By Scientia Professor Matthew Colm Kiernan

Journal articles

Kim SH; Noh MY; Kiernan MC, 2026, 'Neurodegeneration as an evolutionary trade-off: a biological constraint–aware therapeutic perspective', Molecular Neurodegeneration, 21, http://dx.doi.org/10.1186/s13024-026-00958-w

Vucic S; Cheah BC; Krishnan AV; Burke D; Kiernan MC, 2026, 'Corrigendum to “The effects of alterations in conditioning stimulus intensity on short interval intracortical inhibition” [Brain Res. 1273 (2009) 39–47]', Brain Research, 1889, http://dx.doi.org/10.1016/j.brainres.2026.150475

Pavey N; Tu S; Foster S; Geevasinga N; Calma A; Tsuji Y; Kiernan MC; Vucic S; Menon P, 2026, 'Cortical changes in amyotrophic lateral sclerosis: comparing biomarkers of glymphatic flow and cortical excitability', Clinical Neurophysiology, 190, http://dx.doi.org/10.1016/j.clinph.2026.2111949

Shrestha N; Munn Z; Calma A; Pavey N; Tsuji Y; Menon P; Padovani A; Risi B; Ferullo L; Filosto M; Jewett G; Shibuya K; Otani R; Shimizu T; Kuwabara S; Noto YI; Kitaoji T; Johnsen B; Shen D; Cui L; van den Berg LH; van Eijk RPA; van Damme P; Kiernan MC; Giles L; Vucic S, 2026, 'Gold Coast criteria for ALS diagnosis: individual participant data meta-analysis', Journal of Neurology, 273, http://dx.doi.org/10.1007/s00415-026-14046-y

Hannaford AM; Supnet IE; Pavey N; Menon P; van den Bos MAJ; Kiernan MC; van Alfen N; Simon NG; Vucic S, 2026, 'Muscle Ultrasound Is a Sensitive Outcome Measure in ALS', Muscle and Nerve, 74, pp. 590 - 599, http://dx.doi.org/10.1002/mus.70317

Isik FI; Pickford R; Timmins HC; Piguet O; Halliday GM; Kiernan MC; Kim WS, 2026, 'Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum', FEBS Open Bio, 16, pp. 1550 - 1562, http://dx.doi.org/10.1002/2211-5463.70232

D'Silva A; Herbert K; Balaji L; He JM; Kandula T; Sampaio HA; Teoh HL; Tantsis E; Sohn J; Briggs N; Ning N; Kiernan MC; Kariyawasam DS; Farrar MA, 2026, 'The Dynamics of Neurofilament Light Chain in Spinal Muscular Atrophy', Annals of Neurology, 100, pp. 109 - 122, http://dx.doi.org/10.1002/ana.78207

Swart G; Garg N; Yiannikas C; Vucic OS; Pollard J; Carroll A; Silsby M; Kiernan M; Spies J; Park S, 2026, 'Measuring Disease Activity During Maintenance Therapy in Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP) (P7-9.003)', Neurology, 106, http://dx.doi.org/10.1212/wnl.0000000000217482

Swart G; Garg N; Skolka MP; Yiannikas C; Vucic S; Pollard JD; Carroll AS; Silsby M; Spies J; Kiernan MC; Klein CJ; Park SB, 2026, 'Application of a Clinical-Electrophysiological Model for Identifying Chronic Inflammatory Demyelinating Polyradiculoneuropathy in an Australian Cohort', Journal of the Peripheral Nervous System, 31, http://dx.doi.org/10.1111/jns.70125

Henders AK; Ziser L; Garton FC; Adams L; Ernst K; Furlong S; Heads JA; Heggie S; Krasniqi R; Bhadravathi Lokeshappa M; Mazumder S; McNamara E; MacShane A; Mekhael L; Nunn L; Orden B; Ryder J; Thorpe K; Toubia M; Wallace LM; Wickremeratne D; Windebank E; Benyamin B; Ngo S; Nicholson G; Pamphlett R; Steyn FJ; Visscher PM; Willams KL; Henderson R; Kiernan MC; Laing N; Mathers S; McCombe PA; Needham M; Rowe D; Schultz D; Talman P; Vucic S; Blair IP; McRae AF; Wray NR, 2026, 'Strategic Amyotrophic Lateral Sclerosis Australia–Systems Genomics Consortium (SALSA-SGC): cohort profile', BMJ Open, 16, http://dx.doi.org/10.1136/bmjopen-2025-110906

