Select Publications
Book Chapters
2007, 'Inhibitor of apoptosis proteins and caspases', in Apoptosis, Cell Signaling, and Human Diseases, pp. 313 - 334, http://dx.doi.org/10.1007/978-1-59745-199-4_15
,Journal articles
2024, 'Novel paediatric case of a spinal high-grade astrocytoma with piloid features in a patient with Noonan Syndrome', npj Precision Oncology, 8, http://dx.doi.org/10.1038/s41698-024-00734-3
,2024, 'Single-base tiled screen unveils design principles of PspCas13b for potent and off-target-free RNA silencing', Nature Structural and Molecular Biology, 31, pp. 1702 - 1716, http://dx.doi.org/10.1038/s41594-024-01336-0
,2024, 'Abstract A012 Unravelling the role of METTL1 in Myc driven pediatric cancers using CRISPR Cas13d', Cancer Research, 84, pp. A012 - A012, http://dx.doi.org/10.1158/1538-7445.pediatric24-a012
,2024, 'Abstract B002: A novel NTRK2-activating internal tandem duplication characterizes a new mechanism of receptor tyrosine kinase activation', Cancer Research, 84, pp. B002 - B002, http://dx.doi.org/10.1158/1538-7445.pediatric24-b002
,2024, 'Abstract B004: Putting function back into paediatric cancer genomics – modelling the therapeutic implications of novel genomic features', Cancer Research, 84, pp. B004 - B004, http://dx.doi.org/10.1158/1538-7445.pediatric24-b004
,2024, 'Abstract B012: Clinical utility of real-time comprehensive molecular profiling in childhood brain tumors', Cancer Research, 84, pp. B012 - B012, http://dx.doi.org/10.1158/1538-7445.pediatric24-b012
,2024, 'Abstract B014: Increasing the clinical utility of transcriptome analysis in high-risk childhood precision oncology', Cancer Research, 84, pp. B014 - B014, http://dx.doi.org/10.1158/1538-7445.pediatric24-b014
,2024, 'Abstract B015: Transcriptome-based assessment of immune infiltration for molecular selection of pediatric patients with solid tumors for combination immune checkpoint inhibitor therapy', Cancer Research, 84, pp. B015 - B015, http://dx.doi.org/10.1158/1538-7445.pediatric24-b015
,2024, 'Correction to: Functional precision medicine for pediatric cancers (Nature Medicine, (2024), 30, 4, (940-941), 10.1038/s41591-024-02863-5)', Nature Medicine, 30, pp. 2695, http://dx.doi.org/10.1038/s41591-024-03208-y
,2024, 'Patient Experience of Complex Genomic Sequencing Exploring Patient Preference, Barriers, and Enablers for Delivery', JCO Precision Oncology, 8, http://dx.doi.org/10.1200/PO.23.00247
,2024, 'Precision-guided treatment in high-risk pediatric cancers', Nature Medicine, 30, pp. 1913 - 1922, http://dx.doi.org/10.1038/s41591-024-03044-0
,2024, 'Functional precision medicine for pediatric cancers', Nature Medicine, 30, pp. 940 - 941, http://dx.doi.org/10.1038/s41591-024-02863-5
,2024, 'Abstract 1094: Utilizing CRISPR-Cas13 as a novel functional genomics tool to characterize PAX3-FOXO1 in alveolar rhabdomyosarcoma', Cancer Research, 84, pp. 1094 - 1094, http://dx.doi.org/10.1158/1538-7445.am2024-1094
,2024, 'Abstract 1770: Right oncogene, wrong tumor - CBL mutations in pediatric CNS and solid tumors', Cancer Research, 84, pp. 1770 - 1770, http://dx.doi.org/10.1158/1538-7445.am2024-1770
