By Associate Professor Nicola J Smith

Journal articles

Smith NJ; Ward RJ; Stoddart LA; Hudson BD; Kostenis E; Ulven T; Morris JC; Tränkle C; Tikhonova IG; Adams DR; Milligan G, 2011, 'Extracellular loop 2 of the free fatty acid receptor 2 mediates allosterism of a phenylacetamide ago-allosteric modulator', Molecular Pharmacology, 80, pp. 163 - 173, http://dx.doi.org/10.1124/mol.110.070789

Smith NJ; Chan HW; Qian H; Bourne AM; Hannan KM; Warner FJ; Ritchie RH; Pearson RB; Hannan RD; Thomas WG, 2011, 'Determination of the exact molecular requirements for type 1 angiotensin receptor epidermal growth factor receptor transactivation and cardiomyocyte hypertrophy', Hypertension, 57, pp. 973 - 980, http://dx.doi.org/10.1161/HYPERTENSIONAHA.110.166710

Schmidt J; Smith NJ; Christiansen E; Tikhonova IG; Grundmann M; Hudson BD; Ward RJ; Drewke C; Milligan G; Kostenis E; Ulven T, 2011, 'Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: Identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3', Journal of Biological Chemistry, 286, pp. 10628 - 10640, http://dx.doi.org/10.1074/jbc.M110.210872

Flores-Muñoz M; Smith NJ; Haggerty C; Milligan G; Nicklin SA, 2011, 'Angiotensin1-9 antagonises pro-hypertrophic signalling in cardiomyocytes via the angiotensin type 2 receptor', Journal of Physiology, 589, pp. 939 - 951, http://dx.doi.org/10.1113/jphysiol.2010.203075

Smith NJ; Bennett KA; Milligan G, 2011, 'When simple agonism is not enough: Emerging modalities of GPCR ligands', Molecular and Cellular Endocrinology, 331, pp. 241 - 247, http://dx.doi.org/10.1016/j.mce.2010.07.009

Hudson BD; Smith NJ; Milligan G, 2011, 'Experimental Challenges to Targeting Poorly Characterized GPCRs. Uncovering the Therapeutic Potential for Free Fatty Acid Receptors', , 62, pp. 175 - 218, http://dx.doi.org/10.1016/B978-0-12-385952-5.00006-3

Tikhonova IG; Smith NJ; Ward RJ; Stoddart LA; Hudson BD; Kostenis E; Ulven T; Morris JC; Adams DR; Milligan G, 2011, 'Probing Allosteric Binding Site Mapping in the Free Fatty Acid 2 receptor', Biophysical Journal, 100, pp. 52a - 52a, http://dx.doi.org/10.1016/j.bpj.2010.12.483

Jenkins L; Brea J; Smith NJ; Hudson BD; Reilly G; Bryant NJ; Castro M; Loza MI; Milligan G, 2010, 'Identification of novel species-selective agonists of the G-protein-coupled receptor GPR35 that promote recruitment of β-arrestin-2 and activate Gα13', Biochemical Journal, 432, pp. 451 - 459, http://dx.doi.org/10.1042/BJ20101287

Smith NJ; Milligan G, 2010, 'Allostery at G protein-coupled receptor homo- and heteromers: Uncharted pharmacological landscapes', Pharmacological Reviews, 62, pp. 701 - 725, http://dx.doi.org/10.1124/pr.110.002667

Schröder R; Janssen N; Schmidt J; Kebig A; Merten N; Hennen S; Müller A; Blättermann S; Mohr-Andrä M; Zahn S; Wenzel J; Smith NJ; Gomeza J; Drewke C; Milligan G; Mohr K; Kostenis E, 2010, 'Deconvolution of complex G protein-coupled receptor signaling in live cells using dynamic mass redistribution measurements', Nature Biotechnology, 28, pp. 943 - 949, http://dx.doi.org/10.1038/nbt.1671

Milligan G; Stoddart LA; Smith NJ, 2009, 'Agonism and allosterism: The pharmacology of the free fatty acid receptors FFA2 and FFA3', British Journal of Pharmacology, 158, pp. 146 - 153, http://dx.doi.org/10.1111/j.1476-5381.2009.00421.x

Smith NJ; Stoddart LA; Devine NM; Jenkins L; Milligan G, 2009, 'The action and mode of binding of thiazolidinedione ligands at free fatty acid receptor 1', Journal of Biological Chemistry, 284, pp. 17527 - 17539, http://dx.doi.org/10.1074/jbc.M109.012849

Stoddart LA; Smith NJ; Milligan G, 2008, 'International union of pharmacology. LXXI. Free fatty acid receptors FFA1, -2, and -3: Pharmacology and pathophysiological functions', Pharmacological Reviews, 60, pp. 405 - 417, http://dx.doi.org/10.1124/pr.108.00802

Stoddart LA; Smith NJ; Jenkins L; Brown AJ; Milligan G, 2008, 'Conserved polar residues in transmembrane domains V, VI, and VII of free fatty acid receptor 2 and free fatty acid receptor 3 are required for the binding and function of short chain fatty acids', Journal of Biological Chemistry, 283, pp. 32913 - 32924, http://dx.doi.org/10.1074/jbc.M805601200

Milligan G; Smith NJ, 2007, 'Allosteric modulation of heterodimeric G-protein-coupled receptors', Trends in Pharmacological Sciences, 28, pp. 615 - 620, http://dx.doi.org/10.1016/j.tips.2007.11.001

Smith NJ; Luttrell LM, 2006, 'Signal switching, crosstalk, and arrestin scaffolds: Novel G protein-coupled receptor signaling in cardiovascular disease', Hypertension, 48, pp. 173 - 179, http://dx.doi.org/10.1161/01.HYP.0000232641.84521.92

Chan HW; Smith NJ; Hannan RD; Thomas WG, 2006, 'Tackling the EGFR in pathological tissue remodelling', Pulmonary Pharmacology and Therapeutics, 19, pp. 74 - 78, http://dx.doi.org/10.1016/j.pupt.2005.04.005

Smith NJ; Chan HW; Osborne JE; Thomas WG; Hannan RD, 2004, 'Hijacking epidermal growth factor receptors by angiotensin II: New possibilities for understanding and treating cardiac hypertrophy', Cellular and Molecular Life Sciences, 61, pp. 2695 - 2703, http://dx.doi.org/10.1007/s00018-004-4244-3

Thomas WG; Qian H; Smith NJ, 2004, 'When 6 is 9: 'Uncoupled' AT1 receptors turn signalling on its head', Cellular and Molecular Life Sciences, 61, pp. 2687 - 2694, http://dx.doi.org/10.1007/s00018-004-4245-2

Devlin MG; Smith NJ; Ryan OM; Guida E; Sexton PM; Christopoulos A, 2004, 'Regulation of serotonin 5-HT 2C receptors by chronic ligand exposure', European Journal of Pharmacology, 498, pp. 59 - 69, http://dx.doi.org/10.1016/j.ejphar.2004.07.102

Smith NJJ, 2004, 'Travels in Four Dimensions: The Enigmas of Space and Time', Australasian Journal of Philosophy, 82, pp. 527 - 530, http://dx.doi.org/10.1080/713659865

Smith NJ; Hannan RD; Thomas WG; Lew RA, 2003, 'AngiotensinII mediates cardiomyocyte hypertrophic growth pathways via MMP-dependent HB-EGF liberation', Letters in Peptide Science, 10, pp. 431 - 435, http://dx.doi.org/10.1007/BF02442574

Smith NJ; Hannan RD; Thomas WG; Lew RA, 2003, 'AngiotensinII mediates cardiomyocyte hypertrophic growth pathways via MMP-dependent HB-EGF liberation', International Journal of Peptide Research and Therapeutics, 10, pp. 431 - 435, http://dx.doi.org/10.1007/s10989-004-2398-3

SMITH NJ, 1995, 'A SPIRITUAL LANGUAGE + DHOMHNAILL,NUALA,NI ON WRITING IN IRISH', NEW YORK TIMES BOOK REVIEW, pp. 31 - 31

Donovan WH; Hull R; Cifu DX; Brown HD; Smith NJ, 1990, 'Use of plasmid analysis to determine the source of bacterial invasion of the urinary tract', Spinal Cord, 28, pp. 573 - 582, http://dx.doi.org/10.1038/sc.1990.77

McAughey JJ; Samuel AM; Baxter PJ; Smith NJ, 1988, 'Biological monitoring of occupational exposure in the chromate pigment production industry', The Science of The Total Environment, 71, pp. 317 - 322, http://dx.doi.org/10.1016/0048-9697(88)90203-3

SMITH NJ; BLACKWELL BF, 1979, 'HAZARDS IN HYDRAULICS AND PUBLIC-HEALTH ENGINEERING WORK', PROCEEDINGS OF THE INSTITUTION OF CIVIL ENGINEERS PART 1-DESIGN AND CONSTRUCTION, 66, pp. 757 - 759

SMITH NJ, 1978, 'TRUE STORY FROM SAN-FRANCISCO', MOREANA, 15, pp. 12 - 12

Conference Papers

Wilkins BP; Patel K; So SS; Finch A; Chahal K; Ngo T; Kufareva I; Coleman JLJ; Smith NJ, 2023, 'Misgivings and mispairings in orphan G protein-coupled receptor research: GPR37L1, GPR146 and GPR161 should still be considered orphan receptors', in BRITISH JOURNAL OF PHARMACOLOGY, WILEY, SCOTLAND, Glasgow, pp. 659 - 660, presented at 19th World Congress of Basic and Clinical Pharmacology (WCP), SCOTLAND, Glasgow, 02 July 2023 - 07 July 2023

Stavrou MM; So S; Ballouz S; Finch A; Smith NJ, 2023, 'Tasteless organs: why the taste receptors are exclusive to the tongue', in BRITISH JOURNAL OF PHARMACOLOGY, WILEY, SCOTLAND, Glasgow, pp. 694 - 695, presented at 19th World Congress of Basic and Clinical Pharmacology (WCP), SCOTLAND, Glasgow, 02 July 2023 - 07 July 2023

Nicks AM; Holman SR; Chan AY; Pang C-HJ; Tsang M; Naqvi N; Husain A; Li M; Humphreys DT; Smith NJ; Iismaa SE; Graham RM, 2021, 'A Standardized Method to Isolate and Purify Cardiomyocytes from Individual Mouse Hearts Irrespective of Postnatal Age', in CIRCULATION, LIPPINCOTT WILLIAMS & WILKINS, MA, Boston, presented at Annual Scientific Sessions of the American-Heart-Association / Resuscitation Science Symposium, MA, Boston, 12 November 2021 - 15 November 2021

Nicks AM; Humphreys DT; Holman SR; Chan AY; Djordjevic D; Naqvi N; Husain A; Smith NJ; Ho JW; Iismaa SE; Graham RM, 2018, 'Transcription Factors Driving Postnatal Cardiomyocyte Maturation', in CIRCULATION, LIPPINCOTT WILLIAMS & WILKINS, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000528619405230&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Mouat M; Coleman J; Wu J; Jancovski N; Feneley M; Allen A; Graham R; Smith N, 2018, 'SEXUALLY DIMORPHIC ROLES FOR GPR37L1, AN ORPHAN GPCR IN THE CARDIOVASCULAR SYSTEM', in JOURNAL OF HYPERTENSION, LIPPINCOTT WILLIAMS & WILKINS, PEOPLES R CHINA, Beijing, pp. E7 - E7, presented at 27th Scientific Meeting of the International-Society-of-Hypertension, PEOPLES R CHINA, Beijing, 20 September 2018 - 23 September 2018, http://dx.doi.org/10.1097/01.hjh.0000548013.63617.a8

Coleman JL; Mouat MA; Wu J; Jancovski N; Humphreys DT; Stefani M; Dos Remedios CG; Feneley MP; Allen AM; Graham RM; Smith NJ, 2017, 'Blood Pressure is Increased in Female Mice Lacking Orphan G Protein-Coupled Receptor Gpr37L1', in CIRCULATION, LIPPINCOTT WILLIAMS & WILKINS, VA, Pentagon City, presented at Quality of Care and Outcomes Research Scientific Sessions, VA, Pentagon City, 02 April 2017 - 03 April 2017, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000396815605115&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Nicks AM; Holman SR; Chan A; Humphreys DT; Smith NJ; Ho JW; Naqvi N; Husain A; Graham RM; Iismaa SE, 2016, 'Distinct Transcriptomic Signatures Across Postnatal Cardiomyocyte Development', in CIRCULATION, LIPPINCOTT WILLIAMS & WILKINS, LA, New Orleans, presented at Scientific Sessions of the American-Heart-Association / Resuscitation Science Symposium, LA, New Orleans, 12 November 2016 - 16 November 2016, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000396816606015&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Yu Z-Y; Tan J-C; McMahon AC; Lismaa SF; Xiao X-H; Kesteven SH; Reichelt ME; Mohl MC; Dai Y; Sketchley AE; Yanq LL; Gong H; Smith NJ; Fatkin D; Allen D; Head SI; Graham RM; Feneley MP, 2013, 'Critical Role of RhoA/ROCK Signaling in Cardiac Contractility', in CIRCULATION, LIPPINCOTT WILLIAMS & WILKINS, TX, Dallas, presented at Scientific Sessions and Resuscitation Science Symposium of the American-Heart-Association, TX, Dallas, 16 November 2013 - 17 November 2013, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000332162903138&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Smith NJ; Schmidt J; Mrad N; Coleman JL; Hynes CJ; Wu J; Stefani M; Yu Z-Y; Liew CK; dos Remedios C; Graham RM, 2013, 'N-Terminal Processing of an Orphan GPCR: A Novel Mechanistic Target for the Treatment of Cardiovascular Disease?', in CIRCULATION, LIPPINCOTT WILLIAMS & WILKINS, TX, Dallas, presented at Scientific Sessions and Resuscitation Science Symposium of the American-Heart-Association, TX, Dallas, 16 November 2013 - 17 November 2013, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000332162903173&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Flores-Munoz M; Smith NJ; Haggerty C; Thomas WG; Baker AH; Milligan G; Nicklin SA, 2010, 'Angiotensin1-9 Antagonises Cardiomyocyte Hypertrophy via the Angiotensin Type 2 Receptor', in HYPERTENSION, LIPPINCOTT WILLIAMS & WILKINS, DC, Washington, pp. E130 - E131, presented at High Blood Pressure Research Scientific Sessions 2010, DC, Washington, 13 October 2010 - 16 October 2010, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000283240400362&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Chan HW; Jenkins A; Pipolo L; Hannan RD; Thomas WG; Smith NJ, 2006, 'Effect of dominant-negative epidermal growth factor receptors on cardiomyocyte hypertrophy', in Journal of Receptors and Signal Transduction, pp. 659 - 677, http://dx.doi.org/10.1080/10799890600923187

Chan H-W; Jenkins A; Pipolo L; Hannan RD; Thomas WG; Smith NJ, 2006, 'Effect of dominant-negative epidermal growth factor receptors on cardiomyocyte hypertrophy', in JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION, TAYLOR & FRANCIS LTD, SWITZERLAND, Univ Basel, Pharmacenter, Basel, pp. 659 - 677, presented at 10th Swiss Receptor Workshop, SWITZERLAND, Univ Basel, Pharmacenter, Basel, 12 March 2006 - 15 March 2006, http://dx.doi.org/10.1080/10799890600923187