Calma AD; Pavey N; Silva CS; Tsuji Y; Ghapar AA; Morris K; Kiernan MC; Farrar MA; Menon P; Vucic S, 2026, 'Utility of Far-Field Potentials as a Biomarker of Neurodegeneration in Spinal Muscular Atrophy', Muscle and Nerve, 73, pp. 1089 - 1095, http://dx.doi.org/10.1002/mus.70231

Haidar M; Viden A; Daniel C; Cuic B; Wang T; Rosier M; Tomas D; Mills SA; Govier-Cole A; Djouma E; Perera ND; Luikinga S; Rytova V; Barton SK; Gonsalvez DG; Palmer LM; McLean C; Kiernan MC; Vucic S; Turner BJ, 2026, 'Corrigendum to “Cortical hyperexcitability drives dying forward amyotrophic lateral sclerosis symptoms and pathology in mice”[Prog. Neurobiol. 252 (2025) 102809]', Progress in Neurobiology, 260, http://dx.doi.org/10.1016/j.pneurobio.2026.102910

Hop PJ; Kooyman M; Kenna BJ; Zwamborn RAJ; van Eijk KR; Wang Y; van Dijk CH; Bekema E; van Rheenen W; Beele P; van Vugt JJFA; de Carvalho M; van den Berg LH; Van Damme P; Smith BN; Khleifat AA; Iacoangeli A; Cooper-Knock J; Smith BN; Topp S; van der Kooi AJ; Fominykh V; Drory V; Lerner Y; Shovman Y; Rowe DB; Williams KL; McLaughlin RL; Hurt J; Huang Y; Chen CY; Tsai E; Runz H; Aronica E; Groen EJN; van Es MA; Pasterkamp RJ; Farhan SMK; Garton FC; McRae AF; McCombe PA; Henderson RD; Fan D; Šlachtová L; Høyer H; Nishimura AL; Cauchi RJ; Brylev L; Rogelj B; Koritnik B; Zidar J; Salas T; Mora Pardina JS; Gotkine M; Povedano M; Corcia P; Vourc’h P; Couratier P; Weber M; Kiernan MC; Pamphlett R; Blair IP; de Carvalho M; Başak NA; Ingre C; Andersen PM; Zinman L; Rogaeva E; MacKenzie IR; Dupre N; Rouleau GA; Traynor BJ; Ticozzi N; Chiò A; Silani V; Hardiman O; Phatnani H; Harms MB; Dalgard CL; Glass JD; Landers JE; Van Damme P; Morrison KE; Shaw PJ; Shaw CE; Al-Chalabi A; van den Berg LH; Kenna KP; Veldink JH, 2026, 'Large-scale exome analyses reveal new rare variant contributions in amyotrophic lateral sclerosis', Nature Genetics, 58, pp. 717 - 725, http://dx.doi.org/10.1038/s41588-026-02535-9

