By Professor Richard John Epstein

Journal articles

Epstein RJ, 2005, 'Primary prevention of human papillomavirus-dependent neoplasia: No condom, no sex', European Journal of Cancer, 41, pp. 2595 - 2600, http://dx.doi.org/10.1016/j.ejca.2005.06.023

Epstein RJ, 2004, 'The CXCL12-CXCR4 chemotactic pathway as a target of adjuvant breast cancer therapies', Nature Reviews Cancer, 4, pp. 901 - 909, http://dx.doi.org/10.1038/nrc1473

Cheung YB; Wong LC; Tay MH; Toh CK; Koo WH; Epstein R; Goh C, 2004, 'Order effects in the assessment of quality of life in cancer patients', Quality of Life Research, 13, pp. 1217 - 1223, http://dx.doi.org/10.1023/B:QURE.0000037499.80080.07

Lim YP; Wong CY; Ooi LL; Druker BJ; Epstein RJ, 2004, 'Selective tyrosine hyperphosphorylation of cytoskeletal and stress proteins in primary human breast cancers: Implications for adjuvant use of kinase-inhibitory drugs', Clinical Cancer Research, 10, pp. 3980 - 3987, http://dx.doi.org/10.1158/1078-0432.CCR-03-0663

Epstein RJ, 2004, 'Learning from the problems of problem-based learning', BMC Medical Education, 4, pp. 1 - 7, http://dx.doi.org/10.1186/1472-6920-4-1

Epstein RJ, 2004, 'Journal impact factors do not equitably reflect academic staff performance in different medical subspecialties', Journal of Investigative Medicine, 52, pp. 531 - 536, http://dx.doi.org/10.1136/jim-52-08-25

Epstein RJ, 2004, 'Journal Impact Factors Do Not Equitably Reflect Academic Staff Performance in Different Medical Subspecialties', Journal of Investigative Medicine, 52, pp. 531 - 536, http://dx.doi.org/10.1177/108155890405200825

Lim YP; Diong LS; Qi R; Druker BJ; Epstein RJ, 2003, 'Phosphoproteomic fingerprinting of epidermal growth factor signaling and anticancer drug action in human tumor cells', Molecular Cancer Therapeutics, 2, pp. 1369 - 1377

Lin K; Tan SB; Kolatkar PR; Epstein RJ, 2003, 'Nonrandom Intragenic Variations in Patterns of Codon Bias Implicate a Sequential Interplay between Transitional Genetic Drift and Functional Amino Acid Selection', Journal of Molecular Evolution, 57, pp. 538 - 545, http://dx.doi.org/10.1007/s00239-003-2507-5

Zammit C; Yelland A; Deutsch G; Cunnick GH; Mokbel K; Yau T; Epstein RJ; Baroni G; Pedotti A; Orecchia R; George WD; Houghton J; Ellis I; Fentiman IS; Spittle M; Tjalma WAA, 2003, 'Radiotherapy and tamoxifen in women with completely excised ductal carcinoma in situ [1] (multiple letters)', Lancet, 362, pp. 1154 - 1157, http://dx.doi.org/10.1016/S0140-6736(03)14474-1

Epstein RJ, 2003, 'Hormonal contraception and cervical cancer [13]', Lancet, 361, pp. 1915, http://dx.doi.org/10.1016/S0140-6736(03)13531-3

Epstein RJ; Manasciewicz R, 2003, 'Breast self examination [3] (multiple letters)', British Medical Journal, 326, pp. 710 - 711

Cheung YB; Khoo KS; Wong ZW; See HT; Toh HC; Epstein RJ; Ng GY; Tan SB, 2003, 'Quick-FLIC: A short questionnaire for assessing quality of life of cancer patients', Acta Oncologica, 42, pp. 36 - 42, http://dx.doi.org/10.1080/0891060310002212

Epstein RJ, 2003, 'Breast self examination. Breast self examination provides entry strategy.', BMJ (Clinical research ed.), 326, pp. 710

Huang GC; Hobbs S; Walton M; Epstein RJ, 2002, 'Dominant negative knockout of p53 abolishes ErbB2-dependent apoptosis and permits growth acceleration in human breast cancer cells', British Journal of Cancer, 86, pp. 1104 - 1109, http://dx.doi.org/10.1038/sj.bjc.6600219

Chen D; Washbrook E; Sarwar N; Bates GJ; Pace PE; Thirunuvakkarasu V; Taylor J; Epstein RJ; Fuller-Pace FV; Egly JM; Coombes RC; Ali S, 2002, 'Phosphorylation of human estrogen receptor α at serine 118 by two distinct signal transduction pathways revealed by phosphorylation-specific antisera', Oncogene, 21, pp. 4921 - 4931, http://dx.doi.org/10.1038/sj.onc.1205420

Ouyang X; Gulliford T; Zhang H; Smith G; Huang G; Epstein RJ, 2001, 'Association of ErbB2 Ser¹¹¹³ phosphorylation with epidermal growth factor receptor co-expression and poor prognosis in human breast cancer', Molecular and Cellular Biochemistry, 218, pp. 47 - 54, http://dx.doi.org/10.1023/A:1007249004222

