By Associate Professor John Zaunders

Journal articles

Kaufmann D; Kavanagh D; Pereyra F; Zaunders J; Mackey E; Miura T; Palmer S; Brockman M; Rathod A; Piechocka-Trocha A; Baker B; Zhu B; Le Gall S; Waring M; Ahern R; Moss K; Kelleher AD; Coffin J; Freeman G; Rosenberg E; Walker BD, 2007, 'Upregulation of CTLA-4 by HIV-specific CD4(+) T cells correlates with disease progression and defines a reversible immune dysfunction', Nature Immunology, 8, pp. 1246 - 1254

Zaunders J; Dyer W; Munier CM; Ip S; Liu J; Amyes E; Rawlinson WD; Rose RJ; Kent SJ; Sullivan JS; Cooper DA; Kelleher AD, 2006, 'CD127+CCR5+CD38+++CD4+ Th1 Effector Cells Are an Early Component of the Primary Immune Response to Vaccinia Virus and Precede Development of Interleukin-2+ Memory CD4+ T Cells', Journal of Virology, 80, pp. 10151 - 10161

Kelleher AD; Zaunders J, 2006, 'Decimated or missing in action:CD4+ T cells as targets and effectors in the pathogenesis of primary HIV infection. Curr HIV/AIDS Rep 2006;3(1):5-12.', Current HIV/AIDS Reports, 3, pp. 5 - 12

Fazekos de St Groth B; Seddiki N; Santner-Nanan B; Martinson J; Zaunders J; Sasson SC; Landay A; Nanan R; Kelleher AD, 2006, 'Expression of IL-2 and IL-7 receptors discriminates between human regulatory and activated T-cells within CD45RA and CD45RO compartments', Clinical Immunology, 119, pp. S7 - S7

Seddiki N; Santner-Nanan B; Martinson J; Zaunders J; Sasson SC; Landay A; Solomon MJ; Selby W; Alexander S; Nanan R; Kelleher AD; Fazekas de St Groth B; Solomon M, 2006, 'Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells', Journal of Experimental Medicine, 203, pp. 1693 - 1700, http://dx.doi.org/10.1084/jem.20060468

Carlin S; Moore JJ; Zaunders J; Kelleher T; Ma DD, 2006, 'Generation in vitro of T lineage cells from human adult haematopoietic stem cells', Clinical Immunology, 119, pp. S160 - S160

Sasson SC; Zaunders J; Zanetti G; King E; Merlin K; Smith DE; Stanley K; Cooper DA; Kelleher AD, 2006, 'Increased plasma interleukin-7 level correlates with decreased CD127 and increased CD132 extracellular expression on T cell subsets in patients with HIV-1 infection', Journal of Infectious Diseases, 193, pp. 505 - 514

Zaunders J; Ip S; Munier CM; Munier M; Kaufmann D; Suzuki K; Brereton C; Seddiki N; Sasson SC; Koelsch KK; Landay A; Grey PA; Finlayson R; Kaldor JM; Rosenberg E; Walker BD; Fazekas de St Groth B; Cooper DA; Kelleher AD, 2006, 'Infection of CD127(+) (Interleukin-7 receptor+) CD4+ cells and overexpression of CTLA-4 are linked to loss of antigen-specific CD4 T cells during primary human immunodeficiency virus type 1 infection', Journal of Virology, 80, pp. 10162 - 10172

Carlin S; Moore JJ; Zaunders J; Kelleher AD; Ma DD, 2006, 'T lineage differentiation in vitro of adult Haematopoietic Stem Cells', CYTOMETRY PART A, 69A, pp. 399 - 400

Sasson SC; Zaunders J; Kelleher AD, 2006, 'The IL-7/IL-7 receptor axis: understanding its central role in T-cell homeostatis and the challenges facing its utilization as a novel therapy. 2006;7:1571-1582.', Current Drug Targets, 7, pp. 1571 - 1582

Bloch MT; Smith DE; Quan D; Kaldor JM; Zaunders J; Petoumenos K; Irvine K; Law MG; Grey PA; Finlayson R; Mcfarlane R; Kelleher AD; Carr AD; Cooper DA, 2006, 'The role of hydroxyurea in enhancing the virologic control achieved through structured treatment interruption in primary HIV infection: Final results from a randomized clinical trial (Pulse)', JAIDS: Journal of Acquired Immune Deficiency Syndromes, 42, pp. 192 - 202

