By Associate Professor Anthony Michael Joshua

Journal articles

Emmett L; Van Leeuwen PJ; Nandurkar R; Scheltema MJ; Cusick T; Hruby G; Kneebone A; Eade T; Fogarty G; Jagavkar R; Nguyen Q; Ho B; Joshua AM; Stricker P, 2017, 'Treatment outcomes from ⁶⁸Ga-PSMA PET/CT-informed salvage radiation treatment in men with rising PSA after radical prostatectomy: Prognostic value of a negative PSMA PET', Journal of Nuclear Medicine, 58, pp. 1972 - 1976, http://dx.doi.org/10.2967/jnumed.117.196683

Liang Y; Ahmed M; Guo H; Soares F; Hua JT; Gao S; Lu C; Poon C; Han W; Langstein J; Ekram MB; Li B; Davicioni E; Takhar M; Erho N; Karnes RJ; Chadwick D; Van Der Kwast T; Boutros PC; Arrowsmith CH; Feng FY; Joshua AM; Zoubeidi A; Cai C; He HH, 2017, 'LSD1-mediated epigenetic reprogramming drives CENPE expression and prostate cancer progression', Cancer Research, 77, pp. 5479 - 5490, http://dx.doi.org/10.1158/0008-5472.CAN-17-0496

Francini E; Yip S; Ahmed NS; Li H; Ardolino L; Evan CP; Kaymakcalan M; Shaw GK; Kantoff P; Taplin ME; Alimohamed N; Joshua AM; Heng DYC; Sweeney CJ, 2017, 'Outcomes of prechemotherapy (pCRx) abiraterone acetate (AA) or enzalutamide (E) for metastatic castration-resistant prostate cancer (mCRPC) after ADT plus Docetaxel (D) or ADT alone for metastatic hormone sensitive prostate cancer (mHSPC) in a multi-institution hospital-based registry', ANNALS OF ONCOLOGY, 28, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000411324001321&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Fallah-Rad N; Lee R; Ng P; Smith AD; Hansen AR; Joshua AM; Sridhar SS, 2017, 'Strategies to minimize wastage of expensive drugs in expensive times: Cabazitaxel, a single center experience.', Journal of Clinical Oncology, 35, pp. e18297 - e18297, http://dx.doi.org/10.1200/jco.2017.35.15_suppl.e18297

Montgomery B; Tretiakova MS; Joshua AM; Gleave ME; Fleshner N; Bubley GJ; Mostaghel EA; Chi KN; Lin DW; Sanda M; Novotny W; Wu K; Kantoff PW; Marck BT; Plymate S; Balk SP; Nelson PS; Matsumoto AM; Lis RT; Kibel A; Haas GP; Krivoshik A; Hannah A; Taplin ME, 2017, 'Neoadjuvant enzalutamide prior to prostatectomy', Clinical Cancer Research, 23, pp. 2169 - 2176, http://dx.doi.org/10.1158/1078-0432.CCR-16-1357

Tan Q; Joshua AM; Wang M; Bristow RG; Wouters BG; Allen CJ; Tannock IF, 2017, 'Up-regulation of autophagy is a mechanism of resistance to chemotherapy and can be inhibited by pantoprazole to increase drug sensitivity', Cancer Chemotherapy and Pharmacology, 79, pp. 959 - 969, http://dx.doi.org/10.1007/s00280-017-3298-5

Crumbaker M; Khoja L; Joshua AM, 2017, 'AR signaling and the PI3K pathway in prostate cancer', Cancers, 9, pp. 34, http://dx.doi.org/10.3390/cancers9040034

Poudineh M; Aldridge PM; Ahmed S; Green BJ; Kermanshah L; Nguyen V; Tu C; Mohamadi RM; Nam RK; Hansen A; Sridhar SS; Finelli A; Fleshner NE; Joshua AM; Sargent EH; Kelley SO, 2017, 'Tracking the dynamics of circulating tumour cell phenotypes using nanoparticle-mediated magnetic ranking', Nature Nanotechnology, 12, pp. 274 - 281, http://dx.doi.org/10.1038/nnano.2016.239

