By Dr Chantelle Lisa Evelyn Ahlenstiel

Journal articles

Wang TT; Hirons A; Doerflinger M; Morris KV; Ledger S; Purcell DFJ; Kelleher AD; Ahlenstiel CL, 2024, 'Current State of Therapeutics for HTLV-1', Viruses, 16, http://dx.doi.org/10.3390/v16101616

Kitawi R; Ledger S; Kelleher AD; Ahlenstiel CL, 2024, 'Advances in HIV Gene Therapy', International Journal of Molecular Sciences, 25, http://dx.doi.org/10.3390/ijms25052771

Bowden-Reid E; Ledger S; Zhang Y; Di Giallonardo F; Aggarwal A; Stella AO; Akerman A; Milogiannakis V; Walker G; Rawlinson W; Turville S; Kelleher AD; Ahlenstiel C, 2023, 'Novel siRNA therapeutics demonstrate multi-variant efficacy against SARS-CoV-2', Antiviral Research, 217, http://dx.doi.org/10.1016/j.antiviral.2023.105677

Speck P; MacKenzie J; Bull RA; Slobedman B; Drummer H; Fraser J; Herrero L; Helbig K; Londrigan S; Moseley G; Prow N; Hansman G; Edwards R; Ahlenstiel C; Abendroth A; Tscharke D; Hobson-Peter J; Kriiger-Loteri R; Parry R; Marsh G; Harding E; Jacques DA; Gartner MJ; Lee WS; McAuley J; Vaz P; Sainsbury F; Tate MD; Sinclair J; Imrie A; Rawlinson S; Harman A; Carr JM; Monson EA; Hibma M; Mahony TJ; Tu T; Center RJ; Shrestha LB; Hall R; Warner M; Ward V; Anderson DE; Eyre NS; Netzler NE; Peel AJ; Revill P; Beard M; Legione AR; Spencer AJ; Idris A; Forwood J; Sarker S; Purcell DFJ; Bartlett N; Deerain JM; Brew BJ; Asgari S; Farrell H; Khromykh A; Tuipulotu DE; Anderson D; Mese S; Tayyar Y; Edenborough K; Uddin JM; Hussain A; Daymond CJI; Agius J; Johnson KN; Shirmast P; Abedinzadeshahri M; MacDiarmid R; Ashley CL; Laws J; Furfaro LL; Burton TD; Johnson SMR; Telikani Z; Petrone M; Roby JA; Samer C; Suhrbier A; Van Der Kamp A; Cunningham A; Donato C; Mahar J; Black WD; Vasudevan S; Lenchine R; Spann K; Rawle DJ; Rudd P; Neil J; Kingston R; Newsome TP; Kim KW; Mak J; Lowry K; Bryant N, 2023, 'Statement in Support of: "Virology under the Microscope - a Call for Rational Discourse"', mSphere, 8, http://dx.doi.org/10.1128/msphere.00165-23

Speck P; Mackenzie J; Bull RA; Slobedman B; Drummer H; Fraser J; Herrero L; Helbig K; Londrigan S; Moseley G; Prow N; Hansman G; Edwards R; Ahlenstiel C; Abendroth A; Tscharke D; Hobson-Peters J; Kriiger-Loterio R; Parry R; Marsh G; Harding E; Jacques DA; Gartner MJ; Lee WS; McAuley J; Vaz P; Sainsbury F; Tate MD; Sinclair J; Imrie A; Rawlinson S; Harman A; Carr JM; Monson EA; Hibma M; Mahony TJ; Tu T; Center RJ; Shrestha LB; Hall R; Warner M; Ward V; Anderson DE; Eyre NS; Netzler NE; Peel AJ; Revill P; Beard M; Legione AR; Spencer AJ; Idris A; Forwood J; Sarker S; Purcell DFJ; Bartlett N; Deerain JM; Brew BJ; Asgari S; Farrell H; Khromykh A; Tuipulotu DE; Anderson D; Mese S; Tayyar Y; Edenborough K; Uddin JM; Hussain A; Daymond CJI; Agius J; Johnson KN; Shirmast P; Abedinzadeshahri M; MacDiarmid R; Ashley CL; Laws J; Furfaro LL; Burton TD; Johnson SMR; Telikani Z; Petrone M; Roby JA; Samer C; Suhrbier A; Van Der Kamp A; Cunningham A; Donato C; Mahar J; Black WD; Vasudevan S; Lenchine R; Spann K; Rawle DJ; Rudd P; Neil J; Kingston R; Newsome TP; Kim KW; Mak J; Lowry K; Bryant N, 2023, 'Statement in Support of: “Virology under the Microscope—a Call for Rational Discourse”', mBio, 14, http://dx.doi.org/10.1128/mbio.00815-23

