By Associate Professor Carsten Schmitz-Peiffer

Book Chapters

Schmitz-Peiffer C, 2008, 'Protein Kinase C and Insulin Resistance', in , Human Kinetics, pp. 187 - 202, http://dx.doi.org/10.5040/9781492595748.ch-014

Journal articles

Small L; Nguyen T-V; Larance M; Saunders DN; Hoy AJ; Schmitz-Peiffer C; Cooney GJ; Brandon AE, 2024, 'Liver proteomics identifies a disconnect between proteins associated with de novo lipogenesis and triglyceride storage.', J Lipid Res, pp. 100687, http://dx.doi.org/10.1016/j.jlr.2024.100687

Small L; Schmitz-Peiffer C; Brandon A, 2024, 'Liver proteomic assessment of mice fed high carbohydrate and high fat diets identify a disconnect between proteins associated with de novo lipogenesis and fat.', Obesity Research & Clinical Practice, 18, pp. S11 - S11, http://dx.doi.org/10.1016/j.orcp.2024.09.025

Thai LM; O'Reilly L; Reibe-Pal S; Sue N; Holliday H; Small L; Schmitz-Peiffer C; Dhenni R; Wang-Wei Tsai V; Norris N; Yau B; Zhang X; Lee K; Yan C; Shi YC; Kebede MA; Brink R; Cooney GJ; Irvine KM; Breit SN; Phan TG; Swarbrick A; Biden TJ, 2023, 'β-cell function is regulated by metabolic and epigenetic programming of islet-associated macrophages, involving Axl, Mertk, and TGFβ receptor signaling', iScience, 26, http://dx.doi.org/10.1016/j.isci.2023.106477

Schmitz-Peiffer C, 2020, 'PKC is not a one-trick pony. Invited Comment on CrossTalk 47: ‘Intramuscular lipid accumulation causes insulin resistance’', The Journal of Physiology, 598, pp. 3813 - 3814, http://dx.doi.org/10.1113/JP279715

Schmitz-Peiffer C, 2020, 'Deconstructing the Role of PKC Epsilon in Glucose Homeostasis', Trends in Endocrinology and Metabolism, 31, pp. 344 - 356, http://dx.doi.org/10.1016/j.tem.2020.01.016

Brandon AE; Liao BM; Diakanastasis B; Parker BL; Raddatz K; McManus SA; O'Reilly L; Kimber E; van der Kraan AG; Hancock D; Henstridge DC; Meikle PJ; Cooney GJ; James DE; Reibe S; Febbraio MA; Biden TJ; Schmitz-Peiffer C, 2019, 'Protein Kinase C Epsilon Deletion in Adipose Tissue, but Not in Liver, Improves Glucose Tolerance', Cell Metabolism, 29, pp. 183 - 191.e7, http://dx.doi.org/10.1016/j.cmet.2018.09.013

Schmitz-Peiffer C, 2019, 'Invited talk: Protein kinase Ce in adipose tissue – Not merely an effector but a regulator of lipid intermediates?', Obesity Research & Clinical Practice, 13, pp. 32 - 32, http://dx.doi.org/10.1016/j.orcp.2016.10.036

Schmitz-Peiffer C, 2019, 'Tissue-specific actions of protein kinase C epsilon in the modulation of insulin signalling and glucose tolerance', Obesity Research & Clinical Practice, 13, pp. 263 - 264, http://dx.doi.org/10.1016/j.orcp.2018.11.082

Turner N; Lim XY; Toop HD; Osborne B; Brandon AE; Taylor EN; Fiveash CE; Govindaraju H; Teo JD; McEwen HP; Couttas TA; Butler SM; Das A; Kowalski GM; Bruce CR; Hoehn KL; Fath T; Schmitz-Peiffer C; Cooney GJ; Montgomery MK; Morris JC; Don AS; Brandon A, 2018, 'A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism', Nature Communications, 9, pp. 3165, http://dx.doi.org/10.1038/s41467-018-05613-7

Schmitz-Peiffer C, 2018, 'Anarchy in the UPR: A Ca²⁺-insensitive PKC inhibits SERCA activity to promote ER stress', Bioscience Reports, 38, http://dx.doi.org/10.1042/BSR20170966

Chandrashekaran IR; Norton RS; Schmitz-Peiffer C, 2018, 'Characterisation of peptide interactions that regulate PKCε activation', FEBS Letters, 592, pp. 179 - 189, http://dx.doi.org/10.1002/1873-3468.12953

