By Associate Professor Alexis Estelle Whitton

Journal articles

Shvetcov A; Whitton A; Kasturi S; Zheng WY; Beames J; Ibrahim O; Han J; Hoon L; Mouzakis K; Gupta S; Venkatesh S; Christensen H; Newby J, 2023, 'Machine learning identifies a COVID-19-specific phenotype in university students using a mental health app', Internet Interventions, 34, http://dx.doi.org/10.1016/j.invent.2023.100666

Darrow SM; Pizzagalli DA; Smoski M; Mathew SJ; Nurnberger J; Lisanby SH; Iosifescu D; Murrough JW; Yang H; Weiner RD; Sanacora G; Keefe RSE; Song A; Goodman W; Whitton AE; Potter WZ; Krystal AD, 2023, 'Using latent profile analyses to classify subjects with anhedonia based on reward-related measures obtained in the FAST-MAS study', Journal of Affective Disorders, 339, pp. 584 - 592, http://dx.doi.org/10.1016/j.jad.2023.07.081

Huckvale K; Hoon L; Stech E; Newby JM; Zheng WY; Han J; Vasa R; Gupta S; Barnett S; Senadeera M; Cameron S; Kurniawan S; Agarwal A; Kupper JF; Asbury J; Willie D; Grant A; Cutler H; Parkinson B; Ahumada-Canale A; Beames JR; Logothetis R; Bautista M; Rosenberg J; Shvetcov A; Quinn T; MacKinnon A; Rana S; Tran T; Rosenbaum S; Mouzakis K; Werner-Seidler A; Whitton A; Venkatesh S; Christensen H, 2023, 'Protocol for a bandit-based response adaptive trial to evaluate the effectiveness of brief self-guided digital interventions for reducing psychological distress in university students: the Vibe Up study', BMJ Open, 13, http://dx.doi.org/10.1136/bmjopen-2022-066249

Vis C; Schuurmans J; Aouizerate B; Craggs MA; Batterham P; Bührmann L; Calear A; Pashoja AC; Christensen H; Dozeman E; Pedersen CD; Ebert DD; Etzelmueller A; Fanaj N; Finch TL; Hanssen D; Hegerl U; Hoogendoorn A; Mathiasen K; May C; Meksi A; Mustafa S; O'Dea B; Oehler C; Piera-Jiménez J; Potthoff S; Qirjako G; Rapley T; Rosmalen J; Sacco Y; Samalin L; Skjoth MM; Tarp K; Titzler I; Van der Eycken E; van Genugten CR; Whitton A; Zanalda E; Smit JH; Riper H, 2023, 'Effectiveness of Self-guided Tailored Implementation Strategies in Integrating and Embedding Internet-Based Cognitive Behavioral Therapy in Routine Mental Health Care: Results of a Multicenter Stepped-Wedge Cluster Randomized Trial', Journal of Medical Internet Research, 25, http://dx.doi.org/10.2196/41532

Pizzagalli D; Whitton A; Kumar P; Treadway M; Rutherford AV; Ironside ML, 2023, 'Anhedonia and Reward-Related Neural Abnormalities Prospectively Predict Longitudinal Changes in Quality of Life Among Treatment-Seeking Individuals With Mood Disorders', Biological Psychiatry, 93, pp. S2 - S2, http://dx.doi.org/10.1016/j.biopsych.2023.02.026

Pechtel P; Belleau EL; Kaiser RH; Whitton AE; Beltzer M; Clegg R; Goer F; Vitaliano G; Teicher MH; Pizzagalli DA, 2022, 'Stress and reward: A multimodal assessment of childhood sexual abuse', Neurobiology of Stress, 21, http://dx.doi.org/10.1016/j.ynstr.2022.100498

Whitton A; Lewandowski K; Hall M-H, 2022, 'P532. Smoking as a Common Modulator of Sensory Gating and Reward Learning in Individuals with Psychotic Disorders', Biological Psychiatry, 91, pp. S304 - S304, http://dx.doi.org/10.1016/j.biopsych.2022.02.769

Reinen JM; Whitton AE; Pizzagalli DA; Slifstein M; Abi-Dargham A; McGrath PJ; Iosifescu DV; Schneier FR, 2021, 'Differential reinforcement learning responses to positive and negative information in unmedicated individuals with depression', European Neuropsychopharmacology, 53, pp. 89 - 100, http://dx.doi.org/10.1016/j.euroneuro.2021.08.002

