By Professor Richard Bryan Lock

Conference Papers

Houghton P; Kang M; Reynolds P; Gorlick R; Kolb A; Maris J; Keir S; Carol H; Lock R; Billups C; Kurmasheva R; Landesman Y; Shacham S; Kauffman M; Smith MA, 2013, 'Pediatric Preclinical Testing Program (PPTP) stage 1 evaluation of the XPO1/CRM1 inhibitor KPT-330', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, DC, Washington, presented at 104th Annual Meeting of the American-Association-for-Cancer-Research (AACR), DC, Washington, 06 April 2013 - 10 April 2013, http://dx.doi.org/10.1158/1538-7445.AM2013-LB-354

Lee EM; Yee D; Busfield SJ; Vairo G; Lock RB, 2012, 'A Neutralizing Antibody (CSL362) Against the Interleukin-3 Receptor alpha-Chain Augments the Efficacy of a Cytarabine/Daunorubicin Induction-Type Therapy in Preclinical Xenograft Models of Acute Myelogenous Leukemia', in BLOOD, AMER SOC HEMATOLOGY, GA, Atlanta, presented at 54th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), GA, Atlanta, 08 December 2012 - 11 December 2012, http://dx.doi.org/10.1182/blood.V120.21.3599.3599

Smith MA; Carol H; Evans K; Richmond J; Kang M; Reynolds CP; Chunduru S; Graham MA; Geier B; Kurmasheva R; Houghton PJ; Lock RB, 2012, 'Birinapant (TL32711), a Small Molecule Smac Mimetic, Induces Regressions in Childhood Acute Lymphoblastic Leukemia (ALL) Xenografts That Express TNFα and Synergizes with TNFα in Vitro – A Report From the Pediatric Preclinical Testing Program (PPTP)', in Blood, American Society of Hematology, GA, Atlanta, pp. 3565, presented at 54th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), GA, Atlanta, 08 December 2012 - 11 December 2012, http://dx.doi.org/10.1182/blood.v120.21.3565.3565

Busfield SJ; Biondo M; Wong M; Ramshaw HS; Lee EM; Martin K; Ghosh S; Braley H; Tomasetig V; Panousis C; Vairo G; Roberts AW; He SZ; Sprigg N; Thomas D; DeWitte M; Lock RB; Lopez AF; Nash A, 2012, 'CSL362: A Monoclonal Antibody to Human Interleukin-3 Receptor (CD123), Optimized for NK Cell-Mediated Cytotoxicity of AML Stem Cells', in BLOOD, AMER SOC HEMATOLOGY, GA, Atlanta, presented at 54th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), GA, Atlanta, 08 December 2012 - 11 December 2012, http://dx.doi.org/10.1182/blood.V120.21.3598.3598

Suryani S; Sia KCS; Bracken L; Carol H; Evans K; Kurmasheva R; Houghton PJ; Smith MA; Lock RB, 2012, 'Dual Inhibition of JAK/STAT and MAPK Pathways Results in Synergistic Cell Killing of JAK-Mutated Pediatric Acute Lymphoblastic Leukemia', in BLOOD, AMER SOC HEMATOLOGY, GA, Atlanta, presented at 54th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), GA, Atlanta, 08 December 2012 - 11 December 2012, http://dx.doi.org/10.1182/blood.V120.21.3562.3562

Smith M; Kang M; Lock R; Carol H; Gorlick R; Kolb A; Maris J; Keir S; Kurmasheva R; Houghton P, 2012, '345 Pediatric Preclinical Testing Program (PPTP) Stage 1 Evaluation of Eribulin', in European Journal of Cancer, Elsevier, IRELAND, European Org Res & Treatment Canc (EORTC), Dublin, pp. 105, presented at 24th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, IRELAND, European Org Res & Treatment Canc (EORTC), Dublin, 06 November 2012 - 09 November 2012, http://dx.doi.org/10.1016/s0959-8049(12)72143-3

Carol H; Lock R; Maris J; Keir S; Gorlick R; Kolb A; Kang M; Reynolds P; Wu J; Kurmasheva R; Houghton P; Smith M, 2012, 'Pediatric Preclinical Testing Program (PPTP) evaluation of the JAK inhibitor AZD1480', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, http://dx.doi.org/10.1158/1538-7445.AM2012-LB-318

