By Assistant Professor Paul Ekert

Journal articles

Cmero M; Schmidt B; Majewski I; Ekert P; Oshlack A; Davidson N, 2020, 'MINTIE: identifying novel structural and splice variants in transcriptomes using RNA-seq data', , http://dx.doi.org/10.1101/2020.06.03.131532

Fareh M; Zhao W; Hu W; Casan JML; Kumar A; Symons J; Voskoboinik I; Ekert P; Rudraraju R; Lewin S; Trapani J, 2020, 'Reprogrammed CRISPR-Cas13b suppresses SARS-CoV-2 replication and circumvents its mutational escape through mismatch tolerance', , http://dx.doi.org/10.1101/2020.11.18.389312

Ekert P, 2020, 'Signalling in high-risk paediatric cancers – Genomic insights driving therapeutic possibilities', Pathology, 52, pp. S31 - S31, http://dx.doi.org/10.1016/j.pathol.2020.01.128

Meyer C; Lopes BA; Caye-Eude A; Cavé H; Arfeuille C; Cuccuini W; Sutton R; Venn NC; Oh SH; Tsaur G; Escherich G; Feuchtinger T; Kosasih HJ; Khaw SL; Ekert PG; Pombo-de-Oliveira MS; Bidet A; Djahanschiri B; Ebersberger I; Zaliova M; Zuna J; Zermanova Z; Juvonen V; Grümayer RP; Fazio G; Cazzaniga G; Larghero P; Emerenciano M; Marschalek R, 2019, 'Human MLL/KMT2A gene exhibits a second breakpoint cluster region for recurrent MLL–USP2 fusions', Leukemia, 33, pp. 2306 - 2340, http://dx.doi.org/10.1038/s41375-019-0451-7

Salmon J; Pomilio G; Moujalled D; Litalien V; MacRaild S; Teh C; Rijal S; Ivey A; Teh TC; Ekert P; Krous-Berthier L; Kloos I; Schoumacher M; Gray D; Wei A, 2019, 'ENHANCING EXPRESSION OF PRO-APOPTOTIC FACTORS THROUGH INHIBITION OF HDACS DRIVES P53-INDEPENDENT SYNERGY WITH VENETOCLAX FOR THE TREATMENT OF AML', EXPERIMENTAL HEMATOLOGY, 76, pp. S54 - S54, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000844545400090&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Moujalled D; Hanna D; Pomillio G; Litalien V; Fleming S; Chanrion M; Maragno A-L; Kraus-Berthier L; Khaw S; Lessene G; Huang D; Roberts A; Geneste O; Ekert P; Ng A; Wei A, 2019, 'IDENTIFICATION OF POTENT BH3-MIMETIC COMBINATIONS TARGETING PRO-SURVIVAL PATHWAYS IN HUMAN B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA', EXPERIMENTAL HEMATOLOGY, 76, pp. S79 - S80, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000844545400172&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Gayden T; Sepulveda FE; Khuong-Quang DA; Pratt J; Valera ET; Garrigue A; Kelso S; Sicheri F; Mikael LG; Hamel N; Bajic A; Dali R; Deshmukh S; Dervovic D; Schramek D; Guerin F; Taipale M; Nikbakht H; Majewski J; Moshous D; Charlebois J; Abish S; Bole-Feysot C; Nitschke P; Bader-Meunier B; Mitchell D; Thieblemont C; Battistella M; Gravel S; Nguyen VH; Conyers R; Diana JS; McCormack C; Prince HM; Besnard M; Blanche S; Ekert PG; Fraitag S; Foulkes WD; Fischer A; Neven B; Michonneau D; de Saint Basile G; Jabado N, 2019, 'Erratum to: Germline HAVCR2 mutations altering TIM-3 characterize subcutaneous panniculitis-like T cell lymphomas with hemophagocytic lymphohistiocytic syndrome (Nature Genetics, (2018), 50, 12, (1650-1657), 10.1038/s41588-018-0251-4)', Nature Genetics, 51, pp. 196, http://dx.doi.org/10.1038/s41588-018-0304-8

