By Conjoint Professor Samuel Norbert Breit

Journal articles

THORNTON SC; ROBBINS JM; PENNY R; BREIT SN, 2008, 'Fibroblast growth factors in connective tissue disease associated interstitial lung disease', Clinical and Experimental Immunology, 90, pp. 447 - 452, http://dx.doi.org/10.1111/j.1365-2249.1992.tb05866.x

Littler DR; Harrop SJ; Brown LJ; Pankhurst GJ; Mynott AV; Luciani P; Mandyam RA; Mazzanti M; Tanda S; Berryman MA; Breit SN; Curmi PMG, 2008, 'Comparison of vertebrate and invertebrate CLIC proteins: The crystal structures of Caenorhabditis elegans EXC‐4 and Drosophila melanogaster DmCLIC', Proteins: Structure, Function, and Bioinformatics, 71, pp. 364 - 378, http://dx.doi.org/10.1002/prot.21704

Selander KS; Brown DA; Sequeiros GB; Hunter M; Desmond R; Parpala T; Risteli J; Breit SN; Jukkola-Vuorinen A, 2007, 'Serum Macrophage Inhibitory Cytokine-1 Concentrations Correlate with the Presence of Prostate Cancer Bone Metastases', Cancer Epidemiology, Biomarkers & Prevention, 16, pp. 532 - 537, http://dx.doi.org/10.1158/1055-9965.epi-06-0841

Brown DA; Moore J; Johnen H; Smeets TJ; Bauskin AR; Kuffner T; Weedon H; Milliken ST; Tak PP; Smith MD; Breit SN, 2007, 'Serum macrophage inhibitory cytokine 1 in rheumatoid arthritis: A potential marker of erosive joint destruction', Arthritis & Rheumatism, 56, pp. 753 - 764, http://dx.doi.org/10.1002/art.22410

Cromer BA; Gorman MA; Hansen G; Adams JJ; Coggan M; Littler DR; Brown LJ; Mazzanti M; Breit SN; Curmi PMG; Dulhunty AF; Board PG; Parker MW, 2007, 'Structure of the Janus Protein Human CLIC2', Journal of Molecular Biology, 374, pp. 719 - 731, http://dx.doi.org/10.1016/j.jmb.2007.09.041

Johnen H; Lin S; Kuffner T; Brown DA; Tsai VW-W; Bauskin AR; Wu L; Pankhurst G; Jiang L; Junankar S; Hunter M; Fairlie WD; Lee NJ; Enriquez RF; Baldock PA; Corey E; Apple FS; Murakami MM; Lin E-J; Wang C; During MJ; Sainsbury A; Herzog H; Breit SN, 2007, 'Tumor-induced anorexia and weight loss are mediated by the TGF-beta superfamily cytokine MIC-1.', Nat Med, 13, pp. 1333 - 1340, http://dx.doi.org/10.1038/nm1677

Agarwal MK; Hastak K; Jackson MW; Breit SN; Stark GR; Agarwal ML, 2006, 'Macrophage inhibitory cytokine 1 mediates a p53-dependent protective arrest in S phase in response to starvation for DNA precursors', Proceedings of the National Academy of Sciences, 103, pp. 16278 - 16283, http://dx.doi.org/10.1073/pnas.0607210103

Bauskin AR; Brown DA; Kuffner T; Johnen H; Luo XW; Hunter M; Breit SN, 2006, 'Role of macrophage inhibitory cytokine-1 in tumorigenesis and diagnosis of cancer.', Cancer Res, 66, pp. 4983 - 4986, http://dx.doi.org/10.1158/0008-5472.CAN-05-4067

Xu J; Kimball TR; Lorenz JN; Brown DA; Bauskin AR; Klevitsky R; Hewett TE; Breit SN; Molkentin JD, 2006, 'GDF15/MIC-1 Functions As a Protective and Antihypertrophic Factor Released From the Myocardium in Association With SMAD Protein Activation', Circulation Research, 98, pp. 342 - 350, http://dx.doi.org/10.1161/01.res.0000202804.84885.d0

