By Doctor David Anthony Jacques

Journal articles

Dickson CF; Hertel S; Tuckwell AJ; Li N; Ruan J; Al-Izzi SC; Ariotti N; Sierecki E; Gambin Y; Morris RG; Towers GJ; Böcking T; Jacques DA, 2024, 'The HIV capsid mimics karyopherin engagement of FG-nucleoporins', Nature, 626, pp. 836 - 842, http://dx.doi.org/10.1038/s41586-023-06969-7

Faysal KMR; Walsh JC; Renner N; Márquez CL; Shah VB; Tuckwell AJ; Christie MP; Parker MW; Turville SG; Towers GJ; James LC; Jacques DA; Böcking T, 2024, 'Pharmacologic hyperstabilisation of the HIV-1 capsid lattice induces capsid failure', eLife, 13, http://dx.doi.org/10.7554/eLife.83605

Ruan J; Dickson CF; Hertel S; Ariotti N; Jacques DA, 2023, 'The interaction between the HIV capsid and nuclear pore complexes revealed by cryo-electron tomography', Acta Crystallographica Section A Foundations and Advances, 79, pp. C725 - C725, http://dx.doi.org/10.1107/s2053273323088927

Speck P; MacKenzie J; Bull RA; Slobedman B; Drummer H; Fraser J; Herrero L; Helbig K; Londrigan S; Moseley G; Prow N; Hansman G; Edwards R; Ahlenstiel C; Abendroth A; Tscharke D; Hobson-Peter J; Kriiger-Loteri R; Parry R; Marsh G; Harding E; Jacques DA; Gartner MJ; Lee WS; McAuley J; Vaz P; Sainsbury F; Tate MD; Sinclair J; Imrie A; Rawlinson S; Harman A; Carr JM; Monson EA; Hibma M; Mahony TJ; Tu T; Center RJ; Shrestha LB; Hall R; Warner M; Ward V; Anderson DE; Eyre NS; Netzler NE; Peel AJ; Revill P; Beard M; Legione AR; Spencer AJ; Idris A; Forwood J; Sarker S; Purcell DFJ; Bartlett N; Deerain JM; Brew BJ; Asgari S; Farrell H; Khromykh A; Tuipulotu DE; Anderson D; Mese S; Tayyar Y; Edenborough K; Uddin JM; Hussain A; Daymond CJI; Agius J; Johnson KN; Shirmast P; Abedinzadeshahri M; MacDiarmid R; Ashley CL; Laws J; Furfaro LL; Burton TD; Johnson SMR; Telikani Z; Petrone M; Roby JA; Samer C; Suhrbier A; Van Der Kamp A; Cunningham A; Donato C; Mahar J; Black WD; Vasudevan S; Lenchine R; Spann K; Rawle DJ; Rudd P; Neil J; Kingston R; Newsome TP; Kim KW; Mak J; Lowry K; Bryant N, 2023, 'Statement in Support of: "Virology under the Microscope - a Call for Rational Discourse"', mSphere, 8, http://dx.doi.org/10.1128/msphere.00165-23

Speck P; Mackenzie J; Bull RA; Slobedman B; Drummer H; Fraser J; Herrero L; Helbig K; Londrigan S; Moseley G; Prow N; Hansman G; Edwards R; Ahlenstiel C; Abendroth A; Tscharke D; Hobson-Peters J; Kriiger-Loterio R; Parry R; Marsh G; Harding E; Jacques DA; Gartner MJ; Lee WS; McAuley J; Vaz P; Sainsbury F; Tate MD; Sinclair J; Imrie A; Rawlinson S; Harman A; Carr JM; Monson EA; Hibma M; Mahony TJ; Tu T; Center RJ; Shrestha LB; Hall R; Warner M; Ward V; Anderson DE; Eyre NS; Netzler NE; Peel AJ; Revill P; Beard M; Legione AR; Spencer AJ; Idris A; Forwood J; Sarker S; Purcell DFJ; Bartlett N; Deerain JM; Brew BJ; Asgari S; Farrell H; Khromykh A; Tuipulotu DE; Anderson D; Mese S; Tayyar Y; Edenborough K; Uddin JM; Hussain A; Daymond CJI; Agius J; Johnson KN; Shirmast P; Abedinzadeshahri M; MacDiarmid R; Ashley CL; Laws J; Furfaro LL; Burton TD; Johnson SMR; Telikani Z; Petrone M; Roby JA; Samer C; Suhrbier A; Van Der Kamp A; Cunningham A; Donato C; Mahar J; Black WD; Vasudevan S; Lenchine R; Spann K; Rawle DJ; Rudd P; Neil J; Kingston R; Newsome TP; Kim KW; Mak J; Lowry K; Bryant N, 2023, 'Statement in Support of: “Virology under the Microscope—a Call for Rational Discourse”', mBio, 14, http://dx.doi.org/10.1128/mbio.00815-23

