By Associate Professor Anthony Michael Joshua

Journal articles

Joseph RW; Elassaiss-Schaap J; Kefford R; Hwu WJ; Wolchok JD; Joshua AM; Ribas A; Stephen Hodi F; Hamid O; Robert C; Daud A; Dronca R; Hersey P; Weber JS; Patnaik A; de Alwis DP; Perrone A; Zhang J; Peter Kang S; Ebbinghaus S; Anderson KM; Gangadhar TC, 2018, 'Correction: Baseline tumor size is an research independent prognostic factor for overall survival in patients with melanoma treated with pembrolizumab(Clin Cancer Res (2018)24(4960–7)DOI: 10.1158/1078-0432.CCR-17-2386)', Clinical Cancer Research, 24, pp. 6098, http://dx.doi.org/10.1158/1078-0432.CCR-18-3340

Nicholas MN; Khoja L; Atenafu EG; Hogg D; Quirt I; Butler M; Joshua AM, 2018, 'Prognostic factors for first-line therapy and overall survival of metastatic uveal melanoma: The Princess Margaret Cancer Centre experience', Melanoma Research, 28, pp. 571 - 577, http://dx.doi.org/10.1097/CMR.0000000000000468

Tio M; Rai R; Ezeoke OM; McQuade JL; Zimmer L; Khoo C; Park JJ; Spain L; Turajlic S; Ardolino L; Yip D; Goldinger SM; Cohen JV; Millward M; Atkinson V; Kane AY; Ascierto PA; Garbe C; Gutzmer R; Johnson DB; Rizvi HA; Joshua AM; Hellmann MD; Long GV; Menzies AM, 2018, 'Anti-PD-1/PD-L1 immunotherapy in patients with solid organ transplant, HIV or hepatitis B/C infection', European Journal of Cancer, 104, pp. 137 - 144, http://dx.doi.org/10.1016/j.ejca.2018.09.017

Park JJ; Diefenbach RJ; Joshua AM; Kefford RF; Carlino MS; Rizos H, 2018, 'Oncogenic signaling in uveal melanoma', Pigment Cell and Melanoma Research, 31, pp. 661 - 672, http://dx.doi.org/10.1111/pcmr.12708

Joseph RW; Elassaiss-Schaap J; Kefford R; Hwu WJ; Wolchok JD; Joshua AM; Ribas A; Hodi FS; Hamid O; Robert C; Daud A; Dronca R; Hersey P; Weber JS; Patnaik A; De Alwis DP; Perrone A; Zhang J; Kang SP; Ebbinghaus S; Anderson KM; Gangadhar TC, 2018, 'Baseline tumor size is an independent prognostic factor for overall survival in patients with melanoma treated with pembrolizumab', Clinical Cancer Research, 24, pp. 4960 - 4967, http://dx.doi.org/10.1158/1078-0432.CCR-17-2386

Lorente D; De Velasco Oria GA; Carles J; Gillessen S; Fizazi K; Joshua A; Eisenberger M; Sartor O; de Bono JS, 2018, 'Statin use and outcome in metastatic castration-resistant prostate cancer (mCRPC) patients (pts) treated in the TROPIC trial', Annals of oncology : official journal of the European Society for Medical Oncology, 29, pp. viii279 - viii280, http://dx.doi.org/10.1093/annonc/mdy284.018

Gordevicius J; Krisci unas A; Groot DE; Yip SM; Susic M; Kwan A; Kustra R; Joshua AM; Chi KN; Petronis A; Oh G, 2018, 'Cell-free DNA modification dynamics in abiraterone acetate-treated prostate cancer patients', Clinical Cancer Research, 24, pp. 3317 - 3324, http://dx.doi.org/10.1158/1078-0432.CCR-18-0101

Robert C; Ribas A; Hamid O; Daud A; Wolchok JD; Joshua AM; Hwu WJ; Weber JS; Gangadhar TC; Joseph RW; Dronca R; Patnaik A; Zarour H; Kefford R; Hersey P; Zhang J; Anderson J; Diede SJ; Ebbinghaus S; Hodi FS, 2018, 'Durable complete response after discontinuation of pembrolizumab in patients with metastatic melanoma', Journal of Clinical Oncology, 36, pp. 1668 - 1674, http://dx.doi.org/10.1200/JCO.2017.75.6270