,2024, 'A novel MYB::PAIP1 oncogenic fusion in pediatric blastic plasmacytoid dendritic cell neoplasm (BPDCN) is dependent on BCL2 expression and is sensitive to venetoclax', HemaSphere, 8, pp. e1, http://dx.doi.org/10.1002/hem3.1
,2024, '2011 – SUBCLONAL MUTATIONS ALTER CORE SIGNALLING NODES AND DRUG RESPONSES IN PAEDIATRIC ACUTE LYMPHOBLASTIC LEUKAEMIA', Experimental Hematology, 137, pp. 104568 - 104568, http://dx.doi.org/10.1016/j.exphem.2024.104568
,2024, '3153 – CRISPR-DIRECTED CHROMOSOMAL TRANSLOCATIONS PROVIDE NOVEL INSIGHTS INTO LEUKEMIA BIOLOGY', Experimental Hematology, 137, pp. 104474 - 104474, http://dx.doi.org/10.1016/j.exphem.2024.104474
,2024, '438 (PB426): Precision-guided treatment improves outcomes for children with highrisk cancers', European Journal of Cancer, 211, pp. 114946 - 114946, http://dx.doi.org/10.1016/j.ejca.2024.114946
,2024, '57. Developing oncogenicity guidelines for BCR::ABL1-like B-lymphoblastic leukemia/lymphoma through expert consensus', Cancer Genetics, 286-287, pp. S18 - S19, http://dx.doi.org/10.1016/j.cancergen.2024.08.059
,2023, 'TALLSorts: a T-cell acute lymphoblastic leukemia subtype classifier using RNA-seq expression data', Blood Advances, 7, pp. 7402 - 7406, http://dx.doi.org/10.1182/bloodadvances.2023010385
,2023, 'A novel transcriptional signature identifies T-cell infiltration in high-risk paediatric cancer', Genome Medicine, 15, http://dx.doi.org/10.1186/s13073-023-01170-x
,2023, 'Histone H3-wild type diffuse midline gliomas with H3K27me3 loss are a distinct entity with exclusive EGFR or ACVR1 mutation and differential methylation of homeobox genes', Scientific Reports, 13, pp. 3775, http://dx.doi.org/10.1038/s41598-023-30395-4
,2023, 'SYST-15 GENERATION AND MULTI-DIMENSIONAL PROFILING OF A CHILDHOOD CANCER CELL LINE ATLAS DEFINES NEW THERAPEUTIC OPPORTUNITIES', Neuro-Oncology Advances, 5, pp. iii30 - iii30, http://dx.doi.org/10.1093/noajnl/vdad070.119
,2023, 'Distinct Assemblies of Heterodimeric Cytokine Receptors Govern Stemness Programs in Leukemia', Cancer Discovery, 13, pp. 1922 - 1947, http://dx.doi.org/10.1158/2159-8290.CD-22-1396
,2023, 'High-Throughput Drug Screening of Primary Tumor Cells Identifies Therapeutic Strategies for Treating Children with High-Risk Cancer', Cancer Research, 83, pp. 2716 - 2732, http://dx.doi.org/10.1158/0008-5472.CAN-22-3702
,2023, 'Biological and clinical implications of FGFR aberrations in paediatric and young adult cancers', Oncogene, 42, pp. 1875 - 1888, http://dx.doi.org/10.1038/s41388-023-02705-7
,2023, 'Generation and multi-dimensional profiling of a childhood cancer cell line atlas defines new therapeutic opportunities', Cancer Cell, 41, pp. 660 - 677.e7, http://dx.doi.org/10.1016/j.ccell.2023.03.007
,2023, 'T
2023, 'Harnessing immune checkpoint trial data in pediatric cancer', Nature Cancer, 4, pp. 444 - 446, http://dx.doi.org/10.1038/s43018-023-00540-z
,2023, 'Unusual PDGFRB fusion reveals novel mechanism of kinase activation in Ph-like B-ALL', Leukemia, 37, pp. 1 - 5, http://dx.doi.org/10.1038/s41375-023-01843-x
,2023, 'Description of a novel subtype of acute myeloid leukemia defined by recurrent CBFB insertions', Blood, 141, pp. 800 - 805, http://dx.doi.org/10.1182/blood.2022017874
,2023, 'In vivo loss of tumorigenicity in a patient-derived orthotopic xenograft mouse model of ependymoma', Frontiers in Oncology, 13, http://dx.doi.org/10.3389/fonc.2023.1123492