Puts MTE; Sattar S; McWatters K; Lee K; Kulik M; MacDonald ME; Jang R; Amir E; Krzyzanowska MK; Leighl N; Fitch M; Joshua AM; Warde P; Tourangeau AE; Alibhai SMH, 2017, 'Chemotherapy treatment decision-making experiences of older adults with cancer, their family members, oncologists and family physicians: a mixed methods study', Supportive Care in Cancer, 25, pp. 879 - 886, http://dx.doi.org/10.1007/s00520-016-3476-8

Atkinson TM; Hay JL; Shoushtari A; Li Y; Paucar DJ; Smith SC; Kudchadkar RR; Doyle A; Sosman JA; Quevedo JF; Milhem MM; Joshua AM; Linette GP; Gajewski TF; Lutzky J; Lawson DH; Lao CD; Flynn PJ; Albertini MR; Sato T; Lewis K; Marr B; Abramson DH; Dickson MA; Schwartz GK; Carvajal RD, 2017, 'Relationship between physician-adjudicated adverse events and patient-reported health-related quality of life in a phase II clinical trial (NCT01143402) of patients with metastatic uveal melanoma', Journal of Cancer Research and Clinical Oncology, 143, pp. 439 - 445, http://dx.doi.org/10.1007/s00432-016-2318-x

Pitcher B; Khoja L; Hamilton RJ; Abdallah K; Pintilie M; Joshua AM, 2017, 'Assessment of a prognostic model, PSA metrics and toxicities in metastatic castrate resistant prostate cancer using data from Project Data Sphere (PDS)', PLoS ONE, 12, http://dx.doi.org/10.1371/journal.pone.0170544

Todenhöfer T; Azad A; Stewart C; Gao J; Eigl BJ; Gleave ME; Joshua AM; Black PC; Chi KN, 2017, 'AR-V7 Transcripts in Whole Blood RNA of Patients with Metastatic Castration Resistant Prostate Cancer Correlate with Response to Abiraterone Acetate', Journal of Urology, 197, pp. 135 - 142, http://dx.doi.org/10.1016/j.juro.2016.06.094

Gwadry-Sridhar F; Nikan S; Hamou A; Seung SJ; Petrella T; Joshua AM; Ernst S; Mittmann N, 2017, 'Resource utilization and costs of managing patients with advanced melanoma: A canadian population-based study', Current Oncology, 24, pp. 168 - 175, http://dx.doi.org/10.3747/co.24.3432

Kanjanapan Y; Day D; Butler M; Wang L; Joshua AM; Hogg D; Leighl NB; Razak ARA; Hansen AR; Boujos S; Chappell MA; Chow K; Paolo M; Sherwin B; Stayner L-A; Soultani L; Zambrana A; Siu LL; Bedard PL; Spreafico A, 2017, 'Immune related adverse events (irAEs) in early phase immunotherapy (IO) trials: Implications for recommended phase 2 dose (RP2D) determination', Annals of Oncology, 28, pp. v132 - v132, http://dx.doi.org/10.1093/annonc/mdx367.030

Khoja L; Atenafu E; Joshua AM; Ocular Melanoma Group IRCI, 2017, 'Validating prognostic models in metastatic uveal melanoma (MUM), an international rare cancers initiative', Annals of Oncology, 28, pp. v439 - v439, http://dx.doi.org/10.1093/annonc/mdx377.025

Daud AI; Wolchok JD; Robert C; Hwu WJ; Weber JS; Ribas A; Hodi FS; Joshua AM; Kefford R; Hersey P; Joseph R; Gangadhar TC; Dronca R; Patnaik A; Zarour H; Roach C; Toland G; Lunceford JK; Li XN; Emancipator K; Dolled-Filhart M; Kang SP; Ebbinghaus S; Hamid O, 2016, 'Programmed death-ligand 1 expression and response to the anti-programmed death 1 antibody pembrolizumab in melanoma', Journal of Clinical Oncology, 34, pp. 4102 - 4109, http://dx.doi.org/10.1200/JCO.2016.67.2477

Khoja L; Kibiro M; Metser U; Gedye C; Hogg D; Butler MO; Atenafu EG; Joshua AM, 2016, 'Patterns of response to anti-PD-1 treatment: An exploratory comparison of four radiological response criteria and associations with overall survival in metastatic melanoma patients', British Journal of Cancer, 115, pp. 1186 - 1192, http://dx.doi.org/10.1038/bjc.2016.308

