Select Publications

Book Chapters

Yik JJ; Crossley M; Quinlan KG R, 2018, 'Genome editing of erythroid cell culture model systems', in Methods in Molecular Biology, pp. 245 - 257, http://dx.doi.org/10.1007/978-1-4939-7428-3_15

Funnell AP W; Crossley M, 2012, 'Homo- and heterodimerization in transcriptional regulation', in Advances in Experimental Medicine and Biology, pp. 105 - 121, http://dx.doi.org/10.1007/978-1-4614-3229-6-7

Verger A; Crossley M, 2004, 'The transcriptome', in Mammalian Genomics, pp. 118 - 151

Journal articles

Martyn GE; Wienert B; Kurita R; Nakamura Y; Quinlan KG R; Crossley M, 2019, 'A natural regulatory mutation in the proximal promoter elevates fetal globin expression by creating a de novo GATA1 site', Blood, vol. 133, pp. 852 - 856, http://dx.doi.org/10.1182/blood-2018-07-863951

Blobel GA; Crossley M, 2018, 'Charting a noncoding gene for γ-globin activation', Blood, vol. 132, pp. 1865 - 1867, http://dx.doi.org/10.1182/blood-2018-09-873620

Artuz CM; Knights AJ; Funnell AP W; Gonda TJ; Ravid K; Pearson RC M; Quinlan KG R; Crossley M, 2018, 'Partial reprogramming of heterologous cells by defined factors to generate megakaryocyte lineage-restricted biomolecules', Biotechnology Reports, vol. 20, http://dx.doi.org/10.1016/j.btre.2018.e00285

Wienert B; Martyn GE; Funnell AP W; Quinlan KG R; Crossley M, 2018, 'Wake-up Sleepy Gene: Reactivating Fetal Globin for β-Hemoglobinopathies', Trends in Genetics, vol. 34, pp. 927 - 940, http://dx.doi.org/10.1016/j.tig.2018.09.004

Knights AJ; Vohralik EJ; Hoehn KL; Crossley M; Quinlan KG R, 2018, 'Defining Eosinophil Function in Adiposity and Weight Loss', BioEssays, vol. 40, http://dx.doi.org/10.1002/bies.201800098

Martyn GE; Wienert B; Yang L; Shah M; Norton LJ; Burdach J; Kurita R; Nakamura Y; Pearson RC M; Funnell AP W; Quinlan KG R; Crossley M, 2018, 'Natural regulatory mutations elevate the fetal globin gene via disruption of BCL11A or ZBTB7A binding', Nature Genetics, vol. 50, pp. 498 - 503, http://dx.doi.org/10.1038/s41588-018-0085-0

Norton LJ; Funnell AP W; Burdach J; Wienert B; Kurita R; Nakamura Y; Philipsen S; Pearson RC M; Quinlan KG R; Crossley M, 2017, 'KLF1 directly activates expression of the novel fetal globin repressor ZBTB7A/LRF in erythroid cells.', Blood Adv, vol. 1, pp. 685 - 692, http://dx.doi.org/10.1182/bloodadvances.2016002303

Nicol D; Eckstein L; Morrison M; Sherkow JS; Otlowski M; Whitton T; Bubela T; Burdon KP; Chalmers D; Chan S; Charlesworth J; Critchley C; Crossley M; de Lacey S; Dickinson JL; Hewitt AW; Kamens J; Kato K; Kleiderman E; Kodama S; Liddicoat J; Mackey DA; Newson AJ; Nielsen J; Wagner JK; McWhirter RE, 2017, 'Key challenges in bringing CRISPR-mediated somatic cell therapy into the clinic', Genome Medicine, vol. 9, http://dx.doi.org/10.1186/s13073-017-0475-4

Wienert B; Martyn GE; Kurita R; Nakamura Y; Quinlan KG R; Crossley M, 2017, 'KLF1 drives the expression of fetal hemoglobin in British HPFH', Blood, vol. 130, pp. 803 - 807, http://dx.doi.org/10.1182/blood-2017-02-767400

Ilsley MD; Gillinder KR; Magor GW; Huang S; Bailey TL; Crossley M; Perkins AC, 2017, 'Krüppel-like factors compete for promoters and enhancers to fine-tune transcription', Nucleic Acids Research, vol. 45, pp. 6572 - 6588, http://dx.doi.org/10.1093/nar/gkx441

Norton LJ; Hallal S; Stout ES; Funnell AP W; Pearson RC M; Crossley M; Quinlan KG R, 2017, 'Direct competition between DNA binding factors highlights the role of Krüppel-like Factor 1 in the erythroid/megakaryocyte switch', Scientific Reports, vol. 7, http://dx.doi.org/10.1038/s41598-017-03289-5