Costi S; Morris LS; Collins A; Fernandez NF; Patel M; Xie H; Kim-Schulze S; Stern ER; Collins KA; Cathomas F; Parides MK; Whitton AE; Pizzagalli DA; Russo SJ; Murrough JW, 2021, 'Peripheral immune cell reactivity and neural response to reward in patients with depression and anhedonia', Translational Psychiatry, 11, http://dx.doi.org/10.1038/s41398-021-01668-1

Whitton AE; Lewandowski KE; Hall MH, 2021, 'Smoking as a Common Modulator of Sensory Gating and Reward Learning in Individuals with Psychotic Disorders', Brain Sciences, 11, http://dx.doi.org/10.3390/brainsci11121581

Parker BL; Anderson M; Batterham PJ; Gayed A; Subotic-Kerry M; Achilles MR; Chakouch C; Werner-Seidler A; Whitton AE; O Dea B, 2021, 'Examining the Preliminary Effectiveness and Acceptability of a Web-Based Training Program for Australian Secondary School Teachers: Pilot Study of the BEAM (Building Educators Skills in Adolescent Mental Health) Program', Jmir Mental Health, 8, http://dx.doi.org/10.2196/29989

Whitton AE; Rabinovich NE; Lindt JD; Pergadia ML; Pizzagalli DA; Gilbert DG, 2021, 'Genetic and Depressive Traits Moderate the Reward-Enhancing Effects of Acute Nicotine in Young Light Smokers', Nicotine and Tobacco Research, 23, pp. 1779 - 1786, http://dx.doi.org/10.1093/ntr/ntab072

Whitton AE; Hardy R; Cope K; Gieng C; Gow L; MacKinnon A; Gale N; O'Moore K; Anderson J; Proudfoot J; Cockayne N; O'Dea B; Christensen H; Newby JM, 2021, 'Mental health screening in general practices as a means for enhancing uptake of digital mental health interventions: Observational cohort study', Journal of Medical Internet Research, 23, http://dx.doi.org/10.2196/28369

Shaw SR; El-Omar H; Ramanan S; Piguet O; Ahmed RM; Whitton AE; Irish M, 2021, 'Anhedonia in semantic dementia—exploring right hemispheric contributions to the loss of pleasure', Brain Sciences, 11, http://dx.doi.org/10.3390/brainsci11080998

Eren-Yazicioglu CY; Kara B; Sancak S; Uysal SP; Yazici D; Okuroglu N; Whitton AE; Rutherford AV; Yapici-Eser H, 2021, 'Effect of Exenatide Use on Cognitive and Affective Functioning in Obese Patients with Type 2 Diabetes Mellitus: Exenatide Use Mediates Depressive Scores through Increased Perceived Stress Levels', Journal of Clinical Psychopharmacology, 41, pp. 428 - 435, http://dx.doi.org/10.1097/JCP.0000000000001409

Whitton AE; Kumar P; Treadway MT; Rutherford AV; Ironside ML; Foti D; Fitzmaurice G; Du F; Pizzagalli DA, 2021, 'Mapping Disease Course Across the Mood Disorder Spectrum Through a Research Domain Criteria Framework', Biological Psychiatry Cognitive Neuroscience and Neuroimaging, 6, pp. 706 - 715, http://dx.doi.org/10.1016/j.bpsc.2021.01.004

Costi S; Morris LS; Kirkwood KA; Hoch M; Corniquel M; Vo-Le B; Iqbal T; Chadha N; Pizzagalli DA; Whitton A; Bevilacqua L; Jha MK; Ursu S; Swann AC; Collins KA; Salas R; Bagiella E; Parides MK; Stern ER; Iosifescu DV; Han MH; Mathew SJ; Murrough JW, 2021, 'Impact of the KCNQ2/3 channel opener ezogabine on reward circuit activity and clinical symptoms in depression: Results from a randomized controlled trial', American Journal of Psychiatry, 178, pp. 437 - 446, http://dx.doi.org/10.1176/appi.ajp.2020.20050653

Shaw SR; El-Omar H; Roquet D; Hodges JR; Piguet O; Ahmed RM; Whitton AE; Irish M, 2021, 'Uncovering the prevalence and neural substrates of anhedonia in frontotemporal dementia', Brain, 144, pp. 1551 - 1564, http://dx.doi.org/10.1093/brain/awab032

