KG R, 2018, 'Defining Eosinophil Function in Adiposity and Weight Loss', BioEssays, vol. 40,

Martyn GE;Wienert B;Yang L;Shah M;Norton LJ;Burdach J;Kurita R;Nakamura Y;Pearson RC M;Funnell AP W;Quinlan KG R;Crossley M, 2018, 'Natural regulatory mutations elevate the fetal globin gene via disruption of BCL11A or ZBTB7A binding', Nature Genetics, vol. 50, pp. 498 - 503,

Norton LJ;Funnell AP W;Burdach J;Wienert B;Kurita R;Nakamura Y;Philipsen S;Pearson RC M;Quinlan KG R;Crossley M, 2017, 'KLF1 directly activates expression of the novel fetal globin repressor ZBTB7A/LRF in erythroid cells.', Blood Adv, vol. 1, pp. 685 - 692,

Nicol D;Eckstein L;Morrison M;Sherkow JS;Otlowski M;Whitton T;Bubela T;Burdon KP;Chalmers D;Chan S;Charlesworth J;Critchley C;Crossley M;de Lacey S;Dickinson JL;Hewitt AW;Kamens J;Kato K;Kleiderman E;Kodama S;Liddicoat J;Mackey DA;Newson AJ;Nielsen J;Wagner JK;McWhirter RE, 2017, 'Key challenges in bringing CRISPR-mediated somatic cell therapy into the clinic', Genome Medicine, vol. 9,

Wienert B;Martyn GE;Kurita R;Nakamura Y;Quinlan KG R;Crossley M, 2017, 'KLF1 drives the expression of fetal hemoglobin in British HPFH', Blood, vol. 130, pp. 803 - 807,

Ilsley MD;Gillinder KR;Magor GW;Huang S;Bailey TL;Crossley M;Perkins AC, 2017, 'Krüppel-like factors compete for promoters and enhancers to fine-tune transcription', Nucleic Acids Research, vol. 45, pp. 6572 - 6588,

Norton LJ;Hallal S;Stout ES;Funnell AP W;Pearson RC M;Crossley M;Quinlan KG R, 2017, 'Direct competition between DNA binding factors highlights the role of Krüppel-like Factor 1 in the erythroid/megakaryocyte switch', Scientific Reports, vol. 7,

Martyn GE;Quinlan KG R;Crossley M, 2017, 'The regulation of human globin promoters by CCAAT box elements and the recruitment of NF-Y', Biochimica et Biophysica Acta - Gene Regulatory Mechanisms, vol. 1860, pp. 525 - 536,

Knights AJ;Yik JJ;Jusoh HM;Norton LJ;Funnell AP W;Pearson RC M;Bell-Anderson KS;Crossley M;Quinlan KG R, 2016, 'Krüppel-like factor 3 (KLF3/BKLF) is required for widespread repression of the inflammatory modulator galectin-3 (Lgals3)', Journal of Biological Chemistry, vol. 291, pp. 16048 - 16058,

Berber S;Wood M;Llamosas E;Thaivalappil P;Lee K;Liao BM;Chew YL;Rhodes A;Yucel D;Crossley M;Nicholas HR, 2016, 'Homeodomain-Interacting Protein Kinase (HPK-1) regulates stress responses and ageing in C. elegans', Scientific Reports, vol. 6,

Masuda T;Wang X;Maeda M;Canver MC;Sher F;Funnell AP W;Fisher C;Suciu M;Martyn GE;Norton LJ;Zhu C;Kurita R;Nakamura Y;Xu J;Higgs DR;Crossley M;Bauer DE;Orkin SH;Kharchenko PV;Maeda T, 2016, 'Gene regulation: Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin', Science, vol. 351, pp. 285 - 289,

Lim WF;Burdach J;Funnell AP W;Pearson RC M;Quinlan KG R;Crossley M, 2015, 'Directing an artificial zinc finger protein to new targets by fusion to a non-DNA-binding domain', Nucleic Acids Research, vol. 44, pp. 3118 - 3130,

