By Professor Richard Bryan Lock

Conference Papers

Starobova H; McCalmont H; Shatunova S; Tay N; Winkler I; Robertson A; Lock R; Vetter I, 2024, 'NEUROINFLAMMATION DRIVES ACUTE LYMPHOBLASTIC LEUKEMIA THERAPY-INDUCED NEUROPATHY', in JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM, WILEY, CANADA, Montreal, pp. S77 - S78, presented at Annual Meeting of the Peripheral-Nerve-Society (PNS), CANADA, Montreal, 22 June 2024 - 25 June 2024

Tyrrell V; Mayoh C; Ekert P; Cowley M; Ziegler D; Wong M; Barahona P; Pinese M; Haber M; Salomon R; Courtney E; Lock R; Fuentes-Bolanos N; Marshall G; Warby M; Trahair T; Dong AKQ; Wakefield C; Tucker K; Barlow-Stewart K; Padhye B; Lau L, 2024, 'Zero Childhood Cancer National Precision Medicine Program: Improving outcomes for children with high risk cancer cancer utilising comprehensive, integrated multiomic profiling', in EUROPEAN JOURNAL OF HUMAN GENETICS, SPRINGERNATURE, GERMANY, Berlin, pp. 800 - 800, presented at 57th Conference of the European-Society-of-Human-Genetics (ESHG), GERMANY, Berlin, 01 June 2024 - 04 June 2024

Tremblay C; Saw J; Boyle J; Haigh K; Lock R; Jane S; Haigh J; Curtis D, 2023, 'STAT5 ACTIVATION PROMOTES PROGRESSION AND CHEMOTHERAPY-RESISTANCE IN EARLY T-CELL PRECURSOR ACUTE LYMPHOBLASTIC LEUKEMIA', in EXPERIMENTAL HEMATOLOGY, ELSEVIER SCIENCE INC, NY, New York, pp. S151 - S151, presented at 52nd Annual Meeting of the International-Society-for-Experimental-Hematology (ISEH), NY, New York, 17 August 2023 - 20 August 2023

Xie J; Gifford A; Mao J; Cadiz R; Avila A; Yun DY; Zhou A; Dolman E; Fleuren E; Mayoh C; Barahona P; Lau L; Kamili A; Tsoli M; Marshall G; Ziegler D; Trahair T; Haber M; Tyrrell V; Lock R, 2022, 'Establishment and application of patient-derived xenograft models for personalised medicine in paediatric cancer', Sydney, presented at Children’s Cancer Institute - Research Symposium 2022, Sydney, 06 December 2022

Fordham A; Brown L; Mayoh C; Wong M; Barger Z; O'Regan L; Lim Kan Siam T; Xie J; Gunther K; Barahona P; Ajuyah P; Lau L; Ziegler D; Haber M; Tyrrell V; Lock R; Cowley M; Nicholls W; Daly R; Ekert P; Fleuren E, 2022, 'MULTI-PLATFORM TYROSINE KINASE PROFILING REVEALS NOVEL ACTIONABLE FGFR ABERRATIONS ACROSS PEDIATRIC AND ADOLESCENT AND YOUNG ADULT SARCOMAS', Vancouver, Canada, presented at Connective Tissue Oncology Society (CTOS) Annual Meeting 2022, Vancouver, Canada, 17 November 2022

Lock RB; Evans K; Randall J; Erickson SW; Earley EJ; Neuhauser S; Stearns T; Philip V; Teicher BA; Watkins K; Sloss CM; Zweidler-McKay PA; Smith MA, 2022, 'Pediatric Preclinical Testing Consortium Evaluation of the Anti-CD123 Antibody-Drug Conjugate, IMGN632, Against Patient-Derived Xenograft Models of Pediatric Acute Lymphoblastic Leukemia', in Blood, American Society of Hematology, pp. 8983 - 8984, http://dx.doi.org/10.1182/blood-2022-159867