Rudnicki SA; Giacomelli E; Herder K; Ingre C; Kupfer S; Malik FI; Meng L; Paganoni S; Schellenberg K; Scirocco E; Simkins T; Wei J; Shefner JM; Henderson RD; Kiernan MC; Schultz D; Needham M; Vucic S; Johnston W; Zinman L; Genge A; Matte G; O’Connell CM; Korngut L; Dionne A; Turnbull J; Schellenberg K; Shoesmith C; Zwicker J; Salvesen L; Couratier P; Corcia P; Bernard E; Salachas F; Danel V; Attarian S; Soriani MH; Ludolph A; Petri S; Rödiger A; Großkreutz J; Weydt P; Meyer T; Hardiman O; Chio A; Silani V; Cerri F; Calvo A; Lunetta C; van den Berg LH; Kusma-Kozakiewicz M; de Carvalho M; Mora JS; Vazquez-Costa JF; Povedano M; Ingre C; Nilsson C; Weber M; Al-Chalabi A; Young C; Andrews JA; Markgakis NJ; Miller TM; Simmons Z; Heiman-Patterson T; Cudkowicz ME; Bradshaw D; Paganoni S; Statland J; Grogan J; Rothstein J; Oskarsson B; Vu T; Olney N; Lewis R; Katz J; Quan D; Mccluskey L; Goyal N; Pavlakis P; Swenson A; Bayat E; Goutman S; Fee D; Creigh P; Peltier A; Heitzman D; Patee G; Bodkin C; Owegi M; Arcilla-London X; Chahin N; Ladha S; So Y; Rezania K; Tandan R; Kuenzler R; Gwathmey K; Pulley M, 2026, 'The Use of Durable Medical Equipment in COURAGE-ALS, a Phase 3, Multicentre, Randomized Clinical Trial for ALS', Muscle and Nerve, 73, pp. 608 - 614, http://dx.doi.org/10.1002/mus.70150

Wu SSL; McCann EP; Chan Moi Fat S; Grima N; Henden L; Fearnley LG; Chiu P; Williams KL; Rowe DB; Nicholson GA; Kiernan MC; Blair IP; Yang S; Fifita JA, 2026, 'Genetic characterisation of ATXN2 in Australian amyotrophic lateral sclerosis', Brain Disorders, 21, http://dx.doi.org/10.1016/j.dscb.2025.100301

Zussa ZN; Smith AN; van Vugt JJFA; O’Shaughnessy DS; Grima N; Chan Moi Fat S; Blair IP; Rowe DB; Pamphlett R; Nicholson GA; Kiernan MC; van Rheenen W; Veldink J; Williams KL; Henden L, 2026, 'Characterising the motif composition and allele length distribution of ZFHX3 GGC repeat expansions in amyotrophic lateral sclerosis', Journal of Human Genetics, http://dx.doi.org/10.1038/s10038-026-01513-7

Tu S; Mahoney CJ; Huynh W; Vucic S; Kiernan MC, 2026, 'Cortical excitability stratifies neurochemical profiles in amyotrophic lateral sclerosis', Brain Communications, 8, http://dx.doi.org/10.1093/braincomms/fcag292

Calma AD; Pavey N; Tsuji Y; Ghapar AA; Bos MAJVD; Orden B; Lee G; Mekhael L; Ryder J; Silva CS; McDonald D; Kakar F; Yiannikas C; Kiernan MC; Brown DA; Menon P; Vucic S, 2026, 'Integration of Serum Neurofilament Light Chain and Cortical Dysfunction Improves Diagnostic Accuracy in ALS', Annals of Clinical and Translational Neurology, http://dx.doi.org/10.1002/acn3.70454

Bye CR; Qian E; Lim K; Daniszewski M; Garton FC; Trần-Lê BC; Liang HH; Lin T; Lock JG; Crombie DE; Morgan S; Hu Y; Barton SK; Palmer LM; Djouma E; Kodikara S; Lê Cao KA; Dharmadasa T; Henders AK; Ziser LA; Kiernan MC; Talbot K; Needham M; Fletcher S; Talman P; Mathers S; Wray NR; Hewitt AW; Pebay A; Turner BJ, 2026, 'Large-scale drug screening in iPSC-derived motor neurons from sporadic ALS patients identifies a potential combinatorial therapy', Nature Neuroscience, 29, pp. 40 - 52, http://dx.doi.org/10.1038/s41593-025-02118-7

Kiernan MC; Genge A; Grosskreutz J; Kuwabara S; Lillo P; Rosenfeld J; Cummings C, 2026, 'The World Federation of Neurology Specialty Group in ALS/MND: toward strategic partnership and new frontiers', Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 27, pp. 501 - 503, http://dx.doi.org/10.1080/21678421.2026.2663915