Ammaranond P; Zaunders J; Satchell C; Van Bockel DJ; Cooper DA; Kelleher AD, 2005, 'A new variant cytotoxic T lymphocyte escape mutation in HLA-B27-positive individuals infected with HIV type 1', AIDS Research and Human Retroviruses, 21, pp. 395 - 397

Monceaux V; Viollet L; Petit F; Fang R; Cumont M; Zaunders J; Hurtrel B; Estaquier J, 2005, 'CD8(+) T cell dynamics during primary simian immunodeficiency virus infection in macaques: Relationship of effector cell differentiation with the extent of viral replication', Journal of Immunology, 174, pp. 6898 - 6908

Zaunders J; Munier M; Kaufmann D; Ip S; Grey PA; Smith DE; Ramacciotti TP; Quan D; Finlayson RJ; Kaldor JM; Rosenberg E; Walker BD; Cooper DA; Kelleher AD, 2005, 'Early proliferation of CCR5(+) CD38(+++) antigen-specific CD4(+) Th1 effector cells during primary HIV-1 infection', Blood, 106, pp. 1660 - 1667

Sedwell R; Mallon PW; Duarte NL; Zaunders J; Kelleher AD; Cooper DA; Carr AD, 2005, 'Impaired mitochondrial function induced by NRTIs is only detectable in the monocyte (CD14(+)) subset of human PBMC', Antiviral Therapy, 10, pp. L44 - L45

Suzuki K; Shijuuku T; Fukamachi T; Zaunders J; Guillemin GJ; Cooper DA; Kelleher AD, 2005, 'Prolonged transcriptional silencing and CpG methylation induced by siRNAs targeted to the HIV-1 promoter region.', Journal of RNAi and Gene Silencing, 1, pp. 66 - 78

Alter G; Malenfant JM; Delabre RM; Burgett NC; Yu XG; Lichterfeld M; Zaunders J; Altfeld M, 2004, 'Increased natural killer cell activity in viremic HIV-1 infection', Journal of Immunology, 173, pp. 5305 - 5311, http://dx.doi.org/10.4049/jimmunol.173.8.5305

Zaunders JJ; Dyer WB; Wang B; Munier ML; Miranda-Saksena M; Newton R; Moore J; Mackay CR; Cooper DA; Saksena NK; Kelleher AD, 2004, 'Identification of circulating antigen-specific CD4⁺ T lymphocytes with a CCR5⁺, cytotoxic phenotype in an HIV-1 long-term nonprogressor and in CMV infection', Blood, 103, pp. 2238 - 2247, http://dx.doi.org/10.1182/blood-2003-08-2765

Lichterfeld M; Yu XG; Waring M; Mui S; Johnston M; Cohen D; Addo M; Zaunders J; Alter G; Pae E; Strick D; Allen TM; Rosenberg E; Walker BD; Altfeld M, 2004, 'HIV-1-specific cytotoxicity is preferentially mediated by a subset ofCD8(+) T cells producing both interferon-gamma and tumor necrosisfactor-alpha', Blood, 104, pp. 487 - 494

Zaunders J; Dyer W; Wang B; Munier M; Miranda-Saksena M; Newton R; Moore JJ; MacKay CR; Cooper DA; Saksena NK; Kelleher AD, 2004, 'Identification of circulating antigen-specific CD4+ T lymphocytes with a CCR5+, cytotoxic phenotype in an HIV-1 long-term non-progressor and in CMV infection', Blood, 8, pp. 2765 - 2765

Lomas M; Liauw WS; Packham D; Williams KM; Kelleher AD; Zaunders J; Ward RL, 2004, 'Phase I clinical trial of a human idiotypic p53 vaccine in patients with advanced malignancy', Annals of Oncology, 15, pp. 324 - 329

Mukaide M; Tanaka Y; Katayose S; Tano H; Murata M; Hikata M; Fujise K; Sakugawa H; Suzuki K; Zaunders J; Nagasawa Y; Toda G; Mizokami M, 2003, 'Development of real-time detection direct test for hepatitis B virus and comparison with two commercial tests using the WHO international standard', Journal of Gastroenterology and Hepatology (Australia), 18, pp. 1264 - 1271, http://dx.doi.org/10.1046/j.1440-1746.2003.03204.x

Wang B; Mikhail M; Dyer W; Zaunders J; Kelleher AD; Saksena N, 2003, 'First demonstration of a lack of viral sequence evolution in a nonprogressor, defining replication-incompetent HIV-1 infection', Virology, 312, pp. 135 - 135