Speck P; Mackenzie J; Bull RA; Slobedman B; Drummer H; Fraser J; Herrero L; Helbig K; Londrigan S; Moseley G; Prow N; Hansman G; Edwards R; Ahlenstiel C; Abendroth A; Tscharke D; Hobson-Peters J; Kriiger-Loterio R; Parry R; Marsh G; Harding E; Jacques DA; Gartner MJ; Lee WS; McAuley J; Vaz P; Sainsbury F; Tate MD; Sinclair J; Imrie A; Rawlinson S; Harman A; Carr JM; Monson EA; Hibma M; Mahony TJ; Tu T; Center RJ; Shrestha LB; Hall R; Warner M; Ward V; Anderson DE; Eyre NS; Netzler NE; Peel AJ; Revill P; Beard M; Legione AR; Spencer AJ; Idris A; Forwood J; Sarker S; Purcell DFJ; Bartlett N; Deerain JM; Brew BJ; Asgari S; Farrell H; Khromykh A; Tuipulotu DE; Anderson D; Mese S; Tayyar Y; Edenborough K; Uddin JM; Hussain A; Daymond CJI; Agius J; Johnson KN; Shirmast P; Abedinzadeshahri M; MacDiarmid R; Ashley CL; Laws J; Furfaro LL; Burton TD; Johnson SMR; Telikani Z; Petrone M; Roby JA; Samer C; Suhrbier A; Van Der Kamp A; Cunningham A; Donato C; Mahar J; Black WD; Vasudevan S; Lenchine R; Spann K; Rawle DJ; Rudd P; Neil J; Kingston R; Newsome TP; Kim KW; Mak J; Lowry K; Bryant N, 2023, 'Statement in Support of: “Virology under the Microscope-a Call for Rational Discourse”', Journal of Virology, 97, http://dx.doi.org/10.1128/jvi.00451-23

Zuliani-Alvarez L; Govasli ML; Rasaiyaah J; Monit C; Perry SO; Sumner RP; McAlpine-Scott S; Dickson C; Rifat Faysal KM; Hilditch L; Miles RJ; Bibollet-Ruche F; Hahn BH; Boecking T; Pinotsis N; James LC; Jacques DA; Towers GJ, 2022, 'Evasion of cGAS and TRIM5 defines pandemic HIV', Nature Microbiology, 7, pp. 1762 - 1776, http://dx.doi.org/10.1038/s41564-022-01247-0

Zhang MJ; Stear JH; Jacques DA; Böcking T, 2022, 'Insights into HIV uncoating from single-particle imaging techniques', Biophysical Reviews, 14, pp. 23 - 32, http://dx.doi.org/10.1007/s12551-021-00922-6

Böcking T; Jacques DA; Lau D; Walsh JC; Dickson CF; Tuckwell A; Stear JH; Hunter DJB; Bhumkar A; Shah V; Turville SG; Sierecki E; Gambin Y, 2021, 'Rapid HIV-1 capsid interaction screening using fluorescence fluctuation spectroscopy', Analytical Chemistry, 93, pp. 3786 - 3793, http://dx.doi.org/10.1021/acs.analchem.0c04250

Zeng J; Santos AF; Mukadam AS; Osswald M; Jacques DA; Dickson CF; McLaughlin SH; Johnson CM; Kiss L; Luptak J; Renner N; Vaysburd M; McEwan WA; Morais-de-Sá E; Clift D; James LC, 2021, 'Target-induced clustering activates Trim-Away of pathogens and proteins', Nature Structural and Molecular Biology, 28, pp. 278 - 289, http://dx.doi.org/10.1038/s41594-021-00560-2

Renner N; Mallery DL; Faysal KMR; Peng W; Jacques DA; Böcking T; James LC, 2021, 'A lysine ring in HIV capsid pores coordinates IP6 to drive mature capsid assembly', PLoS Pathogens, 17, pp. 1 - 22, http://dx.doi.org/10.1371/JOURNAL.PPAT.1009164

Moustaqil M; Ollivier E; Chiu HP; Van Tol S; Rudolffi-Soto P; Stevens C; Bhumkar A; Hunter DJB; Freiberg AN; Jacques D; Lee B; Sierecki E; Gambin Y, 2021, 'SARS-CoV-2 proteases PLpro and 3CLpro cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation across species', Emerging Microbes and Infections, 10, pp. 178 - 195, http://dx.doi.org/10.1080/22221751.2020.1870414

