By Associate Professor Laurence P. G. Wakelin

Journal articles

Fox K; Wakelin L; Waring M, 1981, 'Kinetics of the interaction between echinomycin and DNA.', Biochemistry, 20, pp. 5768 - 5779

Viswamitra M; Kennard O; Cruze W; Egert E; Sheldrick G; Jones P; Waring M; Wakelin L; Olsen F, 1981, 'The structure of the quinoxaline antibiotic analogue TANDEM and its relevance to the mechanism of bifunctional intercalation.', Nature, 289, pp. 817 - 819

Wright RGMR; Wakelin LPG; Fieldes A; Acheson RM; Waring MJ, 1980, 'Effects of Ring Substituents and Linker Chains on the Bifunctional Intercalation of Diacridines into Deoxyribonucleic Acid', Biochemistry, 19, pp. 5825 - 5836, http://dx.doi.org/10.1021/bi00566a026

Dean P; Wakelin L, 1980, 'Electrostatic components of drug-receptor recognition: I. Structural and sequence analogues of DNA polynucleotides.', Proceedings of the Royal Society, B, 209, pp. 453 - 471

Dean P; Wakelin L, 1980, 'Electrostatic components of drug-receptor recognition: II. The DNA-binding antibiotic actinomycin.', Proceedings of the Royal Society, B, 209, pp. 473 - 489

Wakelin L; Waring M, 1980, 'Kinetics of drug-DNA interaction: dependence of the binding mechanism on structure of the ligand.', Journal of Molecular Biology, 144, pp. 183 - 214

Wakelin L; Creasy T; Waring M, 1979, 'The binding of an homologous series of diacridines to DNA.', FEBS Letters, 104, pp. 261

Dean P; Wakelin L, 1979, 'The docking manoeuvre at a drug receptor: a quantum mechanical study of intercalative attack of ethidium and its carboxylated derivative on a DNA fragment.', Philosphical Transactions of the Royal Society, B, 287, pp. 571 - 607

Balcarová Z; Kleinwächter V; Koudelka J; Klarner R; Löber G, 1978, 'Interaction of phencsafranine with nucleic acids and model polyphosphates. I. Self-aggregation and complex formation with inorganic polyphosphates', Biophysical Chemistry, 8, pp. 17 - 25, http://dx.doi.org/10.1016/0301-4622(78)85019-4

Kleinwachter V; Balcarova Z; Koudelka J; Lober G; Reinert K; Wakelin L; Waring M, 1978, 'Characterisation of different modes of phenosafranine binding to double helical DNAs.', Studia Biophysica, 67, pp. S53 - S54

Balcarova Z; Kleinwà chter V; Koudelka J; Lober G; Reinert K; Wakelin L; Waring M, 1978, 'Interaction of phenosafranine with nucleic acids and model polyphosphates. II. Characterisation of phenosafranine binding to double helical DNAs.', Biophysical Chemistry, 8, pp. 27 - 40

Wakelin L; Romanos M; Chen T; Glaubiger D; Canellakis E; Waring M, 1978, 'Structural limitations on the bifunctional intercalation of diacridines into DNA.', Biochemistry, 17, pp. 5057 - 5063

Wakelin L; Romanos M; Canellakis E; Waring M, 1976, 'Diacridines as bifunctional DNA-intercalating agents.', Studia Biophysica, 60, pp. 111 - 118

Balcarova Z; Kleinwächter V; Waring M; Wakelin L; Lober G, 1976, 'Properties of phenosafranine complexes with deoxyribonucleic acids.', Studia Biophysica, 60, pp. 119 - 124

Wakelin L; Waring M, 1976, 'The binding of echinomycin to DNA.', Biochemical Journal, 157, pp. 721 - 740

Waring M; Wakelin L; Lee J, 1975, 'A solvent partition method for measuring the binding of drugs to DNA: application to the quinoxaline antibiotics echinomycin and triostin A.', BIOCHIMICA ET BIOPHYSICA ACTA, 407, pp. 200 - 212

Waring M; Wakelin L, 1974, 'Echinomycin: a bifunctional intercalating antibiotic.', Nature, 252, pp. 653 - 657, http://dx.doi.org/10.1038/252653a0

Wakelin L, 1974, 'Interaction of platinum II compounds with circular DNA.', Biochemical Society Transactions, 2, pp. 866 - 868

Wakelin L; Waring M, 1974, 'The unwinding of circular deoxyribonucleic acid by phenanthridinium drugs: structure-activity relations for the intercalation reaction.', Molecular Pharmacology, 10, pp. 544 - 561

Wall K; Wakelin L, 1971, 'Measurement of the rate of anion exchange and the effect of organic fouling.', Journal of Applied Chemistry and Biotechnology, 21, pp. 1 - 4

Back to profile page