By Professor Richard Bryan Lock

Conference Abstracts

High LM; Papa RA; Armstrong SA; Lock RB, 2011, 'Abstract LB-23: In vivo exposure of infant leukemia to the BH3-mimetic ABT-263 selects for a cell death-resistant phenotype', in Cancer Research, American Association for Cancer Research (AACR), Vol. 71, pp. lb-23-lb-23, http://dx.doi.org/10.1158/1538-7445.am2011-lb-23

Benito J; Shi Y; Szymanska B; Carol H; Bohem I; Lu H; Konoplev S; Fang W; Kornblau SM; Zweidler-McKay P; Wilson W; Campana D; Borthakur G; Bueso-Ramos CE; Kantarjian HM; Shpall EJ; Thomas DA; Jordan CT; Lock RB; Andreeff M; Konopleva M, 2010, 'Targeting the Leukemia-Associated Hypoxic Microenvironment with Hypoxia-Activated Prodrug PR-104', in Blood, American Society of Hematology, Vol. 116, pp. 868, http://dx.doi.org/10.1182/blood.v116.21.868.868

Bhadri VA; Cowley MJ; Kaplan W; Lock RB, 2010, 'The NOD/SCID Xenograft Model Provides Clinically-Relevant Insights Into Glucocorticoid-Induced Gene Expression In Childhood B-Cell Precursor Acute Lymphoblastic Leukemia (ALL)', in Blood, American Society of Hematology, Vol. 116, pp. 2493, http://dx.doi.org/10.1182/blood.v116.21.2493.2493

Lock RB; Bachmann PS; Piazza RG; Davies C; James M; Wong NC; Bhadri VA; Mogavero A; Magistroni V; Gambacorti-Passerini C; Saffery R; Craig JM; Pimanda JE; Marshall GM, 2009, 'Epigenetic Silencing of the Pro-Apoptotic Bim Gene in Glucocorticoid Poor-Responsive Pediatric Acute Lymphoblastic Leukemia, and Its Reversal by Histone Deacetylase Inhibition.', in Blood, American Society of Hematology, Vol. 114, pp. 939, http://dx.doi.org/10.1182/blood.v114.22.939.939

Smith MA; Morton CL; Carol H; Gorlick RG; Kang MH; Keir ST; Kolb EA; Lock RB; Maris JM; Houghton PJ, 2009, 'Pediatric Preclinical Testing Program (PPTP) testing of the CENP-E inhibitor GSK923295A', in Journal of Clinical Oncology, American Society of Clinical Oncology (ASCO), Vol. 27, pp. 10015 - 10015, http://dx.doi.org/10.1200/jco.2009.27.15_suppl.10015

Choi S; Kwan E; Beesley A; Sutton R; Lock RB; Papa R; Marshall GM; Kees UR; Haber M; Norris MD, 2006, '252A ORAL Relapse in children with acute lymphoblastic leukaemia is associated with selection of a pre-existing drug resistance subclone', in European Journal of Cancer Supplements, Elsevier, Vol. 4, pp. 81, http://dx.doi.org/10.1016/s1359-6349(06)70257-9

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