By Dr Anupriya Aggarwal

Preprints

Perkins G; Hope C; Chai CS; Tunbridge M; Sterling S; Webb K; Yap J; Yeow AEL; Masavuli M; Kireta S; Zuiani J; Akerman A; Aggarwal A; Milogiannakis V; Roberts M; Wilson W; Hurtado P; Turville S; Grubor-Bauk B; Barry S; Coates T; Ravindran J; Hissaria P, 2023, Immune profiling of COVID-19 vaccine responses in people with multiple sclerosis on B cell-depleting therapy, http://dx.doi.org/10.1101/2023.12.04.23299409

Thijssen V; Hurdiss DL; Debski-Antoniak OJ; Spence MA; Franck C; Norman A; Aggarwal A; Mokiem NJ; van Dongen DAA; Vermeir SW; Liu M; Li W; Chatziandreou M; Donselaar T; Du W; Drulyte I; Bosch B-J; Snijder J; Turville S; Payne RJ; Jackson CJ; van Kuppeveld FJM; Jongkees SAK, 2022, A broad-spectrum macrocyclic peptide inhibitor of the SARS-CoV-2 spike protein, http://dx.doi.org/10.1101/2022.11.11.516114

Poumbourios P; Langer C; Boo I; Zakir T; Center R; Akerman A; Milogiannakis V; Aggarwal A; Turville S; Drummer H, 2022, Enhanced stability of the SARS CoV-2 spike glycoprotein trimer following modification of an alanine cavity in the protein core, http://dx.doi.org/10.1101/2022.11.08.515567

Aggarwal A; Stella A; Walker G; Akerman A; Milogiannakis V; Brilot F; Amatayakul-Chantler S; Roth N; Coppola G; Schofield P; Jackson J; Lenthall H; Mazigi O; Langley D; Lu Y; Forster C; McAllery S; Mathivanan V; Fitcher C; Hoppe AC; Munier CML; Jack H-M; Cromer D; Darley D; Matthews G; Christ D; Khoury D; Davenport M; Rawlinson W; Kelleher A; Turville S, 2022, SARS-CoV-2 Omicron: evasion of potent humoral responses and resistance to clinical immunotherapeutics relative to viral variants of concern, http://dx.doi.org/10.21203/rs.3.rs-1207364/v1

Abayasingam A; Balachandran H; Agapiou D; Rodrigo C; Keoshkerian E; Li H; Brasher N; Christ D; Rouet R; Burnett D; Grubor-Bauk B; Rawlinson W; Turville S; Aggarwal A; Brilot F; Mina M; Post JJ; Hudson B; Gilroy N; Dwyer D; Sasson S; Tea F; Pilli D; Tedla N; Lloyd AR; Martinello M; Bull RA; Group CS, 2020, Long-Term Persistence of Neutralizing Memory B Cells in SARS-CoV-2, http://dx.doi.org/10.2139/ssrn.3732365

Counoupas C; Johansen MD; Stella AO; Nguyen DH; Ferguson AL; Aggarwal A; Bhattacharyya ND; Grey A; Patel K; Siddiquee R; Stewart EL; Feng CG; Hansbro NG; Palendira U; Steain MC; Saunders BM; Low JKK; Mackay JP; Kelleher AD; Britton WJ; Turville SG; Hansbro PM; Triccas JA, A single dose, BCG-adjuvanted COVID-19 vaccine provides sterilizing immunity against SARS-CoV-2 infection in mice, http://dx.doi.org/10.1101/2020.12.10.419044

Garcia-Valtanen P; Hope CM; Masavuli MG; Yeow AEL; Balachandran H; Mekonnen ZA; Al-Delfi Z; Abayasingam A; Agapiou D; Stella AO; Aggarwal A; Gummow J; Ferguson C; O’Connor S; McCartney EM; Lynn DJ; Maddern G; Gowans EJ; Reddi BA; Shaw D; Kok-Lim C; Turville SG; Beard MR; Weiskopf D; Sette A; Bull RA; Barry SC; Grubor-Bauk B, COVID-19 convalescents exhibit deficient humoral and T cell responses to variant of concern Spike antigens at 12 month post-infection, http://dx.doi.org/10.1101/2021.11.08.21266035

Johansen-Leete J; Ullrich S; Fry SE; Frkic R; Bedding MJ; Aggarwal A; Ashhurst AS; Ekanayake KB; Mahawaththa MC; Sasi VM; Passioura T; Larance M; Otting G; Turville S; Jackson CJ; Nitsche C; Payne RJ, Discovery of Antiviral Cyclic Peptides Targeting the Main Protease of SARS-CoV-2 via mRNA Display, http://dx.doi.org/10.1101/2021.08.23.457419

Norman A; Franck C; Christie M; Hawkins PME; Patel K; Ashhurst AS; Aggarwal A; Low JKK; Siddiquee R; Ashley CL; Steain M; Triccas JA; Turville S; Mackay JP; Passioura T; Payne RJ, Discovery of Cyclic Peptide Ligands to the SARS-CoV-2 Spike Protein using mRNA Display, http://dx.doi.org/10.1101/2020.12.22.424069