Brown LM; Bartolo RC; Davidson NM; Schmidt B; Brooks I; Challis J; Petrovic V; Khuong-Quang DA; Mechinaud F; Khaw SL; Majewski IJ; Oshlack A; Ekert PG, 2019, 'Targeted therapy and disease monitoring in CNTRL-FGFR1-driven leukaemia', Pediatric Blood and Cancer, 66, http://dx.doi.org/10.1002/pbc.27897

Tsoli M; Wadham C; Pinese M; Failes T; Joshi S; Mould E; Yin JX; Gayevskiy V; Kumar A; Kaplan W; Ekert PG; Saletta F; Franshaw L; Liu J; Gifford A; Weber MA; Rodriguez M; Cohn RJ; Arndt G; Tyrrell V; Haber M; Trahair T; Marshall GM; McDonald K; Cowley MJ; Ziegler DS; Arndt G, 2018, 'Integration of genomics, high throughput drug screening, and personalized xenograft models as a novel precision medicine paradigm for high risk pediatric cancer', Cancer Biology and Therapy, 19, pp. 1078 - 1087, http://dx.doi.org/10.1080/15384047.2018.1491498

Gayden T; Sepulveda FE; Khuong-Quang DA; Pratt J; Valera ET; Garrigue A; Kelso S; Sicheri F; Mikael LG; Hamel N; Bajic A; Dali R; Deshmukh S; Dervovic D; Schramek D; Guerin F; Taipale M; Nikbakht H; Majewski J; Moshous D; Charlebois J; Abish S; Bole-Feysot C; Nitschke P; Bader-Meunier B; Mitchell D; Thieblemont C; Battistella M; Gravel S; Nguyen VH; Conyers R; Diana JS; McCormack C; Prince HM; Besnard M; Blanche S; Ekert PG; Fraitag S; Foulkes WD; Fischer A; Neven B; Michonneau D; de Saint Basile G; Jabado N, 2018, 'Germline HAVCR2 mutations altering TIM-3 characterize subcutaneous panniculitis-like T cell lymphomas with hemophagocytic lymphohistiocytic syndrome', Nature Genetics, 50, pp. 1650 - 1657, http://dx.doi.org/10.1038/s41588-018-0251-4

Ziegler DS; Wong M; Mayoh C; Kumar A; Tsoli M; Mould E; Tyrrell V; Khuong-Quang DA; Pinese M; Gayevskiy V; Cohn RJ; Lau LMS; Reynolds M; Cox MC; Gifford A; Rodriguez M; Cowley MJ; Ekert PG; Marshall GM; Haber M; Wong-Erasmus M, 2018, 'Brief Report: Potent clinical and radiological response to larotrectinib in TRK fusion-driven high-grade glioma', British Journal of Cancer, 119, pp. 693 - 696, http://dx.doi.org/10.1038/s41416-018-0251-2

Salmon J; Pomilio G; Moujalled D; MacRaild S; Teh C; Rijal S; Ivey A; Teh TC; Ekert P; Schoumacher M; Kraus-Berthier L; Kloos I; Gray D; Wei A, 2018, 'COMBINED BCL-2 AND HDAC TARGETING HAS POTENT AND TP53 INDEPENDENT ACTIVITY IN AML', EXPERIMENTAL HEMATOLOGY, 64, pp. S99 - S100, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000975534800214&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Hassannia B; Wiernicki B; Ingold I; Qu F; Van Herck S; Tyurina YY; Bayir H; Abhari BA; Angeli JPF; Choi SM; Meul E; Heyninck K; Declerck K; Chirumamilla CS; Lahtela-Kakkonen M; Van Camp G; Krysko DV; Ekert PG; Fulda S; De Geest BG; Conrad M; Kagan VE; Berghe WV; Vandenabeele P; Berghe TV, 2018, 'Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma', Journal of Clinical Investigation, 128, pp. 3341 - 3355, http://dx.doi.org/10.1172/JCI99032

