By Associate Professor Emily Sau Wai Wong

Preprints

Cornejo-Páramo P; Petrova V; Zhang X; Young R; Wong E, 2022, Emergence of new enhancers at late DNA replicating regions, http://dx.doi.org/10.1101/2022.12.22.521323

Wong E; Tan SZ; Garside V; Vanwalleghem G; Gaiti F; Scott E; McGlinn E; Francois M; Degnan B, 2019, Early origin and deep conservation of enhancers in animals, http://dx.doi.org/10.1101/633651

Friedman CE; Nguyen Q; Lukowski SW; Helfer A; Chiu HS; Voges HK; Suo SS; Han J-DJ; Osteil P; Peng G; Jing N; Baillie GJ; Senabouth A; Christ AN; Bruxner TJ; Murry CE; Wong ES; Ding J; Wang Y; Hudson J; Bar-Joseph Z; Tam PPL; Powell JE; Palpant NJ, 2018, Cardiac Directed Differentiation Using Small Molecule WNT Modulation at Single-Cell Resolution, http://dx.doi.org/10.2139/ssrn.3155757

Friedman C; Nguyen Q; Lukowski S; Chiu HS; Helfer A; Miklas J; Suo SS; Jackie Han J-D; Osteil P; Peng G; Jing N; Baillie G; Senabouth A; Christ A; Bruxner T; Murry C; Wong E; Ding J; Wang Y; Hudson J; Ruohola-Baker H; Bar-Joseph Z; Tam P; Powell J; Palpant N, 2017, Analysis of cardiac differentiation at single cell resolution reveals a requirement of hypertrophic signaling for HOPX transcription, http://dx.doi.org/10.1101/229294

Wong E; Chenoweth S; Blows M; Powell J, 2017, Evidence for stabilizing selection at pleiotropic loci for human complex traits, http://dx.doi.org/10.1101/126888

Cornejo-Páramo P; Zhang X; Louis L; Yang Y-H; Li Z; Humphreys D; Wong ES, A Bag-Of-Motif Model Captures Cell States at Distal Regulatory Sequences, http://dx.doi.org/10.1101/2024.01.03.574012

Medina-Cano D; Islam MT; Petrova V; Dixit S; Balic Z; Yang MG; Stadtfeld M; Wong ES; Vierbuchen T, A MOUSE ORGANOID PLATFORM FOR MODELING CEREBRAL CORTEX DEVELOPMENT AND CIS-REGULATORY EVOLUTION IN VITRO, http://dx.doi.org/10.1101/2024.09.30.615887

Zhuang X; Wang Q; Joost S; Ferrena A; Humphreys DT; Li Z; Blum M; Bastl K; Ding S; Landais Y; Zhan Y; Zhao Y; Chaligne R; Lee J-H; Carrasco SE; Bhanot UK; Koche RP; Bott MJ; Katajisto P; Soto-Feliciano YM; Pisanic T; Thomas T; Zheng D; Wong ES; Tammela T, Aging limits stemness and tumorigenesis in the lung by reprogramming iron homeostasis, http://dx.doi.org/10.1101/2024.06.23.600305

Petrova V; Niu M; Vierbuchen T; Wong ES, ASPEN: Robust detection of allelic dynamics in single cell RNA-seq, http://dx.doi.org/10.1101/2025.04.16.649227

Subramanian S; Thoms JAI; Huang Y; Cornejo P; Koch FC; Jacquelin S; Shen S; Song E; Joshi S; Brownlee C; Woll PS; Fajardo DC; Beck D; Curtis DJ; Yehson K; Antonenas V; Brien TO; Trickett A; Powell JA; Lewis ID; Pitson SM; Gandhi MK; Lane SW; Vafaee F; Wong ES; Göttgens B; Rokny HA; Wong JWH; Pimanda JE, Cell Type-Specific Regulation by a Heptad of Transcription Factors in Human Hematopoietic Stem and Progenitor Cells, http://dx.doi.org/10.1101/2023.04.18.537282

Floc’hlay S; Wong E; Zhao B; Viales RR; Thomas-Chollier M; Thieffry D; Garfield DA; Furlong EE, Cis acting variation is common, can propagates across multiple regulatory layers, but is often buffered in developmental programs, http://dx.doi.org/10.1101/2020.05.21.107961

Cornejo-Páramo P; Roper K; Degnan SM; Degnan BM; Wong ES, Distal regulation, silencers and a shared combinatorial syntax are hallmarks of animal embryogenesis, http://dx.doi.org/10.1101/2021.09.08.459542

DaSilva LF; Senan S; Patel ZM; Reddy AJ; Gabbita S; Nussbaum Z; Córdova CMV; Wenteler A; Weber N; Tunjic TM; Khan TA; Li Z; Smith C; Bejan M; Louis LK; Cornejo P; Connell W; Wong ES; Meuleman W; Pinello L, DNA-Diffusion: Leveraging Generative Models for Controlling Chromatin Accessibility and Gene Expression via Synthetic Regulatory Elements, http://dx.doi.org/10.1101/2024.02.01.578352

Achinger-Kawecka J; Stirzaker C; Portman N; Campbell E; Chia K-M; Du Q; Laven-Law G; Nair SS; Yong A; Wilkinson A; Clifton S; Milioli HH; Alexandrou S; Caldon CE; Song J; Khoury A; Meyer B; Gee JMW; Schmitt A; Wong ES; Hickey TE; Lim E; Clark SJ, Epigenetic therapy targets the 3D epigenome in endocrine-resistant breast cancer, http://dx.doi.org/10.1101/2021.06.21.449340

Zhou Z; Dai F; Cheng D; Ma X; Omidkhoda SF; Clarke J; Zhang H; Laden M; Guo Y; Li JV; Liu R; Wong ES; Zhang Y; Cox CD, MDFIC2 is a sensory neuron-specific PIEZO channel auxiliary subunit, http://dx.doi.org/10.1101/2025.10.26.684595

Contreras O; Smith GD; Santiago C; Dey M; Thekkedam C; Chand R; González-Rajal Á; Zhong L; Lock JG; Wong E; Fatkin D; Harvey RP, Proteo-transcriptomics and morphometrics of teleost cardiac cells define regulatory networks and exercise-induced cardiomyocyte hypertrophy and hyperplasia, http://dx.doi.org/10.64898/2026.01.11.698907

Marjaneh M; Kirk EP; Patrick R; Alankerage D; Humphreys DT; Del Monte-Nieto G; Cornejo-Paramo P; Janbandhu V; Doan TB; Dunwoodie SL; Wong ES; Moran C; Martin ICA; Thomson PC; Harvey RP, Quantitative trait and transcriptome analysis of genetic complexity underpinning cardiac interatrial septation in mice using an advanced intercross line, http://dx.doi.org/10.1101/2022.10.31.514499

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