Koopmann J; Rosenzweig CNW; Zhang Z; Canto MI; Brown DA; Hunter M; Yeo C; Chan DW; Breit SN; Goggins M, 2006, 'Serum Markers in Patients with Resectable Pancreatic Adenocarcinoma: Macrophage Inhibitory Cytokine 1 versus CA19-9', Clinical Cancer Research, 12, pp. 442 - 446, http://dx.doi.org/10.1158/1078-0432.ccr-05-0564

Rasiah KK; Kench JG; Gardiner-Garden M; Biankin AV; Golovsky D; Brenner PC; Kooner R; O'neill GF; Turner JJ; Delprado W; Lee CS; Brown DA; Breit SN; Grygiel JJ; Horvath LG; Stricker PD; Sutherland RL; Henshall SM, 2006, 'Aberrant neuropeptide Y and macrophage inhibitory cytokine-1 expression are early events in prostate cancer development and are associated with poor prognosis.', Cancer Epidemiol Biomarkers Prev, 15, pp. 711 - 716, http://dx.doi.org/10.1158/1055-9965.EPI-05-0752

Brown DA; Stephan C; Ward RL; Law M; Hunter M; Bauskin AR; Amin J; Jung K; Diamandis EP; Hampton GM; Russell PJ; Giles GG; Breit SN, 2006, 'Measurement of serum levels of macrophage inhibitory cytokine 1 combined with prostate-specific antigen improves prostate cancer diagnosis.', Clinical cancer research : an official journal of the American Association for Cancer Research, 12, pp. 89 - 96, http://dx.doi.org/10.1158/1078-0432.ccr-05-1331

Stephan C; Xu C; Brown DA; Breit SN; Michael A; Nakamura T; Diamandis EP; Meyer H; Cammann H; Jung K, 2006, 'Three new serum markers for prostate cancer detection within a percent free PSA‐based artificial neural network', The Prostate, 66, pp. 651 - 659, http://dx.doi.org/10.1002/pros.20381

Bauskin AR; Brown DA; Junankar S; Rasiah KK; Eggleton S; Hunter M; Liu T; Smith D; Kuffner T; Pankhurst GJ; Johnen H; Russell PJ; Barret W; Stricker PD; Grygiel JJ; Kench JG; Henshall SM; Sutherland RL; Breit SN, 2005, 'The Propeptide Mediates Formation of Stromal Stores of PROMIC-1: Role in Determining Prostate Cancer Outcome', Cancer Research, 65, pp. 2330 - 2336, http://dx.doi.org/10.1158/0008-5472.can-04-3827

Littler DR; Assaad NN; Harrop SJ; Brown LJ; Pankhurst GJ; Luciani P; Aguilar M; Mazzanti M; Berryman MA; Breit SN; Curmi PMG, 2005, 'Crystal structure of the soluble form of the redox‐regulated chloride ion channel protein CLIC4', The FEBS Journal, 272, pp. 4996 - 5007, http://dx.doi.org/10.1111/j.1742-4658.2005.04909.x

Saeki K; Yasugi E; Okuma E; Breit SN; Nakamura M; Toda T; Kaburagi Y; Yuo A, 2005, 'Proteomic analysis on insulin signaling in human hematopoietic cells: identification of CLIC1 and SRp20 as novel downstream effectors of insulin', American Journal of Physiology-Endocrinology and Metabolism, 289, pp. E419 - E428, http://dx.doi.org/10.1152/ajpendo.00512.2004

Weber F; Byrne SN; Le S; Brown DA; Breit SN; Scolyer RA; Halliday GM, 2005, 'Transforming growth factor-β1 immobilises dendritic cells within skin tumours and facilitates tumour escape from the immune system', Cancer Immunology, Immunotherapy, 54, pp. 898 - 906, http://dx.doi.org/10.1007/s00262-004-0652-3

Marjono B; Manuelpillai U; Dimitriadis E; Salamonsen L; Breit S; Wallace E, 2004, '270. Macrophage inhibitory cytokine-1 at the maternal–fetal interface in early pregnancy', Reproduction, Fertility and Development, 16, pp. 270 - 270, http://dx.doi.org/10.1071/srb04abs270