Tannock IF; Joshua AM, 2018, 'Purchasing silence', Annals of Oncology, 29, pp. 1339 - 1340, http://dx.doi.org/10.1093/annonc/mdy131

Hamid O; Robert C; Daud A; Hodi FS; Hwu W-J; Kefford R; Wolchok JD; Hersey P; Joseph RW; Weber JS; Dronca RS; Mitchell TC; Patnaik A; Zarour HM; Joshua AM; Jensen E; Ibrahim N; Ahsan S; Ribas A, 2018, '5-year survival outcomes in patients (pts) with advanced melanoma treated with pembrolizumab (pembro) in KEYNOTE-001.', Journal of Clinical Oncology, 36, pp. 9516 - 9516, http://dx.doi.org/10.1200/jco.2018.36.15_suppl.9516

Tabernero J; Luke JJ; Joshua AM; Varga AI; Moreno V; Desai J; Markman B; Gomez-Roca CA; De Braud FG; Patel SP; Carlino MS; Siu LL; Curigliano G; Liu Z; Ishii Y; Phillips P; Wind-Rotolo M; Basciano PA; Azrilevich A; Gelmon KA, 2018, 'BMS-986205, an indoleamine 2,3-dioxygenase 1 inhibitor (IDO1i), in combination with nivolumab (NIVO): Updated safety across all tumor cohorts and efficacy in pts with advanced bladder cancer (advBC).', Journal of Clinical Oncology, 36, pp. 4512 - 4512, http://dx.doi.org/10.1200/jco.2018.36.15_suppl.4512

Crumbaker M; Savdie R; Joshua AM, 2018, 'Refining the Assessment and Implications of AR-V7 in Castrate-resistant Prostate Cancer', European Urology, 73, pp. 736 - 737, http://dx.doi.org/10.1016/j.eururo.2017.11.005

Benidir T; Hersey K; Finelli A; Hamilton R; Joshua AM; Kulkarni G; Zlotta A; Fleshner N, 2018, 'Understanding how prostate cancer patients value the current treatment options for metastatic castration resistant prostate cancer', Urologic Oncology: Seminars and Original Investigations, 36, pp. 240.e13 - 240.e20, http://dx.doi.org/10.1016/j.urolonc.2018.01.011

Yu EY; Ellard SL; Hotte SJ; Gingerich JR; Joshua AM; Gleave ME; Chi KN, 2018, 'A randomized phase 2 study of a HSP27 targeting antisense, apatorsen with prednisone versus prednisone alone, in patients with metastatic castration resistant prostate cancer', Investigational New Drugs, 36, pp. 278 - 287, http://dx.doi.org/10.1007/s10637-017-0553-x

Francini E; Yip S; Ahmed S; Li H; Ardolino L; Evan CP; Kaymakcalan M; Shaw GK; Kantoff PW; Taplin ME; Alimohamed NS; Joshua AM; Heng DYC; Sweeney CJ, 2018, 'Clinical Outcomes of First-line Abiraterone Acetate or Enzalutamide for Metastatic Castration-resistant Prostate Cancer After Androgen Deprivation Therapy + Docetaxel or ADT Alone for Metastatic Hormone-sensitive Prostate Cancer', Clinical Genitourinary Cancer, 16, pp. 130 - 134, http://dx.doi.org/10.1016/j.clgc.2017.12.012

Puts MTE; Sattar S; Kulik M; MacDonald ME; McWatters K; Lee K; Brennenstuhl S; Jang R; Amir E; Krzyzanowska MK; Joshua AM; Monette J; Wan-Chow-Wah D; Alibhai SMH, 2018, 'A randomized phase II trial of geriatric assessment and management for older cancer patients', Supportive Care in Cancer, 26, pp. 109 - 117, http://dx.doi.org/10.1007/s00520-017-3820-7

