By Professor Richard Bryan Lock

Conference Papers

Lock RB; Evans K; Randall J; Erickson SW; Earley EJ; Neuhauser S; Stearns T; Philip V; Teicher BA; Watkins K; Sloss CM; Zweidler-McKay PA; Smith MA, 2022, 'Pediatric Preclinical Testing Consortium Evaluation of the Anti-CD123 Antibody-Drug Conjugate, IMGN632, Against Patient-Derived Xenograft Models of Pediatric Acute Lymphoblastic Leukemia', in BLOOD, AMER SOC HEMATOLOGY, LA, New Orleans, pp. 8983 - 8984, presented at 64th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), LA, New Orleans, 10 December 2022 - 13 December 2022, http://dx.doi.org/10.1182/blood-2022-159867

Lock RB; Evans K; Watts B; Randall J; Toscan CE; Earley EJ; Erickson SW; Belmontes B; Wong P; Teicher BA; Hughes PE; Smith MA, 2022, 'Pediatric Preclinical Testing Consortium Evaluation of the MCL1 Inhibitor, AMG 176, Against Xenograft Models of Acute Lymphoblastic Leukemia', in BLOOD, AMER SOC HEMATOLOGY, LA, New Orleans, pp. 11690 - 11691, presented at 64th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), LA, New Orleans, 10 December 2022 - 13 December 2022, http://dx.doi.org/10.1182/blood-2022-159885

Connerty P; Moles E; deBock C; Jayatilleke N; Smith JL; Meshinchi S; Mayoh C; Kavallaris M; Lock RB, 2021, 'Development of siRNA-loaded lipid nanoparticles targeting long non-coding RNA LINC01257 as a novel and safe therapeutic approach for paediatric acute myeloid leukaemia', in MOLECULAR CANCER THERAPEUTICS, AMER ASSOC CANCER RESEARCH, http://dx.doi.org/10.1158/1535-7163.TARG-21-P143

Lock RB; Evans K; El-Zein N; Lannutti BJ; Jessen KA; Earley EJ; Erickson SW; Smith MA; Kurmasheva R; Houghton PJ, 2021, 'Abstract 3038: Evaluation of ROR1-targeted antibody-drug conjugates against ROR1-expressing pediatric preclinical models - a report from the pediatric preclinical testing consortium (PPTC)', in Cancer Research, American Association for Cancer Research (AACR), pp. 3038 - 3038, http://dx.doi.org/10.1158/1538-7445.am2021-3038

Lock RB; Evans K; El-Zein N; Earley EJ; Erickson SW; Teicher BA; Smith MA, 2021, 'Abstract 3039: Pediatric preclinical testing consortium evaluation of the dual SYK/FLT3 inhibitor TAK-659 in xenograft models of pediatric acute lymphoblastic leukemia', in Cancer Research, American Association for Cancer Research (AACR), pp. 3039 - 3039, http://dx.doi.org/10.1158/1538-7445.am2021-3039

Lock RB; Evans K; El-Zein N; Earley EJ; Erickson SW; Teicher BA; Sung V; Smith MA, 2021, 'Abstract LB171: The differentiated CD47 monoclonal antibody AO-176 exhibits significant in vivo activity against xenograft models of pediatric acute lymphoblastic leukemia (ALL)', in Cancer Research, American Association for Cancer Research (AACR), pp. LB171 - LB171, http://dx.doi.org/10.1158/1538-7445.am2021-lb171

Lock RB; Evans K; Jones CD; Erickson SW; Teicher BA; Unger TJ; Landesman Y; Smith MA, 2020, 'The XPO1 inhibitior, eltanexor, exhibits potent in vivo activity against a broad range of pediatric acute lymphoblastic leukemia subtypes', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, ELECTR NETWORK, presented at AACR Annual Meeting, ELECTR NETWORK, 22 June 2020 - 24 June 2020, http://dx.doi.org/10.1158/1538-7445.AM2020-4181