Smith M; Keir S; Maris J; Kolb A; Reynolds P; Kang M; Carol H; Lock R; Gorlick R; Kurmasheva R; Billups C; Houghton P, 2012, 'Pediatric Preclinical Testing Program (PPTP) evaluation of volasertib (BI 6727), a Polo-like kinase (PLK) inhibitor', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, http://dx.doi.org/10.1158/1538-7445.AM2012-LB-317

Lu H; Battula VL; Shi Y; Lock RB; Spong S; Andreeff M; Konopleva M, 2011, 'Role of Connective Tissue Growth Factor (CTGF) in Survival and Chemosensitivity of Acute Lymphoblastic Leukemia', in BLOOD, AMER SOC HEMATOLOGY, CA, San Diego, pp. 1113 - 1113, presented at 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis, CA, San Diego, 10 December 2011 - 13 December 2011, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000299597103459&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Smith MA; Kang MH; Reynolds CP; Lock RB; Carol H; Gorlick R; Kolb EA; Maris JM; Keir ST; Billups CA; Kurmasheva RT; Houghton PJ, 2011, 'Abstract C103: Pediatric Preclinical Testing Program (PPTP) Stage 1 evaluation of the p53-MDM2 antagonist RG7112: Early evidence for high activity against MLL-rearranged leukemias.', in Molecular Cancer Therapeutics, American Association for Cancer Research (AACR), pp. C103 - C103, http://dx.doi.org/10.1158/1535-7163.targ-11-c103

Houghton PJ; Maris JM; Keir ST; Lock RB; Carol H; Gorlick R; Kolb EA; Kang MH; Reynolds CP; Kurmasheva RT; Whiteman KR; Smith MA, 2011, 'Abstract C105: Pediatric Preclinical Testing Program (PPTP) Stage 1 evaluation of the CD56-targeting antibody-drug conjugate lorvotuzumab mertansine.', in Molecular Cancer Therapeutics, American Association for Cancer Research (AACR), pp. C105 - C105, http://dx.doi.org/10.1158/1535-7163.targ-11-c105

Reynolds CP; Kang MH; Carol H; Lock RB; Gorlick R; Kolb EA; Alexander D; Kurmasheva RT; Keir ST; Maris JM; Wu J; Houghton PJ; Smith MA, 2011, 'Abstract C106: Pediatric Preclinical Testing Program (PPTP) Stage 1 evaluation of the PI3K inhibitor XL147 (SAR245408).', in Molecular Cancer Therapeutics, American Association for Cancer Research (AACR), pp. C106 - C106, http://dx.doi.org/10.1158/1535-7163.targ-11-c106

Lock RB; Carol H; Szymanska B; Boehm I; Evans K; Houghton PJ; Smith MA, 2011, 'Abstract C107: The anti-CD19 antibody-drug conjugate SAR3419 prevents hematolymphoid relapse post induction therapy in preclinical models of pediatric acute lymphoblastic leukemia.', in Molecular Cancer Therapeutics, American Association for Cancer Research (AACR), pp. C107 - C107, http://dx.doi.org/10.1158/1535-7163.targ-11-c107

Keir ST; Morton CL; Kolb EA; Gorlick R; Caroi H; Lock R; Kang MH; Reynolds CP; Maris JM; Wu J; Smith MA; Houghton PJ, 2011, 'Pediatric preclinical testing program (PPTP) evaluation of the DNA methylating agent temozolomide', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, http://dx.doi.org/10.1158/1538-7445.AM2011-5356

Carol H; Lock RB; Maris JM; Keir ST; Gorlick R; Kolb EA; Kang MH; Reynolds CP; Morton CL; Smith PG; Thomas M; McDonald A; Houghton PJ; Smith MA, 2011, 'Pediatric Preclinical Testing Program (PPTP) evaluation of the NEDD8-activating enzyme (NAE) inhibitor MLN4924', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, http://dx.doi.org/10.1158/1538-7445.AM2011-740