Koopmann J; Buckhaults P; Brown DA; Zahurak ML; Sato N; Fukushima N; Sokoll LJ; Chan DW; Yeo CJ; Hruban RH; Breit SN; Kinzler KW; Vogelstein B; Goggins M, 2004, 'Serum Macrophage Inhibitory Cytokine 1 as a Marker of Pancreatic and Other Periampullary Cancers', Clinical Cancer Research, 10, pp. 2386 - 2392, http://dx.doi.org/10.1158/1078-0432.ccr-03-0165

Wallace EM; Marjono B; Brown DA; Crossley J; Tong S; Aitken D; Breit S, 2004, 'Maternal serum and amniotic fluid levels of macrophage inhibitory cytokine 1 in Down syndrome and chromosomally normal pregnancies', Prenatal Diagnosis, 24, pp. 224 - 226, http://dx.doi.org/10.1002/pd.791

Tong S; Marjono B; Brown DA; Mulvey S; Breit SN; Manuelpillai U; Wallace EM, 2004, 'Serum concentrations of macrophage inhibitory cytokine 1 (MIC 1) as a predictor of miscarriage', The Lancet, 363, pp. 129 - 130, http://dx.doi.org/10.1016/s0140-6736(03)15265-8

Littler DR; Harrop SJ; Fairlie WD; Brown LJ; Pankhurst GJ; Pankhurst S; DeMaere MZ; Campbell TJ; Bauskin AR; Tonini R; Mazzanti M; Breit SN; Curmi PMG, 2004, 'The Intracellular Chloride Ion Channel Protein CLIC1 Undergoes a Redox-controlled Structural Transition', Journal of Biological Chemistry, 279, pp. 9298 - 9305, http://dx.doi.org/10.1074/jbc.m308444200

Thornton SC; Walsh BJ; Bennett S; Robbins JM; Foulcher E; Morgan GW; Penny R; Breit SN, 2003, 'Both in vitro and in vivo irradiation are associated with induction of macrophage-derived fibroblast growth factors', Clinical and Experimental Immunology, 103, pp. 67 - 73, http://dx.doi.org/10.1046/j.1365-2249.1996.898598.x

Keelan JA, 2003, 'Macrophage inhibitory cytokine 1 in fetal membranes and amniotic fluid from pregnancies with and without preterm labour and premature rupture of membranes', Molecular Human Reproduction, 9, pp. 535 - 540, http://dx.doi.org/10.1093/molehr/gag068

Liu T; Bauskin AR; Zaunders J; Brown DA; Pankhurst S; Russell PJ; Breit SN, 2003, 'Macrophage inhibitory cytokine 1 reduces cell adhesion and induces apoptosis in prostate cancer cells.', Cancer Res, 63, pp. 5034 - 5040, https://www.ncbi.nlm.nih.gov/pubmed/12941831

Welsh JB; Sapinoso LM; Kern SG; Brown DA; Liu T; Bauskin AR; Ward RL; Hawkins NJ; Quinn DI; Russell PJ; Sutherland RL; Breit SN; Moskaluk CA; Frierson HF; Hampton GM, 2003, 'Large-scale delineation of secreted protein biomarkers overexpressed in cancer tissue and serum', Proceedings of the National Academy of Sciences, 100, pp. 3410 - 3415, http://dx.doi.org/10.1073/pnas.0530278100

Singarayar S; Bursill J; Wyse K; Bauskin A; Wu W; Vandenberg J; Breit S; Campbell T, 2003, 'Extracellular Acidosis Modulates Drug Block of Kv4.3 Currents by Flecainide and Quinidine', Journal of Cardiovascular Electrophysiology, 14, pp. 641 - 650, http://dx.doi.org/10.1046/j.1540-8167.2003.03026.x

Marjono AB; Brown DA; Horton KE; Wallace EM; Breit SN; Manuelpillai U, 2003, 'Macrophage Inhibitory Cytokine-1 in Gestational Tissues and Maternal Serum in Normal and Pre-eclamptic Pregnancy', Placenta, 24, pp. 100 - 106, http://dx.doi.org/10.1053/plac.2002.0881