Smith DE; Kaufmann GR; Kahn JO; Hecht FM; Grey PA; Zaunders J; Cunningham PH; Carr AD; Duncombe CJ; Quan D; Petersen A; Cooper DA, 2003, 'Greater reversal of CD4+ cell abnormalities and viral load reduction after initiation of antiretroviral therapy with zidovudine, lamivudine and nelfinavir before complete HIV type 1 seroconversion', AIDS Research and Human Retroviruses, 19, pp. 189 - 199

Liu T; Bauskin AR; Zaunders J; Brown DA; Pankhurst S; Russell PJ; Breit SN, 2003, 'Macrophage inhibitory cytokine 1 reduces cell adhesion and induces apoptosis in prostate cancer cells', Cancer research, 63, pp. 5034 - 5040

Murray JM; Kaufmann GR; Hodgkin PD; Lewin SR; Kelleher AD; Davenport MP; Zaunders JJ, 2003, 'Naive T cells maintained by thymic output in early ages but by proliferation without phenotypic change after age twenty', Immunology and Cell Biology, 81, pp. 487 - 495

Zaunders J; Moutouh-de Parseval L; Kitada S; Reed JC; Rought S; Genini D; Leoni L; Kelleher AD; Cooper DA; Smith DE; Grey PA; Estaquier J; Little S; Richman DD; Corbeil J, 2003, 'Polyclonal proliferation and apoptosis of CCR5+ T Lymphocytes during primary human immunodeficiency virus type 1 infection: regulation by interleukin (IL)-2, IL-15, and Bcl-2', Journal of Infectious Diseases, 187, pp. 1735 - 1735

Allen TM; Kelleher AD; Zaunders J; Walker BD, 2002, 'Structured treatment interruption and beyond', BIOFUTUR, pp. 52 - 58, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000180098300009&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Allen TM; Kelleher AD; Zaunders J; Walker BD, 2002, 'Supervised or structured treatment interruption (STI) and beyond...', Biofutur, pp. 52 - 58

Davenport MP; Zaunders JJ; Hazenberg MD; Schuitemaker H; van Rij RP, 2002, 'Cell turnover and cell tropism in HIV-1 infection', Trends in Microbiology, 10, pp. 275 - 278

Appay V; Zaunders J; Papagno L; Sutton J; Jaramillo AB; Waters A; Eastbrook P; Grey PA; Smith DE; Mcmichael AJ; Cooper DA; Rowland-Jones SL; Kelleher AD, 2002, 'Characterization of CD4(+) CTLs ex vivo', Journal of Immunology, 168, pp. 5954 - 5958

Wilkinson J; Zaunders J; Carr AD; Guillemin GJ; Cooper DA, 2002, 'Characterization of the phenotypic and lymphokine profile associated with strong CD8+ anti-HIV-1 suppressor activity (CASA', Clinical and Experimental Immunology, 127, pp. 145 - 150

Wang B; Dyer W; Zaunders J; Mikhail M; Sullivan JS; Haddad DM; Williams LA; Harris G; Holt J; Cooper DA; Miranda-Saksena M; Boadle R; Kelleher AD; Saksena NK, 2002, 'Comprehensive analyses of a unique HIV-1-infected nonprogressor reveal a complex association of immunobiological mechanisms in the context of replication-incompetent infection', Virology, 304, pp. 246 - 264

Lewin S; Ribeiro RM; Kaufmann GR; Smith DE; Zaunders J; Law MG; Solomon A; Cameron P; Cooper DA; Perelson AS, 2002, 'Dynamics of T cells and TCR excision circles differ after treatment of acute and chronic HIV infection', Journal of Immunology, 169, pp. 4657 - 4666

Tilling R; Kinloch-De Loes S; Goh L; Cooper DA; Perrin L; Lampe F; Zaunders J; Hoen B; Tsoukas C; Andersson J; Janossy G, 2002, 'Parallel decline of CD8+/CD38++ T cells and viraemia in response to quadruple highly active antiretroviral therapy in primary HIV infection', AIDS, 16, pp. 589 - 596

Allen TM; Kelleher AD; Zaunders J; Walker BD, 2002, 'STI and beyond: the prospects of boosting anti-HIV immune responses', Trends in Immunology, 23, pp. 456 - 460

Kaufmann GR; Bloch MT; Finlayson RJ; Zaunders J; Smith DE; Cooper DA, 2002, 'The extent of HIV-1-related immunodeficiency and age predict the long-term CD4 T lymphocyte response to potent antiretroviral therapy', AIDS, 16, pp. 359 - 367