Miles RJ; Kerridge C; Hilditch L; Monit C; Jacques DA; Towers GJ, 2020, 'Mxb sensitivity of HIV-1 is determined by a highly variable and dynamic capsid surface', eLife, 9, pp. 1 - 17, http://dx.doi.org/10.7554/eLife.56910

Lau D; Walsh JC; Mousapasandi A; Ariotti N; Shah VB; Turville S; Jacques DA; Böcking T, 2020, 'Self-Assembly of Fluorescent HIV Capsid Spheres for Detection of Capsid Binders', Langmuir, 36, pp. 3624 - 3632, http://dx.doi.org/10.1021/acs.langmuir.0c00103

Moustaqil M; Ollivier E; Chiu H-P; Van Tol S; Rudolffi-Soto P; Stevens C; Bhumkar A; Hunter DJB; Freiberg A; Jacques D; Lee B; Sierecki E; Gambin Y, 2020, 'SARS-CoV-2 proteases cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation across species and the search for reservoir hosts', , http://dx.doi.org/10.1101/2020.06.05.135699

Zeng J; Santos AF; Mukadam A; Osswald M; Luptak J; Jacques D; Dickson C; Renner N; Johnson C; Vaysburd M; McEwan W; Morais-de-Sá E; Clift D; James L, 2020, 'Substrate-induced clustering activates Trim-Away of pathogens and proteins', , http://dx.doi.org/10.1101/2020.07.28.225359

Lau D; Walsh JC; Peng W; Shah VB; Turville S; Jacques DA; Böcking T, 2019, 'Fluorescence Biosensor for Real-Time Interaction Dynamics of Host Proteins with HIV-1 Capsid Tubes', ACS Applied Materials and Interfaces, 11, pp. 34586 - 34594, http://dx.doi.org/10.1021/acsami.9b08521

Lau D; Walsh J; Peng W; Shah V; Turville S; Jacques D; Böcking T, 2019, 'Fluorescence biosensor for real-time interaction dynamics of host proteins with HIV-1 capsid tubes', , http://dx.doi.org/10.1101/619841

James LC; Jacques DA, 2018, 'The human immunodeficiency virus capsid is more than just a genome package', Annual Review of Virology, 5, pp. 209 - 225, http://dx.doi.org/10.1146/annurev-virology-092917-043430

Márquez CL; Lau D; Walsh J; Shah V; McGuinness C; Wong A; Aggarwal A; Parker MW; Jacques DA; Turville S; Böcking T, 2018, 'Kinetics of HIV-1 capsid uncoating revealed by single-molecule analysis', eLife, 7, http://dx.doi.org/10.7554/eLife.34772

Mallery DL; Márquez CL; McEwan WA; Dickson CF; Jacques DA; Anandapadamanaban M; Bichel K; Towers GJ; Saiardi A; Böcking T; James LC, 2018, 'IP6 is an HIV pocket factor that prevents capsid collapse and promotes DNA synthesis', eLife, 7, http://dx.doi.org/10.7554/eLife.35335

Bhati M; Llamosas E; Jacques DA; Jeffries CM; Dastmalchi S; Ripin N; Nicholas HR; Matthews JM, 2017, 'Interactions between LHX3-And ISL1-family LIM-homeodomain transcription factors are conserved in Caenorhabditis elegans', Scientific Reports, 7, pp. 4579, http://dx.doi.org/10.1038/s41598-017-04587-8

Trewhella J; Duff AP; Durand D; Gabel F; Guss JM; Hendrickson WA; Hura GL; Jacques DA; Kirby NM; Kwan AH; Pérez J; Pollack L; Ryan TM; Sali A; Schneidman-Duhovny D; Schwede T; Svergun DI; Sugiyama M; Tainer JA; Vachette P; Westbrook J; Whitten AE, 2017, '2017 publication guidelines for structural modelling of small-angle scattering data from biomolecules in solution: An update', Acta Crystallographica Section D: Structural Biology, 73, pp. 710 - 728, http://dx.doi.org/10.1107/S2059798317011597

Jacques DA; McEwan WA; Hilditch L; Price AJ; Towers GJ; James LC, 2016, 'HIV-1 uses dynamic capsid pores to import nucleotides and fuel encapsidated DNA synthesis', Nature, 536, pp. 349 - 353, http://dx.doi.org/10.1038/nature19098