Lee WS; Tan H-X; Reynaldi A; Esterbauer R; Koutsakos M; Nguyen J; Amarasena T; Kent HE; Aggarwal A; Turville SG; Taiaroa G; Kinsella P; Liew KC; Tran T; Williamson DA; Cromer D; Davenport MP; Kent SJ; Juno JA; Khoury DS; Wheatley AK, Durable reprogramming of neutralising antibody responses following breakthrough Omicron infection, http://dx.doi.org/10.1101/2023.02.19.23286159

Loo L; Waller MA; Moreno CL; Cole AJ; Stella AO; Pop O-T; Jochum A-K; Ali OH; Denes CE; Hamoudi Z; Chung F; Aggarwal A; Low JKK; Patel K; Siddiquee R; Kang T; Mathivanan S; Mackay JP; Flatz L; Hesselson D; Turville S; Neely GG, Fibroblast-expressed LRRC15 suppresses SARS-CoV-2 infection and controls antiviral and antifibrotic transcriptional programs, http://dx.doi.org/10.1101/2021.11.09.467981

Phetsouphanh C; Khoo WH; Jackson K; Klemm V; Howe A; Aggarwal A; Akerman A; Milogiannakis V; Stella AO; Rouet R; Schofield P; Faulks ML; Law H; Danwilai T; Starr M; Munier CML; Christ D; Singh M; Croucher PI; Brilot-Turville F; Turville S; Phan TG; Dore GJ; Darley D; Cunningham P; Matthews GV; Kelleher AD; Zaunders JJ, High titre neutralizing antibodies in response to SARS-CoV-2 infection require RBD-specific CD4 T cells that include proliferative memory cells, http://dx.doi.org/10.1101/2022.07.22.22277947

Langer C; Boo I; Zakir T; Mackenzie-Kludas C; Samuel J; Fabb SA; Lee CL; Center RJ; Aggarwal A; Turville S; Pouton C; Subbarao K; Coulibaly F; Drummer HE; Poumbourios P, High-stability, clamp-free soluble Sarbecovirus spike trimers and their potential for pan-Sarbecovirus vaccine development, http://dx.doi.org/10.1101/2025.09.14.676173

Aggarwal A; Stella AO; Henry C; Narayan K; Turville SG, HIV corruption of the Arp2/3-Cdc42-IQGAP1 axis to hijack cortical F-Actin to promote cell-cell viral spread, http://dx.doi.org/10.1101/2019.12.13.873612

Phetsouphanh C; Jacka B; Ballouz S; Jackson KJ; Wilson DB; Manandhar B; Klemm V; Tan H-X; Wheatley A; Aggarwal A; Akerman A; Milogiannakis V; Starr M; Cunningham P; Turville SG; Kent SJ; Byrne A; Brew BJ; Darley DR; Dore GJ; Kelleher AD; Matthews GV, Improvement of immune dysregulation and health-related quality of life in individuals with long COVID at 24-months following SARS-CoV-2 infection, http://dx.doi.org/10.1101/2023.08.27.23294704

Pillay A; Yeola A; Tea F; Denkova M; Houston S; Burrell R; Merheb V; Lee FXZ; Moran L; Jadhav A; Sterling K; Lai CL; Vitagliano TL; Aggarwal A; Catchpoole D; Wood N; Phan TG; Nanan R; Hsu P; Turville SG; Britton PN; Brilot F, Infection and vaccine induced Spike antibody responses against SARS-CoV-2 Variants of concern in immune naïve children and adults, http://dx.doi.org/10.21203/rs.3.rs-2262275/v1

Loo L; Waller M; Cole A; Stella A; Moreno C; Denes C; Hamoudi Z; Chung F; Aggarwal A; Low J; Patel K; Siddiquee R; Mackay J; Turville S; Hesselson D; Neely G, LRRC15 suppresses SARS-CoV-2 infection and controls collagen production, http://dx.doi.org/10.21203/rs.3.rs-1172665/v1

Perkins GB; Tunbridge MJ; Chai CS; Hope CM; Yeow AEL; Salehi T; Singer J; Shi B; Masavuli MG; Mekonnen ZA; Garcia-Valtanen P; Kireta S; Johnston JK; Drogemuller CJ; Sim BZ; Spencer SM; Sallustio BC; Comerford I; Bouras G; Weiskopf D; Sette A; Aggarwal A; Milogiannakis V; Akerman A; Turville S; Hurtado PR; Ying T; Hissaria P; Barry SC; Chadban SJ; Grubor-Bauk B; Coates PT, mTOR inhibition improves the formation of functional T cell memory following COVID-19 vaccination of kidney transplant recipients, http://dx.doi.org/10.1101/2023.03.27.23287773