Lock RB; Evans K; Watts B; Randall J; Toscan CE; Earley EJ; Erickson SW; Belmontes B; Wong P; Teicher BA; Hughes PE; Smith MA, 2022, 'Pediatric Preclinical Testing Consortium Evaluation of the MCL1 Inhibitor, AMG 176, Against Xenograft Models of Acute Lymphoblastic Leukemia', in Blood, American Society of Hematology, pp. 11690 - 11691, http://dx.doi.org/10.1182/blood-2022-159885

Connerty P; Moles E; deBock C; Jayatilleke N; Smith JL; Meshinchi S; Mayoh C; Kavallaris M; Lock RB, 2021, 'Abstract P143: Development of siRNA-loaded lipid nanoparticles targeting long non-coding RNA LINC01257 as a novel and safe therapeutic approach for paediatric acute myeloid leukaemia', in Molecular Cancer Therapeutics, American Association for Cancer Research (AACR), pp. p143 - p143, http://dx.doi.org/10.1158/1535-7163.targ-21-p143

Fordham A; Brown L; Mayoh C; Wong M; Barger Z; Xie J; Gunther K; Trebilcock P; Lock R; Cowley M; Ekert P; Fleuren E, 2021, 'Multi-platform tyrosine kinase profiling reveals novel molecular response signatures to FGFR-inhibitors in paediatric and AYA sarcoma', Sydney (virtual), presented at Kids Cancer Alliance (KCA) Symposium 2021, Sydney (virtual), 02 September 2021

Lock RB; Evans K; El-Zein N; Lannutti BJ; Jessen KA; Earley EJ; Erickson SW; Smith MA; Kurmasheva R; Houghton PJ, 2021, 'Abstract 3038: Evaluation of ROR1-targeted antibody-drug conjugates against ROR1-expressing pediatric preclinical models - a report from the pediatric preclinical testing consortium (PPTC)', in Cancer Research, American Association for Cancer Research (AACR), pp. 3038 - 3038, http://dx.doi.org/10.1158/1538-7445.am2021-3038

Lock RB; Evans K; El-Zein N; Earley EJ; Erickson SW; Teicher BA; Smith MA, 2021, 'Abstract 3039: Pediatric preclinical testing consortium evaluation of the dual SYK/FLT3 inhibitor TAK-659 in xenograft models of pediatric acute lymphoblastic leukemia', in Cancer Research, American Association for Cancer Research (AACR), pp. 3039 - 3039, http://dx.doi.org/10.1158/1538-7445.am2021-3039

Lock RB; Evans K; El-Zein N; Earley EJ; Erickson SW; Teicher BA; Sung V; Smith MA, 2021, 'Abstract LB171: The differentiated CD47 monoclonal antibody AO-176 exhibits significant in vivo activity against xenograft models of pediatric acute lymphoblastic leukemia (ALL)', in Cancer Research, American Association for Cancer Research (AACR), pp. lb171 - lb171, http://dx.doi.org/10.1158/1538-7445.am2021-lb171

Fleuren E; Dolman E; Lau L; Xie J; Batey D; Mayoh C; Barahona P; Khuong Quang DA; Wong M; ZERO PDTT; ZERO OT; Norris M; Haber M; Trahair T; Marshall G; Ziegler D; Tyrrell V; Cowley M; Lock R; Ekert P, 2021, 'Supporting clinical decision-making for PI3K/AKT/mTOR inhibitors for high-risk paediatric and adolescent and young adult (AYA) sarcoma', Virtual, presented at The Australian and New Zealand Children’s Haematology/Oncology Group (ANZCHOG) Annual Scientific Meeting, Virtual, 24 June 2021

Fordham A; Brown L; Mayoh C; Wong M; Barger Z; Xie J; Gunther K; Trebilcock P; Lim Kam Sian T; Lock R; Daly R; Cowley M; Ekert P; Fleuren E, 2021, 'Multi-platform tyrosine kinase profiling reveals novel molecular response signatures to FGFR-inhibitors in paediatric and AYA sarcoma.', Virtual, presented at The Australian Society for Medical Research (ASMR) 2021, Virtual, 10 June 2021