Li J; Troche C; Zhang JH; Shrimp J; Roth JS; Jing D; Swaroop A; Kulis M; Oyer J; Will C; Dupere-Richer D; Riva A; Pipe C; Sobn A; Norton S; Bennett RL; Shen M; Hall MD; Lock RB; Licht JD, 2019, 'A Gain of Function Mutation in the NSD2 Histone Methyltransferase Drives Glucocorticoid Resistance Via Blocking Receptor Auto-Induction and BIM/Bmf Expression in ALL', in BLOOD, AMER SOC HEMATOLOGY, FL, Orlando, presented at 61st Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), FL, Orlando, 07 December 2019 - 10 December 2019, http://dx.doi.org/10.1182/blood-2019-126910

Lock RB; Evans K; Jones CD; El-Zein N; Bendak K; Toscan CE; Mayoh C; Erickson SW; Teicher BA; Smith MA, 2019, 'Pediatric Preclinical Testing Consortium Evaluation of the Novel Anti-Microtubule Drug E7130 in Xenograft Models of Early T-Cell Precursor Acute Lymphoblastic Leukemia', in BLOOD, AMER SOC HEMATOLOGY, FL, Orlando, presented at 61st Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), FL, Orlando, 07 December 2019 - 10 December 2019, http://dx.doi.org/10.1182/blood-2019-123867

Lock RB; Toscan CE; Jing D; Mayoh C, 2019, 'Reversal of glucocorticoid resistance in pediatric acute lymphoblastic leukemia is dependent on restoring BIM expression', in MOLECULAR CANCER THERAPEUTICS, AMER ASSOC CANCER RESEARCH, http://dx.doi.org/10.1158/1535-7163.TARG-19-A123

Lock RB; Evans K; Jones CD; El-Zein N; Erickson SW; Beaussant-Cohen S; Kelley EL; Teicher BA; Smith MA, 2019, 'The CXCR4 inhibitor X4-136 enhances the in vivo efficacy of established drugs against preclinical models of aggressive pediatric acute lymphoblastic leukemia', in MOLECULAR CANCER THERAPEUTICS, AMER ASSOC CANCER RESEARCH, http://dx.doi.org/10.1158/1535-7163.TARG-19-C004

Teicher BA; Lock RB; Evans K; Houghton PJ; Kurmasheva RT; Gorlicki R; Erickson S; Wishka D; Morris J; Difilippantonio M; Collins JE; Smith MA; Doroshow JH, 2019, 'Abstract 3839: Comparison of thio-deoxy-cytidine (TdCyd) and aza-thio-deoxy-cytidine (Aza-TdCyd) in solid and liquid tumor cell lines and PPTC pediatric xenografts', in Cancer Research, American Association for Cancer Research (AACR), pp. 3839 - 3839, http://dx.doi.org/10.1158/1538-7445.am2019-3839

Earley E; Gorlick R; Houghton PJ; Maris JM; Li X-N; Lock RB; Teicher B; Smith MA; Erickson SW, 2019, 'Abstract LB-321: Re-evaluating sample sizes in preclinical testing of patient-derived xenografts', in Tumor Biology, American Association for Cancer Research, presented at Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA, http://dx.doi.org/10.1158/1538-7445.sabcs18-lb-321

Earley E; Gorlick R; Houghton PJ; Mans JM; Li X-N; Lock RB; Teicher B; Smith MA; Erickson SW, 2019, 'Re-evaluating sample sizes in preclinical testing of patient-derived xenografts', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, GA, Atlanta, presented at Annual Meeting of the American-Association-for-Cancer-Research (AACR), GA, Atlanta, 29 March 2019 - 03 April 2019, http://dx.doi.org/10.1158/1538-7445.AM2019-LB-321

Lock RB; Evans K; Pritchard T; Toscan C; Mayoh C; Teicher B; Kurmasheva RT; Houghton PJ; Smith M, 2018, 'A Single Mouse Trial Platform for Evaluation of Novel Agents in Acute Lymphoblastic Leukemia By the Pediatric Preclinical Testing Consortium', in BLOOD, AMER SOC HEMATOLOGY, CA, San Diego, presented at 60th Annual Meeting of the American-Society-of-Hematology (ASH), CA, San Diego, 01 December 2018 - 04 December 2018, http://dx.doi.org/10.1182/blood-2018-99-113207