Rosenfeld J; Abrahams S; McHutchinson C; Ajroud-Driss S; Weber M; Paganoni S; Mitsumoto H; Genge A; Grosskreutz J; Van Den Berg L; Andrews J; Kiernan MC, 2026, 'Utility of patient subgrouping in ALS clinical trials: a World Federation of Neurology white paper', Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 27, pp. 493 - 500, http://dx.doi.org/10.1080/21678421.2025.2593308

, 2026, 'Correction to “Cerebellar neuronal loss in amyotrophic lateral sclerosis cases with ATXN2 intermediate repeat expansions”', Annals of Neurology, 99, pp. 288 - 288, http://dx.doi.org/10.1002/ana.78107

, 2026, 'Corrigendum to “Exploring the Evolution of Cortical Excitability Following Acute Stroke”', Neurorehabilitation and Neural Repair, 40, pp. 598 - 598, http://dx.doi.org/10.1177/15459683261447055

Ribeiro FL; Zhu X; Ye X; Tu S; Ngo ST; Henderson RD; Steyn FJ; Kiernan MC; Barth M; Bollmann S; Shaw TB, 2025, 'An Annotated Multi-Site and Multi-Contrast Magnetic Resonance Imaging Dataset for the study of the Human Tongue Musculature', Scientific Data, 12, http://dx.doi.org/10.1038/s41597-025-05092-8

Krishnan D; Talbot DL; Ashhurst JF; Park SB; Vucic S; Timmins HC; Kiernan MC, 2025, 'Longitudinal assessment of cortical motor function in amyotrophic lateral sclerosis', Scientific Reports, 15, http://dx.doi.org/10.1038/s41598-025-01570-6

Grima N; Smith AN; Shepherd CE; Henden L; Zaw T; Carroll L; Rowe DB; Kiernan MC; Blair IP; Williams KL, 2025, 'Multi-region brain transcriptomic analysis of amyotrophic lateral sclerosis reveals widespread RNA alterations and substantial cerebellum involvement', Molecular Neurodegeneration, 20, http://dx.doi.org/10.1186/s13024-025-00820-5

Graco M; Berlowitz DJ; Sawyer A; Holland AE; Carey KA; Ahamed Y; Ridgers A; Lannin NA; Wu P; Wheatley J; Vucic OS; Viera Souza T; Singh B; Thomas G; Talman P; Szollosi I; Sheean B; Rowe D; Rautela L; Piper A; Michael C; Menadue C; McLean A; Kosky C; Kiernan M; Howard ME; Hannan L; Dalziel K; Curtin D; Chao C; Braat S; Aiyappan V; Aickelin U, 2025, 'Polysomnographic titration of non-invasive ventilation in motor neurone disease (3TLA): protocol for a process evaluation of a clinical trial', Trials, 26, http://dx.doi.org/10.1186/s13063-025-08784-z

Berlowitz DJ; Rowe D; Howard ME; Piper A; Graco M; Braat S; Singh B; Souza TV; Lannin N; McLean A; Sawyer A; Carey KA; Ahamed Y; Wu P; Wheatley J; Vucic OS; Thomas G; Talman P; Szollosi I; Sheean B; Rautela L; Michael C; Menadue C; Kosky C; Kiernan M; Holland A; Hannan L; Dalziel K; Curtin D; Chao C; Aiyappan V; Aickelin U, 2025, 'Polysomnographic titration of non-invasive ventilation in motor neurone disease (3TLA): study protocol for a randomised controlled trial', Trials, 26, http://dx.doi.org/10.1186/s13063-024-08464-4

Kutlubaev MA; Pervushina EV; Kiernan MC, 2025, 'The nature of fatigue in amyotrophic lateral sclerosis: a systematic review and meta-analysis', Acta Neurologica Belgica, 125, pp. 1535 - 1544, http://dx.doi.org/10.1007/s13760-025-02890-0

Douglas A; McPhee M; Fisher F; Cheng C; Henders A; Ziser L; Stout JC; Kiernan MC; Osborne R; Mathers S, 2025, 'Using cluster analysis to identify the health literacy strengths and challenges of people living with motor neurone disease in Australia', BMC Health Services Research, 25, http://dx.doi.org/10.1186/s12913-025-12998-x