Fleuren E; Dolman E; Lau L; Xie J; Batey D; Mayoh C; Barahona P; Sherstyuk A; Khuong Quang DA; Wong M; ZERO PDTT; ZERO OT; Thomas D; Mould E; Norris M; Haber M; Trahair T; Marshall G; Ziegler D; Tyrrell V; Cowley M; Lock R; Ekert P, 2020, 'Supporting clinical decision-making for PI3K/AKT/MTOR inhibitors for high-risk paediatric and AYA sarcoma', Virtual, presented at Connective Tissue Oncology Society (CTOS) Annual Meeting 2020, Virtual, 18 November 2020

Fleuren E; Dolman E; Lau L; Xie J; Batey D; Mayoh C; Barahona P; Khuong Quang DA; Wong M; ZERO PDTT; ZERO OT; Norris M; Haber M; Trahair T; Marshall G; Ziegler D; Tyrrell V; Cowley M; Lock R; Ekert P, 2020, 'Supporting clinical decision-making for PI3K/AKT/MTOR inhibitors for high-risk paediatric sarcoma patients', Virtual, presented at KCA Symposium 2020, Virtual, 17 September 2020

Lock RB; Evans K; Jones CD; Erickson SW; Teicher BA; Unger T; Landesman Y; Smith MA, 2020, 'Abstract 4181: The XPO1 inhibitior, eltanexor, exhibits potent in vivo activity against a broad range of pediatric acute lymphoblastic leukemia subtypes', in Cancer Research, American Association for Cancer Research (AACR), pp. 4181 - 4181, http://dx.doi.org/10.1158/1538-7445.am2020-4181

Haber M; Gamble L; Xiao L; Pandher R; Somers K; Murray J; Khan A; Yu D; Franshaw L; Burns MR; Tsoli M; Ehteda A; Cesare A; O’Connor A; Mussai F; de Santo C; Cheng P; Korotchkina L; Gurova K; Tyrrell V; Mould E; Lau L; Quang DAK; Mayoh C; Arndt G; Barahona P; Failes T; Fletcher J; Bolanos NF; Gauthier M-E; Gifford A; Grebert-Wade D; Kamili A; Kumar A; Nagabushan S; O’Brien T; Strong P; Sherstyuk A; Thomas D; Trahair T; Tucker K; Warby M; Wong M; Xie J; Evans K; Lock R; Chernova OB; Henderson M; Gudkov AV; Ekert P; Cowley MJ; Marshall GM; Ziegler DS; Norris MD, 2020, 'Abstract IA13: Molecular targeted therapies and precision medicine for children with neuroblastoma and other refractory malignancies', in Cancer Research, American Association for Cancer Research (AACR), pp. ia13 - ia13, http://dx.doi.org/10.1158/1538-7445.pedca19-ia13

Fleuren E; Lau L; Barahona P; Sherstyuk A; Mayoh C; Terry R; Khuong Quang DA; Wong M; Xie J; Batey D; Grebert-Wade D; Strong P; Lim JY; Chow S-O; Kumar A; Failes T; Arndt G; Mould E; Haber M; Norris M; Lock R; Trahair T; Marshall G; Ziegler D; Tyrrell V; Cowley M; Ekert P, 2020, 'Precision medicine for high-risk paediatric and AYA sarcomas', Lorne, presented at Lorne Cancer 2020, Lorne, 13 February 2020

Lock RB; Toscan CE; Jing D; Mayoh C, 2019, 'Abstract A123: Reversal of glucocorticoid resistance in pediatric acute lymphoblastic leukemia is dependent on restoring BIM expression', in Molecular Cancer Therapeutics, American Association for Cancer Research (AACR), pp. a123 - a123, http://dx.doi.org/10.1158/1535-7163.targ-19-a123