Martyn GE; Quinlan KG R; Crossley M, 2017, 'The regulation of human globin promoters by CCAAT box elements and the recruitment of NF-Y', Biochimica et Biophysica Acta - Gene Regulatory Mechanisms, vol. 1860, pp. 525 - 536, http://dx.doi.org/10.1016/j.bbagrm.2016.10.002

Knights AJ; Yik JJ; Jusoh HM; Norton LJ; Funnell AP W; Pearson RC M; Bell-Anderson KS; Crossley M; Quinlan KG R, 2016, 'Krüppel-like factor 3 (KLF3/BKLF) is required for widespread repression of the inflammatory modulator galectin-3 (Lgals3)', Journal of Biological Chemistry, vol. 291, pp. 16048 - 16058, http://dx.doi.org/10.1074/jbc.M116.715748

Berber S; Wood M; Llamosas E; Thaivalappil P; Lee K; Liao BM; Chew YL; Rhodes A; Yucel D; Crossley M; Nicholas HR, 2016, 'Homeodomain-Interacting Protein Kinase (HPK-1) regulates stress responses and ageing in C. elegans', Scientific Reports, vol. 6, http://dx.doi.org/10.1038/srep19582

Masuda T; Wang X; Maeda M; Canver MC; Sher F; Funnell AP W; Fisher C; Suciu M; Martyn GE; Norton LJ; Zhu C; Kurita R; Nakamura Y; Xu J; Higgs DR; Crossley M; Bauer DE; Orkin SH; Kharchenko PV; Maeda T, 2016, 'Gene regulation: Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin', Science, vol. 351, pp. 285 - 289, http://dx.doi.org/10.1126/science.aad3312

Lim WF; Burdach J; Funnell AP W; Pearson RC M; Quinlan KG R; Crossley M, 2015, 'Directing an artificial zinc finger protein to new targets by fusion to a non-DNA-binding domain', Nucleic Acids Research, vol. 44, pp. 3118 - 3130, http://dx.doi.org/10.1093/nar/gkv1380

Wienert B; Funnell AP W; Norton LJ; Pearson RC M; Wilkinson-White LE; Lester K; Vadolas J; Porteus MH; Matthews JM; Quinlan KG R; Crossley M, 2015, 'Editing the genome to introduce a beneficial naturally occurring mutation associated with increased fetal globin.', Nature communications, vol. 6, pp. 7085, http://dx.doi.org/10.1038/ncomms8085

Dewi V; Kwok A; Lee S; Lee MM; Tan YM; Nicholas HR; Isono KI; Wienert B; Mak KS; Knights AJ; Quinlan KG R; Cordwell SJ; Funnell AP W; Pearson RC M; Crossley M, 2015, 'Phosphorylation of krüppel-like factor 3 (KLF3/BKLF) and C-terminal binding protein 2 (CtBP2) by homeodomaininteracting protein kinase 2 (HIPK2) modulates KLF3 DNA binding and activity', Journal of Biological Chemistry, vol. 290, pp. 8591 - 8605, http://dx.doi.org/10.1074/jbc.M115.638338

Ballester B; Medina-Rivera A; Schmidt D; Gonzàlez-Porta M; Carlucci M; Chen X; Chessman K; Faure AJ; Funnell AP W; Goncalves A; Kutter C; Lukk M; Menon S; McLaren WM; Stefflova K; Watt S; Weirauch MT; Crossley M; Marioni JC; Odom DT; Flicek P; Wilson MD, 2014, 'Multi-species, multi-transcription factor binding highlights conserved control of tissue-specific biological pathways', eLife, vol. 3, pp. e02626, http://dx.doi.org/10.7554/eLife.02626

Clifton MK; Westman BJ; Thong SY; O'Connell MR; Webster MW; Shepherd NE; Quinlan KG; Crossley M; Blobel GA; Mackay JP, 2014, 'The identification and structure of an N-terminal PR domain show that FOG1 is a member of the PRDM family of proteins', PLoS ONE, vol. 9, http://dx.doi.org/10.1371/journal.pone.0106011

Ballester B; Medina-Rivera A; Schmidt D; Gonzàlez-Porta M; Carlucci M; Chen X; Chessman K; Faure AJ; Funnell AP W; Goncalves A; Kutter C; Lukk M; Menon S; McLaren WM; Stefflova K; Watt S; Weirauch MT; Crossley M; Marioni JC; Odom DT; Flicek P; Wilson MD, 2014, 'Multi-species, multi-transcription factor binding highlights conserved control of tissue-specific biological pathways', eLife, vol. 3, pp. 1 - 29, http://dx.doi.org/10.7554/eLife.02626