Stockley TL; Oza AM; Berman HK; Leighl NB; Knox JJ; Shepherd FA; Chen EX; Krzyzanowska MK; Dhani N; Joshua AM; Tsao MS; Serra S; Clarke B; Roehrl MH; Zhang T; Sukhai MA; Califaretti N; Trinkaus M; Shaw P; van der Kwast T; Wang L; Virtanen C; Kim RH; Razak ARA; Hansen AR; Yu C; Pugh TJ; Kamel-Reid S; Siu LL; Bedard PL, 2016, 'Molecular profiling of advanced solid tumors and patient outcomes with genotype-matched clinical trials: The Princess Margaret IMPACT/COMPACT trial', Genome Medicine, 8, http://dx.doi.org/10.1186/s13073-016-0364-2

Khoja L; Atenafu EG; Templeton A; Qye Y; Chappell MA; Saibil S; Hogg D; Butler MO; Joshua AM, 2016, 'The full blood count as a biomarker of outcome and toxicity in ipilimumab-treated cutaneous metastatic melanoma', Cancer Medicine, 5, pp. 2792 - 2799, http://dx.doi.org/10.1002/cam4.878

Corfield J; Crozier J; Joshua A; Bolton D; Lawrentschuck N, 2016, 'Understanding the role of new systemic agents in the treatment of prostate cancer', BJU International, 118, pp. 8 - 13, http://dx.doi.org/10.1111/bju.13633

Smith AD; Truong M; Bristow R; Yip P; Milosevic MF; Joshua AM, 2016, 'The utility of serum ca9 for prognostication in prostate cancer', Anticancer Research, 36, pp. 4489 - 4492, http://dx.doi.org/10.21873/anticanres.10994

Azad A; Todenhöfer T; Stewart C; Gao J; Eigl BJ; Black PC; Joshua AM; Chi KN, 2016, 'Correlation of AR-V7 expression in whole blood with efficacy of abiraterone acetate (ABI) in metastatic castration-resistant prostate cancer (mCRPC) patients (pts).', Journal of Clinical Oncology, 34, pp. e23075 - e23075, http://dx.doi.org/10.1200/jco.2016.34.15_suppl.e23075

Khoja L; Atenafu EG; Joshua AM, 2016, 'Meta-analysis of phase II trials in metastatic uveal melanoma (MUM) to determine progression-free (PFS) and overall survival (OS) benchmarks for future phase II trials: An irci-ocular melanoma initiative.', Journal of Clinical Oncology, 34, pp. 9567 - 9567, http://dx.doi.org/10.1200/jco.2016.34.15_suppl.9567

Nicholas M; Khoja L; Hogg D; Quirt I; Butler MO; Joshua AM, 2016, 'Prognosticators of first line treatment for metastatic uveal melanoma (MUM).', Journal of Clinical Oncology, 34, pp. 9570 - 9570, http://dx.doi.org/10.1200/jco.2016.34.15_suppl.9570

Robert C; Ribas A; Hamid O; Daud A; Wolchok JD; Joshua AM; Hwu W-J; Weber JS; Gangadhar TC; Joseph RW; Dronca RS; Patnaik A; Zarour HM; Kefford R; Hersey P; Li X; Diede SJ; Ebbinghaus S; Hodi FS, 2016, 'Three-year overall survival for patients with advanced melanoma treated with pembrolizumab in KEYNOTE-001.', Journal of Clinical Oncology, 34, pp. 9503 - 9503, http://dx.doi.org/10.1200/jco.2016.34.15_suppl.9503

Hodi FS; Hwu WJ; Kefford R; Weber JS; Daud A; Hamid O; Patnaik A; Ribas A; Robert C; Gangadhar TC; Joshua AM; Hersey P; Dronca R; Joseph R; Hille D; Xue D; Li XN; Kang SP; Ebbinghaus S; Perrone A; Wolchok JD, 2016, 'Evaluation of immune-related response criteria and RECIST v1.1 in patients with advanced melanoma treated with Pembrolizumab', Journal of Clinical Oncology, 34, pp. 1510 - 1517, http://dx.doi.org/10.1200/JCO.2015.64.0391