Lu H; Battula VL; Korchin B; Spong S; Canizales M; Lock RB; Andreeff M; Konopleva M, 2010, 'Targeting Connective Tissue Growth Factor (CTGF) In Acute Lymphoblastic Leukemia Pre-Clinical Models: Anti-CTGF Monoclonal Antibody Attenuates Tumor Growth In Mouse Models of ALL', in BLOOD, AMER SOC HEMATOLOGY, FL, Orlando, pp. 1335 - 1336, presented at 52nd Annual Meeting of the American-Society-of-Hematology (ASH), FL, Orlando, 04 December 2010 - 07 December 2010, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000289662203588&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Benito J; Shi Y; Szymanska B; Carol H; Bohem I; Lu H; Konoplev S; Fang W; Kornblau SM; Zweidler-McKay P; Wilson W; Campana D; Borthakur G; Bueso-Ramos CE; Kantarjian HM; Shpall EJ; Thomas DA; Jordan CT; Lock RB; Andreeff M; Konopleva M, 2010, 'Targeting the Leukemia-Associated Hypoxic Microenvironment with Hypoxia-Activated Prodrug PR-104', in BLOOD, AMER SOC HEMATOLOGY, FL, Orlando, pp. 379 - 380, presented at 52nd Annual Meeting of the American-Society-of-Hematology (ASH), FL, Orlando, 04 December 2010 - 07 December 2010, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000289662200869&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Bhadri VA; Cowley MJ; Kaplan W; Lock RB, 2010, 'The NOD/SCID Xenograft Model Provides Clinically-Relevant Insights Into Glucocorticoid-Induced Gene Expression In Childhood B-Cell Precursor Acute Lymphoblastic Leukemia (ALL).', in BLOOD, AMER SOC HEMATOLOGY, FL, Orlando, pp. 1033 - 1034, presented at 52nd Annual Meeting of the American-Society-of-Hematology (ASH), FL, Orlando, 04 December 2010 - 07 December 2010, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000289662202716&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Smith MA; Maris JM; Keir ST; Lock RB; Carol H; Kolb EA; Kang MH; Reynolds CP; Hickson I; Houghton PJ, 2010, 'Pediatric Preclinical Testing Program (PPTP) stage 1 evaluation of JNJ-26481585, a second generation histone deacetylase inhibitor', in EJC SUPPLEMENTS, PERGAMON-ELSEVIER SCIENCE LTD, GERMANY, Berlin, pp. 49 - 49, presented at 22nd EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, GERMANY, Berlin, 16 November 2010 - 19 November 2010, http://dx.doi.org/10.1016/S1359-6349(10)71840-1

Thomas D; Powell JA; Barry EF; Woodcock J; Ekert PG; Green BD; Lee EM; Lock RB; Nilsson SK; Haylock DN; Lopez AF; Guthridge MA, 2010, 'THE PROTEIN KINASE ACTIVITY OF PHOSPHOINOSITIDE 3-KINASE ALPHA PROMOTES AUTONOMOUS CELL SURVIVAL IN AML STEM/PROGENITOR CELLS', in EXPERIMENTAL HEMATOLOGY, ELSEVIER SCIENCE INC, AUSTRALIA, Melbourne, pp. S87 - S87, presented at 39th Annual Scientific Meeting of the ISEH - Society-for-Hematology-and-Stem-Cells, AUSTRALIA, Melbourne, 15 September 2010 - 18 September 2010, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000281168900175&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Lock R, 2010, 'XENOGRAFT MODELS OF PEDIATRIC ACUTE LYMPHOBLASTIC LEUKEMIA', in EXPERIMENTAL HEMATOLOGY, ELSEVIER SCIENCE INC, AUSTRALIA, Melbourne, pp. S111 - S112, presented at 39th Annual Scientific Meeting of the ISEH - Society-for-Hematology-and-Stem-Cells, AUSTRALIA, Melbourne, 15 September 2010 - 18 September 2010, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000281168900228&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Houghton PJ; Maris JM; Courtright J; Friedman HS; Kier ST; Lock RB; Carol H; Gorlick R; Kolb EA; Kang M; Reynolds CP; Morton CL; Smith MA, 2010, 'Abstract 5265: Pediatric preclinical testing program (PPTP) stage 1 evaluation of BMS-754807 IGF-1 receptor inhibitor', in Cancer Research, American Association for Cancer Research (AACR), pp. 5265 - 5265, http://dx.doi.org/10.1158/1538-7445.am10-5265

Smith MA; Maris JM; Courtright J; Friedman HS; Kier ST; Lock RB; Carol H; Gorlick R; Kolb EA; Kang M; Reynolds CP; Morton CL; Houghton PJ, 2010, 'Abstract 5266: Pediatric Preclinical Testing Program (PPTP) evaluation of the CDK inhibitor SCH 727965', in Cancer Research, American Association for Cancer Research (AACR), pp. 5266 - 5266, http://dx.doi.org/10.1158/1538-7445.am10-5266