Ouyang X; Gulliford T; Huang GC; Harper-Wynne C; Shousha S; Epstein RJ, 2001, 'Multisite phosphotyping of the ErbB-2 oncoprotein in human breast cancer', Molecular Diagnosis, 6, pp. 17 - 25, http://dx.doi.org/10.2165/00066982-200106010-00003

Smith GL; Doherty AP; Banks LM; Dutton J; Hanham IW; Christmas TJ; Epstein RJ, 2000, 'Dual X-ray absorptiometry detects disease- and treatment-related alterations of bone density in prostate cancer patients', Clinical and Experimental Metastasis, 18, pp. 385 - 390, http://dx.doi.org/10.1023/A:1010991213842

Jefferson K; Dwivedi A; Persad R; Holly J; Smith GL; Epstein RJ, 2000, 'Regulatory mechanisms in prostate cancer (multiple letters)', Lancet, 355, pp. 1100 - 1101, http://dx.doi.org/10.1016/S0140-6736(05)72223-6

Epstein RJ; Lin K; Tan TW, 2000, 'A functional significance for codon third bases', Gene, 245, pp. 291 - 298, http://dx.doi.org/10.1016/S0378-1119(00)00042-1

Smith GL; Doherty AP; Mitchell H; Hanham IW; Christmas TJ; Epstein RJ, 1999, 'Inverse relation between prostate-specific antigen and insulin-like growth factor-binding protein 3 in bone metastases and serum of patients with prostate cancer', Lancet, 354, pp. 2053 - 2054, http://dx.doi.org/10.1016/S0140-6736(99)04805-9

Doherty A; Smith G; Banks L; Christmas T; Epstein RJ, 1999, 'Correlation of the osteoblastic phenotype with prostate-specific antigen expression in metastatic prostate cancer: Implications for paracrine growth', Journal of Pathology, 188, pp. 278 - 281, http://dx.doi.org/10.1002/(SICI)1096-9896(199907)188:3<278::AID-PATH358>3.0.CO;2-G

Huang G; Chantry A; Epstein RJ, 1999, 'Overexpression of ErbB2 impairs ligand-dependent downregulation of epidermal growth factor receptors via a post-transcriptional mechanism', Journal of Cellular Biochemistry, 74, pp. 23 - 30, http://dx.doi.org/10.1002/(SICI)1097-4644(19990701)74:1<23::AID-JCB3>3.0.CO;2-L

Ouyang X; Gulliford T; Doherty A; Cai Huang G; Epstein RJ, 1999, 'Detection of ErbB2 oversignalling in a majority of breast cancers with phosphorylation-state-specific antibodies', Lancet, 353, pp. 1591 - 1592, http://dx.doi.org/10.1016/S0140-6736(99)01095-8

Gulliford T; Ouyang X; Epstein RJ, 1999, 'Intensification of growth factor receptor signalling by phorbol treatment of ligand-primed cells implies a dimer-stabilizing effect of protein kinase C-dependent juxtamembrane domain phosphorylation', Cellular Signalling, 11, pp. 245 - 252, http://dx.doi.org/10.1016/S0898-6568(98)00058-8

Epstein RJ, 1999, 'Review: Adjuvant tamoxifen reduces recurrence and improves survival in early breast cancer', Evidence-Based Medicine, 4, pp. 41

Ouyang X; Gulliford T; Huang G; Epstein RJ, 1999, 'Transforming growth factor-alpha short-circuits downregulation of the epidermal growth factor receptor', Journal of Cellular Physiology, 179, pp. 52 - 57, http://dx.doi.org/10.1002/(SICI)1097-4652(199904)179:1<52::AID-JCP7>3.0.CO;2-M

Smith GL; Doherty AP; Christmas TJ; Hanham IW; Mitchell H; Epstein RJ, 1999, 'TISSUE EXPRESSION OF IGFBP-3 AND THE EFFECT OF TREATMENT ON SERUM IGFBP-3 IN METASTATIC PROSTATE CANCER', The Journal of Urology, pp. 59 - 59, http://dx.doi.org/10.1097/00005392-199904010-00237

Ouyang X; Huang GC; Chantry A; Epstein RJ, 1998, 'Adjacent carboxyterminal tyrosine phosphorylation events identify functionally distinct ErbB2 receptor subsets: Implications for molecular diagnostics', Experimental Cell Research, 241, pp. 467 - 475, http://dx.doi.org/10.1006/excr.1998.4091

Huang GC; Ouyang X; Epstein RJ, 1998, 'Proxy activation of protein ErbB2 by heterologous ligands implies a heterotetrameric mode of receptor tyrosine kinase interaction', Biochemical Journal, 331, pp. 113 - 119, http://dx.doi.org/10.1042/bj3310113

Epstein RJ, 1998, 'Bad genes, bad diseases, and bad luck', QJM: An International Journal of Medicine, 91, pp. 861 - 864, http://dx.doi.org/10.1093/qjmed/91.12.861