Ribas A; Hamid O; Daud A; Hodi FS; Wolchok JD; Kefford R; Joshua AM; Patnaik A; Hwu WJ; Weber JS; Gangadhar TC; Hersey P; Dronca R; Joseph RW; Zarour H; Chmielowski B; Lawrence DP; Algazi A; Rizvi NA; Hoffner B; Mateus C; Gergich K; Lindia JA; Giannotti M; Li XN; Ebbinghaus S; Kang SP; Robert C, 2016, 'Association of pembrolizumab with tumor response and survival among patients with advanced melanoma', JAMA - Journal of the American Medical Association, 315, pp. 1600 - 1609, http://dx.doi.org/10.1001/jama.2016.4059

Chi KN; Kheoh T; Ryan CJ; Molina A; Bellmunt J; Vogelzang NJ; Rathkopf DE; Fizazi K; Kantoff PW; Li J; Azad AA; Eigl BJ; Heng DYC; Joshua AM; de Bono JS; Scher HI, 2016, 'A prognostic index model for predicting overall survival in patients with metastatic castration-resistant prostate cancer treated with abiraterone acetate after docetaxel', Annals of Oncology, 27, pp. 454 - 460, http://dx.doi.org/10.1093/annonc/mdv594

Manokumar T; Aziz S; Breunis H; Rizvi SF; Joshua AM; Tannock IF; Alibhai SMH, 2016, 'A prospective study examining elder-relevant outcomes in older adults with prostate cancer undergoing treatment with chemotherapy or abiraterone', Journal of Geriatric Oncology, 7, pp. 81 - 89, http://dx.doi.org/10.1016/j.jgo.2016.01.003

Khoja L; Maurice C; Chappell M; Macmillan L; Al-Habeeb AS; Al-Faraidy N; Butler MO; Rogalla P; Mason W; Joshua AM; Hogg D, 2016, 'Eosinophilic fasciitis and acute encephalopathy toxicity from pembrolizumab treatment of a patient with metastatic melanoma', Cancer Immunology Research, 4, pp. 175 - 178, http://dx.doi.org/10.1158/2326-6066.CIR-15-0186

Chung C; Khoja L; Kurtz G; Bernstein M; Joshua A; Hogg D; Zadeh G; Laperriere N; Menard C; Millar BA; Kongkham P; Butler M, 2016, 'Local Tumor Flare Following Radiosurgery and Ipilimumab (Ipi) for Melanoma Brain Metastases: Increased Immune Response?', RADIOTHERAPY AND ONCOLOGY, 118, pp. S26 - S26, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000843547000054&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Khoja L; Atenafu EG; Ye Q; Gedye C; Chappell M; Hogg D; Butler MO; Joshua AM, 2016, 'Real-world efficacy, toxicity and clinical management of ipilimumab treatment in metastatic melanoma', Oncology Letters, 11, pp. 1581 - 1585, http://dx.doi.org/10.3892/ol.2015.4069

Niraula S; Templeton AJ; Vera-Badillo FE; Joshua AM; Sridhar SS; Cheung PW; Yip PM; Dodd A; Nugent Z; Tannock IF, 2016, 'Study of testosterone-guided androgen deprivation therapy in management of prostate cancer', Prostate, 76, pp. 235 - 242, http://dx.doi.org/10.1002/pros.23117

Leibowitz-Amit R; Pintilie M; Khoja L; Azad AA; Berger R; Laird AD; Aftab DT; Chi KN; Joshua AM, 2016, 'Changes in plasma biomarkers following treatment with cabozantinib in metastatic castration-resistant prostate cancer: A post hoc analysis of an extension cohort of a phase II trial', Journal of Translational Medicine, 14, pp. 12, http://dx.doi.org/10.1186/s12967-015-0747-y

Singnurkar A; Wang J; Joshua AM; Langer DL; Metser U, 2016, '¹⁸F-FDG-PET/CT in the staging and management of melanoma a prospective multicenter Ontario PET registry study', Clinical Nuclear Medicine, 41, pp. 189 - 193, http://dx.doi.org/10.1097/RLU.0000000000000996

