By Dr Dannielle Upton

Journal articles

Upton DH; Liu J; George SM; Valvi S; Ung C; Rayner BS; Gopalakrishnan A; Pandher R; Khan A; Venkat P; Mayoh C; Holliday H; Yeung N; Nguyen H; Franshaw L; Ehteda A; Shen H; Farruggia G; Orienti I; Reynolds CP; Tsoli M; Ziegler DS, 2025, 'High-throughput in vitro drug screening and in vivo studies identify fenretinide as a brain-penetrant DMG therapeutic.', Neuro Oncol, http://dx.doi.org/10.1093/neuonc/noaf035

Upton DH; Ziegler DS; Tsoli M, 2024, 'Development of Orthotopic Patient-Derived Xenograft Models of Pediatric Intracranial Tumors', , 2806, pp. 75 - 90, http://dx.doi.org/10.1007/978-1-0716-3858-3_7

Ung C; Upton D; Venkat P; Pandher R; Mayoh C; Tsoli M; Ziegler D, 2023, 'DDEL-07. BARRIER TO PROGRESS: DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG) INDUCES A TIGHTENED BLOOD-BRAIN BARRIER PHENOTYPE', Neuro-Oncology, 25, pp. v102 - v103, http://dx.doi.org/10.1093/neuonc/noad179.0386

Hayden E; Franshaw L; Upton D; Liu J; Nguyen H; Joshi S; Tsoli M; Dolman E; Rayner B; Ziegler D, 2023, 'Abstract 1561: Preclinical examination of PLK1 inhibitors for the treatment of diffuse midline gliomas', Cancer Research, 83, pp. 1561 - 1561, http://dx.doi.org/10.1158/1538-7445.am2023-1561

Upton DH; Ung C; George SM; Tsoli M; Kavallaris M; Ziegler DS, 2022, 'Challenges and opportunities to penetrate the blood-brain barrier for brain cancer therapy', Theranostics, 12, pp. 4734 - 4752, http://dx.doi.org/10.7150/THNO.69682

Khan A; Gamble LD; Upton DH; Ung C; Yu DMT; Ehteda A; Pandher R; Mayoh C; Hébert S; Jabado N; Kleinman CL; Burns MR; Norris MD; Haber M; Tsoli M; Ziegler DS, 2021, 'Dual targeting of polyamine synthesis and uptake in diffuse intrinsic pontine gliomas', Nature Communications, 12, pp. 971, http://dx.doi.org/10.1038/s41467-021-20896-z

Ung C; Tsoli M; Liu J; Cassano D; Pocoví-Martínez S; Upton DH; Ehteda A; Mansfeld FM; Failes TW; Farfalla A; Katsinas C; Kavallaris M; Arndt GM; Vittorio O; Cirillo G; Voliani V; Ziegler DS, 2021, 'Doxorubicin-loaded gold nanoarchitectures as a therapeutic strategy against diffuse intrinsic pontine glioma', Cancers, 13, pp. 1 - 20, http://dx.doi.org/10.3390/cancers13061278

Upton DH; Popovic K; Fulton R; Kassiou M, 2020, 'Anaesthetic-dependent changes in gene expression following acute and chronic exposure in the rodent brain', Scientific Reports, 10, pp. 9366, http://dx.doi.org/10.1038/s41598-020-66122-6

Tsoli M; Shen H; Mayoh C; Franshaw L; Ehteda A; Upton D; Carvalho D; Vinci M; Meel MH; van Vuurden D; Plessier A; Castel D; Drissi R; Farrell M; Cryan J; Crimmins D; Caird J; Pears J; Francis S; Ludlow LEA; Carai A; Mastronuzzi A; Liu B; Hansford J; Gottardo NG; Hassall T; Kirby M; Fouladi M; Hawkins C; Monje M; Grill J; Jones C; Hulleman E; Ziegler DS, 2019, 'Correction to: International experience in the development of patient-derived xenograft models of diffuse intrinsic pontine glioma (Journal of Neuro-Oncology, (2019), 141, 2, (253-263), 10.1007/s11060-018-03038-2)', Journal of Neuro-Oncology, 141, pp. 265, http://dx.doi.org/10.1007/s11060-018-03060-4

