By Associate Professor Kate Poole

Book Chapters

Richardson J; Schroeter L; Poole K, 2024, 'Mechanically-Evoked TRPV4-Mediated Currents Are Modulated by Activated Integrin β1', in Springer Series in Biophysics, Springer International Publishing, pp. 1 - 20, http://dx.doi.org/10.1007/978-3-031-45379-3_1

Shrestha S; Richardson J; Poole K, 2023, 'Analysing Mechanically Evoked Currents at Cell-Substrate Junctions', in Methods in Molecular Biology, pp. 155 - 167, http://dx.doi.org/10.1007/978-1-0716-2851-5_10

Poole K; Moroni M; Lewin GR, 2011, 'The Molecular and Genetic Basis of Touch', in The Handbook of Touch Neuroscience, Behavioral, and Health Perspectives, Springer Publishing Company

Ludwig T; Kirmse R; Poole K, 2007, 'Challenges and Approaches - Probing Tumor Cell Invasion by Atomic Force Microscopy.', in Mendez-Vilas A; Diaz J (ed.), Modern research and educational topics in microscopy no. III. vol I, Formatex, Spain, pp. 11 - 11

Journal articles

Cox CD; Poole K; Martinac B, 2024, 'Re-evaluating TRP channel mechanosensitivity', Trends in Biochemical Sciences, 49, pp. 693 - 702, http://dx.doi.org/10.1016/j.tibs.2024.05.004

Chakrabarti S; Klich JD; Khallaf MA; Hulme AJ; Sánchez-Carranza O; Baran ZM; Rossi A; Huang ATL; Pohl T; Fleischer R; Fürst C; Hammes A; Bégay V; Hörnberg H; Finol-Urdaneta RK; Poole K; Dottori M; Lewin GR, 2024, 'Touch sensation requires the mechanically gated ion channel ELKIN1', Science, 383, pp. 992 - 998, http://dx.doi.org/10.1126/science.adl0495

Meier M; Gupta M; Akgül S; McDougall M; Imhof T; Nikodemus D; Reuten R; Moya-Torres A; To V; Ferens F; Heide F; Padilla-Meier GP; Kukura P; Huang W; Gerisch B; Mörgelin M; Poole K; Antebi A; Koch M; Stetefeld J, 2023, 'The dynamic nature of netrin-1 and the structural basis for glycosaminoglycan fragment-induced filament formation', Nature Communications, 14, http://dx.doi.org/10.1038/s41467-023-36692-w

Wazir HU; Narang P; Silvani G; Mehner C; Poole K; Burke C; Chou J, 2023, 'Bacterial Virulence and Prevention for Human Spaceflight', Life, 13, http://dx.doi.org/10.3390/life13030656

Silvani G; Bradbury P; Basirun C; Mehner C; Zalli D; Poole K; Chou J, 2022, 'Testing 3D printed biological platform for advancing simulated microgravity and space mechanobiology research', npj Microgravity, 8, pp. 19, http://dx.doi.org/10.1038/s41526-022-00207-6

Govendir MA; Kempe D; Sianati S; Cremasco J; Mazalo JK; Colakoglu F; Golo M; Poole K; Biro M, 2022, 'T cell cytoskeletal forces shape synapse topography for targeted lysis via membrane curvature bias of perforin', Developmental Cell, 57, pp. 2237 - 2247.e8, http://dx.doi.org/10.1016/j.devcel.2022.08.012

Richardson J; Kotevski A; Poole K, 2022, 'From stretch to deflection: the importance of context in the activation of mammalian, mechanically activated ion channels', FEBS Journal, 289, pp. 4447 - 4469, http://dx.doi.org/10.1111/febs.16041

Poole K, 2022, 'The Diverse Physiological Functions of Mechanically Activated Ion Channels in Mammals', Annual Review of Physiology, 84, pp. 307 - 329, http://dx.doi.org/10.1146/annurev-physiol-060721-100935

Silvani G; Basirun C; Wu H; Mehner C; Poole K; Bradbury P; Chou J, 2021, 'A 3D-Bioprinted Vascularized Glioblastoma-on-a-Chip for Studying the Impact of Simulated Microgravity as a Novel Pre-Clinical Approach in Brain Tumor Therapy', Advanced Therapeutics, 4, http://dx.doi.org/10.1002/adtp.202100106