Montgomery MK; Brown SHJ; Lim XY; Fiveash CE; Osborne B; Bentley NL; Braude JP; Mitchell TW; Coster ACF; Don AS; Cooney GJ; Schmitz-Peiffer C; Turner N, 2016, 'Regulation of glucose homeostasis and insulin action by ceramide acyl-chain length: A beneficial role for very long-chain sphingolipid species', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1861, pp. 1828 - 1839, http://dx.doi.org/10.1016/j.bbalip.2016.08.016

Liao BM; McManus SA; Hughes WE; Schmitz-Peiffer C, 2016, 'Flavin-containing monooxygenase 3 reduces endoplasmic reticulum stress in lipid-treated hepatocytes', Molecular Endocrinology, 30, pp. 417 - 428, http://dx.doi.org/10.1210/me.2015-1217

Hayward B; Molero JC; Windmill K; Sanigorski A; Weir J; McRae NL; Aston-Mourney K; Osborne B; Liao B; Walder KR; Meikle PJ; Konstantopoulos N; Schmitz-Peiffer C, 2016, 'Pathways of Acetyl-CoA Metabolism Involved in the Reversal of Palmitate-Induced Glucose Production by Metformin and Salicylate', Experimental and Clinical Endocrinology and Diabetes, 124, pp. 602 - 612, http://dx.doi.org/10.1055/s-0042-111516

Liao BM; Raddatz K; Zhong L; Parker BL; Raftery MJ; Schmitz-Peiffer C, 2014, 'Proteomic analysis of livers from fat-fed mice deficient in either PKCδ or PKCε identifies Htatip2 as a regulator of lipid metabolism', Proteomics, 14, pp. 2578 - 2587, http://dx.doi.org/10.1002/pmic.201400202

Frangioudakis G; Diakanastasis B; Liao BQM; Saville JT; Hoffman NJ; Mitchell TW; Schmitz-Peiffer C, 2013, 'Ceramide accumulation in L6 skeletal muscle cells due to increased activity of ceramide synthase isoforms has opposing effects on insulin action to those caused by palmitate treatment', Diabetologia, 56, pp. 2697 - 2701, http://dx.doi.org/10.1007/s00125-013-3035-5

Schmitz-Peiffer C, 2013, 'The tail wagging the dog - Regulation of lipid metabolism by protein kinase C', FEBS Journal, 280, pp. 5371 - 5383, http://dx.doi.org/10.1111/febs.12285

Lismaa SE; Aplin M; Holman S; Yiu T; Jackson K; Burchfield JG; Mitchell CJ; O'Reilly L; Davenport A; Cantley J; Schmitz-Peiffer C; Biden TJ; Cooney GJ; Graham RM, 2013, 'Glucose Homeostasis in Mice Is Transglutaminase 2 Independent', PLoS One, 8, pp. Article numbere63346, http://dx.doi.org/10.1371/journal.pone.0063346

Schmitz-Peiffer C; Raddatz K; Liao B-QM; Diakanastasis B, 2012, 'Proteomic analysis of livers from fat-fed PKC epsilon and PKC delta KO mice: insights into the modulation hepatic lipid metabolism as well as insulin action by PKC isoforms', DIABETOLOGIA, 55, pp. S15 - S15, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000208826500022&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Iyota T; Sun L; Hao F; Schmitz-Peiffer C; Xu X; Cui M-Z, 2012, 'Abstract 126: Lysophosphatidic Acid Induces Early Growth Response Protein 1 Expression via the Protein Kinase Cδ-Regulated ERK and JNK Activation in Vascular Smooth Muscle Cells', Arteriosclerosis, Thrombosis, and Vascular Biology, 32, http://dx.doi.org/10.1161/atvb.32.suppl_1.a126

Raddatz K; Frangioudakis G; Diakanastasis B; Liao BM; Leitges M; Schmitz-Peiffer C, 2012, 'Deletion of protein kinase Ce in mice has limited effects on liver metabolite levels but alters fasting ketogenesis and gluconeogenesis', Diabetologia, 55, pp. 2789 - 2793, http://dx.doi.org/10.1007/s00125-012-2647-5

Iyoda T; Zhang F; Sun L; Hao F; Schmitz-Peiffer C; Xu X; Cui M, 2012, 'Lysophosphatidic acid induces early growth response-1 (Egr-1) protein expression via protein kinase Cdelta-regulated extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) activation in vascular smooth muscle cells', The Journal of Biological Chemistry, 287, pp. 22635 - 22642, http://dx.doi.org/10.1074/jbc.M111.335695