Wienert B;Funnell AP W;Norton LJ;Pearson RC M;Wilkinson-White LE;Lester K;Vadolas J;Porteus MH;Matthews JM;Quinlan KG R;Crossley M, 2015, 'Editing the genome to introduce a beneficial naturally occurring mutation associated with increased fetal globin.', Nature communications, vol. 6, pp. 7085,

Dewi V;Kwok A;Lee S;Lee MM;Tan YM;Nicholas HR;Isono KI;Wienert B;Mak KS;Knights AJ;Quinlan KG R;Cordwell SJ;Funnell AP W;Pearson RC M;Crossley M, 2015, 'Phosphorylation of krüppel-like factor 3 (KLF3/BKLF) and C-terminal binding protein 2 (CtBP2) by homeodomaininteracting protein kinase 2 (HIPK2) modulates KLF3 DNA binding and activity', Journal of Biological Chemistry, vol. 290, pp. 8591 - 8605,

Ballester B;Medina-Rivera A;Schmidt D;Gonzàlez-Porta M;Carlucci M;Chen X;Chessman K;Faure AJ;Funnell AP W;Goncalves A;Kutter C;Lukk M;Menon S;McLaren WM;Stefflova K;Watt S;Weirauch MT;Crossley M;Marioni JC;Odom DT;Flicek P;Wilson MD, 2014, 'Multi-species, multi-transcription factor binding highlights conserved control of tissue-specific biological pathways', eLife, vol. 3, pp. e02626,

Clifton MK;Westman BJ;Thong SY;O'Connell MR;Webster MW;Shepherd NE;Quinlan KG;Crossley M;Blobel GA;Mackay JP, 2014, 'The identification and structure of an N-terminal PR domain show that FOG1 is a member of the PRDM family of proteins', PLoS ONE, vol. 9,

Ballester B;Medina-Rivera A;Schmidt D;Gonzàlez-Porta M;Carlucci M;Chen X;Chessman K;Faure AJ;Funnell AP W;Goncalves A;Kutter C;Lukk M;Menon S;McLaren WM;Stefflova K;Watt S;Weirauch MT;Crossley M;Marioni JC;Odom DT;Flicek P;Wilson MD, 2014, 'Multi-species, multi-transcription factor binding highlights conserved control of tissue-specific biological pathways', eLife, vol. 3, pp. 1 - 29,

Reid A;Yücel D;Wood M;Llamosas E;Kant S;Crossley M;Nicholas H, 2014, 'The transcriptional repressor CTBP-1 functions in the nervous system of Caenorhabditis elegans to regulate lifespan', Experimental Gerontology, vol. 60, pp. 153 - 165,

Funnell AP W;Crossley M, 2014, 'Hemophilia B Leyden and once mysterious cis-regulatory mutations.', Trends in genetics : TIG, vol. 30, pp. 18 - 23,

Yücel D;Hoe M;Llamosas E;Kant S;Jamieson C;Nicholas HR;Young PA;Crossley M, 2014, 'SUMV-1 antagonizes the activity of synthetic multivulva genes in Caenorhabditis elegans', Developmental Biology,

Funnell AP W;Vernimmen D;Lim WF;Mak KS;Wienert B;Martyn GE;Artuz CM;Burdach J;Quinlan KG R;Higgs DR;Whitelaw E;Pearson RC M;Crossley M, 2014, 'Differential regulation of the α-globin locus by Krüppel-like factor 3 in erythroid and non-erythroid cells', BMC Molecular Biology, vol. 15,

Mak KS;Burdach J;Norton LJ;Pearson RC M;Crossley M;Funnell AP W, 2014, 'Repression of chimeric transcripts emanating from endogenous retrotransposons by a sequence-specific transcription factor', Genome Biology, vol. 15,