,2023, 'Toblerone: detecting exon deletion events in cancer using RNA-seq', F1000Research, 12, http://dx.doi.org/10.12688/f1000research.129490.1
,2022, 'JAFFAL: detecting fusion genes with long-read transcriptome sequencing', Genome Biology, 23, http://dx.doi.org/10.1186/s13059-021-02588-5
,2022, 'Advances in CAR T cell immunotherapy for paediatric brain tumours', Frontiers in Oncology, 12, http://dx.doi.org/10.3389/fonc.2022.873722
,2022, 'ALLSorts: an RNA-Seq subtype classifier for B-cell acute lymphoblastic leukemia', Blood Advances, 6, pp. 4093 - 4097, http://dx.doi.org/10.1182/bloodadvances.2021005894
,2022, 'Ceramide-induced integrated stress response overcomes Bcl-2 inhibitor resistance in acute myeloid leukemia', Blood, 139, pp. 3737 - 3751, http://dx.doi.org/10.1182/blood.2021013277
,2022, 'Enhancer retargeting of CDX2 and UBTF::ATXN7L3 define a subtype of high-risk B-progenitor acute lymphoblastic leukemia', Blood, 139, pp. 3519 - 3531, http://dx.doi.org/10.1182/blood.2022015444
,2022, 'MODL-17. The Childhood Brain Cancer Cell Line Atlas: A Resource for Biomarker Identification and Therapeutic Development', Neuro-Oncology, 24, pp. i172 - i172, http://dx.doi.org/10.1093/neuonc/noac079.640
,2022, 'SFPQ-ABL1 and BCR-ABL1 use different signaling networks to drive B-cell acute lymphoblastic leukemia', Blood Advances, 6, pp. 2373 - 2387, http://dx.doi.org/10.1182/bloodadvances.2021006076
,2022, 'In vitro and in vivo drug screens of tumor cells identify novel therapies for high-risk child cancer', EMBO Molecular Medicine, 14, pp. emmm202114608, http://dx.doi.org/10.15252/emmm.202114608
,2021, 'Diffuse leptomeningeal glioneuronal tumour (DLGNT) in children: the emerging role of genomic analysis', Acta Neuropathologica Communications, 9, http://dx.doi.org/10.1186/s40478-021-01248-w
,2021, 'Efficacy of MEK inhibition in a recurrent malignant peripheral nerve sheath tumor', npj Precision Oncology, 5, http://dx.doi.org/10.1038/s41698-021-00145-8
,2021, 'Enhancing the potential of immunotherapy in paediatric sarcomas: Breaking the immunosuppressive barrier with receptor tyrosine kinase inhibitors', Biomedicines, 9, pp. 1798, http://dx.doi.org/10.3390/biomedicines9121798
,2021, 'MINTIE: identifying novel structural and splice variants in transcriptomes using RNA-seq data', Genome Biology, 22, http://dx.doi.org/10.1186/s13059-021-02507-8
,2021, 'Precision medicine and phosphoproteomics for the identification of novel targeted therapeutic avenues in sarcomas', Biochimica et Biophysica Acta - Reviews on Cancer, 1876, http://dx.doi.org/10.1016/j.bbcan.2021.188613
,2021, 'Reprogrammed CRISPR-Cas13b suppresses SARS-CoV-2 replication and circumvents its mutational escape through mismatch tolerance', Nature Communications, 12, http://dx.doi.org/10.1038/s41467-021-24577-9
,2021, 'Diagnostic Utility of Multimodal Genomic Profiling for Molecular Classification and MRD Assessment in Adult B-Cell Acute Lymphoblastic Leukemia', BLOOD, 138, http://dx.doi.org/10.1182/blood-2021-146396
,2021, 'Cycling without brakes lets ALL escape', Blood, 138, pp. 1912 - 1913, http://dx.doi.org/10.1182/blood.2021012754
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