Tsoli M; Shen H; Mayoh C; Franshaw L; Ehteda A; Upton D; Carvalho D; Vinci M; Meel MH; van Vuurden D; Plessier A; Castel D; Drissi R; Farrell M; Cryan J; Crimmins D; Caird J; Pears J; Francis S; Ludlow LEA; Carai A; Mastronuzzi A; Liu B; Hansford J; Gottardo N; Hassall T; Kirby M; Fouladi M; Hawkins C; Monje M; Grill J; Jones C; Hulleman E; Ziegler DS, 2019, 'International experience in the development of patient-derived xenograft models of diffuse intrinsic pontine glioma', Journal of Neuro-Oncology, 141, pp. 253 - 263, http://dx.doi.org/10.1007/s11060-018-03038-2

Upton DH; Walters KA; McTavish KJ; Holt J; Handelsman DJ; Allan CM, 2018, 'Reproductive failure in mice expressing transgenic follicle-stimulating hormone is not caused by loss of oocyte quality', Biology of Reproduction, 98, pp. 491 - 500, http://dx.doi.org/10.1093/biolre/ioy015

Upton DH; Walters KA; Allavena RE; Jimenez M; Desai R; Handelsman DJ; Allan CM, 2016, 'Global or Granulosa Cell-Specific Pten Mutations in Combination with Elevated FSH Levels Fail to Cause Ovarian Tumours in Mice', Hormones and Cancer, 7, pp. 316 - 326, http://dx.doi.org/10.1007/s12672-016-0272-3

Hazra R; Upton D; Desai R; Noori O; Jimenez M; Handelsman DJ; Allan CM, 2016, 'Elevated expression of the sertoli cell androgen receptor disrupts male fertility', American Journal of Physiology - Endocrinology and Metabolism, 311, pp. E396 - E404, http://dx.doi.org/10.1152/ajpendo.00159.2016

Powell KL; Stevens V; Upton DH; McCracken SA; Simpson AM; Cheng Y; Tasevski V; Morris JM; Ashton AW, 2016, 'Role for the thromboxane A 2 receptor β-isoform in the pathogenesis of intrauterine growth restriction', Scientific Reports, 6, http://dx.doi.org/10.1038/srep28811

Upton DH; Fuller ES; Colvin EK; Walters KA; Jimenez M; Desai R; Handelsman DJ; Howell VM; Allan CM, 2015, 'Granulosa Cell-Specific Brca1 Loss Alone or Combined with Trp53 Haploinsufficiency and Transgenic FSH Expression Fails to Induce Ovarian Tumors', Hormones and Cancer, 6, pp. 142 - 152, http://dx.doi.org/10.1007/s12672-015-0222-5

Hazra R; Upton D; Jimenez M; Desai R; Handelsman DJ; Allan CM, 2014, 'In vivo actions of the sertoli cell glucocorticoid receptor', Endocrinology, 155, pp. 1120 - 1130, http://dx.doi.org/10.1210/en.2013-1940

Hazra R; Corcoran L; Robson M; McTavish KJ; Upton D; Handelsman DJ; Allan CM, 2013, 'Temporal role of sertoli cell androgen receptor expression in spermatogenic development', Molecular Endocrinology, 27, pp. 12 - 24, http://dx.doi.org/10.1210/me.2012-1219