Houghton PJ; Maris JM; Courtright J; Friedman HS; Keir ST; Lock RB; Carol H; Kolb EA; Gorlick R; Kang M; Reynolds CP; Morton CL; Smith MA, 2009, 'Abstract C57: Pediatric Preclinical Testing Program (PPTP) Stage 1 evaluation of AZD8055 an inhibitor of mTOR Kinase', in Molecular Cancer Therapeutics, American Association for Cancer Research (AACR), pp. C57 - C57, http://dx.doi.org/10.1158/1535-7163.targ-09-c57

Lock RB; Bachmann PS; Piazza RG; Davies C; James M; Wong NC; Bhadri VA; Mogavero A; Magistroni V; Gambacorti-Passerini C; Saffery R; Craig JM; Pimanda JE; Marshall GM, 2009, 'Epigenetic Silencing of the Pro-Apoptotic Bim Gene in Glucocorticoid Poor-Responsive Pediatric Acute Lymphoblastic Leukemia, and Its Reversal by Histone Deacetylase Inhibition', in BLOOD, AMER SOC HEMATOLOGY, LA, New Orleans, pp. 387 - 388, presented at 51st Annual Meeting of the American-Society-of-Hematology, LA, New Orleans, 05 December 2009 - 08 December 2009, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000272725801119&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Mayer L; Carol H; Morton CL; Harasym T; Smith MA; Lock RB, 2009, 'Evaluation of CPX-351 (cytarabine:daunorubicin) liposome injection efficacy in acute lymphoblastic leukemia (ALL) xenograft models', in MOLECULAR CANCER THERAPEUTICS, AMER ASSOC CANCER RESEARCH, http://dx.doi.org/10.1158/1535-7163.TARG-09-A135

Smith MA; Morton CL; Carol H; Gorlick RG; Kang MH; Keir ST; Kolb EA; Lock RB; Maris JM; Houghton PJ, 2009, 'Pediatric Preclinical Testing Program (PPTP) testing of the CENP-E inhibitor GSK923295A', in JOURNAL OF CLINICAL ONCOLOGY, AMER SOC CLINICAL ONCOLOGY, FL, Orlando, presented at 45th Annual Meeting of the American-Society-of-Clinical-Oncology, FL, Orlando, 29 May 2009 - 02 June 2009, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000276606606513&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Dilda P; Decollogne S; Weerakoon L; Allen J; Lock R; Hogg P, 2009, 'Eliminating the pro-drug properties of the tumor angiogenesis inhibitor, 4-(N-(S-glutathionylacetyl)amino)phenylarsinous acid (GSAO), results in markedly enhanced anti-tumor activity', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209702604245&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Nowak D; Akagi T; Papa R; Kawamata N; Thoennissen N; Okamoto R; Hofmann W; Kato M; Ogawa S; Lock R; Koeffler P, 2009, 'High density SNP array allelokaryotyping of human acute lymphoblastic leukemia (ALL) xenografts in immunodeficient mice reveals genomic changes upon in vivo induction of chemoresistance', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209701802253&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Morton C; Houghton P; Maris J; Courtright J; Kolb E; Gorlick R; Carol H; Lock R; Friedman H; Keir S; Kang M; Reynolds C; Smith M, 2009, 'Pediatric Preclinical Testing Program (PPTP) evaluation of PR-104', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209702803489&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Carol H; Lock R; Houghton P; Morton C; Maris J; Courtright J; Kolb E; Gorlick R; Friedman H; Keir S; Kang M; Reynolds C; Smith M, 2009, 'Pediatric preclinical testing program (PPTP) evaluation of the Akt inhibitor GSK690693', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209702803487&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Kolb E; Gorlick R; Houghton P; Morton C; Maris J; Courtright J; Carol H; Lock R; Friedman H; Keir S; Kang M; Reynolds C; Smith M, 2009, 'Pediatric Preclinical Testing Program (PPTP) evaluation of the multi-targeted kinase inhibitor Sorafenib', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209702803490&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Maris J; Courtright J; Houghton P; Morton C; Kolb E; Gorlick R; Carol H; Lock R; Friedman H; Keir S; Kang M; Reynolds C; Smith M, 2009, 'Pediatric Preclinical Testing Program (PPTP) evaluation of the novel polyamine analogue PG11047', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209702803488&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Houghton PJ; Morton CL; Maris JM; Keir ST; Lock RB; Carol H; Gorlick R; Kolb EA; Kang MH; Smith MA, 2008, 'Pediatric Preclinical Testing Program (PPTP) evaluation of rapamycin combined with cytotoxic drugs used frequently in treatment of childhood cancer', in EJC SUPPLEMENTS, PERGAMON-ELSEVIER SCIENCE LTD, SWITZERLAND, Geneva, pp. 60 - 60, presented at 20th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, SWITZERLAND, Geneva, 21 October 2008 - 24 October 2008, http://dx.doi.org/10.1016/S1359-6349(08)72122-0

