By Professor Susan Clark

Journal articles

Wen VW; Wu K; Baksh S; Hinselwood RA; Lock RB; Clark SJ; Moore MA; Mackenzie K, 2006, 'Telomere-driven karyotypic complexity concurs with p16INK4a inactivation in TP53 competent immortal endothelial cells', Cancer research, 66, pp. 10691 - 10700

Rand KN; Ho T; Qu W; Mitchell SM; White R; Clark SJ; Molloy PL, 2005, 'Headloop suppression PCR and its application to selective amplification of methylated DNA sequences.', Nucleic acids research, 33

Rand KN; Ho T; Qu W; Mitchell SM; White R; Clark SJ; Molloy PL, 2005, 'Headloop suppression PCR and its application to selective amplification of methylated DNA sequences', Nucleic Acids Research, 33, pp. 1 - 11, http://dx.doi.org/10.1093/nar/gni120

Frigola J; Munoz MA; Clark SJ; Moreno V; Capella G; Peinado M, 2005, 'Hypermethylation of the prostacyclin synthase (PTGIS) promoter is a frequent event in colorectal cancer and associated with aneuploidy', Oncogene, 24, pp. 7320 - 7326

Sidhu S; Martin E; Gicquel C; Melki J; Clark SJ; Campbell P; Magarey CJ; Schulte KM; Roher HD; Delbridge L; Robinson BG, 2005, 'Mutation and methylation analysis of TP53 in adrenal carcinogenesis', Eur J Surg Oncol, 31, pp. 549 - 554, http://dx.doi.org/10.1016/j.ejso.2005.01.013

Broad A; Links MR; Rosenthal M; Abraham R; Clark SJ; Burns I; Dilulio J; Mitchell P, 2005, 'Oxaliplatin and gemcitabine in advanced NSCLC: A multicentre phase 2 Australian study', Lung Cancer, 49, pp. S239 - S239

Wong NC-L; Wong LH; Quach JM; Canham P; Craig JM; Song JZ; Clark SJ; Choo A, 2005, 'Permissive transcriptional activity at the centromere through pockets of DNA hypomethylation', PLoS Genetics, preprint, pp. e17 - e17, http://dx.doi.org/10.1371/journal.pgen.0020017.eor

Noble JR; Zhong ZH; Neumann AA; Melki JR; Clark SJ; Reddel RR, 2004, 'Alterations in the p16(INK4a) and p53 tumor suppressor genes of hTERT-immortalized human fibroblasts', Oncogene, 23, pp. 3116 - 3121, http://dx.doi.org/10.1038/sj.onc.1207440

Stirzaker C; Song J; Davidson B; Clark SJ, 2004, 'Transcriptional Gene Silencing Promotes DNA Hypermethylation through a sequential Change in Chromatin Modifications in Cancer Cells', Cancer research, 64, pp. 3871 - 3877

Clark SJ; Millar DS; Molloy P, 2003, 'Bisulfite methylation analysis of tumor suppressor genes in prostate cancer from fresh and archival tissue samples', Methods Mol Med, 81, pp. 219 - 240, http://dx.doi.org/10.1385/1-59259-372-0:219

Schmitt JF; Millar DS; Pedersen JS; Clark SL; Venter DJ; Frydenberg M; Molloy PL; Risbridger GP, 2002, 'Hypermethylation of the inhibin α-subunit gene in prostate carcinoma', Molecular Endocrinology, 16, pp. 213 - 220, http://dx.doi.org/10.1210/me.16.2.213

Rand K; Qu W; Ho T; Clark SJ; Molloy P, 2002, 'Conversion-specific detection of DNA methylation using real-time polymerase chain reaction (ConLight-MSP) to avoid false positives', Methods, 27, pp. 114 - 120, http://www.ncbi.nlm.nih.gov/pubmed/12095268

Clark SJ; Warnecke PM, 2002, 'DNA methylation analysis in mammalian cells', Methods, 27, pp. 99 - 100, http://www.ncbi.nlm.nih.gov/pubmed/12095265

Clark SJ; Melki J, 2002, 'DNA methylation and gene silencing in cancer: which is the guilty party?', Oncogene, 21, pp. 5380 - 5387, http://dx.doi.org/10.1038/sj.onc.1205598

Melki JR; Clark SJ, 2002, 'DNA methylation changes in leukaemia', Semin Cancer Biol, 12, pp. 347 - 357, http://www.ncbi.nlm.nih.gov/pubmed/12191634

Schmitt JF; Millar DS; Pedersen JS; Clark SL; Venter DJ; Frydenberg M; Molloy PL; Risbridger GP, 2002, 'Hypermethylation of the inhibin alpha-subunit gene in prostate carcinoma', Mol Endocrinol, 16, pp. 213 - 220, http://dx.doi.org/10.1210/mend.16.2.0771

