By Dr David Herrmann

Journal articles

Johns AL; McKay SH; Humphris JL; Pinese M; Chantrill LA; Mead RS; Tucker K; Andrews L; Goodwin A; Leonard C; High HA; Nones K; Waddell N; Patch AM; Merrett ND; Pavlakis N; Kassahn KS; Samra JS; Miller DK; Chang DK; Pajic M; Pearson JV; Grimmond SM; Zeps N; Gill AJ; Biankin AV; Chin VT; Chou A; Steinmann A; Arshi M; Drury A; Froio D; Morgan A; Timpson P; Hermann D; Vennin C; Warren S; Wu J; Pinho AV; Newell F; Mukhopadhyay P; Addala V; Kazakoff S; Holmes O; Wood S; Xu C; Hofmann O; Wilson PJ; Christ A; Bruxner T; Samra S; Arena J; Mittal A; Asghari R; Pavey D; Das A; Cosman PH; Ismail K; O'Connnor C; Williams D; Spigellman A; Lam W; McLeod D; Nagrial AM; Kirk J; James V; Grimison P; Cooper CL; Sandroussi C; Forest C; Epari KP; Ballal M; Fletcher DR; Mukhedkar S; Beilin M; Feeney K; Nguyen NQ; Ruszkiewicz AR; Worthley C; Brooke-Smith ME; Papangelis V; Clouston AD; Martin P; Barbour AP; O'Rourke TJ; Fawcett JW; Slater K; Hatzifotis M; Hodgkinson P; Hruban RH; Wolfgang CL; Hodgin M; Lawlor RT; Beghelli S; Corbo V; Scardoni M; Bassi C; Bailey P; Martin S; Musgrove EA; Herrmann D, 2017, 'Lost in translation: Returning germline genetic results in genome-scale cancer research', Genome Medicine, 9, pp. 41, http://dx.doi.org/10.1186/s13073-017-0430-4

Vennin C; Chin VT; Warren SC; Lucas MC; Herrmann D; Magenau A; Melenec P; Walters SN; Del Monte-Nieto G; Conway JRW; Nobis M; Allam AH; McCloy RA; Currey N; Pinese M; Boulghourjian A; Zaratzian A; Adam AAS; Heu C; Nagrial AM; Chou A; Steinmann A; Drury A; Froio D; Giry-Laterriere M; Harris NLE; Phan T; Jain R; Weninger W; McGhee EJ; Whan R; Johns AL; Samra JS; Chantrill L; Gill AJ; Kohonen-Corish M; Harvey RP; Biankin AV; Evans TRJ; Anderson KI; Grey ST; Ormandy CJ; Gallego-Ortega D; Wang Y; Samuel MS; Sansom OJ; Burgess A; Cox TR; Morton JP; Pajic M; Timpson P, 2017, 'Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis', Science Translational Medicine, 9, http://dx.doi.org/10.1126/scitranslmed.aai8504

Herrmann D; Erami Z; Warren S; Nobis M; Magenau A; Lucas M; Vennin C; McGhee EJ; Leung W; Reischmann N; Mrowinska A; Schwarz JP; Kadir S; Karim SA; Campbell AD; Gallego-Ortega D; Evans J; Sansom OJ; Morton JP; Anderson KI; Timpson P, 2017, 'A biosensor mouse to predict the dissociation and spread of pancreatic cancer', CANCER RESEARCH, 77, http://dx.doi.org/10.1158/1538-7445.EPSO16-PR07

Young AIJ; Law AMK; Castillo L; Chong S; Cullen HD; Koehler M; Herzog S; Brummer T; Lee EF; Fairlie WD; Lucas MC; Herrmann D; Allam A; Timpson P; Watkins DN; Millar EKA; O'Toole SA; Gallego-Ortega D; Ormandy CJ; Oakes SR, 2016, 'MCL-1 inhibition provides a new way to suppress breast cancer metastasis and increase sensitivity to dasatinib', Breast Cancer Research, 18, http://dx.doi.org/10.1186/s13058-016-0781-6

Nobis M; Herrmann D; Timpson P; Erami Z; Anderson K, 2016, 'Imaging Molecular Dynamics for Drug Discovery', Physiology News, pp. 27 - 29, http://dx.doi.org/10.36866/pn.104.27