Conference Papers

Upton D; Valvi S; Liu J; Yeung N; George S; Ung C; Khan A; Franshaw L; Ehteda A; Shen H; Orienti I; Farruggia G; Nath C; Reynolds P; Tsoli M; Ziegler D, 2020, 'HIGH THROUGHPUT DRUG SCREENING IDENTIFIES POTENTIAL NEW THERAPIES FOR DIFFUSE INTRINSIC PONTINE GLIOMAS (DIPGS)', in NEURO-ONCOLOGY, OXFORD UNIV PRESS INC, pp. 288 - 288, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000606080100059&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Ung C; Tsoli M; Liu J; Cassano D; Upton D; Ehteda A; Mansfield F; Failes T; Kavallaris M; Arndt G; Vittorio O; Voliani V; Cirilo G; Ziegler DS, 2020, 'NANOPARTICLE DELIVERY OF DOXORUBICIN FOR THE TREATMENT OF DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG)', in NEURO-ONCOLOGY, OXFORD UNIV PRESS INC, pp. 286 - 286, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000606080100048&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Khan A; Gamble L; Upton D; Yu D; Ehteda A; Pandher R; Mayoh C; Burns M; Norris M; Haber M; Tsoli M; Ziegler D, 2020, 'POLYAMINE PATHWAY INHIBITION IS A POTENT NOVEL THERAPEUTIC STRATEGY AGAINST DIFFUSE INTRINSIC PONTINE GLIOMA', in NEURO-ONCOLOGY, OXFORD UNIV PRESS INC, pp. 289 - 290, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000606080100066&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Ehteda A; Franshaw L; Liu J; Joshi S; Simon S; Pang CNI; Giorgi F; Pandher R; Ung C; Tolhurst O; Mayoh C; Khan A; Hayden E; Gopalakrishnan A; Trebilcock P; Upton D; Lehmann R; George S; Vittorio O; Tsoli M; Gurova K; Gudkov AG; Norris MD; Haber M; Ziegler DS, 2020, 'TARGETING FACILITATES CHROMATIN TRANSCRIPTION (FACT) AS A NOVEL STRATEGY FOR DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG) THAT ENHANCES RESPONSE TO HISTONE DEACETYLASE (HDAC) INHIBITION', in NEURO-ONCOLOGY, OXFORD UNIV PRESS INC, pp. 292 - 292, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000606080100077&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Stevens VA; Upton D; Simpson A; Morris J; Ashton A, 2011, 'DIFFERENTIAL REGULATION OF TP ISOFORMS IN PREECLAMPSIA', in HYPERTENSION, LIPPINCOTT WILLIAMS & WILKINS, AUSTRALIA, Perth, pp. 500 - 500, presented at 33rd Annual Scientific Meeting of the High-Blood-Pressure-Research-Council-of-Australia (HBPRCA), AUSTRALIA, Perth, 06 December 2011 - 09 December 2011, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000306550900098&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts

Tsoli M; Ung C; Upton DH; Venkat P; Salerno A; Pandher R; Mayoh C; Vittorio O; Ziegler DS, 2024, 'OVERCOMING THE BLOOD-BRAIN BARRIER CHALLENGE IN DIFFUSE MIDLINE GLIOMA', in NEURO-ONCOLOGY, OXFORD UNIV PRESS INC, PA, Philadelphia, Vol. 26, presented at International Symposium on Pediatric Neuro-Oncology (ISPNO), PA, Philadelphia, 29 June 2024 - 02 July 2024, http://dx.doi.org/10.1093/neuonc/noae064.088

Hayden E; Dolman EM; Upton DH; Franshaw L; Liu J; Nguyen H; Tsoli M; Guo X; Mayoh C; Rayner BS; Ziegler DS, 2024, 'TARGETING VULNERABILITIES IN PAEDIATRIC DIFFUSE MIDLINE GLIOMAS: LEVERAGING PLK1 INHIBITION TO EXPLOIT RAS/PI3K PATHWAY DEPENDENCY', in NEURO-ONCOLOGY, OXFORD UNIV PRESS INC, PA, Philadelphia, Vol. 26, presented at International Symposium on Pediatric Neuro-Oncology (ISPNO), PA, Philadelphia, 29 June 2024 - 02 July 2024, http://dx.doi.org/10.1093/neuonc/noae064.103