Basirun C; Ferlazzo ML; Howell NR; Liu GJ; Middleton RJ; Martinac B; Narayanan SA; Poole K; Gentile C; Chou J, 2021, 'Microgravity × Radiation: A Space Mechanobiology Approach Toward Cardiovascular Function and Disease', Frontiers in Cell and Developmental Biology, 9, http://dx.doi.org/10.3389/fcell.2021.750775

Molley TG; Jalandhra GK; Nemec SR; Tiffany AS; Patkunarajah A; Poole K; Harley BAC; Hung TT; Kilian KA, 2021, 'Heterotypic tumor models through freeform printing into photostabilized granular microgels', Biomaterials Science, 9, pp. 4496 - 4509, http://dx.doi.org/10.1039/d1bm00574j

Patkunarajah A; Schroeter L; Sanderson G; Biro M; Poole K, 2021, 'Disrupting ELKIN1-Dependent Mechanoelectrical TransductionModulates Cell-Cell Interactions in Organotypic Tumour Spheroids', BIOPHYSICAL JOURNAL, 120, pp. 65A - 66A, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000629601400320&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Sianati S; Schroeter L; Richardson J; Tay A; Lamandé SR; Poole K, 2021, 'Modulating the Mechanical Activation of TRPV4 at the Cell-Substrate Interface', Frontiers in Bioengineering and Biotechnology, 8, pp. 608951, http://dx.doi.org/10.3389/fbioe.2020.608951

Silvani G; Basirun C; Wu H; Mehner C; Poole K; Bradbury P; Chou J, 2021, 'A 3D‐Bioprinted Vascularized Glioblastoma‐on‐a‐Chip for Studying the Impact of Simulated Microgravity as a Novel Pre‐Clinical Approach in Brain Tumor Therapy (Adv. Therap. 11/2021)', Advanced Therapeutics, 4, http://dx.doi.org/10.1002/adtp.202170033

Servin-Vences MR; Poole K; Sporbert A; Lewin GR; Margineanu A, 2020, 'Collagen Organization Within the Cartilage of Trpv4^−/− Mice Studied with Two-Photon Microscopy and Polarized Second Harmonic Generation', Cytometry Part A, 97, pp. 504 - 514, http://dx.doi.org/10.1002/cyto.a.23900

Beaulieu-Laroche L; Christin M; Donoghue A; Agosti F; Yousefpour N; Petitjean H; Davidova A; Stanton C; Khan U; Dietz C; Faure E; Fatima T; MacPherson A; Mouchbahani-Constance S; Bisson DG; Haglund L; Ouellet JA; Stone LS; Samson J; Smith MJ; Ask K; Ribeiro-da-Silva A; Blunck R; Poole K; Bourinet E; Sharif-Naeini R, 2020, 'TACAN Is an Ion Channel Involved in Sensing Mechanical Pain', Cell, 180, pp. 956 - 967.e17, http://dx.doi.org/10.1016/j.cell.2020.01.033

Patkunarajah A; Stear JH; Moroni M; Schroeter L; Blaszkiewicz J; Tearle JLE; Cox CD; Fuerst C; Sánchez-Carranza O; Fernández M; Fleischer R; Eravci M; Weise C; Martinac B; Biro M; Lewin GR; Poole K, 2020, 'TMEM87a/Elkin1, a component of a novel mechanoelectrical transduction pathway, modulates melanoma adhesion and migration.', eLife, 9, pp. e53308, http://dx.doi.org/10.7554/eLife.53308

Bradbury P; Wu H; Choi JU; Rowan AE; Zhang H; Poole K; Lauko J; Chou J, 2020, 'Modeling the Impact of Microgravity at the Cellular Level: Implications for Human Disease', Frontiers in Cell and Developmental Biology, 8, pp. 96, http://dx.doi.org/10.3389/fcell.2020.00096

Putra VDL; Song MJ; McBride-Gagyi S; Chang H; Poole K; Whan R; Dean D; Sansalone V; Knothe Tate ML, 2020, 'Mechanomics Approaches to Understand Cell Behavior in Context of Tissue Neogenesis, During Prenatal Development and Postnatal Healing', Frontiers in Cell and Developmental Biology, 7, pp. 354, http://dx.doi.org/10.3389/fcell.2019.00354

