Researcher

Associate Professor Megan Lord

My Expertise

A specialist in understanding how the cell microenvironment regulates cell behaviour and applying those insights to direct tissue repair with biomaterials and biologically active molecules.

Keywords

Field of Research (FoR)

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Biography

Megan Lord is Associate Professor of Biomedical Engineering and Director of the Molecular Surface Interaction Network Laboratory at UNSW.

Associate Professor Lord has a Doctor of Philosophy in Engineering, Master of Biomedical Engineering and First class Honours degree in Chemical Engineering from UNSW. She publishes widely in biomaterials and extracellular matrix biochemistry with a focus on blood contacting applications. Her research has...view more

Megan Lord is Associate Professor of Biomedical Engineering and Director of the Molecular Surface Interaction Network Laboratory at UNSW.

Associate Professor Lord has a Doctor of Philosophy in Engineering, Master of Biomedical Engineering and First class Honours degree in Chemical Engineering from UNSW. She publishes widely in biomaterials and extracellular matrix biochemistry with a focus on blood contacting applications. Her research has been supported by a number of grants including a prestigious Australian Research Council Postdoctoral Fellowship (2010-2012). She has published over 80 peer-reviewed scholarly articles and delivered invited keynote lectures in Australia and internationally.

Associate Professor Lord serves on the Standards Australia committee HE-030 Biological and Clinical Evaluation of Medical Devices that reviews and ratifies the International Standard ISO 10993 and TC 194. She is the President of the Matrix Biology Society of Australia and New Zealand. In 2014, Associate Professor Lord was named a NSW Young Tall Poppy by the Australian Institute of Policy and Science.

Megan's research is interdisciplinary combining the fields of biomaterials and extracellular matrix biochemistry with a focus on blood contacting applications and utilises her expertise on the analysis of dynamic interactions between cells, proteins and biomaterials. She utilises biomimetic approaches to develop biomaterials that effectively interface with the vasculature for applications as anticoagulant therapies, blood component storage, vascular grafts, soft tissue repair such as diabetic wounds and targeting the vasculature for cancer drug delivery therapy. Megan collaborates widely with industry and international academic institutions and is driven to make novel contributions to science that will benefit society. 

More details at https://research.unsw.edu.au/people/associate-professor-megan-lord

 


My Grants

Diabetes Australia General Grant (2019) Bioengineered growth factor binding scaffolds.
Australian Research Council Linkage Infrastructure, Equipment and Facilities (2019) Advanced mechanical property testing suite.
Australian Research Council Discovery Project (2015-2019) Novel biomimetic vascular biomaterials using extracellular matrix molecules.
Australian Research Council Linkage Project with the Australian Red Cross Blood Service (2014-2019) Biomimetic blood bag materials for prolonged platelet storage.
Australian Research Council Linkage Project with Cochlear Ltd (2014-2018) Biological determinants of the safety and stability of neuroprosthetic stimulation electrodes.
National Heart Foundation (2011-2012) The roles of perlecan heparan sulphate in modulating vascular intimal hyperplasia.
Australian Research Council Linkage Project with Synedgen Inc (including Australian Postdoctoral Fellowship) (2010-2014) Targeted growth factor delivery using natural polysaccharide materials for bone regeneration.
Australian Research Council Discovery Project (2010-2013) Advanced nanoparticles as biocompatible antioxidant agents with targeting functionality.
Australian Research Council Linkage Project with HemCon Medical Technologies (2007-2010) Blood component interactions with polysaccharide biomaterials for vascular applications.

In addition, Associate Professor Lord has been awarded grant funding from UNSW through the Research Infrastructure Scheme, Career Advancement Fund, Faculty of Engineering Carers Award, Faculty of Engineering Early Career Researcher fund and School project support.