Reid A; Yücel D; Wood M; Llamosas E; Kant S; Crossley M; Nicholas H, 2014, 'The transcriptional repressor CTBP-1 functions in the nervous system of Caenorhabditis elegans to regulate lifespan', Experimental Gerontology, vol. 60, pp. 153 - 165, http://dx.doi.org/10.1016/j.exger.2014.09.022

Funnell AP W; Crossley M, 2014, 'Hemophilia B Leyden and once mysterious cis-regulatory mutations.', Trends in genetics : TIG, vol. 30, pp. 18 - 23, http://dx.doi.org/10.1016/j.tig.2013.09.007

Yücel D; Hoe M; Llamosas E; Kant S; Jamieson C; Young PA; Crossley M; Nicholas HR, 2014, 'SUMV-1 antagonizes the activity of synthetic multivulva genes in Caenorhabditis elegans', Developmental Biology, vol. 392, pp. 266 - 282, http://dx.doi.org/10.1016/j.ydbio.2014.05.018

Funnell AP W; Vernimmen D; Lim WF; Mak KS; Wienert B; Martyn GE; Artuz CM; Burdach J; Quinlan KG R; Higgs DR; Whitelaw E; Pearson RC M; Crossley M, 2014, 'Differential regulation of the α-globin locus by Krüppel-like factor 3 in erythroid and non-erythroid cells', BMC Molecular Biology, vol. 15, http://dx.doi.org/10.1186/1471-2199-15-8

Mak KS; Burdach J; Norton LJ; Pearson RC M; Crossley M; Funnell AP W, 2014, 'Repression of chimeric transcripts emanating from endogenous retrotransposons by a sequence-specific transcription factor', Genome Biology, vol. 15, http://dx.doi.org/10.1186/gb-2014-15-4-r58

Knights AJ; Funnell AP; Pearson RC; Crossley M; Bell-Anderson KS, 2014, 'Adipokines and insulin action: A sensitive issue.', Adipocyte, vol. 3, pp. 88 - 96, http://dx.doi.org/10.4161/adip.27552

Burdach J; Funnell AP W; Mak KS; Artuz CM; Wienert B; Lim WF; Tan LY; Pearson RC M; Crossley M, 2014, 'Regions outside the DNA-binding domain are critical for proper in vivo specificity of an archetypal zinc finger transcription factor', Nucleic Acids Research, vol. 42, pp. 276 - 289, http://dx.doi.org/10.1093/nar/gkt895

Bell-Anderson KS; Funnell AP; Williams H; Jusoh HM; Scully T; Lim WF; Burdach JG; Mak KS; Knights AJ; Hoy AJ; Nicholas HR; Sainsbury A; Turner N; Pearson RC; Crossley M, 2013, 'Loss of Krüppel-Like Factor 3 (KLF3/BKLF) Leads to Upregulation of the Insulin-Sensitizing Factor Adipolin (FAM132A/CTRP12/C1qdc2)', Diabetes, vol. 62, pp. 2728 - 2737, http://dx.doi.org/10.2337/db12-1745

Berber S; Llamosas E; Thaivalappil P; Boag PR; Crossley M; Nicholas HR, 2013, 'Homeodomain interacting protein kinase (HPK-1) is required in the soma for robust germline proliferation in C. elegans', Developmental Dynamics, vol. 242, pp. 1250 - 1261, http://dx.doi.org/10.1002/dvdy.24023

Mackay JP; Segal DJ; Crossley M, 2013, 'Is there a telltale RH fingerprint in zinc fingers that recognizes methylated CpG dinucleotides?', Trends in Biochemical Sciences, vol. 38, pp. 421 - 422, http://dx.doi.org/10.1016/j.tibs.2013.06.005

Vandevenne M; Jacques DA; Artuz C; Nguyen CD; Kwan AH Y; Segal DJ; Matthews JM; Crossley M; Guss JM; MacKay JP, 2013, 'New insights into DNA recognition by zinc fingers revealed by structural analysis of the oncoprotein ZNF217', Journal of Biological Chemistry, vol. 288, pp. 10616 - 10627, http://dx.doi.org/10.1074/jbc.M112.441451

Funnell AP W; Wilson MD; Ballester B; Mak KS; Burdach J; Magan N; Pearson RC M; Lemaigre FP; Stowell KM; Odom DT; Flicek P; Crossley M, 2013, 'A CpG mutational hotspot in a ONECUT binding site accounts for the prevalent variant of hemophilia B leyden', American Journal of Human Genetics, vol. 92, pp. 460 - 467, http://dx.doi.org/10.1016/j.ajhg.2013.02.003

Funnell AP W; Mak KS; Twine NA; Pelka GJ; Norton LJ; Radziewic T; Power M; Wilkins MR; Bell-Anderson KS; Fraser ST; Perkins AC; Tam PP; Pearson RC M; Crossley M, 2013, 'Generation of Mice Deficient in both KLF3/BKLF and KLF8 Reveals a Genetic Interaction and a Role for These Factors in Embryonic Globin Gene Silencing', Molecular and Cellular Biology, vol. 33, pp. 2976 - 2987, http://dx.doi.org/10.1128/MCB.00074-13