Hewavisenti RV; Arena J; Ahlenstiel CL; Sasson SC, 2023, 'Human papillomavirus in the setting of immunodeficiency: Pathogenesis and the emergence of next-generation therapies to reduce the high associated cancer risk', Frontiers in Immunology, 14, http://dx.doi.org/10.3389/fimmu.2023.1112513

Speck P; Mackenzie J; Bull RA; Slobedman B; Drummer H; Fraser J; Herrero L; Helbig K; Londrigan S; Moseley G; Prow N; Hansman G; Edwards R; Ahlenstiel C; Abendroth A; Tscharke D; Hobson-Peters J; Kriiger-Loterio R; Parry R; Marsh G; Harding E; Jacques DA; Gartner MJ; Lee WS; McAuley J; Vaz P; Sainsbury F; Tate MD; Sinclair J; Imrie A; Rawlinson S; Harman A; Carr JM; Monson EA; Hibma M; Mahony TJ; Tu T; Center RJ; Shrestha LB; Hall R; Warner M; Ward V; Anderson DE; Eyre NS; Netzler NE; Peel AJ; Revill P; Beard M; Legione AR; Spencer AJ; Idris A; Forwood J; Sarker S; Purcell DFJ; Bartlett N; Deerain JM; Brew BJ; Asgari S; Farrell H; Khromykh A; Tuipulotu DE; Anderson D; Mese S; Tayyar Y; Edenborough K; Uddin JM; Hussain A; Daymond CJI; Agius J; Johnson KN; Shirmast P; Abedinzadeshahri M; MacDiarmid R; Ashley CL; Laws J; Furfaro LL; Burton TD; Johnson SMR; Telikani Z; Petrone M; Roby JA; Samer C; Suhrbier A; Van Der Kamp A; Cunningham A; Donato C; Mahar J; Black WD; Vasudevan S; Lenchine R; Spann K; Rawle DJ; Rudd P; Neil J; Kingston R; Newsome TP; Kim KW; Mak J; Lowry K; Bryant N, 2023, 'Statement in Support of: “Virology under the Microscope-a Call for Rational Discourse”', Journal of Virology, 97, http://dx.doi.org/10.1128/jvi.00451-23

Afrasiabi A; Ahlenstiel C; Swaminathan S; Parnell GP, 2023, 'The interaction between Epstein–Barr virus and multiple sclerosis genetic risk loci: insights into disease pathogenesis and therapeutic opportunities', Clinical and Translational Immunology, 12, http://dx.doi.org/10.1002/cti2.1454

Agbosu EE; Ledger S; Kelleher AD; Wen J; Ahlenstiel CL, 2022, 'Targeted Nanocarrier Delivery of RNA Therapeutics to Control HIV Infection', Pharmaceutics, 14, http://dx.doi.org/10.3390/pharmaceutics14071352

Zhang Y; Almazi JG; Ong HX; Johansen MD; Ledger S; Traini D; Hansbro PM; Kelleher AD; Ahlenstiel CL, 2022, 'Nanoparticle Delivery Platforms for RNAi Therapeutics Targeting COVID-19 Disease in the Respiratory Tract', International Journal of Molecular Sciences, 23, http://dx.doi.org/10.3390/ijms23052408

Amodio A; Cassani M; Mummolo L; Cortez-Jugo C; Bhangu SK; Symons J; Ahlenstiel CL; Forte G; Ricci F; Kelleher AD; Lewin SR; Cavalieri F; Caruso F, 2022, 'Nanoscale probing and imaging of HIV-1 RNA in cells with a chimeric LNA-DNA sensor', Nanoscale, 14, pp. 3049 - 3061, http://dx.doi.org/10.1039/d1nr08418f