Niraula S; Templeton AJ; Vera-Badillo F; Dodd A; Nugent Z; Joshua AM; Tannock IF, 2018, 'Duration of suppression of bone turnover following treatment with zoledronic acid in men with metastatic castration-resistant prostate cancer', Future Science OA, 4, http://dx.doi.org/10.4155/fsoa-2017-0094

Aung KL; Bedard PL; Yu C; Boerner SL; Zuzarte PC; Ghai S; Berman HK; Serra S; Giesler A; Ahmed L; Joshua AM; Moore MJ; Oza AM; Amir E; McPherson JD; Zhang T; Sukhai MA; Stockley TL; Kamel-Reid S; Siu LL; Hansen AR, 2018, 'Minimally invasive real-time detection of actionable mutations in patients with metastatic solid tumors using fine-needle and liquid biopsies', JCO Precision Oncology, 2, pp. 1 - 20, http://dx.doi.org/10.1200/PO.17.00248

Emmett L; Van Leeuwen PJ; Nandurkar R; Scheltema MJ; Cusick T; Hruby G; Kneebone A; Eade T; Fogarty G; Jagavkar R; Nguyen Q; Ho B; Joshua AM; Stricker P, 2017, 'Treatment outcomes from ⁶⁸Ga-PSMA PET/CT-informed salvage radiation treatment in men with rising PSA after radical prostatectomy: Prognostic value of a negative PSMA PET', Journal of Nuclear Medicine, 58, pp. 1972 - 1976, http://dx.doi.org/10.2967/jnumed.117.196683

Liang Y; Ahmed M; Guo H; Soares F; Hua JT; Gao S; Lu C; Poon C; Han W; Langstein J; Ekram MB; Li B; Davicioni E; Takhar M; Erho N; Karnes RJ; Chadwick D; Van Der Kwast T; Boutros PC; Arrowsmith CH; Feng FY; Joshua AM; Zoubeidi A; Cai C; He HH, 2017, 'LSD1-mediated epigenetic reprogramming drives CENPE expression and prostate cancer progression', Cancer Research, 77, pp. 5479 - 5490, http://dx.doi.org/10.1158/0008-5472.CAN-17-0496

Francini E; Yip S; Ahmed NS; Li H; Ardolino L; Evan CP; Kaymakcalan M; Shaw GK; Kantoff P; Taplin ME; Alimohamed N; Joshua AM; Heng DYC; Sweeney CJ, 2017, 'Outcomes of prechemotherapy (pCRx) abiraterone acetate (AA) or enzalutamide (E) for metastatic castration-resistant prostate cancer (mCRPC) after ADT plus Docetaxel (D) or ADT alone for metastatic hormone sensitive prostate cancer (mHSPC) in a multi-institution hospital-based registry', ANNALS OF ONCOLOGY, 28, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000411324001321&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Fallah-Rad N; Lee R; Ng P; Smith AD; Hansen AR; Joshua AM; Sridhar SS, 2017, 'Strategies to minimize wastage of expensive drugs in expensive times: Cabazitaxel, a single center experience.', Journal of Clinical Oncology, 35, pp. e18297 - e18297, http://dx.doi.org/10.1200/jco.2017.35.15_suppl.e18297

Montgomery B; Tretiakova MS; Joshua AM; Gleave ME; Fleshner N; Bubley GJ; Mostaghel EA; Chi KN; Lin DW; Sanda M; Novotny W; Wu K; Kantoff PW; Marck BT; Plymate S; Balk SP; Nelson PS; Matsumoto AM; Lis RT; Kibel A; Haas GP; Krivoshik A; Hannah A; Taplin ME, 2017, 'Neoadjuvant enzalutamide prior to prostatectomy', Clinical Cancer Research, 23, pp. 2169 - 2176, http://dx.doi.org/10.1158/1078-0432.CCR-16-1357

Tan Q; Joshua AM; Wang M; Bristow RG; Wouters BG; Allen CJ; Tannock IF, 2017, 'Up-regulation of autophagy is a mechanism of resistance to chemotherapy and can be inhibited by pantoprazole to increase drug sensitivity', Cancer Chemotherapy and Pharmacology, 79, pp. 959 - 969, http://dx.doi.org/10.1007/s00280-017-3298-5