Ouyang X; Gulliford T; Epstein RJ, 1998, 'The duration of phorbol-inducible ErbB2 tyrosine dephosphorylation parallels that of receptor endocytosis rather than threonine-686 phosphorylation: Implications for the physiological role of protein kinase C in growth factor receptor signalling', Carcinogenesis, 19, pp. 2013 - 2019, http://dx.doi.org/10.1093/carcin/19.11.2013

Ouyang X; Gulliford T; Shousha S; Epstein RJ, 1998, 'Multisite phosphotyping of the ErbB2 oncoprotein in 102 human breast cancers', European Journal of Cancer, 34, pp. S116 - S116, http://dx.doi.org/10.1016/s0959-8049(98)80487-5

Doherty AP; Smith GL; Christmas TJ; Epstein RJ, 1997, 'The osteoblastic phenotype of metastatic prostate cancer correlates with intralesional proteolysis of IGF binding protein-3 by PSA', British Journal of Urology, 79, pp. 25

Gulliford T; Opomu M; Wilson E; Hanham I; Epstein R, 1997, 'Popularity of less frequent follow up for breast cancer in randomised study: Initial findings from the hotline study', British Medical Journal, 314, pp. 174 - 177, http://dx.doi.org/10.1136/bmj.314.7075.174

Epstein R; Hanham I; Dale R, 1997, 'Radiotherapy-induced second cancers: Are we doing enough to protect young patients?', European Journal of Cancer Part A, 33, pp. 526 - 530, http://dx.doi.org/10.1016/S0959-8049(97)00056-7

Gulliford TJ; Huang GC; Ouyang X; Epstein RJ, 1997, 'Reduced ability of transforming growth factor-alpha to induce EGF receptor heterodimerization and downregulation suggests a mechanism of oncogenic synergy with ErbB2', Oncogene, 15, pp. 2219 - 2223, http://dx.doi.org/10.1038/sj.onc.1201595

Ouyang X; Gulliford T; Doherty A; Huang G; Epstein R, 1997, 'Phosphotyping of c-ErbB-2 in human breast tumours', European Journal of Cancer, 33, pp. S8 - S8, http://dx.doi.org/10.1016/s0959-8049(97)84403-6

Epstein R, 1996, 'Treating breast cancer before surgery - Cure rates could be improved by better matching of drugs to disease', British Medical Journal, 313, pp. 1345 - 1346

Epstein RJ; Kelly SA; Cook M; Bateman A; Paddick I; Kam KC; Dunn P; Hanham IW; Dale RG; Price PM, 1996, 'Active minimisation of radiation scatter during breast radiotherapy: Management implications for young patients with good-prognosis primary neoplasms', Radiotherapy and Oncology, 40, pp. 69 - 74, http://dx.doi.org/10.1016/0167-8140(96)01760-4

Gulliford T; Epstein RJ, 1996, 'Endocrine treatment of cancer', Journal of the Royal Society of Medicine, 89, pp. 448 - 453, http://dx.doi.org/10.1177/014107689608900808

Ouyang X; Gulliford T; Zhang H; Huang GC; Epstein R, 1996, 'Human cancer cells exhibit protein kinase C-dependent c-erbB-2 transmodulation that correlates with phosphatase sensitivity and kinase activity', Journal of Biological Chemistry, 271, pp. 21786 - 21792, http://dx.doi.org/10.1074/jbc.271.36.21786

Fentiman IS; Epstein R; Barr L, 1996, 'Is routine axillary nodal dissection necessary in the treatment of breast cancer?', European Journal of Cancer Part A, 32, pp. 1460 - 1461, http://dx.doi.org/10.1016/0959-8049(95)00656-7

Epstein R, 1996, 'Is routine axillary nodal dissection necessary in the treatment of breast cancer?', European Journal of Cancer, 32, pp. 1461 - 1463, http://dx.doi.org/10.1016/s0959-8049(96)90056-8

Epstein RJ, 1995, 'Preferential detection of catalytically inactive c-erbB-2 by antibodies to unphosphorylated peptides mimicking receptor tyrosine autophosphorylation sites', Oncogene, 11, pp. 314 - 323

Epstein R, 1995, 'Calcium-inducible transmodulation of receptor tyrosine kinase activity', Cellular Signalling, 7, pp. 377 - 388, http://dx.doi.org/10.1016/0898-6568(95)00006-B

Epstein RJ, 1995, 'Routine or delayed axillary dissection for primary breast cancer?', European Journal of Cancer, 31, pp. 1570 - 1573, http://dx.doi.org/10.1016/0959-8049(95)00319-E

Epstein RJ, 1993, 'Six authors in search of a citation: Villains or victims of the Vancouver convention?', British Medical Journal, 306, pp. 765 - 767

Epstein R, 1992, 'Analysis of natural history of breast cancer in young women', The Lancet, 340, pp. 1287, http://dx.doi.org/10.1016/0140-6736(92)92985-O

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