Lock RB; Evans K; Jones CD; El-Zein N; Erickson SW; Beaussant-Cohen S; Kelley EL; Teicher BA; Smith MA, 2019, 'Abstract C004: The CXCR4 inhibitor X4-136 enhances the in vivo efficacy of established drugs against preclinical models of aggressive pediatric acute lymphoblastic leukemia', in Molecular Cancer Therapeutics, American Association for Cancer Research (AACR), pp. c004 - c004, http://dx.doi.org/10.1158/1535-7163.targ-19-c004

Fleuren E; Xie J; Barahona P; Sherstyuk A; Batey D; Jin Yi L; Lau L; Khuong Quang DA; Failes T; Chow S-O; Mayoh C; Wong M; Kumar A; ZERO OT; ZERO PDTT; ZERO SMT; Thomas D; Trahair T; Haber M; Mould E; Lock R; Ziegler D; Tyrrell V; Cowley M; Ekert P, 2019, 'Personalised medicine for high-risk paediatric and AYA sarcoma patients', Tokyo, Japan, presented at Connective Tissue Oncology Society (CTOS) Annual Meeting, Tokyo, Japan, 13 November 2019, https://www.ctos.org/Portals/0/PDF/2019%20CTOS%20Final%20Program.pdf

Li J; Troche C; Zhang JH; Shrimp J; Roth JS; Jing D; Swaroop A; Kulis M; Oyer J; Will C; Dupere-Richer D; Riva A; Pipe C; Sobn A; Norton S; Bennett RL; Shen M; Hall MD; Lock RB; Licht JD, 2019, 'A Gain of Function Mutation in the NSD2 Histone Methyltransferase Drives Glucocorticoid Resistance Via Blocking Receptor Auto-Induction and BIM/Bmf Expression in ALL', in Blood, American Society of Hematology, pp. 3758, http://dx.doi.org/10.1182/blood-2019-126910

Lock RB; Evans K; Jones CD; El-Zein N; Bendak K; Toscan CE; Mayoh C; Erickson SW; Teicher BA; Smith MA, 2019, 'Pediatric Preclinical Testing Consortium Evaluation of the Novel Anti-Microtubule Drug E7130 in Xenograft Models of Early T-Cell Precursor Acute Lymphoblastic Leukemia', in Blood, American Society of Hematology, pp. 3875, http://dx.doi.org/10.1182/blood-2019-123867

Fleuren E; Lau L; Barahona P; Sherstyuk A; Mayoh C; Khuong Quang DA; Wong M; Xie J; Batey D; Grebert-Wade D; Strong P; Lim JL; Chow S-O; Kumar A; Failes T; Arndt G; Mould E; Haber M; Lock R; Trahair T; Marshall G; Ziegler D; Tyrrell V; Cowley M; Ekert P, 2019, 'Precision medicine for high-risk paediatric and AYA sarcomas', Sydney, presented at Kids Cancer Alliance - Annual Meeting, Sydney, 31 October 2019, https://kca.org.au/wp-content/uploads/2019/11/2019-ECR-and-Student-Event-Program.pdf

Teicher BA; Lock RB; Evans K; Houghton PJ; Kurmasheva RT; Gorlicki R; Erickson S; Wishka D; Morris J; Difilippantonio M; Collins JE; Smith MA; Doroshow JH, 2019, 'Abstract 3839: Comparison of thio-deoxy-cytidine (TdCyd) and aza-thio-deoxy-cytidine (Aza-TdCyd) in solid and liquid tumor cell lines and PPTC pediatric xenografts', in Cancer Research, American Association for Cancer Research (AACR), pp. 3839 - 3839, http://dx.doi.org/10.1158/1538-7445.am2019-3839

Earley E; Gorlick R; Houghton PJ; Maris JM; Li X-N; Lock RB; Teicher B; Smith MA; Erickson SW, 2019, 'Abstract LB-321: Re-evaluating sample sizes in preclinical testing of patient-derived xenografts', in Cancer Research, American Association for Cancer Research (AACR), pp. lb-321-lb-321, http://dx.doi.org/10.1158/1538-7445.am2019-lb-321