Crumbaker M; Khoja L; Joshua AM, 2017, 'AR signaling and the PI3K pathway in prostate cancer', Cancers, 9, pp. 34, http://dx.doi.org/10.3390/cancers9040034

Poudineh M; Aldridge PM; Ahmed S; Green BJ; Kermanshah L; Nguyen V; Tu C; Mohamadi RM; Nam RK; Hansen A; Sridhar SS; Finelli A; Fleshner NE; Joshua AM; Sargent EH; Kelley SO, 2017, 'Tracking the dynamics of circulating tumour cell phenotypes using nanoparticle-mediated magnetic ranking', Nature Nanotechnology, 12, pp. 274 - 281, http://dx.doi.org/10.1038/nnano.2016.239

Puts MTE; Sattar S; McWatters K; Lee K; Kulik M; MacDonald ME; Jang R; Amir E; Krzyzanowska MK; Leighl N; Fitch M; Joshua AM; Warde P; Tourangeau AE; Alibhai SMH, 2017, 'Chemotherapy treatment decision-making experiences of older adults with cancer, their family members, oncologists and family physicians: a mixed methods study', Supportive Care in Cancer, 25, pp. 879 - 886, http://dx.doi.org/10.1007/s00520-016-3476-8

Atkinson TM; Hay JL; Shoushtari A; Li Y; Paucar DJ; Smith SC; Kudchadkar RR; Doyle A; Sosman JA; Quevedo JF; Milhem MM; Joshua AM; Linette GP; Gajewski TF; Lutzky J; Lawson DH; Lao CD; Flynn PJ; Albertini MR; Sato T; Lewis K; Marr B; Abramson DH; Dickson MA; Schwartz GK; Carvajal RD, 2017, 'Relationship between physician-adjudicated adverse events and patient-reported health-related quality of life in a phase II clinical trial (NCT01143402) of patients with metastatic uveal melanoma', Journal of Cancer Research and Clinical Oncology, 143, pp. 439 - 445, http://dx.doi.org/10.1007/s00432-016-2318-x

Pitcher B; Khoja L; Hamilton RJ; Abdallah K; Pintilie M; Joshua AM, 2017, 'Assessment of a prognostic model, PSA metrics and toxicities in metastatic castrate resistant prostate cancer using data from Project Data Sphere (PDS)', PLoS ONE, 12, http://dx.doi.org/10.1371/journal.pone.0170544

Todenhöfer T; Azad A; Stewart C; Gao J; Eigl BJ; Gleave ME; Joshua AM; Black PC; Chi KN, 2017, 'AR-V7 Transcripts in Whole Blood RNA of Patients with Metastatic Castration Resistant Prostate Cancer Correlate with Response to Abiraterone Acetate', Journal of Urology, 197, pp. 135 - 142, http://dx.doi.org/10.1016/j.juro.2016.06.094

Gwadry-Sridhar F; Nikan S; Hamou A; Seung SJ; Petrella T; Joshua AM; Ernst S; Mittmann N, 2017, 'Resource utilization and costs of managing patients with advanced melanoma: A canadian population-based study', Current Oncology, 24, pp. 168 - 175, http://dx.doi.org/10.3747/co.24.3432

Kanjanapan Y; Day D; Butler M; Wang L; Joshua AM; Hogg D; Leighl NB; Razak ARA; Hansen AR; Boujos S; Chappell MA; Chow K; Paolo M; Sherwin B; Stayner L-A; Soultani L; Zambrana A; Siu LL; Bedard PL; Spreafico A, 2017, 'Immune related adverse events (irAEs) in early phase immunotherapy (IO) trials: Implications for recommended phase 2 dose (RP2D) determination', Annals of Oncology, 28, pp. v132 - v132, http://dx.doi.org/10.1093/annonc/mdx367.030

Khoja L; Atenafu E; Joshua AM; Ocular Melanoma Group IRCI, 2017, 'Validating prognostic models in metastatic uveal melanoma (MUM), an international rare cancers initiative', Annals of Oncology, 28, pp. v439 - v439, http://dx.doi.org/10.1093/annonc/mdx377.025

