My main research question is to understand the molecular basis of drug resistance in paediatric acute leukaemia and devise and test new treatments to improve outcome. I have developed what is recognised on an international scale as the most clinically relevant experimental model to investigate paediatric acute lymphoblastic leukaemia (ALL). My research has also contributed to a greater understanding of mechanisms of glucocorticoid resistance in paediatric ALL. I am the only overseas Principal Investigator ever to be involved in the US NCI-funded Paediatric Preclinical Testing Consortium (PPTC) and have received continuous NCI funding for 21 years. My international leadership role in preclinical drug testing in acute leukaemias is evident from my research having initiated several clinical trials for the treatment of relapsed/refractory paediatric and adult acute leukaemia.