My Qualifications

BE (Hons I), MBiomedE, PhD, UNSW 
 


My Awards

NSW Young Tall Poppy Science Award in recognition of the achievements of Australia’s outstanding young scientific researchers and communicators. (2014)
UNSW Emeritus Professor Maria Skyllas-Kazacos Young Professional Award for Outstanding Achievement Award for female alumni from UNSW Engineering in recognition of a significant achievement in their field. (2013)
Finalist in the Scopus Young Scientist of the Year Awards, Engineering and Technology Category. (2011)
Trans-continental award for a young scientist from the Federation of European Biochemical Societies. (2011)
New Investigator Award from the Matrix Biology Society of Australia and New Zealand recognised the research achievements of early career researchers in the field of matrix biology with less than 10 years post-doctoral experience. (2008)
UNSW Early Career Researcher Travel Award supported attendance at an international conference. (2007)
COST Action 537 Early Career Research Short Term Scientific Mission Award. European initiative that identified emerging researchers with a capacity for independent research in areas with direct health outcomes. (2007)
Australasian Society for Biomaterials and Tissue Engineering International Travel Award. Society award for travel to international collaborator laboratory. (2006)
Joan Waugh Scholarship. Award from Tara Anglican School for Girls Old Girls' Association for excellence in chosen field and supported doctoral studies. (2004)
Boehringer Ingelheim Fonds Award. Supported international laboratory research visits to expand research skills and build collaborations. (2003)


My Research Activities

Bioengineering biologically active molecules. This program produces biologically active molecules via either isolation from natural sources, chemical synthesis or enzymatic biosynthesis in mammalian cells. These molecules are inspired by extracellular matrix molecules that control the signalling of growth factors, called proteoglycans. These bioengineered molecules are explored for application alone, such as biosynthetic heparin for use as an anticoagulant or incorporated into biomaterials for medical device and tissue repair applications.

Biomimetic biomaterials for medical devices and tissue regeneration. This program develops biomaterials that effectively interface with the vasculature for applications in blood component storage, vascular grafts, wound healing and targeting the vasculature for cancer drug delivery therapy. Biologically active molecules are physicochemically incorporated into different synthetic (eg. teflon, polyvinyl chloride, polyurethane, cerium oxide nanoparticles) and natural (eg. chitosan, collagen) biomaterials in different formats such as films, gels, scaffolds and nanoparticles and their performance explored in in vitro  and in vivo models. 


My Research Supervision


Supervision keywords


Areas of supervision

Megan welcomes expressions of interest to join her team at the Honours, Masters and PhD levels.


Currently supervising

Postdoctoral Research Fellows
Dr Zehra Elgundi

PhD students
Teddy Chang, Development of polymeric micelles for cancer drug delivery
Lu Fu, Glycosaminoglycan functionalised nanoparticles with active cell-targeting
Amy Jiang, In vitro and in vivo performance of perlecan coated biomaterials for vascular applications.
Ha Na Kim, Bioengineering serglycin for the vascular tissue repair.
Kieran Lau, Silk biomaterials for vascular applications.
Joel Yong, Nanoparticles for cancer treatment.

Megan has supervised to completion 13 PhD, 5 Masters by Research, 2 Bachelor of Medical Science (Honours) and over 120 Engineering thesis students. She has also supervised and mentored 6 postdoctoral fellows and 15 international exchange students and postdoctoral fellows from countries including France, Germany, Denmark, Netherlands and UK.


My Engagement

University centres and affiliations
Director, Molecular Surface Interaction Network Laboratory
Associate Member, Centre for Advanced Macromolecular Design

University administrative responsibilities
School Postgraduate Research Student Coordinator
Faculty of Engineering Higher Degree Committee

Professional memberships
President, Matrix Biology Society of Australia and New Zealand
Member, Standards Australia Committee HE-030 Biological and Clinical Evaluation of Medical Devices
Council Member, International Society for Matrix Biology
Member, Australasian Society for Biomaterials and Tissue Engineering

Editorial positions
Editorial Board, Cellular Signalling
Associate Editor, IEEE Engineering in Medicine and Biology Society Conference Proceedings
Guest Editor for Special Issue of Frontiers in Immunology entitled 'Proteoglycans and glycosaminoglycan modification in immune regulation and inflammation'


My Teaching

Cellular and Tissue Engineering (BIOM9333)

 

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Location

Samuels Building F25
Level 5, Room 505
UNSW
Sydney NSW 2052
AUSTRALIA


Map reference (Google map)

Contact

+61 2 9385 3910
+61 2 9663 2108

Research Activities