Daud AI; Wolchok JD; Robert C; Hwu WJ; Weber JS; Ribas A; Hodi FS; Joshua AM; Kefford R; Hersey P; Joseph R; Gangadhar TC; Dronca R; Patnaik A; Zarour H; Roach C; Toland G; Lunceford JK; Li XN; Emancipator K; Dolled-Filhart M; Kang SP; Ebbinghaus S; Hamid O, 2016, 'Programmed death-ligand 1 expression and response to the anti-programmed death 1 antibody pembrolizumab in melanoma', Journal of Clinical Oncology, 34, pp. 4102 - 4109, http://dx.doi.org/10.1200/JCO.2016.67.2477

Khoja L; Kibiro M; Metser U; Gedye C; Hogg D; Butler MO; Atenafu EG; Joshua AM, 2016, 'Patterns of response to anti-PD-1 treatment: An exploratory comparison of four radiological response criteria and associations with overall survival in metastatic melanoma patients', British Journal of Cancer, 115, pp. 1186 - 1192, http://dx.doi.org/10.1038/bjc.2016.308

Stockley TL; Oza AM; Berman HK; Leighl NB; Knox JJ; Shepherd FA; Chen EX; Krzyzanowska MK; Dhani N; Joshua AM; Tsao MS; Serra S; Clarke B; Roehrl MH; Zhang T; Sukhai MA; Califaretti N; Trinkaus M; Shaw P; van der Kwast T; Wang L; Virtanen C; Kim RH; Razak ARA; Hansen AR; Yu C; Pugh TJ; Kamel-Reid S; Siu LL; Bedard PL, 2016, 'Molecular profiling of advanced solid tumors and patient outcomes with genotype-matched clinical trials: The Princess Margaret IMPACT/COMPACT trial', Genome Medicine, 8, http://dx.doi.org/10.1186/s13073-016-0364-2

Khoja L; Atenafu EG; Templeton A; Qye Y; Chappell MA; Saibil S; Hogg D; Butler MO; Joshua AM, 2016, 'The full blood count as a biomarker of outcome and toxicity in ipilimumab-treated cutaneous metastatic melanoma', Cancer Medicine, 5, pp. 2792 - 2799, http://dx.doi.org/10.1002/cam4.878

Corfield J; Crozier J; Joshua A; Bolton D; Lawrentschuck N, 2016, 'Understanding the role of new systemic agents in the treatment of prostate cancer', BJU International, 118, pp. 8 - 13, http://dx.doi.org/10.1111/bju.13633

Smith AD; Truong M; Bristow R; Yip P; Milosevic MF; Joshua AM, 2016, 'The utility of serum ca9 for prognostication in prostate cancer', Anticancer Research, 36, pp. 4489 - 4492, http://dx.doi.org/10.21873/anticanres.10994

Azad A; Todenhöfer T; Stewart C; Gao J; Eigl BJ; Black PC; Joshua AM; Chi KN, 2016, 'Correlation of AR-V7 expression in whole blood with efficacy of abiraterone acetate (ABI) in metastatic castration-resistant prostate cancer (mCRPC) patients (pts).', Journal of Clinical Oncology, 34, pp. e23075 - e23075, http://dx.doi.org/10.1200/jco.2016.34.15_suppl.e23075

Khoja L; Atenafu EG; Joshua AM, 2016, 'Meta-analysis of phase II trials in metastatic uveal melanoma (MUM) to determine progression-free (PFS) and overall survival (OS) benchmarks for future phase II trials: An irci-ocular melanoma initiative.', Journal of Clinical Oncology, 34, pp. 9567 - 9567, http://dx.doi.org/10.1200/jco.2016.34.15_suppl.9567

Nicholas M; Khoja L; Hogg D; Quirt I; Butler MO; Joshua AM, 2016, 'Prognosticators of first line treatment for metastatic uveal melanoma (MUM).', Journal of Clinical Oncology, 34, pp. 9570 - 9570, http://dx.doi.org/10.1200/jco.2016.34.15_suppl.9570