Hageman MGJS; Bossen JK; Neuhaus V; Mudgal CS; Ring D; Joshua AM; Adams J; Arbelaez GF; Aspard T; Balfour GW; Bamberger BH; Romero JCB; Baskies M; Batson AW; Baxamusa T; De Bedout R; Beldner S; Benhaim P; Benson L; Boretto JG; Boyer M; Dee GB; Calfee RP; Zambrano CGC; Cassidy C; Catalano L; Chivers K; Costanzo RM; Dantuluri P; DeSilva G; Dodds S; Evans JP; Escobar LFN; Fernandes CH; Fischer TJ; Fischer J; Fricker RM; Frykman GK; Garcia AE; Gaston GR; Giovanni Di FJ; Goldfarb CA; Grafe MW; Grunwald HW; Hammert WC; Hauck R; Hernandez RG; Hofmeister E; Hutchison RL; Ilyas A; Isaacs J; Jacoby SM; Jebson P; Jones CM; Jones M; Kakar S; Kalainov DM; Thomas KD; Kaplan S; Katolik L; Kennedy SA; Kessler MW; Kimball HL; Kraan GA; Martineau PA; McAuliffe J; McCabe SJ; McKee DM; Merrell G; Metzger C; Nancollas M; Nelson DL; Nyszkiewicz R; Ortiz JA; Owens PW; Palmer JM; Paz L; Pess GM; Polatsch D; Frank Raia J; Richard MJ; Rizzo M; Rozental ; Ruchelsman D; Semenkin OM; Aguilar JFS; Siff T; Sodha S; Spath C; Spruijt S; Stackhouse TG; Swigart C; Szabo RM; Taras J; Tavakolian JD; Terrono AL; Varecka TF; Wahegaonkar AL; Walsh CJ; Walter FL, 2016, 'Assessment of decisional conflict about the treatment of carpal tunnel syndrome, comparing patients and physicians', Archives of Bone and Joint Surgery, 4, pp. 150 - 155

Ernst DS; Petrella T; Joshua AM; Hamou A; Thabane M; Vantyghem S; Gwadry-Sridhar F, 2016, 'Burden of illness for metastatic melanoma in Canada, 2011–2013', Current Oncology, 23, pp. e563 - e570, http://dx.doi.org/10.3747/co.23.3161

Todenhöfer T; Azad A; Gao J; Stewart C; Eigl B; Stenzl A; Black P; Teich M; Joshua A; Chi K, 2016, '774 ARV7 detected by a novel whole-blood RT-PCR assay correlates with outcomes in metastatic castration-resistant prostate cancer (mCRPC) patients treated with abiraterone acetate (ABI)', European Urology Supplements, 15, pp. e774 - e774, http://dx.doi.org/10.1016/s1569-9056(16)60776-5

Todenhöfer T; Azad A; Gao J; Stewart C; Eigl B; Stenzl A; Teich M; Black P; Joshua A; Chi K, 2016, 'PD28-04 DETECTION OF ANDROGEN RECEPTOR VARIANT 7 (AR-V7) IN WHOLE BLOOD RNA OF METASTATIC CASTRATION-RESISTANT PROSTATE CANCER (MCRPC) PATIENTS TREATED WITH ABIRATERONE ACETATE (ABI)', Journal of Urology, 195, http://dx.doi.org/10.1016/j.juro.2016.02.391

Robert C; Ribas A; Hamid O; Daud A; Wolchok JD; Joshua AM; Hwu W-J; Weber JS; Gangadhar TC; Joseph R; Dronca R; Patnaik A; Zarour H; Kefford R; Hersey P; Li XN; Diede SJ; Ebbinghaus S; Hodi S, 2016, 'Survie à 3 ans des patients traités pour mélanome métastatique par prembrolizumab (Keynote-001) et devenir des patients en réponse complète', Annales de Dermatologie et de Vénéréologie, 143, pp. S209 - S210, http://dx.doi.org/10.1016/j.annder.2016.09.264