Lock R; Carol H; Houghton P; Morton C; Phelps D; Tucker C; Payne-Turner D; Zuany-Amorim C; Smith M, 2008, 'Pediatric Preclinical Testing Program (PPTP) evaluation of the anti-CD19-DM4 conjugated antibody SAR3419', in EJC SUPPLEMENTS, PERGAMON-ELSEVIER SCIENCE LTD, SWITZERLAND, Geneva, pp. 61 - 61, presented at 20th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, SWITZERLAND, Geneva, 21 October 2008 - 24 October 2008, http://dx.doi.org/10.1016/S1359-6349(08)72124-4

Smith MA; Houghton PJ; Morton CL; Maris JM; Courtright J; Carol H; Lock RB; Yang Y; Manfredi MG, 2008, 'Pediatric Preclinical Testing Program (PPTP) stage 2 testing of the Aurora A kinase inhibitor MLN8237', in EJC SUPPLEMENTS, PERGAMON-ELSEVIER SCIENCE LTD, SWITZERLAND, Geneva, pp. 92 - 93, presented at 20th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, SWITZERLAND, Geneva, 21 October 2008 - 24 October 2008, http://dx.doi.org/10.1016/S1359-6349(08)72220-1

Lock RB; Jin L; Lee EM; Ramshaw H; Busfield S; Peoppl A; Wilkinson L; Guthridge M; Boyd AW; Gearing D; Vairo G; Lopez A; Dick J, 2007, 'CD123 (IL-3 receptor a chain) neutralization by a monoclonal antibody selectively eliminates human acute myeloid leukemic stem tells', in Broze G (ed.), Blood, American Society of Hematology, USA, pp. 161 - 161, presented at 49th Annual Meeting of the American-Society-of-Hematology, Atlanta, Georgia USA, 08 December 2007 - 11 December 2007

Liaw T; Burke P; Chen X; LaVallee T; Lock RB; Kavallaris M, 2007, 'ENMD-1198 in combination with vincristine shows synergistic activity in leukemia cells and prolonged mouse survival in human leukemia xenografts', in Broze G (ed.), Blood, American Society of Hematology, USA, pp. 859 - 859, presented at 49th Annual Meeting of the American-Society-of-Hematology, Atlanta, Georgia USA, 08 December 2007 - 11 December 2007

Lock RB; Jin L; Lee EM; Ramshaw HS; Busfield S; Peoppl AG; Wilkinson L; Guthridge MA; Boyd A; Gearing D; Vairo G; Lopez A; Dick JE, 2007, 'CD123 (IL-3 receptor a chain) neutralization by a monoclonal antibody selectively eliminates human acute myeloid leukemic stem tells', in BLOOD, AMER SOC HEMATOLOGY, GA, Atlanta, pp. 55A - 55A, presented at 49th Annual Meeting of the American-Society-of-Hematology, GA, Atlanta, 08 December 2007 - 11 December 2007, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000251100800162&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Liaw TTYE; Burke PPA; Chen X; LaVallee TTM; Lock R; Kavallaris M, 2007, 'ENMD-1198 in combination with vincristine shows synergistic activity in leukemia cells and prolonged mouse survival in human leukemia xenografts', in BLOOD, AMER SOC HEMATOLOGY, GA, Atlanta, pp. 263A - 263A, presented at 49th Annual Meeting of the American-Society-of-Hematology, GA, Atlanta, 08 December 2007 - 11 December 2007, http://dx.doi.org/10.1182/blood.V110.11.859.859