Robert C; Ribas A; Hamid O; Daud A; Wolchok JD; Joshua AM; Hwu W-J; Weber JS; Gangadhar TC; Joseph RW; Dronca RS; Patnaik A; Zarour HM; Kefford R; Hersey P; Li X; Diede SJ; Ebbinghaus S; Hodi FS, 2016, 'Three-year overall survival for patients with advanced melanoma treated with pembrolizumab in KEYNOTE-001.', Journal of Clinical Oncology, 34, pp. 9503 - 9503, http://dx.doi.org/10.1200/jco.2016.34.15_suppl.9503

Hodi FS; Hwu WJ; Kefford R; Weber JS; Daud A; Hamid O; Patnaik A; Ribas A; Robert C; Gangadhar TC; Joshua AM; Hersey P; Dronca R; Joseph R; Hille D; Xue D; Li XN; Kang SP; Ebbinghaus S; Perrone A; Wolchok JD, 2016, 'Evaluation of immune-related response criteria and RECIST v1.1 in patients with advanced melanoma treated with Pembrolizumab', Journal of Clinical Oncology, 34, pp. 1510 - 1517, http://dx.doi.org/10.1200/JCO.2015.64.0391

Ribas A; Hamid O; Daud A; Hodi FS; Wolchok JD; Kefford R; Joshua AM; Patnaik A; Hwu WJ; Weber JS; Gangadhar TC; Hersey P; Dronca R; Joseph RW; Zarour H; Chmielowski B; Lawrence DP; Algazi A; Rizvi NA; Hoffner B; Mateus C; Gergich K; Lindia JA; Giannotti M; Li XN; Ebbinghaus S; Kang SP; Robert C, 2016, 'Association of pembrolizumab with tumor response and survival among patients with advanced melanoma', JAMA - Journal of the American Medical Association, 315, pp. 1600 - 1609, http://dx.doi.org/10.1001/jama.2016.4059

Chi KN; Kheoh T; Ryan CJ; Molina A; Bellmunt J; Vogelzang NJ; Rathkopf DE; Fizazi K; Kantoff PW; Li J; Azad AA; Eigl BJ; Heng DYC; Joshua AM; de Bono JS; Scher HI, 2016, 'A prognostic index model for predicting overall survival in patients with metastatic castration-resistant prostate cancer treated with abiraterone acetate after docetaxel', Annals of Oncology, 27, pp. 454 - 460, http://dx.doi.org/10.1093/annonc/mdv594

Manokumar T; Aziz S; Breunis H; Rizvi SF; Joshua AM; Tannock IF; Alibhai SMH, 2016, 'A prospective study examining elder-relevant outcomes in older adults with prostate cancer undergoing treatment with chemotherapy or abiraterone', Journal of Geriatric Oncology, 7, pp. 81 - 89, http://dx.doi.org/10.1016/j.jgo.2016.01.003

Khoja L; Maurice C; Chappell M; Macmillan L; Al-Habeeb AS; Al-Faraidy N; Butler MO; Rogalla P; Mason W; Joshua AM; Hogg D, 2016, 'Eosinophilic fasciitis and acute encephalopathy toxicity from pembrolizumab treatment of a patient with metastatic melanoma', Cancer Immunology Research, 4, pp. 175 - 178, http://dx.doi.org/10.1158/2326-6066.CIR-15-0186

Chung C; Khoja L; Kurtz G; Bernstein M; Joshua A; Hogg D; Zadeh G; Laperriere N; Menard C; Millar BA; Kongkham P; Butler M, 2016, 'Local Tumor Flare Following Radiosurgery and Ipilimumab (Ipi) for Melanoma Brain Metastases: Increased Immune Response?', RADIOTHERAPY AND ONCOLOGY, 118, pp. S26 - S26, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000843547000054&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Khoja L; Atenafu EG; Ye Q; Gedye C; Chappell M; Hogg D; Butler MO; Joshua AM, 2016, 'Real-world efficacy, toxicity and clinical management of ipilimumab treatment in metastatic melanoma', Oncology Letters, 11, pp. 1581 - 1585, http://dx.doi.org/10.3892/ol.2015.4069

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