Kelleher AD; Cortez-Jugo C; Cavalieri F; Qu Y; Glanville AR; Caruso F; Symonds G; Ahlenstiel CL, 2020, 'RNAi therapeutics: an antiviral strategy for human infections', Current Opinion in Pharmacology, 54, pp. 121 - 129, http://dx.doi.org/10.1016/j.coph.2020.09.011

Ahlenstiel CL; Symonds G; Kent SJ; Kelleher AD, 2020, 'Block and Lock HIV Cure Strategies to Control the Latent Reservoir', Frontiers in Cellular and Infection Microbiology, 10, http://dx.doi.org/10.3389/fcimb.2020.00424

Read SA; Obeid S; Ahlenstiel C; Ahlenstiel G, 2019, 'The Role of Zinc in Antiviral Immunity', Advances in Nutrition, 10, pp. 696 - 710, http://dx.doi.org/10.1093/advances/nmz013

Ahlenstiel CL; Turville SG, 2019, 'Delivery of gene therapy to resting immune cells for an HIV cure', Current Opinion in HIV and AIDS, 14, pp. 129 - 136, http://dx.doi.org/10.1097/COH.0000000000000531

Méndez C; Ledger S; Petoumenos K; Ahlenstiel C; Kelleher AD, 2018, 'RNA-induced epigenetic silencing inhibits HIV-1 reactivation from latency', Retrovirology, 15, pp. 67, http://dx.doi.org/10.1186/s12977-018-0451-0

Tsukamoto T, 2018, 'Transcriptional gene silencing limits CXCR4-associated depletion of bone marrow CD34(+) cells in HIV-1 infection', AIDS, 32, pp. 1737 - 1747, http://dx.doi.org/10.1097/QAD.0000000000001882

Tsukamoto T; Kariya R; Marks K; Hattori S; Ahlenstiel C; Symonds G; Okada S; Kelleher AD, 2018, 'Erratum: Transcriptional gene silencing limits CXCR4-associated depletion of bone marrow CD34R cells in HIV-1 infection (AIDS (2018) (2018) 32 (1737–1747) DOI: 10.1097/QAD.0000000000001882)', AIDS, 32, pp. 2857 - 2858, http://dx.doi.org/10.1097/01.aids.0000547984.16868.93

Read SA; O'Connor KS; Suppiah V; Ahlenstiel CLE; Obeid S; Cook KM; Cunningham A; Douglas MW; Hogg PJ; Booth D; George J; Ahlenstiel G, 2017, 'Zinc is a potent and specific inhibitor of IFN-λ3 signalling', Nature Communications, 8, http://dx.doi.org/10.1038/ncomms15245

Klemm V; Mitchell J; Cortez-Jugo C; Cavalieri F; Symonds G; Caruso F; Kelleher AD; Ahlenstiel C, 2016, 'Achieving HIV-1 control through RNA-directed gene regulation', Genes, 7, http://dx.doi.org/10.3390/genes7120119

McAllery SA; Ahlenstiel CL; Suzuki K; Symonds GP; Kelleher AD; Turville SG, 2016, 'The feasibility of incorporating Vpx into lentiviral gene therapy vectors', Molecular Therapy Methods and Clinical Development, 3, pp. 16066, http://dx.doi.org/10.1038/mtm.2016.66

Ahlenstiel C; Mendez C; Lim STH; Marks K; Turville S; Cooper DA; Kelleher AD; Suzuki K, 2015, 'Novel RNA duplex locks HIV-1 in a latent state via chromatin-mediated transcriptional silencing', Molecular Therapy Nucleic Acids, 4, pp. e261, http://dx.doi.org/10.1038/mtna.2015.31

Suzuki K; Ahlenstiel C; Marks K; Kelleher AD, 2015, 'Promoter targeting RNAs: Unexpected contributors to the control of HIV-1 transcription', Molecular Therapy Nucleic Acids, 4, pp. e222, http://dx.doi.org/10.1038/mtna.2014.67

Ahlenstiel CL; Suzuki K; Marks K; Symonds GP; Kelleher AD, 2015, 'Controlling HIV-1: Non-coding RNA gene therapy approaches to a functional cure', Frontiers in Immunology, 6, pp. 474, http://dx.doi.org/10.3389/fimmu.2015.00474