Smith MA; Maris JM; Keir ST; Lock RB; Carol H; Gorlick R; Kolb EA; Keshelava N; Reynolds CP; Morton C; Houghton PJ, 2007, 'Pediatric preclinical testing program (PPTP) efficacy and pharmacodynamic evaluation of the Hsp90 inhibitor 17-DMAG', in JOURNAL OF CLINICAL ONCOLOGY, AMER SOC CLINICAL ONCOLOGY, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000455043700627&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Hsu A; Kerr B; Lock R; Hart D; Rice A, 2007, 'Anti-leukaemic CTL control the kinetics of leukaemic growth in the NOD-SCID mouse model', in BONE MARROW TRANSPLANTATION, NATURE PUBLISHING GROUP, FRANCE, Lyon, pp. S31 - S32, presented at 33rd Annual Meeting of the European-Group-for-Blood-and-Marrow-Transplantation, FRANCE, Lyon, 25 March 2007 - 28 March 2007, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000245207400083&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Hsu AKW; Kerr BM; Lock RB; Hart DNJ; Rice AM, 2006, 'Anti-leukemic CTL generated by RNA loaded cord blood-derived dendritic cells control leukaemia in a NOD-SCID mouse model.', in BLOOD, AMER SOC HEMATOLOGY, FL, Orlando, pp. 1057A - 1057A, presented at 48th Annual Meeting of the American-Society-of-Hematology, FL, Orlando, 09 December 2006 - 12 December 2006, http://dx.doi.org/10.1182/blood.V108.11.3699.3699

Hsu AK; Kerr BM; Lock RB; Hart DN; Rice AM, 2006, 'RNA transfected cord blood-derived dendritic cells generate anti-leukemic cytotoxic T lymphocytes', in BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, CARDEN JENNINGS PUBL CO LTD, HI, Honolulu, pp. 65 - 65, presented at 32nd Annual Meeting of the American-Society-for-Blood-and-Marrow-Transplantation, HI, Honolulu, 16 February 2006 - 20 February 2006, http://dx.doi.org/10.1016/j.bbmt.2005.11.204

Hsu AKW; Kerr BM; Lock RB; Hart DNJ; Rice AM, 2005, 'Assembling the players for evaluation of anti-leukemic CTL activity in NOD-SCID mice.', in BLOOD, AMER SOC HEMATOLOGY, GA, Atlanta, pp. 226B - 226B, presented at 47th Annual Meeting of the American-Society-of-Hematology, GA, Atlanta, 10 December 2005 - 13 December 2005, http://dx.doi.org/10.1182/blood.V106.11.4586.4586

Lock RB; Davies C; Bardell J, 2005, 'Differential sensitivity of childhood acute lymphoblastic leukemia xenografts to vorinostat reflects p21WAF1/CIP1 functional status.', in CLINICAL CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, PA, Philadelphia, pp. 8986S - 8986S, presented at AACR/NCI/EORTC International Conference on Molecular Targets and Cancer Therapeutics, PA, Philadelphia, 14 November 2005 - 18 November 2005, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000234382700092&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Houghton PJ; Maris JM; Friedman HS; Keir ST; Lock RB; Gorlick R; Kolb EA; Reynolds CP; Morton C; Smith MA, 2005, 'Evaluation of bortezomib against childhood tumor models by the pediatric preclinical testing program (PPTP)', in CLINICAL CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, PA, Philadelphia, pp. 8987S - 8988S, presented at 17th EORTC/AACR/NCI International Conference on Molecular Targets and Cancer Therapeutics, PA, Philadelphia, 14 November 2005 - 18 November 2005, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000234382700098&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Lock RB; Bachmann P, 2003, 'Induction of the pro-apoptotic Bcl-2 family member, Bim, is critical for glucocorticoid-induced apoptosis of acute lymphoblastic leukemia cells.', in CLINICAL CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, MASSACHUSETTS, BOSTON, pp. 6211S - 6211S, presented at AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, MASSACHUSETTS, BOSTON, 17 November 2003 - 21 November 2003, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000187467300581&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Lock RB; Liem N, 2003, 'Specific down regulatlon of stathmin in childhood acute leukemiaxenografts selected for vincristine resistance in vivo', in Blood, American Society of Hematology, pp. 591A - 591A

Bendall LJ; Khan NI; Bonnet C; Lock RB; Nilsson S; Bradstock KF; Gottlieb DJ, 2002, 'CD44v6 expression results in increased aggressiveness of acute lymphoblastic leukemia in NOD/SCID mice.', in BLOOD, AMER SOC HEMATOLOGY, PENNSYLVANIA, PHILADELPHIA, pp. 757A - 757A, presented at 44th Annual Meeting of the American-Society-of-Hematology, PENNSYLVANIA, PHILADELPHIA, 06 December 2002 - 10 December 2002, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000179184702999&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

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