Tse NY; Orlando IF; O'Callaghan C; Taylor NL; Shine JM; Zalesky A; Tu S; Ahmed RM; Halliday GM; Piguet O; Hodges JR; Kiernan MC; Lewis SJG; Devenney EM, 2025, 'Susceptibility to visual hallucinations in the amyotrophic lateral sclerosis-frontotemporal dementia spectrum: The role of dysfunctional attentional networks', Cortex, 192, pp. 213 - 226, http://dx.doi.org/10.1016/j.cortex.2025.08.014

Adler GL; Kiernan MC; Tan RH, 2025, 'The FindMNDBiomarker Program: Protein Changes in Motor Neuron Disease/Amyotrophic Lateral Sclerosis Postmortem Tissue and Biofluids', Annals of Neurology, 98, pp. 788 - 800, http://dx.doi.org/10.1002/ana.27300

Kiernan M; Thaung C; Vahdani K, 2025, 'Mantle cell lymphoma presenting as bilateral upper eyelid entropion', Orbit, 44, pp. 680 - 680, http://dx.doi.org/10.1080/01676830.2022.2025858

Haidar M; Viden A; Daniel C; Cuic B; Wang T; Rosier M; Tomas D; Mills SA; Govier-Cole A; Djouma E; Perera ND; Luikinga S; Rytova V; Barton SK; Gonsalvez DG; Palmer LM; McLean C; Kiernan MC; Vucic S; Turner BJ, 2025, 'Cortical hyperexcitability drives dying forward amyotrophic lateral sclerosis symptoms and pathology in mice', Progress in Neurobiology, 252, http://dx.doi.org/10.1016/j.pneurobio.2025.102809

Vucic S; Shahrizaila N; Kano O; Menon P; Agustini S; Kulkantrakorn K; Atchayaram N; Lee YC; Prado MB; Ng KWP; Chai J; Son B; Talman P; Nghia HTT; Tuan LTQ; Shibuya K; Izumi Y; Atsuta N; Henderson RD; Cui L; Liu M; Ohnmar O; Rabani R; Hong YH; Sung JJ; Fan D; Raykar V; Kuwabara S; Kim SH; Sobue G; Kiernan MC, 2025, 'Pan-Asian consortium for treatment and research in ALS (PACTALS) guidelines for management of amyotrophic lateral sclerosis', Lancet Regional Health Western Pacific, 62, http://dx.doi.org/10.1016/j.lanwpc.2025.101684

Shaw TB; Ribeiro FL; Zhu X; Aiken P; Bollmann S; Bollmann S; Chang J; Chidley K; Dempsey-Jones H; Eftekhari Z; Gillespie J; Henderson RD; Kiernan MC; Ktena I; McCombe PA; Ngo ST; Taubert ST; Whelan BM; Ye X; Steyn FJ; Tu S; Barth M, 2025, 'Segmentation of the human tongue musculature using MRI: Field guide and validation in motor neuron disease', Computers in Biology and Medicine, 196, http://dx.doi.org/10.1016/j.compbiomed.2025.110824

Calma AD; Pavey N; Silva CS; van den Bos MAJ; Yiannikas C; Farrar MA; Kiernan MC; Menon P; Vucic S, 2025, 'Diagnostic utility of threshold tracking TMS paradigms in early amyotrophic lateral sclerosis', Clinical Neurophysiology, 174, pp. 105 - 113, http://dx.doi.org/10.1016/j.clinph.2025.03.044

Santos Silva C; Pavey N; Calma AD; Kiernan MC; Menon P; van den Bos M; Vucic S, 2025, 'Utility of Cortical Inhibitory and Facilitatory Neuronal Circuits in Amyotrophic Lateral Sclerosis Diagnosis', European Journal of Neurology, 32, http://dx.doi.org/10.1111/ene.70203

Swart G; Garg N; Skolka M; Yiannikas C; Vucic OS; Pollard J; Carroll A; Spies J; Kiernan M; Klein C; Park S, 2025, 'Application of a Clinical-electrophysiologic Model for Distinguishing Chronic Inflammatory Demyelinating Neuropathy (CIDP) in an Australian Cohort (P10-11.033)', Neurology, 104, http://dx.doi.org/10.1212/wnl.0000000000212523