Putra VDL; Jalilian I; Campbell M; Poole K; Whan R; Tomasetig F; Knothe Tate ML, 2019, 'Mapping the Mechanome–A Protocol for Simultaneous Live Imaging and Quantitative Analysis of Cell Mechanoadaptation and Ingression', Bio-protocol, 9, http://dx.doi.org/10.21769/BioProtoc.3439

Bavi N; Richardson J; Heu C; Martinac B; Poole K, 2019, 'PIEZO1-Mediated Currents Are Modulated by Substrate Mechanics', ACS Nano, 13, pp. 13545 - 13559, http://dx.doi.org/10.1021/acsnano.9b07499

Sianati S; Kurumlian A; Bailey E; Poole K, 2019, 'Analysis of mechanically activated ion channels at the cell-substrate interface: Combining pillar arrays and whole-cell patch-clamp', Frontiers in Bioengineering and Biotechnology, 7, pp. 47, http://dx.doi.org/10.3389/fbioe.2019.00047

Tay A; Sohrabi A; Poole K; Seidlits S; Di Carlo D, 2018, 'A 3D Magnetic Hyaluronic Acid Hydrogel for Magnetomechanical Neuromodulation of Primary Dorsal Root Ganglion Neurons', Advanced Materials, 30, http://dx.doi.org/10.1002/adma.201800927

Servin-Vences MR; Richardson J; Lewin GR; Poole K, 2018, 'Mechanoelectrical transduction in chondrocytes', Clinical and Experimental Pharmacology and Physiology, 45, pp. 481 - 488, http://dx.doi.org/10.1111/1440-1681.12917

Martinac B; Poole K, 2018, 'Mechanically activated ion channels', International Journal of Biochemistry and Cell Biology, 97, pp. 104 - 107, http://dx.doi.org/10.1016/j.biocel.2018.02.011

Ma Y; Poole K; Goyette J; Gaus K, 2017, 'Introducing membrane charge and membrane potential to T cell signaling', Frontiers in Immunology, 8, pp. 1513, http://dx.doi.org/10.3389/fimmu.2017.01513

Wetzel C; Pifferi S; Picci C; Gök C; Hoffmann D; Bali KK; Lampe A; Lapatsina L; Fleischer R; Smith ESJ; Bégay V; Moroni M; Estebanez L; Kühnemund J; Walcher J; Specker E; Neuenschwander M; Von Kries JP; Haucke V; Kuner R; Poulet JFA; Schmoranzer J; Poole K; Lewin GR, 2017, 'Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity', Nature Neuroscience, 20, pp. 209 - 218, http://dx.doi.org/10.1038/nn.4454

Servin-Vences MR; Moroni M; Lewin GR; Poole K, 2017, 'Direct measurement of TRPV4 and PIEZO1 activity reveals multiple mechanotransduction pathways in chondrocytes', eLife, 6, pp. e21074, http://dx.doi.org/10.7554/eLife.21074

Grandin M; Meier M; Delcros JG; Nikodemus D; Reuten R; Patel TR; Goldschneider D; Orriss G; Krahn N; Boussouar A; Abes R; Dean Y; Neves D; Bernet A; Depil S; Schneiders F; Poole K; Dante R; Koch M; Mehlen P; Stetefeld J, 2016, 'Structural Decoding of the Netrin-1/UNC5 Interaction and its Therapeutical Implications in Cancers', Cancer Cell, 29, pp. 173 - 185, http://dx.doi.org/10.1016/j.ccell.2016.01.001

Poole K; Moroni M; Lewin GR, 2015, 'Sensory mechanotransduction at membrane-matrix interfaces', Pflugers Archiv European Journal of Physiology, 467, pp. 121 - 132, http://dx.doi.org/10.1007/s00424-014-1563-6

Poole K; Herget R; Lapatsina L; Ngo HD; Lewin GR, 2014, 'Tuning Piezo ion channels to detect molecular-scale movements relevant for fine touch', Nature Communications, 5, pp. 3520, http://dx.doi.org/10.1038/ncomms4520

Brand J; Smith ESJ; Schwefel D; Lapatsina L; Poole K; Omerbašić D; Kozlenkov A; Behlke J; Lewin GR; Daumke O, 2012, 'A stomatin dimer modulates the activity of acid-sensing ion channels', EMBO Journal, 31, pp. 3635 - 3646, http://dx.doi.org/10.1038/emboj.2012.203