Khan A; Upton D; Gopalakrishnan A; Chen Y; Tsoli M; Ziegler DS, 2024, 'TOTAL THERAPY FOR DIFFUSE MIDLINE GLIOMAS: A SEQUENTIAL, INTENSIVE, MULTI-AGENT COMBINATION PLATFORM IS A POTENT TREATMENT STRATEGY', in NEURO-ONCOLOGY, OXFORD UNIV PRESS INC, PA, Philadelphia, Vol. 26, presented at International Symposium on Pediatric Neuro-Oncology (ISPNO), PA, Philadelphia, 29 June 2024 - 02 July 2024, http://dx.doi.org/10.1093/neuonc/noae064.099

Pajic M; McLean B; Fajardo DC; Porazinski S; Upton DH; Schuhmacher D; Istadi A; Cox T; Timpson P; Wilcock DJ; Anderson KJ; Mason H; Guisot NE; Jones CD; Phillips C; Armer R, 2024, 'Combining zelasudil, a small molecule ROCK2 inhibitor, with chemotherapy or immunotherapy improves response in preclinical models of pancreatic cancer', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, CA, San Diego, Vol. 84, presented at Annual Meeting of the American-Association-for-Cancer-Research (AACR), CA, San Diego, 05 April 2024 - 10 April 2024, http://dx.doi.org/10.1158/1538-7445.AM2024-720

Upton D; Fajardo DC; Omari S; Porazinski S; McLean B; Schuhmacher D; Istadi A; Kothari V; Finkelstein D; Machajewski T; Rock F; Turner S; Pajic M, 2024, 'Selective targeting of integrins αVβ8 and αVβ1 within the dynamic ecosystem of pancreatic cancer to improve the overall anti-tumor response', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, CA, San Diego, Vol. 84, presented at Annual Meeting of the American-Association-for-Cancer-Research (AACR), CA, San Diego, 05 April 2024 - 10 April 2024, http://dx.doi.org/10.1158/1538-7445.AM2024-6575

Ung C; Upton DH; Venkat P; Pandher R; Curnis F; Corti A; Nicolazzo J; Mayoh C; Tsoli M; Ziegler DS, 2022, 'DIPG CELLS ALTER THE PERMEABILITY OF THE BLOOD-BRAIN BARRIER IN THE BRAINSTEM LEADING TO TREATMENT FAILURE', in NEURO-ONCOLOGY, OXFORD UNIV PRESS INC, GERMANY, Hamburg, Vol. 24, pp. 22 - 22, presented at 20th International Symposium on Pediatric Neuro-Oncology (ISPNO) / Annual Meeting of the Brain-Tumor-Group-of-SIOP-Europe (SIOPE-BTG), GERMANY, Hamburg, 11 June 2022 - 15 June 2022

Upton D; George S; Liu J; Cai DD; Su SY-C; Rayner B; Tsoli M; Ziegler D, 2022, 'DIPG-08. The development of ACT001 as a novel therapeutic for diffuse intrinsic pontine gliomas', in Neuro-Oncology, Oxford University Press (OUP), Vol. 24, pp. i19 - i19, http://dx.doi.org/10.1093/neuonc/noac079.065

Upton D; George S; Liu J; Cai DD; Su SY-C; Rayner B; Tsoli M; Ziegler D, 2022, 'THE DEVELOPMENT OF ACT001 AS A NOVEL THERAPEUTIC FOR DIFFUSE INTRINSIC PONTINE GLIOMAS', in NEURO-ONCOLOGY, OXFORD UNIV PRESS INC, Vol. 24, pp. 19 - 19, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000840122400067&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Upton D; George S; Liu J; Cai D; Su SY-C; Manoharan N; Foresto S; Hassall T; Tsoli M; Ziegler D, 2021, 'ACT001-A PROMISING THERAPEUTIC FOR DIFFUSE INTRINSIC PONTINE GLIOMAS', in NEURO-ONCOLOGY, OXFORD UNIV PRESS INC, Vol. 23, pp. 20 - 20, http://dx.doi.org/10.1093/neuonc/noab090.080