Jing D; Huang Y; Liu X; Sia K; Poulos RC; Span M; Zhang C; Mi J; Wong JWH; Beck D; Pimanda JE; Lock RB, 2018, 'Lymphocyte-specific chromatin accessibility predetermines glucocorticoid resistance in acute lymphoblastic leukemia', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, IL, Chicago, presented at Annual Meeting of the American-Association-for-Cancer-Research (AACR), IL, Chicago, 14 April 2018 - 18 April 2018, http://dx.doi.org/10.1158/1538-7445.AM2018-3173

Lock RB; Evans K; Pritchard T; Erickson SW; Guo Y; Claremon DA; McGeehan GM; Teicher BA; Smith MA, 2018, 'Pediatric Preclinical Testing Consortium evaluation of the menin inhibitor, VTP-50469, against xenograft models of MLL-rearranged infant acute lymphoblastic leukemia', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, IL, Chicago, presented at Annual Meeting of the American-Association-for-Cancer-Research (AACR), IL, Chicago, 14 April 2018 - 18 April 2018, http://dx.doi.org/10.1158/1538-7445.AM2018-3187

Teicher BA; Lock RB; Collins JM; Gorlick R; Kolb EA; Houghton PJ; Kurmasheva RT; Li X-N; Erickson SW; Guo Y; Evans K; Qi L; Smith MA, 2018, 'Pediatric Preclinical Testing Consortium evaluation of 4 '-thio-2 '-deoxycytidine (TdCyd) and 5-aza-4 '-thio-2 '-deoxycytidine (Aza-TdCyd)', in MOLECULAR CANCER THERAPEUTICS, AMER ASSOC CANCER RESEARCH, http://dx.doi.org/10.1158/1535-7163.TARG-17-LB-B12

Krytska K; Evans K; Pritchard T; Tsang M; Yung R; Mosse YP; Erickson SW; Guo Y; Baloglu E; Landesman Y; Jensen KA; Senapedis W; Teicher BA; Smith MA; Lock RB; Maris JM, 2018, 'Pediatric Preclinical Testing Consortium evaluation of the second-generation selective inhibitor of nuclear export (SINE) compound KPT-8602', in MOLECULAR CANCER THERAPEUTICS, AMER ASSOC CANCER RESEARCH, http://dx.doi.org/10.1158/1535-7163.TARG-17-LB-B14

Lock RB; Evans K; Yung R; Pritchard T; Teicher BA; Duan J; Guo Y; Erickson SW; Smith MA, 2018, 'The AKR1C3-Activated Prodrug OBI-3424 Exerts Profound In Vivo Efficacy Against Preclinical Models of T-Cell Acute Lymphoblastic Leukemia (T-ALL); a Pediatric Preclinical Testing Consortium Study', in MOLECULAR CANCER THERAPEUTICS, AMER ASSOC CANCER RESEARCH, http://dx.doi.org/10.1158/1535-7163.TARG-17-LB-B16

Wakefield C; Quinn V; Doolan E; Fardell J; Tucker K; Patenaude A; Marshall K; Lock R; Signorelli C; Georgiou G; Cohn R, 2017, 'The use of Murine Models of Chemosensitivity to Anticancer Agents in Childhood Cancer Clinical Care: Survivor, Parent and Community Acceptability and Willingness-to-Pay', in PEDIATRIC BLOOD & CANCER, WILEY, pp. S60 - S61, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000408978201113&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Somers K; Middlemiss S; Biktasova A; Karsa M; Cheung L; Kosciolek A; Evans K; Mayoh C; Kees UR; Korotchkina L; Chernova OB; Lock RB; Gudkov AV; Haber M; Norris MD; Henderson MJ, 2017, 'Inhibition of NAMPT as a novel therapeutic strategy for infant leukemia', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, DC, Washington, presented at Annual Meeting of the American-Association-for-Cancer-Research (AACR), DC, Washington, 01 April 2017 - 05 April 2017, http://dx.doi.org/10.1158/1538-7445.AM2017-1175