Yang H; Filipovic Z; Brown D; Breit SN; Vassilev LT, 2003, 'Macrophage inhibitory cytokine-1: a novel biomarker for p53 pathway activation.', Mol Cancer Ther, 2, pp. 1023 - 1029, https://www.ncbi.nlm.nih.gov/pubmed/14578467

Brown DA; Ward RL; Buckhaults P; Liu T; Romans KE; Hawkins NJ; Bauskin AR; Kinzler KW; Vogelstein B; Breit SN, 2003, 'MIC-1 serum level and genotype: associations with progress and prognosis of colorectal carcinoma.', Clin Cancer Res, 9, pp. 2642 - 2650, https://www.ncbi.nlm.nih.gov/pubmed/12855642

Torres AM; Bansal PS; Sunde M; Clarke CE; Bursill JA; Smith DJ; Bauskin A; Breit SN; Campbell TJ; Alewood PF; Kuchel PW; Vandenberg JI, 2003, 'Structure of the HERG K+ Channel S5P Extracellular Linker', Journal of Biological Chemistry, 278, pp. 42136 - 42148, http://dx.doi.org/10.1074/jbc.m212824200

Qiu MR; Campbell TJ; Breit SN, 2002, 'A potassium ion channel is involved in cytokine production by activated human macrophages (vol 130, pg 67, 2002)', CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 130, pp. 559 - 561, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000179409900028&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Warton K; Tonini R; Fairlie WD; Matthews JM; Valenzuela SM; Qiu MR; Wu WM; Pankhurst S; Bauskin AR; Harrop SJ; Campbell TJ; Curmi PMG; Breit SN; Mazzanti M, 2002, 'Recombinant CLIC1 (NCC27) assembles in lipid bilayers via a pH-dependent two-state process to form chloride ion channels with identical characteristics to those observed in Chinese hamster ovary cells expressing CLIC1.', J Biol Chem, 277, pp. 26003 - 26011, http://dx.doi.org/10.1074/jbc.M203666200

Albertoni M; Shaw PH; Nozaki M; Godard S; Tenan M; Hamou M-F; Fairlie DW; Breit SN; Paralkar VM; de Tribolet N; Van Meir EG; Hegi ME, 2002, 'Anoxia induces macrophage inhibitory cytokine-1 (MIC-1) in glioblastoma cells independently of p53 and HIF-1', Oncogene, 21, pp. 4212 - 4219, http://dx.doi.org/10.1038/sj.onc.1205610

Min DQ; Moore AG; Bain MA; Breit SN; Lyons JG, 2002, 'Activation of macrophage promatrix metalloproteinase-9 by lipopolysaccharide-associated proteinases', JOURNAL OF IMMUNOLOGY, 168, pp. 2449 - 2455, http://dx.doi.org/10.4049/jimmunol.168.5.2449

Parson D; Schlieder B; Beatty P, 2002, 'Extension language automation of embedded system debugging', Automated Software Engineering, 9, pp. 7 - 39, http://dx.doi.org/10.1023/A:1013276002164

Qiu MR; Campbell TJ; Breit SN, 2002, 'A potassium ion channel is involved in cytokine production by activated human macrophages.', Clin Exp Immunol, 130, pp. 67 - 74, http://dx.doi.org/10.1046/j.1365-2249.2002.01965.x

Brown DA; Bauskin AR; Fairlie WD; Smith MD; Liu T; Xu N; Breit SN, 2002, 'Antibody-based approach to high-volume genotyping for MIC-1 polymorphism', BIOTECHNIQUES, 33, pp. 118 - +, http://dx.doi.org/10.2144/02331rr03

Brown DA; Breit SN; Buring J; Fairlie WD; Bauskin AR; Liu T; Ridker PM, 2002, 'Concentration in plasma of macrophage inhibitory cytokine-1 and risk of cardiovascular events in women: a nested case-control study', The Lancet, 359, pp. 2159 - 2163, http://dx.doi.org/10.1016/s0140-6736(02)09093-1

Singarayar S; Singleton C; Tie H; Wyse K; Bursill J; Bauskin A; Wu W; Valenzuela S; Breit S; Campbell T, 2002, 'Effects of Components of Ischemia on the Kv4.3 Current Stably Expressed in Chinese Hamster Ovary Cells', Journal of Molecular and Cellular Cardiology, 34, pp. 197 - 207, http://dx.doi.org/10.1006/jmcc.2001.1502