Schmidt BM; Davidson NM; Hawkins ADK; Bartolo R; Majewski IJ; Ekert PG; Oshlack A, 2018, 'Clinker: visualizing fusion genes detected in RNA-seq data', GigaScience, 7, pp. giy079, http://dx.doi.org/10.1093/gigascience/giy079

Lee B; Tran B; Hsu AL; Taylor GR; Fox SB; Fellowes A; Marquis R; Mooi J; Desai J; Doig K; Ekert P; Gaff C; Herath D; Hamilton A; James P; Roberts A; Snyder R; Waring P; McArthur G, 2018, 'Exploring the feasibility and utility of exome-scale tumour sequencing in a clinical setting', Internal Medicine Journal, 48, pp. 786 - 794, http://dx.doi.org/10.1111/imj.13806

Narayan N; Bracken CP; Ekert PG, 2018, 'MicroRNA-155 expression and function in AML: An evolving paradigm', Experimental Hematology, 62, pp. 1 - 6, http://dx.doi.org/10.1016/j.exphem.2018.03.007

Hercus TR; Kan WLT; Broughton SE; Tvorogov D; Ramshaw HS; Sandow JJ; Nero TL; Dhagat U; Thompson EJ; Tung Shing KSC; McKenzie DR; Wilson NJ; Owczarek CM; Vairo G; Nash AD; Tergaonkar V; Hughes T; Ekert PG; Samuel MS; Bonder CS; Grimbaldeston MA; Parker MW; Lopez AF, 2018, 'Role of the β common (βc) family of cytokines in health and disease', Cold Spring Harbor Perspectives in Biology, 10, http://dx.doi.org/10.1101/cshperspect.a028514

Teh TC; Nguyen NY; Moujalled DM; Segal D; Pomilio G; Rijal S; Jabbour A; Cummins K; Lackovic K; Blombery P; Thompson E; Ekert PG; Lessene G; Glaser SP; Huang DCS; Roberts AW; Guthridge MA; Wei AH, 2018, 'Enhancing venetoclax activity in acute myeloid leukemia by co-targeting MCL1', Leukemia, 32, pp. 303 - 312, http://dx.doi.org/10.1038/leu.2017.243

Schmidt B; Davidson N; Hawkins ADK; Bartolo R; Majewski I; Ekert P; Oshlack A, 2017, 'Clinker: visualising fusion genes detected in RNA-seq data', , http://dx.doi.org/10.1101/218586

Ekert PG; Jabbour AM; Manoharan A, 2017, 'Cell death provoked by loss of interleukin-3 signaling is independent of Bad, Bim, and PI3 kinase, but depends in part on Puma (vol 108, pg 1461, 2006)', BLOOD, 130, pp. 1684 - 1684, http://dx.doi.org/10.1182/blood-2017-08-802397

Conyers R; Costello B; La Gerche A; Tripaydonis A; Burns C; Ludlow L; Lange P; Ekert P; Mechinaud F; Cheung M; Martin M; Elliot D, 2017, 'Chemotherapy-related cardiotoxicity: are Australian practitioners missing the point?', Internal Medicine Journal, 47, pp. 1166 - 1172, http://dx.doi.org/10.1111/imj.13481

Fischer K; Masouras D; Daunt C; Dias S; Ekert P; Strasser A; Vaux D; Jabbour A, 2017, 'CYTOKINE SIGNALLING IN HAEMATOPOIETIC CELLS', EXPERIMENTAL HEMATOLOGY, 53, pp. S107 - S107, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000972742900241&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Brown LM; Hanna DT; Khaw SL; Ekert PG, 2017, 'Dysregulation of BCL-2 family proteins by leukemia fusion genes', Journal of Biological Chemistry, 292, pp. 14325 - 14333, http://dx.doi.org/10.1074/jbc.R117.799056