Evans K; Pritchard T; Henderson MJ; Somers K; Karsa M; Cheung L; Yung R; Erickson SW; Korotchkina L; Chernova O; Gudkov A; Smith MA; Lock RB, 2017, 'The nicotinamide phosphoribosyltransferase (NAMPT) inhibitor, OT-82, exhibits in vitro and in vivo efficacy against patient-derived xenograft models of high-risk acute lymphoblastic leukemia', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, DC, Washington, presented at Annual Meeting of the American-Association-for-Cancer-Research (AACR), DC, Washington, 01 April 2017 - 05 April 2017, http://dx.doi.org/10.1158/1538-7445.AM2017-1942

Li KL; Bray SC; Iarossi D; Adams J; Zhong L; Noll B; Rahaman MH; Richmond J; To LB; Lewis ID; Lock RB; Wang S; D'Andrea RJ, 2015, 'Investigation of a Novel Cyclin-Dependent-Kinase (CDK) Inhibitor Cdki-73 As an Effective Treatment Option for MLL-AML', in BLOOD, AMER SOC HEMATOLOGY, FL, Orlando, presented at 57th Annual Meeting of the American-Society-of-Hematology, FL, Orlando, 05 December 2015 - 08 December 2015, http://dx.doi.org/10.1182/blood.V126.23.1365.1365

Jones L; Richmond J; Evans K; Lock RB, 2015, 'Bioluminescence imaging enhances analysis of drug response in a patient-derived xenograft model of pediatric acute lymphoblastic leukemia', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, PA, Philadelphia, presented at 106th Annual Meeting of the American-Association-for-Cancer-Research (AACR), PA, Philadelphia, 18 April 2015 - 22 April 2015, http://dx.doi.org/10.1158/1538-7445.AM2015-1631

Richmond J; Evans K; Robbins A; Kurmasheva RT; Houghton PJ; Smith MA; Lock RB, 2015, 'In vivo and in vitro efficacy of birinapant in preclinical models of Ph-like pediatric acute lymphoblastic leukemia', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, PA, Philadelphia, presented at 106th Annual Meeting of the American-Association-for-Cancer-Research (AACR), PA, Philadelphia, 18 April 2015 - 22 April 2015, http://dx.doi.org/10.1158/1538-7445.AM2015-1620

Smith MA; Kang M; Reynolds PC; Lock RB; Carol H; Gorlick R; Kolb AE; Maris JM; Keir ST; Billups CA; Kurmasheva R; Houghton PJ, 2015, 'Initial testing (stage 1) of the Curaxin, CBL0137, by the Pediatric Preclinical Testing Program (PPTP)', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, PA, Philadelphia, presented at 106th Annual Meeting of the American-Association-for-Cancer-Research (AACR), PA, Philadelphia, 18 April 2015 - 22 April 2015, http://dx.doi.org/10.1158/1538-7445.AM2015-1615

Smith MA; Lock R; Carol H; Maris JM; Gorlick R; Kolb EA; Keir ST; Wu J; Landesman Y; Shacham S; Lyalin D; Kurmasheva RT; Houghton PJ, 2015, 'Pharmacodynamic and genomic markers associated with response to the XPO1/CRM1 inhibitor selinexor (KPT-330): a report from the Pediatric Preclinical Testing Program', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, PA, Philadelphia, presented at 106th Annual Meeting of the American-Association-for-Cancer-Research (AACR), PA, Philadelphia, 18 April 2015 - 22 April 2015, http://dx.doi.org/10.1158/1538-7445.AM2015-1616