Birch MR; Learmont JC; Dyer WB; Deacon NJ; Zaunders JJ; Saksena N; Cunningham AL; Mills J; Sullivan JS, 2001, 'An examination of signs of disease progression in survivors of the Sydney Blood Bank Cohort (SBBC)', Journal of Clinical Virology, 22, pp. 263 - 270, http://dx.doi.org/10.1016/S1386-6532(01)00198-6

Genini D; Sheeter D; Rought S; Zaunders JJ; Susin SA; Kroemer G; Richman DD; Carson DA; Corbeil J; Leoni LM, 2001, 'HIV induces lymphocyte apoptosis by a p53-initiated, mitochondrial-mediated mechanism.', The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 15, pp. 5 - 6, http://dx.doi.org/10.1096/fj.00-0336fje

Suzuki K; Cunningham P; Harris C; Leas L; Zaunders J; Cooper DA; Kaufmann GR; Pett SL; Kelleher A; Mukaide M; Imai M; Kondo M; Finlayson R, 2001, 'Novel deletion of HIV type 1 reverse transcriptase residue 69 conferring selective high-level resistance to nevirapine', AIDS Research and Human Retroviruses, 17, pp. 1293 - 1296, http://dx.doi.org/10.1089/088922201750461366

Kaufmann GR; Suzuki K; Cunningham PH; Mukaide M; Kondo M; Imai M; Zaunders J; Cooper DA, 2001, 'Impact of HIV type 1 protease, reverse transcriptase, cleavage site, and p6 mutations on the virological response to quadruple therapy with saquinavir, ritonavir, and two nucleoside analogs', AIDS Research and Human Retroviruses, 17, pp. 487 - 497

Zaunders J; Kaufmann GR; Cunningham PH; Smith DE; Grey PA; Suzuki K; Carr AD; Goh L; Cooper DA, 2001, 'Increased turnover of CCR5+ and redistribution of CCR5- CD4 T lymphocytes during primary human immunodeficiency virus type 1 infection.', Journal of Infectious Diseases, 183, pp. 736 - 743

Kaufmann GR; Zaunders J; Murray JM; Kelleher AD; Lewin S; Solomon A; Smith DE; Cooper DA, 2001, 'Relative significance of different pathways of immune reconstitution in HIV type 1 infection as estimated by mathematical modelling.', AIDS Research and Human Retroviruses, 17, pp. 147 - 159

Zaunders J; Geczy AF; Dyer W; Mcintyre LB; Cooley MA; Ashton LJ; Raynes-Greenow CH; Learmont JC; Cooper DA; Sullivan JS, 2000, 'Effect of long-term infection with nef-defective attenuated HIV type 1 on CD4+ and CD8+ T lymphocytes: increased CD45RO+CD4+ T lymphocytes and limited activation of CD8+ T lymphocytes', AIDS Research and Human Retroviruses, 15, pp. 1519 - 1527

Kaufmann GR; Bloch M; Zaunders J; Smith DE; Cooper DA, 2000, 'Long-term immunological response in HIV-1-infected subjects receiving potent antiretroviral therapy', AIDS, 14, pp. 959 - 969

Zaunders J; Cunningham PH; Kaufmann GR; Cooper DA, 2000, 'Questions about results reported with potent antiretroviral therapy for human immunodeficiency virus type 1 infection. (Authors¿ reply)', Journal of Infectious Diseases, 181, pp. 1519 - 1520

Kaufmann GR; Zaunders J; Kelleher AD; Grey PA; Smith DE; Carr AD; Cooper DA, 2000, 'Rapid restoration of CD4 T cell subsets in subjects receiving antiretroviral therapy during primary HIV-1 infection', AIDS, 14, pp. 2543 - 2551

Wilkinson JG; Zaunders J; Carr AD; Cooper DA, 1999, 'CD8+ anti-human immunodeficiency virus suppressor activity (CASA) in response to antiretroviral therapy: loss of CASA is associated with loss of viremia', Journal of Infectious Diseases, 180, pp. 68 - 75

Kaufmann GR; Zaunders J; Cooper DA, 1999, 'Immune reconstitution in HIV-1 infected subjects treated with potent antiretroviral therapy', Sexually Transmitted Infections, pp. 218 - 224

Kaufmann GR; Cunningham PH; Zaunders J; Law MG; Vizzard J; Carr AD; Cooper DA, 1999, 'Impact of early HIV-1 RNA and T-lymphocyte dynamics during primary HIV-1 infection on the subsequent course of HIV-1 RNA levels and CD4+ T-lymphocyte counts in the first year of HIV-1 infection', Journal of acquired immune deficiency syndrome and human retrovirology, pp. 437 - 444

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