Earley E; Gorlick R; Houghton PJ; Maris JM; Li X-N; Lock RB; Teicher B; Smith MA; Erickson SW, 2019, 'Abstract LB-321: Re-evaluating sample sizes in preclinical testing of patient-derived xenografts', American Association for Cancer Research (AACR), pp. lb-321-lb-321, presented at Tumor Biology, http://dx.doi.org/10.1158/1538-7445.sabcs18-lb-321

Lock RB; Evans K; Pritchard T; Toscan C; Mayoh C; Teicher B; Kurmasheva RT; Houghton PJ; Smith M, 2018, 'A Single Mouse Trial Platform for Evaluation of Novel Agents in Acute Lymphoblastic Leukemia By the Pediatric Preclinical Testing Consortium', in Blood, American Society of Hematology, pp. 4010, http://dx.doi.org/10.1182/blood-2018-99-113207

Jing D; Huang Y; Liu X; Sia K; Poulos RC; Span M; Zhang C; Mi J; Wong JW; Beck D; Pimanda JE; Lock RB, 2018, 'Abstract 3173: Lymphocyte-specific chromatin accessibility predetermines glucocorticoid resistance in acute lymphoblastic leukemia', in Cancer Research, American Association for Cancer Research (AACR), pp. 3173 - 3173, http://dx.doi.org/10.1158/1538-7445.am2018-3173

Lock RB; Evans K; Pritchard T; Erickson SW; Guo Y; Claremon DA; McGeehan GM; Teicher BA; Smith MA, 2018, 'Abstract 3187: Pediatric Preclinical Testing Consortium evaluation of the menin inhibitor, VTP-50469, against xenograft models of MLL-rearranged infant acute lymphoblastic leukemia', in Cancer Research, American Association for Cancer Research (AACR), pp. 3187 - 3187, http://dx.doi.org/10.1158/1538-7445.am2018-3187

Teicher BA; Lock RB; Collins JM; Gorlick R; Kolb EA; Houghton PJ; Kurmasheva RT; Li X-N; Erickson SW; Guo Y; Evans K; Qi L; Smith MA, 2018, 'Abstract LB-B12: Pediatric Preclinical Testing Consortium evaluation of 4’-thio-2’-deoxycytidine (TdCyd) and 5-aza-4’-thio-2’-deoxycytidine (Aza-TdCyd)', in Molecular Cancer Therapeutics, American Association for Cancer Research (AACR), pp. lb-b12-lb-b12, http://dx.doi.org/10.1158/1535-7163.targ-17-lb-b12

Krytska K; Evans K; Pritchard T; Tsang M; Yung R; Mosse YP; Erickson SW; Guo Y; Baloglu E; Landesman Y; Jensen KA; Senapedis W; Teicher BA; Smith MA; Lock RB; Maris JM, 2018, 'Abstract LB-B14: Pediatric Preclinical Testing Consortium evaluation of the second-generation selective inhibitor of nuclear export (SINE) compound KPT-8602', in Molecular Cancer Therapeutics, American Association for Cancer Research (AACR), pp. lb-b14-lb-b14, http://dx.doi.org/10.1158/1535-7163.targ-17-lb-b14

Lock RB; Evans K; Yung R; Pritchard T; Teicher BA; Duan J; Guo Y; Erickson SW; Smith MA, 2018, 'Abstract LB-B16: The AKR1C3-Activated Prodrug OBI-3424 Exerts Profound In Vivo Efficacy Against Preclinical Models of T-Cell Acute Lymphoblastic Leukemia (T-ALL); a Pediatric Preclinical Testing Consortium Study', in Molecular Cancer Therapeutics, American Association for Cancer Research (AACR), pp. lb-b16-lb-b16, http://dx.doi.org/10.1158/1535-7163.targ-17-lb-b16