Long D; Wilkinson KL; Poole K; Taylor DK; Warren T; Astorga AM; Jiranek V, 2012, 'Rapid method for proline determination in grape juice and wine', Journal of Agricultural and Food Chemistry, 60, pp. 4259 - 4264, http://dx.doi.org/10.1021/jf300403b

Lapatsina L; Jira JA; Smith ESJ; Poole K; Kozlenkov A; Bilbao D; Lewin GR; Heppenstall PA, 2012, 'Regulation of ASIC channels by a stomatin/STOML3 complex located in a mobile vesicle pool in sensory neurons', Open Biology, 2, http://dx.doi.org/10.1098/rsob.120096

Lapatsina L; Brand J; Poole K; Daumke O; Lewin GR, 2012, 'Stomatin-domain proteins', European Journal of Cell Biology, 91, pp. 240 - 245, http://dx.doi.org/10.1016/j.ejcb.2011.01.018

Chiang LY; Poole K; Oliveira BE; Duarte N; Sierra YAB; Bruckner-Tuderman L; Koch M; Hu J; Lewin GR, 2011, 'Laminin-332 coordinates mechanotransduction and growth cone bifurcation in sensory neurons', Nature Neuroscience, 14, pp. 993 - 1000, http://dx.doi.org/10.1038/nn.2873

Lechner SG; Markworth S; Poole K; Smith ESJ; Lapatsina L; Frahm S; May M; Pischke S; Suzuki M; Ibañez-Tallon I; Luft FC; Jordan J; Lewin GR, 2011, 'The molecular and cellular identity of peripheral osmoreceptors', Neuron, 69, pp. 332 - 344, http://dx.doi.org/10.1016/j.neuron.2010.12.028

Poole K; Walker ME; Warren T; Gardner J; McBryde C; Lopes MDB; Jiranek V, 2009, 'Proline transport and stress tolerance of ammonia-insensitive mutants of the PUT4-encoded proline-specific permease in yeast', Journal of General and Applied Microbiology, 55, pp. 427 - 439, http://dx.doi.org/10.2323/jgam.55.427

Ludwig T; Kirmse R; Poole K; Schwarz US, 2008, 'Probing cellular microenvironments and tissue remodeling by atomic force microscopy', Pflugers Archiv European Journal of Physiology, 456, pp. 29 - 49, http://dx.doi.org/10.1007/s00424-007-0398-9

Balzar M; Poole K, 2008, 'Confocal and Atomic Force Microscopy', Imaging & Microscopy, 10, pp. 56 - 57, http://dx.doi.org/10.1002/imic.200890049

Puech PH; Poole K; Knebel D; Muller DJ, 2006, 'A new technical approach to quantify cell-cell adhesion forces by AFM', Ultramicroscopy, 106, pp. 637 - 644, http://dx.doi.org/10.1016/j.ultramic.2005.08.003

Poole K, 2006, 'Two Microscopes, One Software', Imaging & Microscopy, 8, pp. 43 - 44, http://dx.doi.org/10.1002/imic.200790067

Poole K; Müller DJ, 2005, 'Connections between surface structure and functional state of cell membrane of cancer cells', BioSpektrum, 11, pp. 465 - 466

Poole K; Khairy K; Friedrichs J; Franz C; Cisneros DA; Howard J; Mueller D; Baumeister W, 2005, 'Molecular-scale topographic cues induce the orientation and directional movement of fibroblasts on two-dimensional collagen surfaces', Journal of Molecular Biology, 349, pp. 380 - 386, http://dx.doi.org/10.1016/j.jmb.2005.03.064

Poole K; Müller D, 2005, 'Flexible, actin-based ridges colocalise with the β1 integrin on the surface of melanoma cells', British Journal of Cancer, 92, pp. 1499 - 1505, http://dx.doi.org/10.1038/sj.bjc.6602515

Poole K; Meder D; Simons K; Müller D, 2004, 'The effect of raft lipid depletion on microvilli formation in MDCK cells, visualized by atomic force microscopy', FEBS Letters, 565, pp. 53 - 58, http://dx.doi.org/10.1016/j.febslet.2004.03.095

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