Knights AJ;Funnell AP;Pearson RC;Crossley M;Bell-Anderson KS, 2014, 'Adipokines and insulin action: A sensitive issue.', Adipocyte, vol. 3, pp. 88 - 96,

Burdach J;Funnell AP W;Mak KS;Artuz CM;Wienert B;Lim WF;Tan LY;Pearson RC M;Crossley M, 2014, 'Regions outside the DNA-binding domain are critical for proper in vivo specificity of an archetypal zinc finger transcription factor', Nucleic Acids Research, vol. 42, pp. 276 - 289,

Bell-Anderson KS;Funnell AP;Williams H;Jusoh HM;Scully T;Lim WF;Burdach JG;Mak KS;Knights AJ;Hoy AJ;Nicholas HR;Sainsbury A;Turner N;Pearson RC;Crossley M, 2013, 'Loss of Krüppel-Like Factor 3 (KLF3/BKLF) Leads to Upregulation of the Insulin-Sensitizing Factor Adipolin (FAM132A/CTRP12/C1qdc2)', Diabetes, vol. 62, pp. 2728 - 2737,

Berber S;Llamosas E;Thaivalappil P;Boag PR;Crossley M;Nicholas HR, 2013, 'Homeodomain interacting protein kinase (HPK-1) is required in the soma for robust germline proliferation in C. elegans', Developmental Dynamics, vol. 242, pp. 1250 - 1261,

Mackay JP;Segal DJ;Crossley M, 2013, 'Is there a telltale RH fingerprint in zinc fingers that recognizes methylated CpG dinucleotides?', Trends in Biochemical Sciences, vol. 38, pp. 421 - 422,

Vandevenne M;Jacques DA;Artuz C;Nguyen CD;Kwan AH Y;Segal DJ;Matthews JM;Crossley M;Guss JM;MacKay JP, 2013, 'New insights into DNA recognition by zinc fingers revealed by structural analysis of the oncoprotein ZNF217', Journal of Biological Chemistry, vol. 288, pp. 10616 - 10627,

Funnell AP W;Wilson MD;Ballester B;Mak KS;Burdach J;Magan N;Pearson RC M;Lemaigre FP;Stowell KM;Odom DT;Flicek P;Crossley M, 2013, 'A CpG mutational hotspot in a ONECUT binding site accounts for the prevalent variant of hemophilia B leyden', American Journal of Human Genetics, vol. 92, pp. 460 - 467,

Funnell AP W;Mak KS;Twine NA;Pelka GJ;Norton LJ;Radziewic T;Power M;Wilkins MR;Bell-Anderson KS;Fraser ST;Perkins AC;Tam PP;Pearson RC M;Crossley M, 2013, 'Generation of Mice Deficient in both KLF3/BKLF and KLF8 Reveals a Genetic Interaction and a Role for These Factors in Embryonic Globin Gene Silencing', Molecular and Cellular Biology, vol. 33, pp. 2976 - 2987,

Kelsey L;Flenniken AM;Qu D;Funnell AP W;Pearson R;Zhou YQ;Voronina I;Berberovic Z;Wood G;Newbigging S;Weiss ES;Wong M;Quach I;Yeh SY S;Deshwar AR;Scott IC;McKerlie C;Henkelman M;Backx P;Simpson J;Osborne L;Rossant J;Crossley M;Bruneau B;Adamson SL, 2013, 'ENU-induced Mutation in the DNA-binding Domain of KLF3 Reveals Important Roles for KLF3 in Cardiovascular Development and Function in Mice', PLoS Genetics, vol. 9,

Burdach J;O'Connell MR;Mackay JP;Crossley M, 2012, 'Two-timing zinc finger transcription factors liaising with RNA', Trends in Biochemical Sciences, vol. 37, pp. 199 - 205,

Bendak K;Loughlin FE;Cheung V;O'Connell MR;Crossley M;MacKay JP, 2012, 'A rapid method for assessing the RNA-binding potential of a protein', Nucleic Acids Research, vol. 40,

