By Associate Professor Laurence P. G. Wakelin

Conference Papers

Pracey CP; Serobian A; Thomas DS; Ball GE; Wakelin LP, 2017, 'Solution structure of the Mitoxantrone-DNA complex: A NMR and molecular modelling study', in EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, SPRINGER, SCOTLAND, British Biophys Soc, Edinburgh, pp. S228 - S228, presented at 19th IUPAB Congress / 11th EBSA Congress, SCOTLAND, British Biophys Soc, Edinburgh, 16 July 2017 - 20 July 2017, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000416406201323&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Zihlif M; Wakelin L; Catchpool D; Stewart BBW, 2010, 'Insights into the cellular responses against different DNA-binding agents', in EJC SUPPLEMENTS, PERGAMON-ELSEVIER SCIENCE LTD, GERMANY, Berlin, pp. 105 - 105, presented at 22nd EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, GERMANY, Berlin, 16 November 2010 - 19 November 2010, http://dx.doi.org/10.1016/S1359-6349(10)72036-X

Khazaly AN; He Z; Stewart BW; Edwards GL; Wakelin L, 2008, 'Bisintercalating threading agents as cytotoxic inhibitors of transcription', in EJC Supplements, Pergamon-Elsevier Science Ltd, Kidlington, Oxford, England, pp. 83 - 84, presented at 20th Meeting of the European Association for Cancer Research, Lyon, FRANCE, 05 July 2008 - 08 July 2008

Freewan M; Denny WA; Wakelin L, 2008, 'Poisoning of human topoisomerase II alpha by acridinecarboxamides and related cytotoxins', in EJC Supplements, Pergamon-Elsevier Science Ltd, Kidlington, Oxford, England, pp. 28 - 28, presented at 20th Meeting of the European Association for Cancer Research, Lyon, FRANCE, 05 July 2008 - 08 July 2008

Edwards GL; Black DS; Deacon G; Wakelin L, 2006, 'Cycometallated platinum and palladium complexes as anticancer agents: Everything old is new again', in Australia and New Zealand Symposium on Organometallic Chemistry OZOM3, Monash university, Gippsland, Australia, pp. 47 - 47, presented at 3rd Australian and New Zealand Symposium on Oranometallic Chemistry, Monash university, Gippsland, Australia, 08 January 2006 - 11 January 2006

Peters FB; Serobian A; Ball GE; Denny WA; Wakelin L, 2005, 'DNA Intercalation by bix(phenazinecarboxamides): Structural Insights Into Anticancer Activity', in Apte S; Kable S; Baker AT (eds.), Connect 2005 - Chemical Challenges for the 21st Century, Sydney, Convention Centre, Darling Harbour, Sydney, pp. M017 PO Bi - -, presented at Connect 2005 - Chemical Challenges for the 21st Century, Sydney, Convention Centre, Darling Harbour, Sydney, 03 July 2005 - 07 July 2005

Tam R; Suzuki M; Denny WA; Dawes I; Wakelin L, 2005, 'Mutations within the alpha4 helix of human DNA topoisomerase IIalpha confer differential sensitivities to topoisomerase poisons.', in Proceedings of the American Association for Cancer Research vol 46, American Association for Cancer Research, Philadelphia, USA, pp. 2401 - 2401, presented at 96th AACR Annual Meeting, Anaheim, USA, -

Catchpoole DR; Guo D; Stewart BW; Eleftheriou A; Wakelin L, 2003, 'Effects of bisintercalating DNA threading agents on transcription in human leukemic CCRF-CEM cells studied by microarray analysis', in CLINICAL CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, MASSACHUSETTS, BOSTON, pp. 6082S - 6082S, presented at AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, MASSACHUSETTS, BOSTON, 17 November 2003 - 21 November 2003, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000187467300053&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Adams A; Guss JM; Denny WA; Wakelin LP, 2002, 'CRYSTAL STRUCTURES OF ACRIDINE-4-CARBOXAMIDES COMPLEXED WITH THE DNA HEXANUCLEOTIDE d(CGTACG)2', in ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, INT UNION CRYSTALLOGRAPHY, pp. C55 - C55, http://dx.doi.org/10.1107/S0108767302087317

Majid AA; Fonseka T; Smythe GA; Shiel M; Denny WA; Wakelin L, 2001, 'Characterisation of the DNA complex of an antitumour-active bifunctional polybenzamide alkylating agent using electrospray and MALDI-TOF mass spectrometry.', in Clinical Cancer Research vol 7, AMER ASSOC CANCER RESEARCH, PO BOX 11806, BIRMINGHAM, AL 35202 USA, Birmingham, USA., pp. 3796S - 3796S, presented at AACR-NCI-EORTC Conference on Molecular Targets and Cancer Therapeutics., Florida, USA

Adams A; Guss M; Denny WA; Wakelin L, 2001, 'Crystal structure of 9-amino[N-(2-morpholino)ethyl]acridine-4-carboxamide bound to d(CGTACG)2: A DNA complex of a biologically inactive derivative of the acridinecarboxamide topoisomerase poisons.', in Clinical Cancer Research vol 7, AMER ASSOC CANCER RESEARCH, PO BOX 11806, BIRMINGHAM, AL 35202 USA, Birmingham, USA., pp. 3798S - 3798S, presented at AACR-NCI-EORTC Conference on Molecular Targets and Cancer Therapeutics., Florida, USA.