Wakefield C; Quinn V; Doolan E; Fardell J; Tucker K; Patenaude A; Marshall K; Lock R; Signorelli C; Georgiou G; Cohn R, 2017, 'The use of Murine Models of Chemosensitivity to Anticancer Agents in Childhood Cancer Clinical Care: Survivor, Parent and Community Acceptability and Willingness-to-Pay', in PEDIATRIC BLOOD & CANCER, WILEY, pp. S60 - S61, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000408978201113&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Somers K; Middlemiss S; Biktasova A; Karsa M; Cheung L; Kosciolek A; Evans K; Mayoh C; Kees UR; Korotchkina L; Chernova OB; Lock RB; Gudkov AV; Haber M; Norris MD; Henderson MJ, 2017, 'Abstract 1175: Inhibition of NAMPT as a novel therapeutic strategy for infant leukemia', in Cancer Research, American Association for Cancer Research (AACR), pp. 1175 - 1175, http://dx.doi.org/10.1158/1538-7445.am2017-1175

Evans K; Pritchard T; Henderson MJ; Somers K; Karsa M; Cheung L; Yung R; Erickson SW; Korotchkina L; Chernova O; Gudkov A; Smith MA; Lock RB, 2017, 'Abstract 1942: The nicotinamide phosphoribosyltransferase (NAMPT) inhibitor, OT-82, exhibits in vitro and in vivo efficacy against patient-derived xenograft models of high-risk acute lymphoblastic leukemia', in Cancer Research, American Association for Cancer Research (AACR), pp. 1942 - 1942, http://dx.doi.org/10.1158/1538-7445.am2017-1942

Li KL; Bray SC; Iarossi D; Adams J; Zhong L; Noll B; Rahaman MH; Richmond J; To LB; Lewis ID; Lock RB; Wang S; D'Andrea RJ, 2015, 'Investigation of a Novel Cyclin-Dependent-Kinase (CDK) Inhibitor Cdki-73 As an Effective Treatment Option for MLL-AML', in Blood, American Society of Hematology, pp. 1365, http://dx.doi.org/10.1182/blood.v126.23.1365.1365

Smith MA; Lock R; Carol H; Maris JM; Gorlick R; Kolb EA; Keir ST; Wu J; Landesman Y; Shacham S; Lyalin D; Kurmasheva RT; Houghton PJ, 2015, 'Abstract 1616: Pharmacodynamic and genomic markers associated with response to the XPO1/CRM1 inhibitor selinexor (KPT-330): a report from the Pediatric Preclinical Testing Program', in Cancer Research, American Association for Cancer Research (AACR), pp. 1616 - 1616, http://dx.doi.org/10.1158/1538-7445.am2015-1616

Richmond J; Evans K; Robbins A; Kurmasheva RT; Houghton PJ; Smith MA; Lock RB, 2015, 'Abstract 1620: In vivo and in vitro efficacy of birinapant in preclinical models of Ph-like pediatric acute lymphoblastic leukemia', in Cancer Research, American Association for Cancer Research (AACR), pp. 1620 - 1620, http://dx.doi.org/10.1158/1538-7445.am2015-1620

Jones L; Richmond J; Evans K; Lock RB, 2015, 'Abstract 1631: Bioluminescence imaging enhances analysis of drug response in a patient-derived xenograft model of pediatric acute lymphoblastic leukemia', in Cancer Research, American Association for Cancer Research (AACR), pp. 1631 - 1631, http://dx.doi.org/10.1158/1538-7445.am2015-1631

Smith MA; Kang M; Reynolds PC; Lock RB; Carol H; Gorlick R; Kolb AE; Maris JM; Keir ST; Billups CA; Kurmasheva R; Houghton PJ, 2015, 'Abstract 1615: Initial testing (stage 1) of the Curaxin, CBL0137, by the Pediatric Preclinical Testing Program (PPTP)', in Cancer Research, American Association for Cancer Research (AACR), PA, Philadelphia, pp. 1615 - 1615, presented at 106th Annual Meeting of the American-Association-for-Cancer-Research (AACR), PA, Philadelphia, 18 April 2015 - 22 April 2015, http://dx.doi.org/10.1158/1538-7445.am2015-1615