Eisen A; Vucic S; Kiernan MC, 2025, 'Amyotrophic lateral sclerosis represents corticomotoneuronal system failure', Muscle and Nerve, 71, pp. 499 - 511, http://dx.doi.org/10.1002/mus.28290

van den Bos MAJ; Menon P; Pavey N; Higashihara M; Kiernan MC; Vucic S, 2025, 'Direct interrogation of cortical interneuron circuits in amyotrophic lateral sclerosis', Brain, 148, pp. 1169 - 1179, http://dx.doi.org/10.1093/brain/awae317

Kiernan MC; Timmins HC, 2025, 'Utility of the Gold Coast criteria for amyotrophic lateral sclerosis: Experience with fast progressors', Journal of the Neurological Sciences, 470, http://dx.doi.org/10.1016/j.jns.2025.123417

Almgren H; Mahoney CJ; Huynh W; D’Souza A; Berte S; Lv J; Wang C; Kiernan MC; Calamante F; Tu S, 2025, 'Quantifying neurodegeneration within subdivisions of core motor pathways in amyotrophic lateral sclerosis using diffusion MRI', Journal of Neurology, 272, http://dx.doi.org/10.1007/s00415-025-12920-9

Kiernan MC, 2025, 'Recent developments in consensus diagnostic criteria for amyotrophic lateral sclerosis', Eneurologicalsci, 38, http://dx.doi.org/10.1016/j.ensci.2025.100559

Serra G; Tomietto M; McGill A; Kiernan M, 2025, 'Developing a nationwide registry of UK veterans seeking help from sector charities—a machine learning approach to stratification', European Journal of Public Health, 35, pp. 5 - 10, http://dx.doi.org/10.1093/eurpub/ckae141

Hannaford A; Pavey N; Menon P; van den Bos MAJ; Kiernan MC; Simon N; Vucic S, 2025, 'Muscle ultrasound aids diagnosis in amyotrophic lateral sclerosis', Clinical Neurophysiology, 170, pp. 234 - 243, http://dx.doi.org/10.1016/j.clinph.2024.11.008

Vucic S; Pavey N; Menon P; Babayev M; Maslyukova A; Muraviev A; Kiernan MC, 2025, 'Neurophysiological assessment of cortical motor function: A direct comparison of methodologies', Clinical Neurophysiology, 170, pp. 14 - 21, http://dx.doi.org/10.1016/j.clinph.2024.12.001

Badrising UA; Henderson R; Reddel S; Corbett A; Liang C; Reardon K; Ghaoui R; Bulsara M; Brady S; Brusch A; Chan D; Coudert JD; Fairchild T; Jain G; Kiernan MC; Leonard D; Lloyd T; Schmidt J; McDermot MP; Sanders L; Lowe C; van der Kooi AJ; Weihl C; Mohassel P; Simpson M; Carrol A; Cooper I; Beer K; Hiscock K; Walters S; Panicker A; Doverty A; Heim AJ; van Heur-Neuman M; Benveniste O; Dimachki MM; Needham M, 2025, 'Optimism in inclusion body myositis: a double-blind randomised controlled phase III trial investigating the effect of sirolimus on disease progression in patients with IBM as measured by the IBM Functional Rating Scale', Clinical and Experimental Rheumatology, 43, pp. 316 - 325, http://dx.doi.org/10.55563/clinexprheumatol/zvffa0

Eisen A; Kiernan MC, 2025, 'The Neonatal Microbiome: Implications for Amyotrophic Lateral Sclerosis and Other Neurodegenerations', Brain Sciences, 15, http://dx.doi.org/10.3390/brainsci15020195

Feldman EL; Sattler R; Kiernan MC; Goutman SA; Chiò A; Al-Chalabi A, 2025, 'Transforming amyotrophic lateral sclerosis into a liveable disease', Lancet Neurology, 24, pp. 100 - 101, http://dx.doi.org/10.1016/S1474-4422(24)00523-4

Back to profile page