Schmitz-Peiffer C; Biden TJ, 2010, 'PKCδ blues for the β-cell', Diabetes, 59, pp. 1 - 3, http://dx.doi.org/10.2337/db09-1439

Frangioudakis G; Garrard J; Raddatz K; Nadler JL; Mitchell T; Schmitz-Peiffer C, 2010, 'Saturated and n-6 polyunsaturated-fat diets each induce ceramide accumulation in moue skeletal muscle: reversal and improvement of glucose tolerance by lipid metabolism inhibitors', Endocrinology, 151, pp. 4187 - 4196

Schmitz-Peiffer C, 2010, 'Targeting ceramide synthesis to reverse insulin resistance', Diabetes, 59, pp. 2351 - 2353

Cantley J; Burchfield JG; Pearson G; Schmitz-Peiffer C; Leitges M; Biden TJ, 2009, 'Deletion of PKC epsilon Selectively Enhances the Amplifying Pathways of Glucose-Stimulated Insulin Secretion via Increased Lipolysis in Mouse beta-Cells', Diabetes, 58, pp. 1826 - 1834

Frangioudakis G; Burchfield JG; Narasimhan S; Cooney GJ; Leitges M; Biden TJ; Schmitz-Peiffer C, 2009, 'Diverse roles for protein kinase C delta and protein kinase C epsilon in the generation of high-fat-diet-induced glucose intolerance in mice: regulation of lipogenesis by protein kinase C delta', Diabetologia, 52, pp. 2616, http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19809797

Schmitz-Peiffer C; Biden TJ, 2008, 'Protein kinase C function in muscle, liver, and beta-cells and its therapeutic implications for type 2 diabetes', Diabetes, 57, pp. 1774 - 1783

Biden TJ; Schmitz-Peiffer C; Burchfield JG; Gurisik E; Cantley J; Mitchell CJ; Carpenter L, 2008, 'The diverse roles of protein kinase C in pancreatic beta-cell function', Biochemical Society Transactions

Cazzolli R; Mitchell T; Burchfield JG; Pedersen D; Turner N; Biden TJ; Schmitz-Peiffer C, 2007, 'Dilinoleoyl-phosphatidic acid mediates reduced IRS-1 tyrosine phosphorylation in rat skeletal muscle cells and mouse muscle', Diabetologia, 50, pp. 1732 - 1742

Schmitz-Peiffer C; Laybutt DR; Burchfield JG; Gurisik E; Narasimhan S; Mitchell CJ; Pedersen D; Braun U; Cooney GJ; Leitges M; Biden TJ, 2007, 'Inhibition of PKC epsilon improves glucose-stimulated insulin secretion and reduces insulin clearance', Cell Metabolism, 6, pp. 320 - 328

Rolph MS; Young TR; Shum BOV; Gorgun CZ; Schmitz-Peiffer C; Ramshaw IA; Hotamisligil GS; Mackay CR, 2006, 'Regulation of dendritic cell function and T cell priming by the fatty acid-binding protein aP2', Journal of Immunology, 177, pp. 7794 - 7801, http://dx.doi.org/10.4049/jimmunol.177.11.7794

Taylor AJ; Ye J; Schmitz-Peiffer C, 2006, 'Inhibition of glycogen synthesis by increased lipid availability is associated with subcellular redistribution of glycogen synthase', Journal of Endocrinology, 188, pp. 11 - 23

Ludowyke RI; Elgund Z; Kranenburg T; Stehn J; Schmitz-Peiffer C; Hughes WE; Biden TJ, 2006, 'Phosphorylation of non-muscle myosin heavy chain IIA on serine-1917 is mediated by protein kinase CâII and coincides with the onset of stimulated degranulation of RBL-2H3 mast cells', Journal of Immunology, 177, pp. 1492 - 1499

Thomas E; Zhe Y; Molero JC; Schmitz-Peiffer C; Ramm G; James DE; Whitehead J, 2006, 'The subcellular fractionation properties and function of insulin receptor substrate-1 (IRS-1) are independent of cytoskeletal integrity', International Journal of Biochemistry and Cell Biology, 38, pp. 1686 - 1699

Schmitz-Peiffer C, 2005, 'Targeting protein kinase C epsilon or theta as a therapeutic strategy for insulin resistance', Drug Discovery Today: Therapeutic Strategies, 2, pp. 105 - 110, http://dx.doi.org/10.1016/j.ddstr.2005.04.002