Parker BL; Chakouch C; Subotic-Kerry M; Batterham PJ; Mackinnon A; Newby JM; Whitton AE; McGoldrick J; Cockayne N; O'Dea B, 2021, 'The building educators’ skills in adolescent mental health training program for secondary school educators: Protocol for a cluster randomized controlled trial', Jmir Research Protocols, 10, http://dx.doi.org/10.2196/25870

Reilly EE; Whitton AE; Pizzagalli DA; Rutherford AV; Stein MB; Paulus MP; Taylor CT, 2020, 'Diagnostic and dimensional evaluation of implicit reward learning in social anxiety disorder and major depression', Depression and Anxiety, 37, pp. 1221 - 1230, http://dx.doi.org/10.1002/da.23081

Murphy M; Whitton AE; Deccy S; Ironside ML; Rutherford A; Beltzer M; Sacchet M; Pizzagalli DA, 2020, 'Abnormalities in electroencephalographic microstates are state and trait markers of major depressive disorder', Neuropsychopharmacology, 45, pp. 2030 - 2037, http://dx.doi.org/10.1038/s41386-020-0749-1

Whitton AE; Merchant JT; Lewandowski KE, 2020, 'Dissociable mechanisms underpinning effort-cost decision-making across the psychosis spectrum', Schizophrenia Research, 224, pp. 133 - 140, http://dx.doi.org/10.1016/j.schres.2020.09.014

Pizzagalli DA; Smoski M; Ang YS; Whitton AE; Sanacora G; Mathew SJ; Nurnberger J; Lisanby SH; Iosifescu DV; Murrough JW; Yang H; Weiner RD; Calabrese JR; Goodman W; Potter WZ; Krystal AD, 2020, 'Selective kappa-opioid antagonism ameliorates anhedonic behavior: evidence from the Fast-fail Trial in Mood and Anxiety Spectrum Disorders (FAST-MAS)', Neuropsychopharmacology, 45, pp. 1656 - 1663, http://dx.doi.org/10.1038/s41386-020-0738-4

Tan A; Costi S; Morris LS; Van Dam NT; Kautz M; Whitton AE; Friedman AK; Collins KA; Ahle G; Chadha N; Do B; Pizzagalli DA; Iosifescu DV; Nestler EJ; Han MH; Murrough JW, 2020, 'Effects of the KCNQ channel opener ezogabine on functional connectivity of the ventral striatum and clinical symptoms in patients with major depressive disorder', Molecular Psychiatry, 25, pp. 1323 - 1333, http://dx.doi.org/10.1038/s41380-018-0283-2

Krystal AD; Pizzagalli DA; Smoski M; Mathew SJ; Nurnberger J; Lisanby SH; Iosifescu D; Murrough JW; Yang H; Weiner RD; Calabrese JR; Sanacora G; Hermes G; Keefe RSE; Song A; Goodman W; Szabo ST; Whitton AE; Gao K; Potter WZ, 2020, 'A randomized proof-of-mechanism trial applying the ‘fast-fail’ approach to evaluating κ-opioid antagonism as a treatment for anhedonia', Nature Medicine, 26, pp. 760 - 768, http://dx.doi.org/10.1038/s41591-020-0806-7

Carpenter JS; Iorfino F; Cross S; Nichles A; Zmicerevska N; Crouse JJ; Palmer JR; Whitton AE; White D; Naismith SL; Guastella AJ; Hermens DF; Scott J; Scott EM; Hickie IB, 2020, 'Cohort profile: The Brain and Mind Centre Optymise cohort: Tracking multidimensional outcomes in young people presenting for mental healthcare', BMJ Open, 10, http://dx.doi.org/10.1136/bmjopen-2019-030985

Whitton AE; Reinen JM; Slifstein M; Ang YS; McGrath PJ; Iosifescu DV; Abi-Dargham A; Pizzagalli DA; Schneier FR, 2020, 'Baseline reward processing and ventrostriatal dopamine function are associated with pramipexole response in depression', Brain, 143, pp. 701 - 710, http://dx.doi.org/10.1093/brain/awaa002

Murphy M; Whitton A; Deccy S; Ironside M; Beltzer M; Sacchet M; Pizzagalli D, 2020, 'Abnormal Electroencephalographic Microstate Dynamics Are Associated With Active but Not Remitted Major Depressive Disorder', Biological Psychiatry, 87, pp. s137 - s138, http://dx.doi.org/10.1016/j.biopsych.2020.02.367