Sandow JJ; Infusini G; Holik AZ; Brumatti G; Averink TV; Ekert PG; Webb AI, 2017, 'Quantitative proteomic analysis of EZH2 inhibition in acute myeloid leukemia reveals the targets and pathways that precede the induction of cell death', Proteomics - Clinical Applications, 11, http://dx.doi.org/10.1002/prca.201700013

Wittwer NL; Brumatti G; Marchant C; Sandow JJ; Pudney MK; Dottore M; D’Andrea RJ; Lopez AF; Ekert PG; Ramshaw HS, 2017, 'High CD123 levels enhance proliferation in response to IL-3, but reduce chemotaxis by downregulating CXCR4 expression', Blood Advances, 1, pp. 1067 - 1079, http://dx.doi.org/10.1182/bloodadvances.2016002931

Brumatti G; Ma C; Lalaoui N; Nguyen N-Y; Navarro M; Tanzer MC; Richmond J; Ghisi M; Salmon JM; Silke N; Pomilio G; Glaser SP; de Valle E; Gugasyan R; Gurthridge MA; Condon SM; Johnstone RW; Lock R; Salvesen G; Wei A; Vaux DL; Ekert PG; Silke J, 2017, 'The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia (vol 8, 339ra69, 2016)', SCIENCE TRANSLATIONAL MEDICINE, 9, http://dx.doi.org/10.1126/scitranslmed.aan8181

Narayan N; Morenos L; Phipson B; Willis SN; Brumatti G; Eggers S; Lalaoui N; Brown LM; Kosasih HJ; Bartolo RC; Zhou L; Catchpoole D; Saffery R; Oshlack A; Goodall GJ; Ekert PG, 2017, 'Functionally distinct roles for different miR-155 expression levels through contrasting effects on gene expression, in acute myeloid leukaemia', Leukemia, 31, pp. 808 - 820, http://dx.doi.org/10.1038/leu.2016.279

Craig LA; Ekert PG; Conyers R; Elliott DA, 2017, 'Genetic determinants of anthracycline cardiotoxicity – ready for the clinic?', British Journal of Clinical Pharmacology, 83, pp. 1141 - 1142, http://dx.doi.org/10.1111/bcp.13195

Perini G; Milazzo G; Narayan N; Ekert PG, 2016, 'Letting the breaks off MYCN', Cell Death and Differentiation, 23, pp. 1904 - 1905, http://dx.doi.org/10.1038/cdd.2016.112

Stark Z; Tan TY; Chong B; Brett GR; Yap P; Walsh M; Yeung A; Peters H; Mordaunt D; Cowie S; Amor DJ; Savarirayan R; McGillivray G; Downie L; Ekert PG; Theda C; James PA; Yaplito-Lee J; Ryan MM; Leventer RJ; Creed E; Macciocca I; Bell KM; Oshlack A; Sadedin S; Georgeson P; Anderson C; Thorne N; Gaff C; White SM, 2016, 'A prospective evaluation of whole-exome sequencing as a first-tier molecular test in infants with suspected monogenic disorders', Genetics in Medicine, 18, pp. 1090 - 1096, http://dx.doi.org/10.1038/gim.2016.1

Goodall KJ; Finch-Edmondson ML; Van Vuuren J; Yeoh GC; Gentle IE; Vince JE; Ekert PG; Vaux DL; Callus BA, 2016, 'Cycloheximide can induce bax/bak dependent myeloid cell death independently of multiple BH3-only proteins', PLoS ONE, 11, http://dx.doi.org/10.1371/journal.pone.0164003

Lalaoui N; Hänggi K; Brumatti G; Chau D; Nguyen NYN; Vasilikos L; Spilgies LM; Heckmann DA; Ma C; Ghisi M; Salmon JM; Matthews GM; de Valle E; Moujalled DM; Menon MB; Spall SK; Glaser SP; Richmond J; Lock RB; Condon SM; Gugasyan R; Gaestel M; Guthridge M; Johnstone RW; Munoz L; Wei A; Ekert PG; Vaux DL; Wong WWL; Silke J, 2016, 'Correction: Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics (Cancer Cell (2016) 30(3) (499–500) (S1535610816000350) (10.1016/j.ccell.2016.01.006))', Cancer Cell, 30, pp. 499 - 500, http://dx.doi.org/10.1016/j.ccell.2016.08.009