Harrop SJ; DeMaere MZ; Fairlie WD; Reztsova T; Valenzuela SM; Mazzanti M; Tonini R; Qiu MR; Jankova L; Warton K; Bauskin AR; Wu WM; Pankhurst S; Campbell TJ; Breit SN; Curmi PM, 2001, 'Crystal structure of a soluble form of the intracellular chloride ion channel CLIC1 (NCC27) at 1.4-A resolution.', J Biol Chem, 276, pp. 44993 - 45000, http://dx.doi.org/10.1074/jbc.M107804200

Christofi FL; Zhang H; Yu J; Guzman J; Xue J; Kim M; Wang Y; Cooke HJ, 2001, 'Differential gene expression of adenosine A1, A2a, A2b, and A3 receptors in the human enteric nervous system', Journal of Comparative Neurology, 439, pp. 46 - 64, http://dx.doi.org/10.1002/cne.1334

Schober A; Böttner M; Strelau J; Kinscherf R; Bonaterra GA; Barth M; Schilling L; Fairlie WD; Breit SN; Unsicker K, 2001, 'Expression of growth differentiation factor‐15/ macrophage inhibitory cytokine‐1 (GDF‐15/MIC‐1) in the perinatal, adult, and injured rat brain', Journal of Comparative Neurology, 439, pp. 32 - 45, http://dx.doi.org/10.1002/cne.1333

Fairlie WD; Russell PK; Wu WM; Moore AG; Zhang H-P; Brown PK; Bauskin AR; Breit SN, 2001, 'Epitope Mapping of the Transforming Growth Factor-β Superfamily Protein, Macrophage Inhibitory Cytokine-1 (MIC-1):  Identification of at Least Five Distinct Epitope Specificities', Biochemistry, 40, pp. 65 - 73, http://dx.doi.org/10.1021/bi001064p

Tie H; Walker BD; Singleton CB; Bursill JA; Wyse KR; Campbell TJ; Valenzuela SM; Breit SN, 2001, 'Clozapine and Sudden Death', Journal of Clinical Psychopharmacology, 21, pp. 630 - 632, http://dx.doi.org/10.1097/00004714-200112000-00023

Fairlie WD; Zhang H-P; Wu WM; Pankhurst SL; Bauskin AR; Russell PK; Brown PK; Breit SN, 2001, 'The Propeptide of the Transforming Growth Factor-β Superfamily Member, Macrophage Inhibitory Cytokine-1 (MIC-1), Is a Multifunctional Domain That Can Facilitate Protein Folding and Secretion', Journal of Biological Chemistry, 276, pp. 16911 - 16918, http://dx.doi.org/10.1074/jbc.m010000200

Moore AG, 2000, 'The Transforming Growth Factor-  Superfamily Cytokine Macrophage Inhibitory Cytokine-1 Is Present in High Concentrations in the Serum of Pregnant Women', Journal of Clinical Endocrinology & Metabolism, 85, pp. 4781 - 4788, http://dx.doi.org/10.1210/jc.85.12.4781

Warton K; Valenzuela S; Tonini R; Mazzanti M; Breit S, 2000, 'Intracellular Ion Channel NCC27 Moves between a Soluble and a Transmembrane State', Biochemical Society Transactions, 28, pp. A471 - A471, http://dx.doi.org/10.1042/bst028a471c

Bauskin AR; Zhang H; Fairlie WD; He XY; Russell PK; Moore AG; Brown DA; Stanley KK; Breit SN, 2000, 'The propeptide of macrophage inhibitory cytokine (MIC‐1), a TGF‐β superfamily member, acts as a quality control determinant for correctly folded MIC‐1', The EMBO Journal, 19, pp. 2212 - 2220, http://dx.doi.org/10.1093/emboj/19.10.2212

Gilmour TK; Wilkinson B; Breit SN; Kossard S, 2000, 'Analysis of dendritic cell populations using a revised histological staging of morphoea', British Journal of Dermatology, 143, pp. 1183 - 1192, http://dx.doi.org/10.1046/j.1365-2133.2000.03886.x

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