Erami Z; Herrmann D; Warren SC; Nobis M; McGhee EJ; Lucas MC; Leung W; Reischmann N; Mrowinska A; Schwarz JP; Kadir S; Conway JRW; Vennin C; Karim SA; Campbell AD; Gallego-Ortega D; Magenau A; Murphy KJ; Ridgway RA; Law AM; Walters SN; Grey ST; Croucher DR; Zhang L; Herzog H; Hardeman EC; Gunning PW; Ormandy CJ; Evans TRJ; Strathdee D; Sansom OJ; Morton JP; Anderson KI; Timpson P; Zhang L, 2016, 'Intravital FRAP Imaging using an E-cadherin-GFP Mouse Reveals Disease- and Drug-Dependent Dynamic Regulation of Cell-Cell Junctions in Live Tissue', Cell Reports, 14, pp. 152 - 167, http://dx.doi.org/10.1016/j.celrep.2015.12.020

Vennin C; Herrmann D; Lucas MC; Timpson P, 2016, 'Intravital imaging reveals new ancillary mechanisms co-opted by cancer cells to drive tumor progression.', F1000research, 5, http://dx.doi.org/10.12688/F1000RESEARCH.8090.1

Gallego-Ortega D; Ledger A; Roden DL; Law AMK; Magenau A; Kikhtyak Z; Cho C; Allerdice SL; Lee HJ; Valdes-Mora F; Herrmann D; Salomon R; Young AIJ; Lee BY; Sergio CM; Kaplan W; Piggin C; Conway JRW; Rabinovich B; Millar EKA; Oakes SR; Chtanova T; Swarbrick A; Naylor MJ; O’Toole S; Green AR; Timpson P; Gee JMW; Ellis IO; Clark SJ; Ormandy CJ, 2015, 'ELF5 Drives Lung Metastasis in Luminal Breast Cancer through Recruitment of Gr1+ CD11b+ Myeloid-Derived Suppressor Cells', Plos Biology, 13, http://dx.doi.org/10.1371/journal.pbio.1002330

Belle L; Ali N; Lonic A; Li X; Paltridge JL; Roslan S; Herrmann D; Conway JRW; Gehling FK; Bert AG; Crocker LA; Tsykin A; Farshid G; Goodall GJ; Timpson P; Daly RJ; Khew-Goodall Y, 2015, 'The tyrosine phosphatase PTPN14 (Pez) inhibits metastasis by altering protein trafficking', Science Signaling, 8, http://dx.doi.org/10.1126/scisignal.2005547

Pajic M; Herrmann D; Vennin C; Conway JRW; Chin VT; Johnsson AKE; Welch HCE; Timpson P, 2015, 'The dynamics of Rho GTPase signaling and implications for targeting cancer and the tumor microenvironment', Small Gtpases, 6, pp. 123 - 133, http://dx.doi.org/10.4161/21541248.2014.973749

Nobis M; McGhee EJ; Herrmann D; Magenau A; Morton JP; Anderson KI; Timpson P, 2014, 'Monitoring the dynamics of Src activity in response to anti-invasive dasatinib treatment at a subcellular level using dual intravital imaging', Cell Adhesion and Migration, 8, pp. 478 - 486, http://dx.doi.org/10.4161/19336918.2014.970004

Herrmann D; Conway JRW; Vennin C; Magenau A; Hughes WG; Morton JP; Timpson P, 2014, 'Three-dimensional cancer models mimic cell-matrix interactions in the tumour microenvironment', Carcinogenesis, 35, pp. 1671 - 1679, http://dx.doi.org/10.1093/carcin/bgu108

Fuchs A; Inthal A; Herrmann D; Cheng S; Nakatomi M; Peters H; Neubüser A, 2010, 'Regulation of Tbx22 during facial and palatal development', Developmental Dynamics, 239, pp. 2860 - 2874, http://dx.doi.org/10.1002/dvdy.22421

Herrmann D; Ferrer-Vaquer A; Lahsnig C; Firnberg N; Leibbrandt A; Neubüser A, 2010, 'Expression and regulation of ANTXR1 in the chick embryo', Developmental Dynamics, 239, pp. 688 - 702, http://dx.doi.org/10.1002/dvdy.22196

Conference Papers

Burns C; Murphy K; Cock T-A; Devlin M; Herrmann D; Timpson P, 2023, 'The effect of adding a selective FAK inhibitor AMP945 to FOLFIRINOX in a model of pancreatic cancer.', in JOURNAL OF CLINICAL ONCOLOGY, LIPPINCOTT WILLIAMS & WILKINS, IL, Chicago, presented at Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), IL, Chicago, 02 June 2023 - 06 June 2023

Pinho AV; Van Bulck M; Chantrill L; Arshi M; Herrmann D; Vennin C, 2019, 'ROBO2 is a stroma suppressor gene in the pancreas through regulation of TGF-beta', in CANCER IMMUNOLOGY RESEARCH, AMER ASSOC CANCER RESEARCH, http://dx.doi.org/10.1158/2326-6074.CRICIMTEATIAACR18-A100

Warren SC; Magenau A; Nobis M; