Select Publications
Journal articles
2016, 'Left ventricular hypertrophy is a predictor of cardiovascular events in elderly hypertensive patients: Hypertension in the Very Elderly Trial', Journal of Hypertension, 34, pp. 2280 - 2286, http://dx.doi.org/10.1097/HJH.0000000000001073
,2016, 'The risk of overweight/obesity in mid-life and late life for the development of dementia: A systematic review and meta-analysis of longitudinal studies', Age and Ageing, 45, pp. 14 - 21, http://dx.doi.org/10.1093/ageing/afv151
,2015, 'Is air pollution associated with increased risk of cognitive decline? A systematic review', Age and Ageing, 44, pp. 755 - 760, http://dx.doi.org/10.1093/ageing/afv087
,2015, 'No evidence that frailty modifies the positive impact of antihypertensive treatment in very elderly people: An investigation of the impact of frailty upon treatment effect in the HYpertension in the Very Elderly Trial (HYVET) study, a double-blind, placebo-controlled study of antihypertensives in people with hypertension aged 80 and over', BMC Medicine, 13, http://dx.doi.org/10.1186/s12916-015-0328-1
,2015, 'The clock drawing test, mortality, incident cardiovascular events and dementia', International Journal of Geriatric Psychiatry, 30, pp. 416 - 421, http://dx.doi.org/10.1002/gps.4153
,2015, 'Antihypertensive drug use and risk of cognitive decline in the very old: An observational study - The Newcastle 85+ Study', Journal of Hypertension, 33, pp. 2156 - 2164, http://dx.doi.org/10.1097/HJH.0000000000000653
,2015, 'Potential for specific dihydropyridine calcium channel blockers to have a positive impact on cognitive function in humans: A systematic review', Therapeutic Advances in Chronic Disease, 6, pp. 160 - 169, http://dx.doi.org/10.1177/2040622315582353
,2014, 'A systematic review of calciumchannel blocker use and cognitive decline/dementia in the elderly', Journal of Hypertension, 32, pp. 1945 - 1958, http://dx.doi.org/10.1097/HJH.0000000000000273
,2014, 'Treating hypertension in the very elderly-Benefits, risks, and future directions, a focus on the hypertension in the very elderly trial', European Heart Journal, 35, pp. 1712 - 1718, http://dx.doi.org/10.1093/eurheartj/eht464
,2014, 'Balancing benefit and risk of medicines: A systematic review and classification of available methodologies', Pharmacoepidemiology and Drug Safety, 23, pp. 667 - 678, http://dx.doi.org/10.1002/pds.3636
,2014, 'Benefit-risk assessment in a post-market setting: A case study integrating real-life experience into benefit-risk methodology', Pharmacoepidemiology and Drug Safety, 23, pp. 974 - 983, http://dx.doi.org/10.1002/pds.3676
,2014, 'Subgroup and per-protocol analyses fromthe hypertension in the very elderly trial', Journal of Hypertension, 32, pp. 1478 - 1487, http://dx.doi.org/10.1097/HJH.0000000000000195
,2013, 'Limitations, including the misclassification of former drinkers', Addiction Research and Theory, 21, pp. 196 - 197, http://dx.doi.org/10.3109/16066359.2012.759214
,2013, 'Response to HYVET ambulatory blood pressure substudy', Hypertension, 61, http://dx.doi.org/10.1161/HYPERTENSIONAHA.111.00897
,2013, 'Kidney function in the very elderly with hypertension: Data from the hypertension in the very elderly (HYVET) trial', Age and Ageing, 42, pp. 253 - 258, http://dx.doi.org/10.1093/ageing/afs109
,2013, 'Atrial fibrillation is associated with an increased risk of cognitive and functional decline', Evidence-Based Medicine, 18, http://dx.doi.org/10.1136/eb-2012-100809
,2013, 'Does white coat hypertension require treatment over age 80?: Results of the hypertension in the very elderly trial ambulatory blood pressure side project', Hypertension, 61, pp. 89 - 94, http://dx.doi.org/10.1161/HYPERTENSIONAHA.112.191791
,2013, 'Impact of transiently elevated diastolic pressure on cause of death: 29-year follow-up from the General Practice Hypertension Study Group', Journal of Hypertension, 31, pp. 71 - 76, http://dx.doi.org/10.1097/HJH.0b013e32835a4dd8
,2013, 'Increased pulse pressure linked to dementia: Further results from the Hypertension in the Very Elderly Trial - HYVET', Journal of Hypertension, 31, pp. 1868 - 1875, http://dx.doi.org/10.1097/HJH.0b013e3283622cc6
,2013, 'Prevalence and covariates of electrocardiographic left ventricular hypertrophy in the Hypertension in the Very Elderly Trial', Journal of Hypertension, 31, pp. 1224 - 1232, http://dx.doi.org/10.1097/HJH.0b013e32836040a4
,2012, 'Blood pressure, smoking and alcohol use, association with vascular dementia', Experimental Gerontology, 47, pp. 865 - 872, http://dx.doi.org/10.1016/j.exger.2012.05.018
,2012, 'Blood pressure control in the Hypertension in the Very Elderly Trial (HYVET)', Journal of Human Hypertension, 26, pp. 157 - 163, http://dx.doi.org/10.1038/jhh.2011.10
,2012, 'Immediate and late benefits of treating very elderly people with hypertension: Results from active treatment extension to hypertension in the very elderly randomised controlled trial', BMJ (Online), 344, http://dx.doi.org/10.1136/bmj.d7541
,2011, 'Latest advances on interventions that may prevent, delay or ameliorate dementia', Therapeutic Advances in Chronic Disease, 2, pp. 161 - 173, http://dx.doi.org/10.1177/2040622310397636
,2010, 'Modelling cognitive decline in the hypertension in the very elderly trial [HYVET] and proposed risk tables for population use', PLoS ONE, 5, http://dx.doi.org/10.1371/journal.pone.0011775
,2010, 'Despite evidence-based guidelines, systolic blood pressure remains inadequately controlled in older hypertensive adults', Journal of Human Hypertension, 24, pp. 439 - 446, http://dx.doi.org/10.1038/jhh.2009.85
,, 2010, 'News and Reviews', Age and Ageing, 39, pp. 424 - 425, http://dx.doi.org/10.1093/ageing/afq058
2010, 'The effect of treatment based on a diuretic (indapamide) ± ACE inhibitor (perindopril) on fractures in the hypertension in the very elderly trial (HYVET)', Age and Ageing, 39, pp. 609 - 616, http://dx.doi.org/10.1093/ageing/afq071
,2010, 'Association of depression with subsequent mortality, cardiovascular morbidity and incident dementia in people aged 80 and over and suffering from hypertension. Data from the Hypertension in the Very Elderly Trial (HYVET)', Age and Ageing, 39, pp. 439 - 445, http://dx.doi.org/10.1093/ageing/afq042
,2009, 'Antihypertensive treatment after diagnosis of alzheimer's disease', American Journal of Hypertension, 22, pp. 1031, http://dx.doi.org/10.1038/ajh.2009.152
,2009, 'Sociodemographic and lifestyle risk factors for incident dementia and cognitive decline in the HYVET', Age and Ageing, 38, pp. 521 - 527, http://dx.doi.org/10.1093/ageing/afp094
,2009, 'Hypertension, dementia, and antihypertensive treatment: Implications for the very elderly', Current Hypertension Reports, 11, pp. 277 - 282, http://dx.doi.org/10.1007/s11906-009-0047-0
,2009, 'Baseline characteristics of participants in the Hypertension in the Very Elderly Trial (HYVET)', Blood Pressure, 18, pp. 17 - 22, http://dx.doi.org/10.1080/08037050902836779
,2009, 'The prevention of Dementia', International Journal of Geriatric Psychiatry, 24, pp. 452 - 458, http://dx.doi.org/10.1002/gps.2153
,2009, 'Vascular risk factors and cognitive function among 3763 participants in the Hypertension in the Very Elderly Trial (HYVET): A cross-sectional analysis', International Psychogeriatrics, 21, pp. 359 - 368, http://dx.doi.org/10.1017/S1041610208008302
,2009, 'Literature review of the Clock Drawing Test as a tool for cognitive screening', Dementia and Geriatric Cognitive Disorders, 27, pp. 201 - 213, http://dx.doi.org/10.1159/000203344
,2009, 'Cardiovascular and biochemical risk factors for incident dementia in the hypertension in the very elderly trial', Journal of Hypertension, 27, pp. 2055 - 2062, http://dx.doi.org/10.1097/HJH.0b013e32832f4f02
,2008, 'Smoking, dementia and cognitive decline in the elderly, a systematic review', BMC Geriatrics, 8, pp. 36, http://dx.doi.org/10.1186/1471-2318-8-36
,2008, 'Predictive value of the clock drawing test: A review of the literature', Dementia and Geriatric Cognitive Disorders, 26, pp. 351 - 355, http://dx.doi.org/10.1159/000162261
,2008, 'Alcohol, dementia and cognitive decline in the elderly: A systematic review', Age and Ageing, 37, pp. 505 - 512, http://dx.doi.org/10.1093/ageing/afn095
,2008, 'Haemoglobin, anaemia, dementia and cognitive decline in the elderly, a systematic review', BMC Geriatrics, 8, pp. 18, http://dx.doi.org/10.1186/1471-2318-8-18
,2008, 'Characteristics of the Chinese subjects entered the hypertension in the very elderly trial', Chinese Medical Journal, 121, pp. 1509 - 1512, http://dx.doi.org/10.1097/00029330-200808020-00002
,2008, 'Incident dementia and blood pressure lowering in the Hypertension in the Very Elderly Trial cognitive function assessment (HYVET-COG): a double-blind, placebo controlled trial', The Lancet Neurology, 7, pp. 683 - 689, http://dx.doi.org/10.1016/S1474-4422(08)70143-1
,2008, 'Treatment of hypertension in patients 80 years of age or older', New England Journal of Medicine, 358, pp. 1887 - 1898, http://dx.doi.org/10.1056/NEJMoa0801369
,2007, 'Hypertension in the very elderly', Future Medicine, 3, pp. 517 - 525
,2007, 'Diagnosis and treatment of stable angina in older people', Prescriber, 18, pp. 38 - 49, http://dx.doi.org/10.1002/psb.46
,2006, 'Fracture risk and the use of a diuretic (indapamide sr) ± perindopril: A substudy of the Hypertension in the Very Elderly Trial (HYVET)', Trials, 7, http://dx.doi.org/10.1186/1745-6215-7-33
,2006, 'A substudy protocol of the Hypertension in the Very Elderly Trial assessing cognitive decline and dementia incidence (HYVET-COG): An ongoing randomised, double-blind, placebo-controlled trial', Drugs and Aging, 23, pp. 83 - 92, http://dx.doi.org/10.2165/00002512-200623010-00008
,2006, 'Ageing and the brain', Postgraduate Medical Journal, 82, pp. 84 - 88, http://dx.doi.org/10.1136/pgmj.2005.036665
,2006, 'Rationale and methodology of monitoring ambulatory blood pressure and arterial compliance in the Hypertension in the Very Elderly Trial', Blood Pressure Monitoring, 11, pp. 3 - 8, http://dx.doi.org/10.1097/01.mbp.0000184965.30220.10
,