Whitton A; Reinen J; Slifstein M; Ang Y-S; McGrath P; Iosifescu D; Abi-Dargham A; Pizzagalli D; Schneier F, 2020, 'Computational Approaches to Improving Treatment Precision for Anhedonia', Biological Psychiatry, 87, pp. S50 - S51, http://dx.doi.org/10.1016/j.biopsych.2020.02.153

Murrough J; Costi S; Morris L; Collins A; Collins K; Whitton A; Pizzagalli D; Russo S, 2020, 'Dynamic Peripheral Immune Profiles and Neurocircuit Responses to Reward in Depression', Biological Psychiatry, 87, pp. S15 - S16, http://dx.doi.org/10.1016/j.biopsych.2020.02.066

Whitton AE; Green AI; Pizzagalli DA; Roth RM; Williams JM; Brunette MF, 2019, 'Potent Dopamine D2 Antagonists Block the Reward-Enhancing Effects of Nicotine in Smokers with Schizophrenia', Schizophrenia Bulletin, 45, pp. 1300 - 1308, http://dx.doi.org/10.1093/schbul/sby185

Whitton A; Kumar P; Treadway M; Foti D; Rutherford A; Ironside ML; Du F; Pizzagalli D, 2019, 'Multimodal Assessment of Frontostriatal Circuitry as a Tool for Parsing Motivational Impairments', BIOLOGICAL PSYCHIATRY, 85, pp. S26 - S26, http://dx.doi.org/10.1016/j.biopsych.2019.03.076

Whitton AE; Webb CA; Dillon DG; Kayser J; Rutherford A; Goer F; Fava M; McGrath P; Weissman M; Parsey R; Adams P; Trombello JM; Cooper C; Deldin P; Oquendo MA; McInnis MG; Carmody T; Bruder G; Trivedi MH; Pizzagalli DA, 2019, 'Pretreatment Rostral Anterior Cingulate Cortex Connectivity With Salience Network Predicts Depression Recovery: Findings From the EMBARC Randomized Clinical Trial', Biological Psychiatry, 85, pp. 872 - 880, http://dx.doi.org/10.1016/j.biopsych.2018.12.007

Finan PH; Whitton AE; Letzen JE; Remeniuk B; Robinson ML; Irwin MR; Pizzagalli DA; Smith MT, 2019, 'Experimental sleep disruption and reward learning: Moderating role of positive affect responses', Sleep, 42, http://dx.doi.org/10.1093/sleep/zsz026

Sperl MFJ; Panitz C; Rosso IM; Dillon DG; Kumar P; Hermann A; Whitton AE; Hermann C; Pizzagalli DA; Mueller EM, 2019, 'Fear Extinction Recall Modulates Human Frontomedial Theta and Amygdala Activity', Cerebral Cortex, 29, pp. 701 - 715, http://dx.doi.org/10.1093/cercor/bhx353

Kaiser RH; Treadway MT; Wooten DW; Kumar P; Goer F; Murray L; Beltzer M; Pechtel P; Whitton A; Cohen AL; Alpert NM; El Fakhri G; Normandin MD; Pizzagalli DA, 2018, 'Frontostriatal and dopamine markers of individual differences in reinforcement learning: A multi-modal investigation', Cerebral Cortex, 28, pp. 4281 - 4290, http://dx.doi.org/10.1093/cercor/bhx281

Schneier FR; Slifstein M; Whitton AE; Pizzagalli DA; Reinen J; McGrath PJ; Iosifescu DV; Abi-Dargham A, 2018, 'Dopamine Release in Antidepressant-Naive Major Depressive Disorder: A Multimodal [11C]-(+)-PHNO Positron Emission Tomography and Functional Magnetic Resonance Imaging Study', Biological Psychiatry, 84, pp. 563 - 573, http://dx.doi.org/10.1016/j.biopsych.2018.05.014

Whitton AE; Mehta M; Ironside ML; Murray G; Pizzagalli DA, 2018, 'Evidence of a diurnal rhythm in implicit reward learning', Chronobiology International, 35, pp. 1104 - 1114, http://dx.doi.org/10.1080/07420528.2018.1459662