Kelsey L; Flenniken AM; Qu D; Funnell AP W; Pearson R; Zhou YQ; Voronina I; Berberovic Z; Wood G; Newbigging S; Weiss ES; Wong M; Quach I; Yeh SY S; Deshwar AR; Scott IC; McKerlie C; Henkelman M; Backx P; Simpson J; Osborne L; Rossant J; Crossley M; Bruneau B; Adamson SL, 2013, 'ENU-induced Mutation in the DNA-binding Domain of KLF3 Reveals Important Roles for KLF3 in Cardiovascular Development and Function in Mice', PLoS Genetics, vol. 9, http://dx.doi.org/10.1371/journal.pgen.1003612

Burdach J; O'Connell MR; Mackay JP; Crossley M, 2012, 'Two-timing zinc finger transcription factors liaising with RNA', Trends in Biochemical Sciences, vol. 37, pp. 199 - 205, http://dx.doi.org/10.1016/j.tibs.2012.02.001

Bendak K; Loughlin FE; Cheung V; O'Connell MR; Crossley M; MacKay JP, 2012, 'A rapid method for assessing the RNA-binding potential of a protein', Nucleic Acids Research, vol. 40, http://dx.doi.org/10.1093/nar/gks285

Knights AJ; Funnell AP W; Crossley M; Pearson RC M, 2012, 'Holding Tight: Cell Junctions and Cancer Spread.', Trends Cancer Res, vol. 8, pp. 61 - 69, https://www.ncbi.nlm.nih.gov/pubmed/23450077

Funnell AP W; Crossley M, 2012, 'Homo- and heterodimerization in transcriptional regulation', Advances in Experimental Medicine and Biology, vol. 747, pp. 105 - 121, http://dx.doi.org/10.1007/978-1-4614-3229-6_7

Yang H; Galea A; Sytnyk V; Crossley M, 2012, 'Controlling the size of lipid droplets: Lipid and protein factors', Current Opinion in Cell Biology, vol. 24, pp. 509 - 516, http://dx.doi.org/10.1016/j.ceb.2012.05.012

Funnell AP W; Norton LJ; Mak KS; Burdach J; Artuz CM; Twine NA; Wilkins MR; Power CA; Hung TT; Perdomo J; Koh P; Bell-Anderson KS; Orkin SH; Fraser ST; Perkins AC; Pearson RC M; Crossley M, 2012, 'The CACCC-binding protein KLF3/BKLF represses a subset of KLF1/EKLF target genes and is required for proper erythroid maturation in vivo', Molecular and Cellular Biology, vol. 32, pp. 3281 - 3292, http://dx.doi.org/10.1128/MCB.00173-12

Wissmueller S; Font J; Liew CW; Cram E; Schroeder T; Turner J; Crossley M; Mackay JP; Matthews JM, 2011, 'Protein-protein interactions: Analysis of a false positive GST pulldown result', Proteins: Structure, Function and Bioinformatics, vol. 79, pp. 2365 - 2371, http://dx.doi.org/10.1002/prot.23068

Pearson RC M; Funnell AP W; Crossley M, 2011, 'The mammalian zinc finger transcription factor Krüppel-like factor 3 (KLF3/BKLF)', IUBMB Life, vol. 63, pp. 86 - 93, http://dx.doi.org/10.1002/iub.422

Jack BH A; Pearson RC; Crossley M, 2011, 'C-terminal binding protein: A metabolic sensor implicated in regulating adipogenesis', International Journal of Biochemistry and Cell Biology, vol. 43, pp. 693 - 696, http://dx.doi.org/10.1016/j.biocel.2011.01.017

Crossley M; Norton LJ; Funnell AP W; Pearson RC M, 2011, 'Cellular reprogramming toward the erythroid lineage', International Journal of Cell Biology, http://dx.doi.org/10.1155/2011/501464

Nunez N; Clifton MM K; Funnell AP W; Artuz C; Hallal S; Quinlan KG R; Font J; Vandevenne M; Setiyaputra S; Pearson RC M; Mackay JP; Crossley M, 2011, 'The multi-zinc finger protein ZNF217 contacts DNA through a two-finger domain', Journal of Biological Chemistry, vol. 286, pp. 38190 - 38201, http://dx.doi.org/10.1074/jbc.M111.301234

Mak KS; Funnell AP W; Pearson RC M; Crossley M, 2011, 'PU.1 and haematopoietic cell fate: Dosage matters', International Journal of Cell Biology, http://dx.doi.org/10.1155/2011/808524


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