Wilkinson-White L; Lester KL; Ripin N; Jacques DA; Mitchell Guss J; Matthews JM, 2015, 'GATA1 directly mediates interactions with closely spaced pseudopalindromic but not distantly spaced double GATA sites on DNA', Protein Science, 24, pp. 1649 - 1659, http://dx.doi.org/10.1002/pro.2760

Wood K; Jeffries CM; Knott RB; Sokolova A; Jacques DA; Duff AP, 2015, 'Exploring the structure of biological macromolecules in solution using Quokka, the small angle neutron scattering instrument, at ANSTO', Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 798, pp. 44 - 51, http://dx.doi.org/10.1016/j.nima.2015.06.034

Dickson CF; Jacques DA; Clubb RT; Guss JM; Gell DA, 2015, 'The structure of haemoglobin bound to the haemoglobin receptor IsdH from Staphylococcus aureus shows disruption of the native α-globin haem pocket', Acta Crystallographica Section D: Biological Crystallography, 71, pp. 1295 - 1306, http://dx.doi.org/10.1107/S1399004715005817

Price AJ; Jacques DA; McEwan WA; Fletcher AJ; Essig S; Chin JW; Halambage UD; Aiken C; James LC, 2014, 'Host Cofactors and Pharmacologic Ligands Share an Essential Interface in HIV-1 Capsid That Is Lost upon Disassembly', PLoS Pathogens, 10, http://dx.doi.org/10.1371/journal.ppat.1004459

Price A; Jacques D; Essig S; Elliott T; Halambage U; Chin J; Aiken C; James L, 2014, 'HIV-1 capsid binds host cofactors to mediate nuclear import', Acta Crystallographica Section A Foundations and Advances, 70, pp. C120 - C120, http://dx.doi.org/10.1107/s2053273314098799

Jacques D; Jeffries C; Caines M; Lammers M; Mallery D; Price A; McLaughlin S; Johnson C; Svergun D; James L, 2014, 'TRIM protein domain topology and implications for antiviral immunity', Acta Crystallographica Section A Foundations and Advances, 70, pp. C243 - C243, http://dx.doi.org/10.1107/s2053273314097563

Dickson CF; Kumar KK; Jacques DA; Malmirchegini GR; Spirig T; Mackay JP; Clubb RT; Guss JM; Gell DA, 2014, 'Structure of the hemoglobin-isdh complex reveals the molecular basis of iron capture by staphylococcus aureus', Journal of Biological Chemistry, 289, pp. 6728 - 6738, http://dx.doi.org/10.1074/jbc.M113.545566

Tam JCH; Jacques DA, 2014, 'Intracellular immunity: Finding the enemy within-how cells recognize and respond to intracellular pathogens', Journal of Leukocyte Biology, 96, pp. 233 - 244, http://dx.doi.org/10.1189/jlb.4RI0214-090R

Kumar KK; Jacques DA; Guss JM; Gell DA, 2014, 'The structure of α-haemoglobin in complex with a haemoglobin-binding domain from Staphylococcus aureus reveals the elusive α-haemoglobin dimerization interface', Acta Crystallographica Section F:Structural Biology Communications, 70, pp. 1032 - 1037, http://dx.doi.org/10.1107/S2053230X14012175

Rasaiyaah J; Tan CP; Fletcher AJ; Price AJ; Blondeau C; Hilditch L; Jacques DA; Selwood DL; James LC; Noursadeghi M; Towers GJ, 2013, 'HIV-1 evades innate immune recognition through specific cofactor recruitment', Nature, 503, pp. 402 - 405, http://dx.doi.org/10.1038/nature12769

Gadd MS; Jacques DA; Nisevic I; Craig VJ; Kwan AH; Guss JM; Matthews JM, 2013, 'A structural basis for the regulation of the LIM-homeodomain protein islet 1 (Isl1) by intra- and intermolecular interactions', Journal of Biological Chemistry, 288, pp. 21924 - 21935, http://dx.doi.org/10.1074/jbc.M113.478586

Vandevenne M; Jacques DA; Artuz C; Nguyen CD; Kwan AH; Segal DJ; Matthews JM; Crossley M; Guss JM; Mackay JP, 2013, 'New insights into DNA recognition by zinc fingers revealed by structural analysis of the oncoprotein ZNF217', J Biol Chem, 288, pp. 10616 - 10627, http://dx.doi.org/10.1074/jbc.M112.441451

Gadd MS; Jacques DA; Guss JM; Matthews JM, 2012, 'Crystallization and diffraction of an Isl1-Ldb1 complex', Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 68, pp. 1398 - 1401, http://dx.doi.org/10.1107/S1744309112040031