Schneier F; Slifstein M; Whitton A; Pizzagalli D; Reinen J; McGrath P; Iosifescu D; Abi-Dargham A, 2018, 'Dopamine Release in Treatment-Naive Major Depressive Disorder: A [11C]-(+)-PHNO Positron Emission Tomography Study', BIOLOGICAL PSYCHIATRY, 83, pp. S101 - S101, http://dx.doi.org/10.1016/j.biopsych.2018.02.270

Whitton A; Green A; Pizzagalli D; Williams J; Brunette M, 2018, 'Potent Dopamine D2 Receptor Antagonists Block the Reward-Enhancing Effects of Nicotine in Smokers With Schizophrenia', BIOLOGICAL PSYCHIATRY, 83, pp. S443 - S443, http://dx.doi.org/10.1016/j.biopsych.2018.02.1136

Robinson ML; Whitton AE; Remeniuk B; Smith MT; Letzen JE; Irwin MR; Pizzagalli DA; Finan PH, 2018, '0099 Effects of Sleep Disruption on Reward Learning in Healthy Adults', Sleep, 41, pp. a40 - a40, http://dx.doi.org/10.1093/sleep/zsy061.098

Nangle MR; Bailey PE; Henry JD; Khlentzos GS; Varcin KJ; Whitton AE, 2018, 'Age invariance in rapid facial affective reactions to emotionally valenced stimuli', Quarterly Journal of Experimental Psychology, 71, pp. 1687 - 1697, http://dx.doi.org/10.1080/17470218.2017.1345960

Whitton AE; Deccy S; Ironside ML; Kumar P; Beltzer M; Pizzagalli DA, 2018, 'Electroencephalography Source Functional Connectivity Reveals Abnormal High-Frequency Communication Among Large-Scale Functional Networks in Depression', Biological Psychiatry Cognitive Neuroscience and Neuroimaging, 3, pp. 50 - 58, http://dx.doi.org/10.1016/j.bpsc.2017.07.001

Whitton AE; Van't Veer A; Kakani P; Dillon DG; Ironside ML; Haile A; Crowley DJ; Pizzagalli DA, 2017, 'Acute stress impairs frontocingulate activation during error monitoring in remitted depression', Psychoneuroendocrinology, 75, pp. 164 - 172, http://dx.doi.org/10.1016/j.psyneuen.2016.10.007

Whitton AE; Kakani P; Foti D; Van'T Veer A; Haile A; Crowley DJ; Pizzagalli DA, 2016, 'Blunted Neural Responses to Reward in Remitted Major Depression: A High-Density Event-Related Potential Study', Biological Psychiatry Cognitive Neuroscience and Neuroimaging, 1, pp. 87 - 95, http://dx.doi.org/10.1016/j.bpsc.2015.09.007

Lewandowski KE; Whitton AE; Pizzagalli DA; Norris LA; Ongur D; Hall MH, 2016, 'Reward learning, neurocognition, social cognition, and symptomatology in psychosis', Frontiers in Psychiatry, 7, http://dx.doi.org/10.3389/fpsyt.2016.00100

Clarke J; Proudfoot J; Whitton A; Birch MR; Boyd M; Parker G; Manicavasagar V; Hadzi-Pavlovic D; Fogarty A, 2016, 'Therapeutic Alliance With a Fully Automated Mobile Phone and Web-Based Intervention: Secondary Analysis of a Randomized Controlled Trial', Jmir Mental Health, 3, http://dx.doi.org/10.2196/mental.4656

Peechatka AL; Whitton AE; Farmer SL; Pizzagalli DA; Janes AC, 2015, 'Cigarette craving is associated with blunted reward processing in nicotine-dependent smokers', Drug and Alcohol Dependence, 155, pp. 202 - 207, http://dx.doi.org/10.1016/j.drugalcdep.2015.07.015

Janes AC; Pedrelli P; Whitton AE; Pechtel P; Douglas S; Martinson MA; Huz I; Fava M; Pizzagalli DA; Evins AE, 2015, 'Reward responsiveness varies by smoking status in women with a history of major depressive disorder', Neuropsychopharmacology, 40, pp. 1940 - 1946, http://dx.doi.org/10.1038/npp.2015.43

Whitton AE; Henry JD; Grisham JR, 2015, 'Cognitive and psychophysiological correlates of disgust in obsessive-compulsive disorder', British Journal of Clinical Psychology, 54, pp. 16 - 33, http://dx.doi.org/10.1111/bjc.12058

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