Chi K; Hotte SJ; Joshua AM; North S; Wyatt AW; Collins LL; Saad F, 2015, 'Treatment of mCRPC in the AR-axis-targeted therapy-resistant state', Annals of Oncology, 26, pp. 2044 - 2056, http://dx.doi.org/10.1093/annonc/mdv267

Khoja L; Butler MO; Chappell MA; Hogg D; Joshua AM, 2015, 'Increased treatment-related toxicity subsequent to an anti–PD-1 agent', Current Oncology, 22, pp. e320 - e322, http://dx.doi.org/10.3747/co.22.2418

Khoja L; Butler MO; Kang SP; Ebbinghaus S; Joshua AM, 2015, 'Pembrolizumab', Journal for ImmunoTherapy of Cancer, 3, http://dx.doi.org/10.1186/s40425-015-0078-9

Seah JA; Leibowitz-Amit R; Atenafu EG; Alimohamed N; Knox JJ; Joshua AM; Sridhar SS, 2015, 'Neutrophil-Lymphocyte Ratio and Pathological Response to Neoadjuvant Chemotherapy in Patients with Muscle-Invasive Bladder Cancer', Clinical Genitourinary Cancer, 13, pp. e229 - e233, http://dx.doi.org/10.1016/j.clgc.2015.02.001

Joshua AM; Monzon JG; Mihalcioiu C; Hogg D; Smylie M; Cheng T, 2015, 'A phase 2 study of tremelimumab in patients with advanced uveal melanoma', Melanoma Research, 25, pp. 342 - 347, http://dx.doi.org/10.1097/CMR.0000000000000175

Joshua AM; Shore ND; Saad F; Chi KN; Olsson CA; Emmenegger U; Scholz M; Berry W; Mukherjee SD; Winquist E; Haas NB; Foley MA; Dmuchowski C; Perabo F; Hirmand M; Hasabou N; Rathkopf D, 2015, 'Safety of enzalutamide in patients with metastatic castration-resistant prostate cancer previously treated with docetaxel: Expanded access in North America', Prostate, 75, pp. 836 - 844, http://dx.doi.org/10.1002/pros.22965

Puts M; Sattar S; McWatters K; Lee K; Amir E; Krzyzanowska MK; Joshua AM; Monette J; Wan-Chow-Wah D; Jang RW-J; Alibhai SMH, 2015, 'A feasibility trial of geriatric assessment and integrated care plan for older cancer patients.', Journal of Clinical Oncology, 33, pp. TPS9634 - TPS9634, http://dx.doi.org/10.1200/jco.2015.33.15_suppl.tps9634

McWhirter E; Hamid O; Chmielowski B; Carvajal RD; Jaffray DA; Driscoll B; Shek T; Yeung I; Keller H; McKee TD; Pearce TE; Kroll S; Joshua AM, 2015, 'A Phase 2 biomarker-enriched study of evofosfamide (TH-302) in patients with advanced melanoma.', Journal of Clinical Oncology, 33, pp. TPS9089 - TPS9089, http://dx.doi.org/10.1200/jco.2015.33.15_suppl.tps9089

Robert C; Joshua AM; Kefford R; Joseph RW; Wolchok JD; Hodi FS; Hamid O; Weber JS; Gangadhar TC; Dronca RS; Patnaik A; Zarour HM; Hwu W-J; Hersey P; Daud A; Giannotti M; Li XN; Ebbinghaus S; Kang SP; Ribas A, 2015, 'Association of immune-related thyroid disorders with pembrolizumab (pembro, MK-3475) in patients (pts) with advanced melanoma treated in KEYNOTE-001.', Journal of Clinical Oncology, 33, pp. 9050 - 9050, http://dx.doi.org/10.1200/jco.2015.33.15_suppl.9050

Khoja L; Kurtz G; Bernstein M; Joshua AM; Hogg D; Zadeh G; Laperriere N; Menard C; Miller B-A; Kongkham PN; Atenafu EG; Butler MO; Chung C, 2015, 'Brain radiosurgery and ipilimumab (Ipi) in melanoma brain metastases (MBM) patients: Does an enhanced immune response induce radionecrosis (RN)?', Journal of Clinical Oncology, 33, pp. e20019 - e20019, http://dx.doi.org/10.1200/jco.2015.33.15_suppl.e20019

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