Knights AJ;Funnell AP W;Crossley M;Pearson RC M, 2012, 'Holding Tight: Cell Junctions and Cancer Spread.', Trends Cancer Res, vol. 8, pp. 61 - 69,

Funnell AP W;Crossley M, 2012, 'Homo- and heterodimerization in transcriptional regulation', Advances in Experimental Medicine and Biology, vol. 747, pp. 105 - 121,

Yang H;Galea A;Sytnyk V;Crossley M, 2012, 'Controlling the size of lipid droplets: Lipid and protein factors', Current Opinion in Cell Biology, vol. 24, pp. 509 - 516,

Funnell AP W;Norton LJ;Mak KS;Burdach J;Artuz CM;Twine NA;Wilkins MR;Power CA;Hung TT;Perdomo J;Koh P;Bell-Anderson KS;Orkin SH;Fraser ST;Perkins AC;Pearson RC M;Crossley M, 2012, 'The CACCC-binding protein KLF3/BKLF represses a subset of KLF1/EKLF target genes and is required for proper erythroid maturation in vivo', Molecular and Cellular Biology, vol. 32, pp. 3281 - 3292,

Wissmueller S;Font J;Liew CW;Cram E;Schroeder T;Turner J;Crossley M;Mackay JP;Matthews JM, 2011, 'Protein-protein interactions: Analysis of a false positive GST pulldown result', Proteins: Structure, Function and Bioinformatics, vol. 79, pp. 2365 - 2371,

Pearson RC M;Funnell AP W;Crossley M, 2011, 'The mammalian zinc finger transcription factor Krüppel-like factor 3 (KLF3/BKLF)', IUBMB Life, vol. 63, pp. 86 - 93,

Jack BH A;Pearson RC;Crossley M, 2011, 'C-terminal binding protein: A metabolic sensor implicated in regulating adipogenesis', International Journal of Biochemistry and Cell Biology, vol. 43, pp. 693 - 696,

Crossley M;Norton LJ;Funnell AP W;Pearson RC M, 2011, 'Cellular reprogramming toward the erythroid lineage', International Journal of Cell Biology,

Nunez N;Clifton MM K;Funnell AP W;Artuz C;Hallal S;Quinlan KG R;Font J;Vandevenne M;Setiyaputra S;Pearson RC M;Mackay JP;Crossley M, 2011, 'The multi-zinc finger protein ZNF217 contacts DNA through a two-finger domain', Journal of Biological Chemistry, vol. 286, pp. 38190 - 38201,

Mak KS;Funnell AP W;Pearson RC M;Crossley M, 2011, 'PU.1 and haematopoietic cell fate: Dosage matters', International Journal of Cell Biology,

Wilkinson-White L;Gamsjaeger R;Dastmalchi S;Wienert B;Stokes PH;Crossley M;Mackay JP;Matthews JM, 2011, 'Structural basis of simultaneous recruitment of the transcriptional regulators LMO2 and FOG1/ZFPM1 by the transcription factor GATA1', Proceedings of the National Academy of Sciences of the United States of America, vol. 108, pp. 14443 - 14448,

Turchinovich G;Thanh VT;Frommer F;Kranich J;Schmid S;Alles M;Loubert JB;Goulet JP;Zimber-Strobl U;Schneider P;Bachl J;Pearson R;Crossley M;Fabien A;Kirberg J, 2011, 'Programming of marginal zone B-cell fate by basic Krüppel-like factor(BKLF/KLF3)', Blood, vol. 117, pp. 3780 - 3792,

Vu TT;Gatto D;Turner V;Funnell AP W;Mak KS;Norton LJ;Kaplan W;Cowley MJ;Agenès F;Kirberg J;Brink R;Pearson RC M;Crossley M, 2011, 'Impaired B cell development in the absence of Krüppel-like factor 3', Journal of Immunology, vol. 187, pp. 5032 - 5042,

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