Brumatti G; Ma C; Lalaoui N; Nguyen NY; Navarro M; Tanzer MC; Richmond J; Ghisi M; Salmon JM; Silke N; Pomilio G; Glaser SP; De Valle E; Gugasyan R; Gurthridge MA; Condon SM; Johnstone RW; Lock R; Salvesen G; Wei A; Vaux DL; Ekert PG; Silke J, 2016, 'The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia', Science Translational Medicine, 8, http://dx.doi.org/10.1126/scitranslmed.aad3099

Lalaoui N; Hänggi K; Brumatti G; Chau D; Nguyen NYN; Vasilikos L; Spilgies LM; Heckmann DA; Ma C; Ghisi M; Salmon JM; Matthews GM; de Valle E; Moujalled DM; Menon MB; Spall SK; Glaser SP; Richmond J; Lock RB; Condon SM; Gugasyan R; Gaestel M; Guthridge M; Johnstone RW; Munoz L; Wei A; Ekert PG; Vaux DL; Wong WWL; Silke J, 2016, 'Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics', Cancer Cell, 29, pp. 145 - 158, http://dx.doi.org/10.1016/j.ccell.2016.01.006

Lalaoui N; Johnstone R; Ekert PG, 2016, 'Autophagy and AML - Food for thought', Cell Death and Differentiation, 23, pp. 5 - 6, http://dx.doi.org/10.1038/cdd.2015.136

Lalaoui N; Lindqvist LM; Sandow JJ; Ekert PG, 2015, 'The molecular relationships between apoptosis, autophagy and necroptosis', Seminars in Cell and Developmental Biology, 39, pp. 63 - 69, http://dx.doi.org/10.1016/j.semcdb.2015.02.003

Gangoda L; Doerflinger M; Srivastava R; Narayan N; Edgington LE; Orian J; Hawkins C; O'Reilly LA; Gu H; Bogyo M; Ekert P; Strasser A; Puthalakath H, 2014, 'Loss of Prkar1a leads to Bcl-2 family protein induction and cachexia in mice', Cell Death and Differentiation, 21, pp. 1815 - 1824, http://dx.doi.org/10.1038/cdd.2014.98

Rickard JA; O'Donnell JA; Evans JM; Lalaoui N; Poh AR; Rogers T; Vince JE; Lawlor KE; Ninnis RL; Anderton H; Hall C; Spall SK; Phesse TJ; Abud HE; Cengia LH; Corbin J; Mifsud S; Di Rago L; Metcalf D; Ernst M; Dewson G; Roberts AW; Alexander WS; Murphy JM; Ekert PG; Masters SL; Vaux DL; Croker BA; Gerlic M; Silke J, 2014, 'RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis', Cell, 157, pp. 1175 - 1188, http://dx.doi.org/10.1016/j.cell.2014.04.019

Sandow JJ; Dorstyn L; O'Reilly LA; Tailler M; Kumar S; Strasser A; Ekert PG, 2014, 'ER stress does not cause upregulation and activation of caspase-2 to initiate apoptosis', Cell Death and Differentiation, 21, pp. 475 - 480, http://dx.doi.org/10.1038/cdd.2013.168

Sadras T; Perugini M; Kok CH; Iarossi DG; Heatley SL; Brumatti G; Samuel MS; To LB; Lewis ID; Lopez AF; Ekert PG; Ramshaw HS; D'Andrea RJ, 2014, 'Interleukin-3-mediated regulation of β-catenin in myeloid transformation and acute myeloid leukemia', Journal of Leukocyte Biology, 96, pp. 83 - 91, http://dx.doi.org/10.1189/jlb.2AB1013-559R