Song JZ; Stirzaker C; Harrison J; Melki JR; Clark SJ, 2002, 'Hypermethylation trigger of the glutathione-S-transferase gene (GSTP1) in prostate cancer cells', Oncogene, 21, pp. 1048 - 1061, http://dx.doi.org/10.1038/sj.onc.1205153

Warnecke PM; Stirzaker C; Song J; Grunau C; Melki JR; Clark SJ, 2002, 'Identification and resolution of artifacts in bisulfite sequencing', Methods, 27, pp. 101 - 107, http://www.ncbi.nlm.nih.gov/pubmed/12095266

Millar DS; Warnecke PM; Melki JR; Clark SJ, 2002, 'Methylation sequencing from limiting DNA: embryonic, fixed, and microdissected cells', Methods, 27, pp. 108 - 113, http://www.ncbi.nlm.nih.gov/pubmed/12095267

Grunau C; Renault E; Rosenthal A; Roizes G, 2001, 'MethDB - a public database for DNA methylation data', NUCLEIC ACIDS RESEARCH, 29, pp. 270 - 274, http://dx.doi.org/10.1093/nar/29.1.270

Grunau C; Clark SJ; Rosenthal A, 2001, 'Bisulfite genomic sequencing: systematic investigation of critical experimental parameters', Nucleic Acids Res, 29, pp. E65 - E65, http://www.ncbi.nlm.nih.gov/pubmed/11433041

Welch J; Millar D; Goldman A; Heenan P; Stark M; Eldon M; Clark S; Martin NG; Hayward NK, 2001, 'Lack of genetic and epigenetic changes in CDKN2A in melanocytic nevi', J Invest Dermatol, 117, pp. 383 - 384, http://dx.doi.org/10.1046/j.0022-202x.2001.01391.x

Chetcuti A; Margan SH; Russell P; Mann S; Millar DS; Clark SJ; Rogers J; Handelsman DJ; Dong Q, 2001, 'Loss of annexin II heavy and light chains in prostate cancer and its precursors', Cancer Res, 61, pp. 6331 - 6334, http://www.ncbi.nlm.nih.gov/pubmed/11522620

Jackson P; Millar D; Kingsley E; Yardley G; Ow K; Clark S; Russell PJ, 2000, 'Methylation of a CpG island within the promoter region of the KAI1 metastasis suppressor gene is not responsible for down-regulation of KAI1 expression in invasive cancers or cancer cell lines', Cancer Letters, 157, pp. 169 - 176, http://dx.doi.org/10.1016/S0304-3835(00)00483-3

Millar DS; Paul CL; Molloy PL; Clark SJ, 2000, 'A distinct sequence (ATAAA)n separates methylated and unmethylated domains at the 5'-end of the GSTP1 CpG island', J Biol Chem, 275, pp. 24893 - 24899, http://dx.doi.org/10.1074/jbc.M906538199

Melki JR; Vincent PC; Brown RD; Clark SJ, 2000, 'Hypermethylation of E-cadherin in leukemia', Blood, 95, pp. 3208 - 3213, http://www.ncbi.nlm.nih.gov/pubmed/10807790

Jackson P; Mills DR; Kingsley EA; Yardley G; Ow KT; Clark SJ; Russell PJ, 2000, 'Methylation of a CpG island within the KAI1 promoter region is not responsible for reduced KAI1 expression in invasive bladder cancer or bladder cancer cell lines', Cancer Letters, 157, pp. 169 - 175

Veitch C; Harte J; Hays R; Pashen D; Clark S, 1999, 'Community participation in the recruitment and retention of rural doctors: methodological and logistical considerations.', The Australian journal of rural health, 7, pp. 206 - 211, http://dx.doi.org/10.1046/j.1440-1584.1999.00213.x

Melki JR; Vincent PC; Clark SJ, 1999, 'Cancer-specific region of hypermethylation identified within the HIC1 putative tumour suppressor gene in acute myeloid leukaemia', Leukemia, 13, pp. 877 - 883, http://www.ncbi.nlm.nih.gov/pubmed/10360376

Melki JR; Vincent PC; Clark SJ, 1999, 'Concurrent DNA hypermethylation of multiple genes in acute myeloid leukemia', Cancer Res, 59, pp. 3730 - 3740, http://www.ncbi.nlm.nih.gov/pubmed/10446989

Millar DS; Ow KT; Paul CL; Russell PJ; Molloy PL; Clark SJ, 1999, 'Detailed methylation analysis of the glutathione S-transferase pi (GSTP1) gene in prostate cancer', Oncogene, 18, pp. 1313 - 1324

Warnecke PM; Clark SJ, 1999, 'DNA methylation profile of the mouse skeletal alpha-actin promoter during development and differentiation', Mol Cell Biol, 19, pp. 164 - 172, http://www.ncbi.nlm.nih.gov/pubmed/9858541

Molloy PL; Millar DS; Russell PJ; Clark SJ, 1999, 'Prostate Cancer DNA Methylation assay', Today's Life Science, 11, pp. 34 - 35