Dolnikov A; Rossi S; Xu N; Klamer G; Shen S; Micklethwaite KP; Lock RB; O’Brien T, 2014, '5-Aza-2′-Deoxycytidine Promotes Cytotoxic Effect of CART-Cells on Leukaemia Cells', in Blood, American Society of Hematology, pp. 5812, http://dx.doi.org/10.1182/blood.v124.21.5812.5812

Maude SL; Dolai S; Delgado-Martin C; Hunger SP; Loh ML; Mullighan CG; Hermiston ML; Grupp SA; Lock R; Teachey DT, 2014, 'EARLY T-CELL PRECURSOR (ETP) ACUTE LYMPHOBLASTIC LEUKEMIA IS CHARACTERIZED BY ABERRANT ACTIVATION OF THE JAK/STAT PATHWAY AND PROFOUND RESPONSES TO RUXOLITINIB IN XENOGRAFT MODELS', in PEDIATRIC BLOOD & CANCER, WILEY-BLACKWELL, pp. S109 - S109, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000343932100014&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Suryani S; Carol H; Frimantas V; Bornhauser B; Sarmah C; Chonghaile T; Evans K; Tonna E; Jones L; Letai A; Bourquin J-P; Houghton PJ; Smith MA; Lock RB, 2014, 'Abstract B26: Cell and molecular determinants of in vivo efficacy of the BH3 mimetic ABT-263 against pediatric acute lymphoblastic leukemia xenografts', in Cancer Research, American Association for Cancer Research (AACR), pp. b26 - b26, http://dx.doi.org/10.1158/1538-7445.pedcan-b26

Smith M; Kang M; Reynolds P; Lock R; Carol H; Gorlick R; Kolb A; Maris J; Keir S; Wu J; Kurmasheva R; Houghton P, 2014, '410 Pediatric Preclinical Testing Program (PPTP) Evaluation of the p53-MDM2 Antagonist MK-8242', in European Journal of Cancer, Elsevier, pp. 131, http://dx.doi.org/10.1016/s0959-8049(14)70536-2

Houghton P; Lock R; Carol H; Gorlick R; Kolb A; Maris J; Keir S; Wu J; Kang M; Reynolds P; Kurmasheva R; Smith M, 2014, '412 The Pediatric Preclinical Testing Program (PPTP): Analysis of the first 10 years in vivo testing', in European Journal of Cancer, Elsevier, pp. 131 - 132, http://dx.doi.org/10.1016/s0959-8049(14)70538-6

Lock RB; Richmond J; High L; Carol H; Evans K; Mendomo AM; Kurmasheva RT; Houghton PJ; Smith MA, 2013, 'Effective Targeting Of The P53/MDM2 Axis In Preclinical Models Of Infant MLL-Rearranged Acute Lymphoblastic Leukemia', in Blood, American Society of Hematology, pp. 71, http://dx.doi.org/10.1182/blood.v122.21.71.71

Thomas D; Powell JA; Parker MW; Ekert PG; Lock RB; Huang DC; Nilsson SK; Recher C; Wei AH; Guthridge MA, 2013, 'The selective targeting of cell survival pathways in leukemia', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, http://dx.doi.org/10.1158/1538-7445.FBCR13-A19

Shahbazi J; Lock R; Liu T, 2013, 'BET bromodomain inhibition as a therapeutic strategy to target N-Myc in neuroblastoma', in EUROPEAN JOURNAL OF CANCER, ELSEVIER SCI LTD, NETHERLANDS, Amsterdam, pp. S356 - S356, presented at European Cancer Congress 2013 - 17th ECCO / 38th ESMO / 32nd ESTRO, NETHERLANDS, Amsterdam, 27 September 2013 - 01 October 2013, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000326843602301&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Back to profile page