Dolnikov A; Rossi S; Xu N; Klamer G; Shen S; Micklethwaite KP; Lock RB; O'Brien T, 2014, '5-Aza-2 '-Deoxycytidine Promotes Cytotoxic Effect of CART-Cells on Leukaemia Cells', in BLOOD, AMER SOC HEMATOLOGY, CA, San Francisco, presented at 56th Annual Meeting of the American-Society-of-Hematology, CA, San Francisco, 06 December 2014 - 09 December 2014, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000349233806021&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Maude SL; Dolai S; Delgado-Martin C; Hunger SP; Loh ML; Mullighan CG; Hermiston ML; Grupp SA; Lock R; Teachey DT, 2014, 'EARLY T-CELL PRECURSOR (ETP) ACUTE LYMPHOBLASTIC LEUKEMIA IS CHARACTERIZED BY ABERRANT ACTIVATION OF THE JAK/STAT PATHWAY AND PROFOUND RESPONSES TO RUXOLITINIB IN XENOGRAFT MODELS', in PEDIATRIC BLOOD & CANCER, WILEY-BLACKWELL, pp. S109 - S109, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000343932100014&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Smith M; Kang M; Reynolds P; Lock R; Carol H; Gorlick R; Kolb A; Maris J; Keir S; Wu J; Kurmasheva R; Houghton P, 2014, 'Pediatric Preclinical Testing Program (PPTP) Evaluation of the p53-MDM2 Antagonist MK-8242', in EUROPEAN JOURNAL OF CANCER, ELSEVIER SCI LTD, SPAIN, European Org Res & Treatment Canc, Barcelona, pp. 131 - 131, presented at 26th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, SPAIN, European Org Res & Treatment Canc, Barcelona, 18 November 2014 - 21 November 2014, http://dx.doi.org/10.1016/S0959-8049(14)70536-2

Houghton P; Lock R; Carol H; Gorlick R; Kolb A; Maris J; Keir S; Wu J; Kang M; Reynolds P; Kurmasheva R; Smith M, 2014, 'The Pediatric Preclinical Testing Program (PPTP): Analysis of the first 10 years in vivo testing', in EUROPEAN JOURNAL OF CANCER, ELSEVIER SCI LTD, SPAIN, European Org Res & Treatment Canc, Barcelona, pp. 131 - 132, presented at 26th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, SPAIN, European Org Res & Treatment Canc, Barcelona, 18 November 2014 - 21 November 2014, http://dx.doi.org/10.1016/S0959-8049(14)70538-6

Lock RB; Richmond J; High L; Carol H; Evans K; Mendomo AM; Kurmasheva RT; Houghton PJ; Smith MA, 2013, 'Effective Targeting Of The P53/MDM2 As In Preclinical Models Of Infant MLL-Rearranged Acute Lymphoblastic Leukemia', in BLOOD, AMER SOC HEMATOLOGY, LA, New Orleans, presented at 55th Annual Meeting of the American-Society-of-Hematology, LA, New Orleans, 07 December 2013 - 10 December 2013, http://dx.doi.org/10.1182/blood.V122.21.71.71

Suryani S; Carol H; Frimantas V; Bornhauser B; Sarmah C; Chonghaile T; Evans K; Tonna E; Jones L; Letai A; Bourquin J-P; Houghton PJ; Smith MA; Lock RB, 2013, 'Cell and molecular determinants of in vivo efficacy of the BH3 mimetic ABT-263 against pediatric acute lymphoblastic leukemia xenografts', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, CA, San Diego, presented at AACR Special Conference on Pediatric Cancer at the Crossroads - Translating Discovery into Improved Outcomes, CA, San Diego, 03 November 2013 - 06 November 2013, http://dx.doi.org/10.1158/1538-7445.PEDCAN-B26

Thomas D; Powell JA; Parker MW; Ekert PG; Lock RB; Huang DC; Nilsson SK; Recher C; Wei AH; Guthridge MA, 2013, 'The selective targeting of cell survival pathways in leukemia', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, http://dx.doi.org/10.1158/1538-7445.FBCR13-A19