Warnecke PM; Mann JR; Frommer M; Clark SJ, 1998, 'Bisulfite sequencing in preimplantation embryos: DNA methylation profile of the upstream region of the mouse imprinted H19 gene', Genomics, 51, pp. 182 - 190, http://dx.doi.org/10.1006/geno.1998.5371

Harrison J; Stirzaker C; Clark SJ, 1998, 'Cytosines adjacent to methylated CpG sites can be partially resistant to conversion in genomic bisulfite sequencing leading to methylation artifacts', Anal Biochem, 264, pp. 129 - 132, http://dx.doi.org/10.1006/abio.1998.2833

Melki JR; Warnecke P; Vincent PC; Clark SJ, 1998, 'Increased DNA methyltransferase expression in leukaemia', Leukemia, 12, pp. 311 - 316, http://www.ncbi.nlm.nih.gov/pubmed/9529124

Huschtscha LI; Noble JR; Neumann AA; Moy EL; Barry P; Melki JR; Clark SJ; Reddel RR, 1998, 'Loss of p16INK4 expression by methylation is associated with lifespan extension of human mammary epithelial cells', Cancer Res, 58, pp. 3508 - 3512, http://www.ncbi.nlm.nih.gov/pubmed/9721850

Warnecke PM; Biniszkiewicz D; Jaenisch R; Frommer M; Clark SJ, 1998, 'Sequence-specific methylation of the mouse H19 gene in embryonic cells deficient in the Dnmt-1 gene', Dev Genet, 22, pp. 111 - 121, http://dx.doi.org/10.1002/(SICI)1520-6408(1998)22:2<111::AID-DVG1>3.0.CO;2-9

Melki JR; Vincent PC; Clark SJ, 1997, 'DNA methylation in leukemia', Experimental Hematology, 25, pp. 855

Stirzaker C; Millar DS; Paul CL; Warnecke PM; Harrison J; Vincent PC; Frommer M; Clark SJ, 1997, 'Extensive DNA methylation spanning the Rb promoter in retinoblastoma tumors', Cancer Research, 57, pp. 2229 - 2237

Warnecke PM; Stirzaker C; Melki JR; Millar DS; Paul CL; Clark SJ, 1997, 'Detection and measurement of PCR bias in quantitative methylation analysis of bisulphite-treated DNA', Nucleic Acids Res, 25, pp. 4422 - 4426, http://www.ncbi.nlm.nih.gov/pubmed/9336479

Clark SJ; Harrison J; Molloy PL, 1997, 'Sp1 binding is inhibited by (m)Cp(m)CpG methylation', Gene, 195, pp. 67 - 71, http://www.ncbi.nlm.nih.gov/pubmed/9300822

Paul CL; Clark SJ, 1996, 'Cytosine methylation: quantitation by automated genomic sequencing and GENESCAN analysis', Biotechniques, 21, pp. 126 - 133, http://www.ncbi.nlm.nih.gov/pubmed/8816247

Clark SJ; Harrison J; Frommer M, 1995, 'CpNpG methylation in mammalian cells', Nat Genet, 10, pp. 20 - 27, http://dx.doi.org/10.1038/ng0595-20

Harrison J; Molloy PL; Clark SJ, 1994, 'Direct cloning of polymerase chain reaction products in an XcmI T-vector', Anal Biochem, 216, pp. 235 - 236, http://www.ncbi.nlm.nih.gov/pubmed/8135360

Clark SJ; Harrison J; Paul CL; Frommer M, 1994, 'High sensitivity mapping of methylated cytosines', Nucleic Acids Res, 22, pp. 2990 - 2997, http://www.ncbi.nlm.nih.gov/pubmed/8065911

Grigg G; Clark S, 1994, 'Sequencing 5-methylcytosine residues in genomic DNA', Bioessays, 16, pp. 431 - 436, http://dx.doi.org/10.1002/bies.950160612

Greenwood PE; Clark SJ; Cahill AD; Trevallyn-Jones J; Tzipori S, 1988, 'Development and protective efficacy of a recombinant-DNA derived fimbrial vaccine against enterotoxic colibacillosis in neonatal piglets', Vaccine, 6, pp. 389 - 392, http://www.ncbi.nlm.nih.gov/pubmed/3057758

Rickles R; Marashi F; Sierra F; Clark S; Wells J; Stein J; Stein G, 1982, 'Analysis of histone gene expression during the cell cycle in HeLa cells by using cloned human histone genes', Proceedings of the National Academy of Sciences of the United States of America, 79, pp. 749 - 753, http://dx.doi.org/10.1073/pnas.79.3.749

Rickles R; Marashi F; Sierra F; Clark S; Wells J; Stein J; Stein G, 1982, 'Analysis of histone gene expression during the cell cycle in HeLa cells by using cloned human histone genes', Proc Natl Acad Sci U S A, 79, pp. 749 - 753, http://www.ncbi.nlm.nih.gov/pubmed/6461006

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