Méndez C; Ahlenstiel CL; Kelleher AD, 2015, 'Post-transcriptional gene silencing, transcriptional gene silencing and human immunodeficiency virus.', World Journal of Virology, 4, pp. 219 - 244, http://dx.doi.org/10.5501/wjv.v4.i3.219

Suzuki K; Hattori S; Marks K; Ahlenstiel C; Maeda Y; Ishida T; Millington M; Boyd M; Symonds G; Cooper DA; Okada S; Kelleher AD, 2013, 'Promoter Targeting shRNA Suppresses HIV-1 Infection In vivo Through Transcriptional Gene Silencing', Molecular Therapy Nucleic Acids, 2, pp. e137, http://dx.doi.org/10.1038/mtna.2013.64

Swaminathan S; Suzuki K; Seddiki N; Kaplan W; Cowley MJ; Hood CL; Clancy JL; Murray DD; Mendez Ortega C; Gelgor L; Anderson B; Roth N; Cooper DA; Kelleher AD, 2012, 'Differential regulation of the Let-7 family of microRNAs in CD4+ T cells alters IL-10 expression.', Journal of Immunology, 188, pp. 6238 - 6246, http://dx.doi.org/10.4049/jimmunol.1101196

Ahlenstiel C; Lim HGW; Cooper DA; Ishida T; Kelleher AD; Suzuki K, 2012, 'Direct evidence of nuclear Argonaute distribution during transcriptional silencing links the actin cytoskeleton to nuclear RNAi machinary in human cells', Nucleic Acids Research, 40, pp. 1579 - 1595, http://nar.oxfordjournals.org/content/40/4/1579

Suzuki K; Yamagishi M; Ahlenstiel C; Swaminathan S; Marks K; Murray D; McCartney EM; Beard MR; Alexander M; Purcell DFJ; Cooper DA; Watanabe T; Kelleher AD, 2011, 'Transcriptional gene silencing of HIV-1 through promoter targeted RNA is highly specific', RNA Biology, 8, pp. 1035 - 1046, http://www.landesbioscience.com/journals/rnabiology/SuzukiRNA8-6.pdf

Suzuki K; Ishida T; Yamagishi M; Ahlenstiel C; Swaminathan S; Marks K; Murray D; McCartney EM; Beard MR; Alexander M; Purcell DF; Cooper DA; Watanabe T; Kelleher AD, 2011, 'Transcriptional gene silencing of HIV-1 through promoter targeted RNA is highly specific.', RNA biology, 8, pp. 1035 - 1046

Swaminathan S; Hood CL; Suzuki K; Kelleher AD, 2010, 'RNA duplexes in transcriptional regulation', Biomolecular Concepts, 1, pp. 285 - 296, http://dx.doi.org/10.1515/bmc.2010.021

Hood CL; Abraham J; Boyington JC; Leung K; Kwong PD; Nabel GJ, 2010, 'Biochemical and structural characterization of cathepsin L-processed Ebola virus glycoprotein: Implications for viral entry and immunogenicity', Journal of Virology, 84, pp. 2972 - 2982, http://dx.doi.org/10.1128/JVI.02151-09

Kong WP; Hood C; Yang ZY; Wei CJ; Xu L; García-Sastre A; Tumpey TM; Nabel GJ, 2006, 'Protective immunity to lethal challenge of the 1918 pandemic influenza virus by vaccination', Proceedings of the National Academy of Sciences of the United States of America, 103, pp. 15987 - 15991, http://dx.doi.org/10.1073/pnas.0607564103

Hood C; Cunningham AL; Slobedman B; Arvin AM; Sommer MH; Kinchington PR; Abendroth A, 2006, 'Varicella-Zoster virus ORF63 inhibits apoptosis of primary human neurons', Journal of Virology, 80, pp. 1025 - 1031, http://dx.doi.org/10.1128/JVI.80.2.1025-1031.2006

Hood C; Cunningham AL; Slobedman B; Boadle RA; Abendroth A, 2003, 'Varicella-Zoster Virus-Infected Human Sensory Neurons Are Resistant to Apoptosis, yet Human Foreskin Fibroblasts Are Susceptible: Evidence for a Cell-Type-Specific Apoptotic Response', Journal of Virology, 77, pp. 12852 - 12864, http://dx.doi.org/10.1128/JVI.77.23.12852-12864.2003

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