Shahbazi J; Lock R; Liu T, 2013, 'BET bromodomain inhibition as a therapeutic strategy to target N-Myc in neuroblastoma', in EUROPEAN JOURNAL OF CANCER, ELSEVIER SCI LTD, NETHERLANDS, Amsterdam, pp. S356 - S356, presented at European Cancer Congress 2013 - 17th ECCO / 38th ESMO / 32nd ESTRO, NETHERLANDS, Amsterdam, 27 September 2013 - 01 October 2013, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000326843602301&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Houghton PJ; Kang M; Reynolds CP; Lock RB; Carol H; Gorlick R; Kolb EA; Maris JM; Keir ST; Billups CA; Kurmasheva RT; Smith MA, 2013, 'Abstract 2754: Pediatric Preclinical Testing Program (PPTP) stage 1 evaluation of the antimicrotubule agents cabazitaxel and docetaxel.', in Cancer Research, American Association for Cancer Research (AACR), pp. 2754 - 2754, http://dx.doi.org/10.1158/1538-7445.am2013-2754

Houghton P; Kang MH; Reynolds P; Lock R; Carol H; Gorlick R; Kolb A; Maris J; Keir S; Billups C; Kurmasheva R; Smith M, 2013, 'Abstract 2758: Pediatric preclinical testing program (PPTP) stage 1 evaluation of MLN0128, a potent TOR kinase inhibitor.', in Cancer Research, American Association for Cancer Research (AACR), pp. 2758 - 2758, http://dx.doi.org/10.1158/1538-7445.am2013-2758

Manesh DM; Carol H; Evans K; Richmond J; Jamieson S; Wilson WR; Houghton PJ; Smith MA; Lock RB, 2013, 'AKR1C3 is a potential biomarker of T-cell acute lymphoblastic leukemia sensitivity to the pre-prodrug PR-104.', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Washington, DC, presented at 104th Annual Meeting of the American-Association-for-Cancer-Research (AACR), Washington, DC, 06 April 2013 - 10 April 2013, http://dx.doi.org/10.1158/1538-7445.AM2013-2745

Toscan C; Failes T; Arndt G; Lock R, 2013, 'High throughput screen to identify compounds that reverse glucocorticoid resistance in pediatric leukemia', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, DC, Washington, presented at 104th Annual Meeting of the American-Association-for-Cancer-Research (AACR), DC, Washington, 06 April 2013 - 10 April 2013, http://dx.doi.org/10.1158/1538-7445.AM2013-4550

Houghton P; Kang M; Reynolds P; Gorlick R; Kolb A; Maris J; Keir S; Carol H; Lock R; Billups C; Kurmasheva R; Landesman Y; Shacham S; Kauffman M; Smith MA, 2013, 'Pediatric Preclinical Testing Program (PPTP) stage 1 evaluation of the XPO1/CRM1 inhibitor KPT-330', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, DC, Washington, presented at 104th Annual Meeting of the American-Association-for-Cancer-Research (AACR), DC, Washington, 06 April 2013 - 10 April 2013, http://dx.doi.org/10.1158/1538-7445.AM2013-LB-354

Lee EM; Yee D; Busfield SJ; Vairo G; Lock RB, 2012, 'A Neutralizing Antibody (CSL362) Against the Interleukin-3 Receptor alpha-Chain Augments the Efficacy of a Cytarabine/Daunorubicin Induction-Type Therapy in Preclinical Xenograft Models of Acute Myelogenous Leukemia', in BLOOD, AMER SOC HEMATOLOGY, GA, Atlanta, presented at 54th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), GA, Atlanta, 08 December 2012 - 11 December 2012, http://dx.doi.org/10.1182/blood.V120.21.3599.3599

Smith MA; Carol H; Evans K; Richmond J; Kang M; Reynolds CP; Chunduru S; Graham MA; Geier B; Kurmasheva R; Houghton PJ; Lock RB, 2012, 'Birinapant (TL32711), a Small Molecule Smac Mimetic, Induces Regressions in Childhood Acute Lymphoblastic Leukemia (ALL) Xenografts That Express TNF alpha and Synergizes with TNF alpha in Vitro - A Report From the Pediatric Preclinical Testing Program (PPTP)', in BLOOD, AMER SOC HEMATOLOGY, GA, Atlanta, presented at 54th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), GA, Atlanta, 08 December 2012 - 11 December 2012, http://dx.doi.org/10.1182/blood.V120.21.3565.3565