Jacques DA; Guss JM; Trewhella J, 2012, 'Reliable structural interpretation of small-angle scattering data from bio-molecules in solution - The importance of quality control and a standard reporting framework', BMC Structural Biology, 12, http://dx.doi.org/10.1186/1472-6807-12-9

Jacques DA; Guss JM; Svergun DI; Trewhella J, 2012, 'Publication guidelines for structural modelling of small-angle scattering data from biomolecules in solution', Acta Crystallographica Section D: Biological Crystallography, 68, pp. 620 - 626, http://dx.doi.org/10.1107/S0907444912012073

Kumar KK; Jacques DA; Pishchany G; Caradoc-Davies T; Spirig T; Malmirchegini GR; Langley DB; Dickson CF; Mackay JP; Clubb RT; Skaar EP; Guss JM; Gell DA, 2011, 'Structural basis for hemoglobin capture by Staphylococcus aureus cell-surface protein, IsdH', Journal of Biological Chemistry, 286, pp. 38439 - 38447, http://dx.doi.org/10.1074/jbc.M111.287300

Jacques DA; Langley DB; Kuramitsu S; Yokoyama S; Trewhella J; Guss JM, 2011, 'The structure of TTHA0988 from Thermus thermophilus, a KipI-KipA homologue incorrectly annotated as an allophanate hydrolase', Acta Crystallographica Section D: Biological Crystallography, 67, pp. 105 - 111, http://dx.doi.org/10.1107/S0907444910051127

Jacques DA; Langley DB; Hynson RMG; Whitten AE; Kwan A; Guss JM; Trewhella J, 2011, 'A novel structure of an antikinase and its inhibitor', Journal of Molecular Biology, 405, pp. 214 - 226, http://dx.doi.org/10.1016/j.jmb.2010.10.047

Hynson RMG; Kwan AH; Jacques DA; MacKay JP; Trewhella J, 2010, '¹H, ¹³C and ¹⁵N backbone and side chain resonance assignments of the N-terminal domain of the histidine kinase inhibitor KipI from Bacillus subtilis', Biomolecular NMR Assignments, 4, pp. 167 - 169, http://dx.doi.org/10.1007/s12104-010-9237-6

Jacques DA; Trewhella J, 2010, 'Small-angle scattering for structural biology - Expanding the frontier while avoiding the pitfalls', Protein Science, 19, pp. 642 - 657, http://dx.doi.org/10.1002/pro.351

Jacques DA; Streamer M; Rowland SL; King GF; Guss JM; Trewhella J; Langley DB, 2009, 'Structure of the sporulation histidine kinase inhibitor Sda from Bacillus subtilis and insights into its solution state', Acta Crystallographica Section D: Biological Crystallography, 65, pp. 574 - 581, http://dx.doi.org/10.1107/S090744490901169X

Jacques DA; Langley DB; Jeffries CM; Cunningham KA; Burkholder WF; Guss JM; Trewhella J, 2008, 'Histidine Kinase Regulation by a Cyclophilin-like Inhibitor', Journal of Molecular Biology, 384, pp. 422 - 435, http://dx.doi.org/10.1016/j.jmb.2008.09.017

Jacques DA; Langley DB; Whitten AE; Jeffries CM; Trewhella J, 2008, 'Inhibition of histidine kinase A inBacillus subtilis: a neutron contrast variation study', Acta Crystallographica Section A Foundations of Crystallography, 64, pp. C214 - C214, http://dx.doi.org/10.1107/s0108767308093124

Langley DB; Jacques DA; Whitten A; Trewhella J, 2008, 'The KipI–KipA complex and histidine kinase regulation inBacillus subtilis', Acta Crystallographica Section A Foundations of Crystallography, 64, pp. C214 - C215, http://dx.doi.org/10.1107/s0108767308093112

Whitten AE; Jacques DA; Hammouda B; Hanley T; King GF; Guss JM; Trewhella J; Langley DB, 2007, 'The Structure of the KinA-Sda Complex Suggests an Allosteric Mechanism of Histidine Kinase Inhibition', Journal of Molecular Biology, 368, pp. 407 - 420, http://dx.doi.org/10.1016/j.jmb.2007.01.064

Finnie KS; Jacques DA; McGann MJ; Blackford MG; Barbé CJ, 2006, 'Encapsulation and controlled release of biomolecules from silica microparticles', Journal of Materials Chemistry, 16, pp. 4494 - 4498, http://dx.doi.org/10.1039/b611840b

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