Ashhurst A; Johansen M; Maxwell J; Ashley C; Aggarwal A; Siddiquee R; Miemczyk S; Nguyen D; Mackay J; Counoupas C; Byrne S; Turville S; Steain M; Triccas J; Hansbro P; Payne R; Britton W, Mucosal TLR2-activating protein-based vaccination induces potent pulmonary immunity and protection against SARS-CoV-2 in mice, http://dx.doi.org/10.21203/rs.3.rs-1179181/v1

Counoupas C; Pino P; Stella AO; Ashley C; Lukeman H; Bhattacharyya ND; Tada T; Anchisi S; Metayer C; Martinis J; Aggarwal A; Dcosta BM; Kint J; Wurm MJ; Landau NR; Steain M; Turville SG; Wurm FM; David SA; Triccas JA, Neutralising antibodies against the SARS-CoV-2 Delta variant induced by Alhydroxyquim-II-adjuvanted trimeric spike antigens, http://dx.doi.org/10.1101/2021.08.18.456891

Moreno CL; Castanheira FVS; Stella AO; Chung F; Aggarwal A; Cole AJ; Loo L; Dupuy A; Kong Y; Hagimola L; Fenwick J; Coleman P; Willson M; Bui-Marinos M; Hesselson D; Gamble J; Passam F; Turville S; Kubes P; Neely GG, P-Selectin promotes SARS-CoV-2 interactions with platelets and the endothelium, http://dx.doi.org/10.1101/2023.02.13.528235

Ashhurst AS; Tang AH; Fajtová P; Yoon M; Aggarwal A; Stoye A; Larance M; Beretta L; Drelich A; Skinner D; Li L; Meek TD; McKerrow JH; Hook V; Tseng C-TK; Turville S; Gerwick WH; O’Donoghue AJ; Payne RJ, Potent in vitro anti-SARS-CoV-2 activity by gallinamide A and analogues via inhibition of cathepsin L, http://dx.doi.org/10.1101/2020.12.23.424111

Aggarwal A; Stella A; Akerman A; Walker G; Milogiannakis V; McAllery S; Esneau C; Silva MR; Lu Y; Forster C; Hal SV; Mathivanan V; Fitcher C; Hoppe AC; Munier CML; Darley D; Matthews G; Starck D; Robosa R; Bartlett N; Rawlinson W; Kelleher A; Turville S, Rapid isolation and resolution immune evasion and viral fitness across contemporary SARS-CoV-2 variants, http://dx.doi.org/10.21203/rs.3.rs-1210846/v1

Tea F; Stella AO; Aggarwal A; Darley DR; Pilli D; Vitale D; Merheb V; Lee FXZ; Cunningham P; Walker GJ; Brown DA; Rawlinson WD; Isaacs SR; Mathivanan V; Hoffman M; Pöhlmann S; Dwyer DE; Rockett R; Sintchenko V; Hoad VC; Irving DO; Dore GJ; Gosbell IB; Kelleher AD; Matthews GV; Brilot F; Turville SG, SARS-CoV-2 neutralizing antibodies; longevity, breadth, and evasion by emerging viral variants, http://dx.doi.org/10.1101/2020.12.19.20248567

Aggarwal A; Akerman A; Milogiannakis V; Silva MR; Walker G; Kidinger A; Angelovich T; Waring E; Amatayakul-Chantler S; Roth N; Coppola G; Yeang M; Jean T; Foster C; Hoppe AC; Munier CML; Darley D; Churchill M; Starck D; Christ D; Matthews G; Rawlinson W; Kelleher AD; Turville S, SARS-CoV-2 Omicron BA.5: Evolving tropism and evasion of potent humoral responses and resistance to clinical immunotherapeutics relative to viral variants of concern, http://dx.doi.org/10.1101/2022.07.07.22277128

Edwards ESJ; Gugasyan R; Varese N; Sun S; Canning JE; Blight EG; Aui PM; Boo I; Turville S; Aggarwal A; Ojaimi S; Bosco JJ; Stojanovic S; Hogarth PM; Drummer HE; Bornheimer SJ; O’Hehir RE; van Zelm MC, Third dose COVID-19 vaccination elicits immune memory in patients with inborn errors of immunity even in absence of neutralizing antibodies, http://dx.doi.org/10.1101/2025.11.09.25339598

Aggarwal A; Fichter C; Milogiannakis V; Ison T; Silva MR; Esneau C; Bartlett N; Burrell LM; Patel SK; Churchill M; Angelovich T; Walker G; Rawlinson W; Yeang M; Kok J; Sintchenkov V; Chandra D; Kindinger A; Akerman A; Parry R; Sng JD; Neely G; Moreno C; Loo L; Kelleher AD; Brilot F; Khromykh A; Turville SG, TMPRSS2 activation of Omicron lineage Spike glycoprotein is regulated by Collectrin-like domain of ACE2, http://dx.doi.org/10.1101/2023.09.22.558930

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