Busfield SJ; Biondo M; Wong M; Ramshaw HS; Lee EM; Martin K; Ghosh S; Braley H; Tomasetig V; Panousis C; Vairo G; Roberts AW; He SZ; Sprigg N; Thomas D; DeWitte M; Lock RB; Lopez AF; Nash A, 2012, 'CSL362: A Monoclonal Antibody to Human Interleukin-3 Receptor (CD123), Optimized for NK Cell-Mediated Cytotoxicity of AML Stem Cells', in BLOOD, AMER SOC HEMATOLOGY, GA, Atlanta, presented at 54th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), GA, Atlanta, 08 December 2012 - 11 December 2012, http://dx.doi.org/10.1182/blood.V120.21.3598.3598

Suryani S; Sia KCS; Bracken L; Carol H; Evans K; Kurmasheva R; Houghton PJ; Smith MA; Lock RB, 2012, 'Dual Inhibition of JAK/STAT and MAPK Pathways Results in Synergistic Cell Killing of JAK-Mutated Pediatric Acute Lymphoblastic Leukemia', in BLOOD, AMER SOC HEMATOLOGY, GA, Atlanta, presented at 54th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), GA, Atlanta, 08 December 2012 - 11 December 2012, http://dx.doi.org/10.1182/blood.V120.21.3562.3562

Smith M; Kang M; Lock R; Carol H; Gorlick R; Kolb A; Maris J; Keir S; Kurmasheva R; Houghton P, 2012, 'Pediatric Preclinical Testing Program (PPTP) Stage 1 Evaluation of Eribulin', in EUROPEAN JOURNAL OF CANCER, ELSEVIER SCI LTD, IRELAND, European Org Res & Treatment Canc (EORTC), Dublin, pp. 105 - 105, presented at 24th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, IRELAND, European Org Res & Treatment Canc (EORTC), Dublin, 06 November 2012 - 09 November 2012, http://dx.doi.org/10.1016/S0959-8049(12)72143-3

Carol H; Lock R; Maris J; Keir S; Gorlick R; Kolb A; Kang M; Reynolds P; Wu J; Kurmasheva R; Houghton P; Smith M, 2012, 'Pediatric Preclinical Testing Program (PPTP) evaluation of the JAK inhibitor AZD1480', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, http://dx.doi.org/10.1158/1538-7445.AM2012-LB-318

Smith M; Keir S; Maris J; Kolb A; Reynolds P; Kang M; Carol H; Lock R; Gorlick R; Kurmasheva R; Billups C; Houghton P, 2012, 'Pediatric Preclinical Testing Program (PPTP) evaluation of volasertib (BI 6727), a Polo-like kinase (PLK) inhibitor', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, http://dx.doi.org/10.1158/1538-7445.AM2012-LB-317

Lu H; Battula VL; Shi Y; Lock RB; Spong S; Andreeff M; Konopleva M, 2011, 'Role of Connective Tissue Growth Factor (CTGF) in Survival and Chemosensitivity of Acute Lymphoblastic Leukemia', in BLOOD, AMER SOC HEMATOLOGY, CA, San Diego, pp. 1113 - 1113, presented at 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis, CA, San Diego, 10 December 2011 - 13 December 2011, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000299597103459&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Smith MA; Kang MH; Reynolds CP; Lock RB; Carol H; Gorlick R; Kolb EA; Maris JM; Keir ST; Billups CA; Kurmasheva RT; Houghton PJ, 2011, 'Abstract C103: Pediatric Preclinical Testing Program (PPTP) Stage 1 evaluation of the p53-MDM2 antagonist RG7112: Early evidence for high activity against MLL-rearranged leukemias.', in Molecular Cancer Therapeutics, American Association for Cancer Research (AACR), pp. C103 - C103, http://dx.doi.org/10.1158/1535-7163.targ-11-c103

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