Cazzolli R; Craig DL; Biden TJ; Schmitz-Peiffer C, 2002, 'Inhibition of glycogen synthesis by fatty acid in C2C12 muscle cells is independent of PKC-alpha, -epsilon, and -theta', AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 282, pp. E1204 - E1213, http://dx.doi.org/10.1152/ajpendo.00487.2001

Schmitz-Peiffer C, 2002, 'Protein kinase C and lipid-induced insulin resistance in skeletal muscle', Annals of the New York Academy of Sciences, 967, pp. 146 - 157, http://dx.doi.org/10.1111/j.1749-6632.2002.tb04272.x

Cazzolli R; Carpenter L; Biden TJ; Schmitz-Peiffer C, 2001, 'A Role for Protein Phosphatase 2A-Like Activity, but Not Atypical Protein Kinase Cζ, in the Inhibition of Protein Kinase B/Akt and Glycogen Synthesis by Palmitate', Diabetes, 50, pp. 2210 - 2218, http://dx.doi.org/10.2337/diabetes.50.10.2210

Schmitz-Peiffer C, 2000, 'Signalling aspects of insulin resistance in skeletal muscle: Mechanisms induced by lipid oversupply', Cellular Signalling, 12, pp. 583 - 594, http://dx.doi.org/10.1016/S0898-6568(00)00110-8

Bell KS; Schmitz-Peiffer C; Lim-Fraser M; Biden TJ; Cooney GJ; Kraegen EW, 2000, 'Acute reversal of lipid-induced muscle insulin resistance is associated with rapid alteration in PKC-theta localization', AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 279, pp. E1196 - E1201, http://dx.doi.org/10.1152/ajpendo.2000.279.5.E1196

Bell KS; Schmitz-Peiffer C; Lim-Fraser M; Biden TJ; Cooney GJ; Kraegen EW, 2000, 'Acute reversal of lipid-induced muscle insulin resistance is associated with rapid alteration in PKC-θ localization', American Journal of Physiology - Endocrinology and Metabolism, 279, http://dx.doi.org/10.1152/ajpendo.2000.279.5.e1196

Schmitz-Peiffer C; Browne CL; Oakes ND; Watkinson A; Chisholm DJ; Kraegen EW; Biden TJ, 1997, 'Alterations in the Expression and Cellular Localization of Protein Kinase C Isozymes ε and θ Are Associated With Insulin Resistance in Skeletal Muscle of the High-Fat–Fed Rat', Diabetes, 46, pp. 169 - 178, http://dx.doi.org/10.2337/diab.46.2.169

Schmitz-Peiffer C; Browne CL; Biden TJ, 1996, 'Characterization of two forms of protein kinase C α, with different substrate specificities, from skeletal muscle', Biochemical Journal, 320, pp. 207 - 214, http://dx.doi.org/10.1042/bj3200207

Schmitz-Peiffer C; Browne CL; Oakes ND; Watkinson A; Chisholm DJ; Kraegen EW; Biden TJ, 1996, 'P-101: Alterations in the expression and cellular localization of protein kinase C isozymes are associated with insulin resistance in skeletal muscle of the high-fat-fed rat', Experimental and Clinical Endocrinology and Diabetes, 104, pp. 161 - 162, http://dx.doi.org/10.1055/s-0029-1211645

Selbie LA; Schmitz-Peiffer C; Sheng Y; Biden TJ, 1993, 'Molecular cloning and characterization of PKCi, an atypical isoform of protein kinase C derived from insulin-secreting cells', Journal of Biological Chemistry, 268, pp. 24296 - 24302

Schmitz-Peiffer C; Reeves ML; Denton RM, 1992, 'Characterization of the cyclic nucleotide phosphodiesterase isoenzymes present in rat epididymal fat cells', Cellular Signalling, 4, pp. 37 - 49, http://dx.doi.org/10.1016/0898-6568(92)90006-T

Denton RM; Tavare JM; Borthwick A; Dickens M; Diggle TA; Edgell NJ; Heesom KJ; Isaad T; Lynch DF; Moule SK; Schmitz-Peiffer C; Welsh GI, 1992, 'Insulin-activated protein kinases in fat and other cells', Biochemical Society Transactions, 20, pp. 659 - 664, http://dx.doi.org/10.1042/bst0200659

Diggle TA; Schmitz-Peiffer C; Borthwick AC; Welsh GI; Denton RM, 1991, 'Evidence that insulin activates casein kinase 2 in rat epididymal fat-cells and that this may result in the increased phosphorylation of an acid-soluble 22 kDa protein', Biochemical Journal, 279, pp. 545 - 551, http://dx.doi.org/10.1042/bj2790545

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