Ung C; Upton D; Tsoli M; Ziegler D, 2021, 'HGG-10. THE BLOOD-BRAIN BARRIER IN DIPG: INVESTIGATING REGION-SPECIFIC DIFFERENCES IN PERMEABILITY', in Neuro-Oncology, Oxford University Press (OUP), Vol. 23, pp. i19 - i19, http://dx.doi.org/10.1093/neuonc/noab090.076

Khan A; Gamble L; Upton D; Yu D; Pandher R; Mayoh C; Burns MR; Norris MD; Haber M; Tsoli M; Ziegler DS, 2021, 'POLYAMINE PATHWAY INHIBITION IS A POTENT NOVEL THERAPEUTIC STRATEGY AGAINST DIFFUSE INTRINSIC PONTINE GLIOMA', in NEURO-ONCOLOGY, OXFORD UNIV PRESS INC, Vol. 23, pp. 40 - 41, http://dx.doi.org/10.1093/neuonc/noab090.163

Upton D; Valvi S; Liu J; Yeung N; George S; Ung C; Khan A; Franshaw L; Ehteda A; Shen H; Orienti I; Farruggia G; Reynolds P; Tsoli M; Ziegler D, 2021, 'POTENTIAL NEW THERAPIES FOR DIFFUSE INTRINSIC PONTINE GLIOMAS IDENTIFIED THROUGH HIGH THROUGHPUT DRUG SCREENING', in NEURO-ONCOLOGY, OXFORD UNIV PRESS INC, Vol. 23, pp. 42 - 42, http://dx.doi.org/10.1093/neuonc/noab090.169

Ung C; Tsoli M; Liu J; Cassano D; Upton D; Ehteda A; Mansfield F; Failes T; Kavallaris M; Arndt G; Vittorio O; Voliani V; Cirilo G; Ziegler DS, 2020, 'DDEL-12. NANOPARTICLE DELIVERY OF DOXORUBICIN FOR THE TREATMENT OF DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG)', in Neuro-Oncology, Oxford University Press (OUP), Vol. 22, pp. iii286 - iii286, http://dx.doi.org/10.1093/neuonc/noaa222.047

Upton D; Valvi S; Liu J; Yeung N; George S; Ung C; Khan A; Franshaw L; Ehteda A; Shen H; Orienti I; Farruggia G; Nath C; Reynolds P; Tsoli M; Ziegler D, 2020, 'DIPG-07. HIGH THROUGHPUT DRUG SCREENING IDENTIFIES POTENTIAL NEW THERAPIES FOR DIFFUSE INTRINSIC PONTINE GLIOMAS (DIPGs)', in Neuro-Oncology, Oxford University Press (OUP), Vol. 22, pp. iii288 - iii288, http://dx.doi.org/10.1093/neuonc/noaa222.058

Khan A; Gamble L; Upton D; Yu D; Ehteda A; Pandher R; Mayoh C; Burns M; Norris M; Haber M; Tsoli M; Ziegler D, 2020, 'DIPG-15. POLYAMINE PATHWAY INHIBITION IS A POTENT NOVEL THERAPEUTIC STRATEGY AGAINST DIFFUSE INTRINSIC PONTINE GLIOMA', in Neuro-Oncology, Oxford University Press (OUP), Vol. 22, pp. iii289 - iii290, http://dx.doi.org/10.1093/neuonc/noaa222.065

Ehteda A; Franshaw L; Liu J; Joshi S; Simon S; Pang CNI; Giorgi F; Pandher R; Ung C; Tolhurst O; Mayoh C; Khan A; Hayden E; Gopalakrishnan A; Trebilcock P; Upton D; Lehmann R; George S; Vittorio O; Tsoli M; Gurova K; Gudkov AG; Norris MD; Haber M; Ziegler DS, 2020, 'DIPG-27. TARGETING FACILITATES CHROMATIN TRANSCRIPTION (FACT) AS A NOVEL STRATEGY FOR DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG) THAT ENHANCES RESPONSE TO HISTONE DEACETYLASE (HDAC) INHIBITION', in Neuro-Oncology, Oxford University Press (OUP), Vol. 22, pp. iii292 - iii292, http://dx.doi.org/10.1093/neuonc/noaa222.076

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