Smith NJ; Chan H-W; Hannan RD; Thomas Baker WG, 2006, 'Role of arrestin-dependent signalling in cellular proliferation and apoptosis', in ACTA PHARMACOLOGICA SINICA, BLACKWELL PUBLISHING, pp. 389 - 389

Conference Abstracts

Mouat M; Jackson K; Coleman J; Paterson M; Graham R; Head G; Smith N, 2020, 'Deletion of orphan GPCR, GPR37L1, alters autonomic control of cardiovascular homeostasis in mice', in BRITISH JOURNAL OF PHARMACOLOGY, WILEY, ELECTR NETWORK, Vol. 178, pp. 444 - 445, presented at 2000 Meeting of the British-Pharmacological-Society (PHARMACOLOGY), ELECTR NETWORK, 14 December 2020 - 18 December 2020, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000603490400089&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Montgomery MK; Brandon AE; O'Reilly L; Osborne B; Fiveash CE; Brown SH; Smith NJ; Mitchell TW; Biden TJ; Cooney GJ; Turner N, 2016, 'The free fatty acid receptor GPR84: A new player in glucose tolerance and mitochondrial function?', in DIABETOLOGIA, SPRINGER, GERMANY, Munich, Vol. 59, pp. S322 - S322, presented at 52nd Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), GERMANY, Munich, 12 September 2016 - 16 September 2016

Foster SR; Porrello ER; Stefani M; Smith NJ; Molenaar P; dos Remedios CG; Thomas WG; Ramialison M, 2014, 'Transcriptional Regulation of Taste Receptor Genes: Novel Insights From In Silico and Cardiac Gene Expression Analyses', in CHEMICAL SENSES, OXFORD UNIV PRESS, AUSTRALIA, Brisbane, Vol. 40, pp. 366 - 367, presented at 15th Scientific Meeting of the Australasian-Association-for-ChemoSensory-Science (AACSS), AUSTRALIA, Brisbane, 03 December 2014 - 05 December 2014, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000357868900036&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Nicks AM; Li M; Wu J; Kesteven SH; Fenely MP; Smith NJ; Iismaa SE; Graham RM, 2014, 'A SURGICAL MODEL OF HYPERTENSION AND LEFT VENTRICULAR HYPERTROPHY IN MICE BY SUPRARENAL AORTIC CONSTRICTION', in HYPERTENSION, LIPPINCOTT WILLIAMS & WILKINS, AUSTRALIA, Adelaide, Vol. 65, pp. E39 - E39, presented at 36th Annual Scientific Meeting of the High-Blood-Pressure-Research-Council-of-Australia (HBPRCA), AUSTRALIA, Adelaide, 26 November 2014 - 28 November 2014, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000352490400055&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Preprints

Ngo T; Wilkins B; So S; Keov P; Chahal K; Finch A; Coleman JLJ; Kufareva I; Smith N, 2020, Orphan G protein-coupled receptor, GPR37L1: pharmacological toolbox empty once again, http://dx.doi.org/10.1101/2020.09.11.290486

So SS; Ngo T; Ilatovskiy AV; Finch AM; Riek RP; Abagyan R; Smith NJ; Kufareva I, Pharmacological proximities in the GPCR family discovered using contact-informed amino-acid and binding pocket similarities, http://dx.doi.org/10.64898/2026.05.02.720972

Nicks AM; Holman SR; Chan AY; Tsang M; Young PE; Humphreys DT; Naqvi N; Husain A; Li M; Smith NJ; Iismaa SE; Graham RM, Standardised method for cardiomyocyte isolation and purification from individual murine neonatal, infant, and adult hearts, http://dx.doi.org/10.1101/2021.09.30.462562

Coleman JLJ; Ngo T; Smythe RE; Cleave AJ; Jones NM; Graham RM; Smith NJ, The N-terminus of GPR37L1 is proteolytically processed by matrix metalloproteases, http://dx.doi.org/10.1101/2020.06.27.174847

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