Adams A; Guss M; Collyer C; Prakash AS; Denny WA; Wakelin L, 2000, 'Acridinecarboxamide topoisomerase poisons: structural and kinetic studies of the DNA complexes of 5-substituted 9-amino-(N-(2-dimethylamino)ethyl)-acridine-4-carboxamides.', in Clinical Cancer Research vol 6, AMER ASSOC CANCER RESEARCH, PO BOX 11806, BIRMINGHAM, AL 35202 USA, Birmingham, USA, pp. 4531S - 4531S, presented at 11th NCI-EORTC-AACR Symposium on New Drugs in Cancer Therapy., Amsterdam, Holland.

Adams A; Collyer C; Guss M; Denny WA; Wakelin L, 1999, 'Crystal structure of the topoisomerase II poison 9-amino-[N-(2-dimethylamino)ethyl]acridine-4-carboxamide bound to the DNA hexanucleotide d(CGTACG)2.', in Clinical Cancer Research vol 5, AMER ASSOC CANCER RESEARCH, PO BOX 11806, BIRMINGHAM, AL 35202 USA, Birmingham, USA., pp. 3854S - 3854S, presented at 10th NCI-EORTC-AACR Symposium on New Drugs in Cancer Therapy, Washington, USA.

Major B; Wickham G; Prakash AS; Wakelin L; Cotton R; Denny WA; Leaver D, 1990, 'CONFORMATIONAL DISTORTIONS INDUCED IN DNA UPON BINDING OF CISPLATIN AND INTERCALATING ANALOGS', in European Journal of Pharmacology Vol 183, Elsevier, Amsterdam, Netherlands, pp. 191 - 192, http://dx.doi.org/10.1016/0014-2999(90)93025-L

Mcfadyen DW; Wakelin L; Leopold V; Roos I; Hillcoat B, 1984, 'Cytotoxicity of DNA intercalating platinum (II) complexes.', in Medical and Pediatric Oncology vol 13, WILEY-LISS, DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012, New York, USA, pp. 137 - 138, presented at Clinical Oncology Society of Australia Meeting, Melbourne, Australia

Wakelin L; Denny WA; Atwel G, 1984, 'Kinetics of the interaction between 9-aminoacridinecarboxamides and DNA.', in Medical and Pediatric Oncology vol 13, WILEY-LISS, DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012, New York, USA, pp. 134 - 135, presented at Clinical Oncology Society of Australia Meeting, Melbourne, Australia

Mcfadyen DW; Wakelin L; Leopold V; Roos I; Hillcoat B, 1984, 'Cytotoxicity of DNA intercalating platinum (II) complexes.', in Proceedings of the Australian Biochemical Society 1984, PROC AUST BIOCHEMICAL SOC, MONASH UNIV DEPT BIOCHEMISTRY, CLAYTON VICTORIA 3168, AUSTRALIA, Clayton, Victoria, Australia, pp. S44 - S44, presented at Australian Biochemical Society Meeting, Sydney, Australia

Adams A; Jarrott B; Elmes B; Denny WA; Wakelin L, 1984, 'Interaction of diacridines and diquinolines with adrenoceptors.', in Proceedings of the Australian Biochemical Society vol 16, PROC AUST BIOCHEMICAL SOC, MONASH UNIV DEPT BIOCHEMISTRY, CLAYTON VICTORIA 3168, AUSTRALIA, Clayton, Victoria, Australia, pp. S87 - S87, presented at Australian Biochemical Society Meeting, Sydney

Roos I; Wakelin L; Henry S, 1984, 'Interaction of diacridines with intracellular DNA.', in Proceedings of the Australian Biochemical Society Vol 16, PROC AUST BIOCHEMICAL SOC, MONASH UNIV DEPT BIOCHEMISTRY, CLAYTON VICTORIA 3168, AUSTR, Clayton, Victoria, Australia, pp. S19 - S19, presented at Australian Biochemical Society, Sydney, Australia

Roos I; Wakelin L; Hillcoat B; Henry S, 1983, 'The interaction of diacridines with cellular DNA.', in Medical and Pediatric Oncology vol 12, WILEY-LISS, DIV JOHN WILEY & SONS INC, 605 THIRD AVE, NEW YORK, NY 10158-0012, New York, USA, pp. 278 - 278, presented at Clinical Oncology Society of Australia Meeting, Brisbane, Australia

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