Bandopadhayay P; Jabbour AM; Riffkin C; Salmanidis M; Gordon L; Popovski D; Rigby L; Ashley DM; Watkins DN; Thomas DM; Algar E; Ekert PG, 2013, 'The oncogenic properties of EWS/WT1 of desmoplastic small round cell tumors are unmasked by loss of p53 in murine embryonic fibroblasts', BMC Cancer, 13, http://dx.doi.org/10.1186/1471-2407-13-585

Rahimi A; Lee YY; Abdella H; Doerflinger M; Gangoda L; Srivastava R; Xiao K; Ekert PG; Puthalakath H, 2013, 'Role of p53 in cAMP/PKA pathway mediated apoptosis', Apoptosis, 18, pp. 1492 - 1499, http://dx.doi.org/10.1007/s10495-013-0895-6

Wensveen FM; Geest CR; Libregts SFWM; Derks IAM; Ekert PG; Labi V; Villunger A; Nolte MA; Eldering E, 2013, 'BH3-only protein Noxa contributes to apoptotic control of stress-erythropoiesis', Apoptosis, 18, pp. 1306 - 1318, http://dx.doi.org/10.1007/s10495-013-0890-y

Brumatti G; Ekert PG, 2013, 'Seeking a MCL-1 inhibitor', Cell Death and Differentiation, 20, pp. 1440 - 1441, http://dx.doi.org/10.1038/cdd.2013.114

Green BD; Jabbour AM; Sandow JJ; Riffkin CD; Masouras D; Daunt CP; Salmanidis M; Brumatti G; Hemmings BA; Guthridge MA; Pearson RB; Ekert PG, 2013, 'Akt1 is the principal Akt isoform regulating apoptosis in limiting cytokine concentrations', Cell Death and Differentiation, 20, pp. 1341 - 1349, http://dx.doi.org/10.1038/cdd.2013.63

Salmanidis M; Brumatti G; Narayan N; Green BD; Van Den Bergen JA; Sandow JJ; Bert AG; Silke N; Sladic R; Puthalakath H; Rohrbeck L; Okamoto T; Bouillet P; Herold MJ; Goodall GJ; Jabbour AM; Ekert PG, 2013, 'Hoxb8 regulates expression of microRNAs to control cell death and differentiation', Cell Death and Differentiation, 20, pp. 1370 - 1380, http://dx.doi.org/10.1038/cdd.2013.92

Wong NC; Ng J; Hall NE; Lunke S; Salmanidis M; Brumatti G; Ekert PG; Craig JM; Saffery R, 2013, 'Exploring the utility of human DNA methylation arrays for profiling mouse genomic DNA', Genomics, 102, pp. 38 - 46, http://dx.doi.org/10.1016/j.ygeno.2013.04.014

Hercus TR; Dhagat U; Kan WLT; Broughton SE; Nero TL; Perugini M; Sandow JJ; D'Andrea RJ; Ekert PG; Hughes T; Parker MW; Lopez AF, 2013, 'Signalling by the βc family of cytokines', Cytokine and Growth Factor Reviews, 24, pp. 189 - 201, http://dx.doi.org/10.1016/j.cytogfr.2013.03.002

Gurzeler U; Rabachini T; Dahinden CA; Salmanidis M; Brumatti G; Ekert PG; Echeverry N; Bachmann D; Simon HU; Kaufmann T, 2013, 'In vitro differentiation of near-unlimited numbers of functional mouse basophils using conditional Hoxb8', Allergy: European Journal of Allergy and Clinical Immunology, 68, pp. 604 - 613, http://dx.doi.org/10.1111/all.12140

Thomas D; Powell JA; Green BD; Barry EF; Ma Y; Woodcock J; Fitter S; Zannettino ACW; Pitson SM; Hughes TP; Lopez AF; Shepherd PR; Wei AH; Ekert PG; Guthridge MA, 2013, 'Protein Kinase Activity of Phosphoinositide 3-Kinase Regulates Cytokine-Dependent Cell Survival', PLoS Biology, 11, http://dx.doi.org/10.1371/journal.pbio.1001515

Back to profile page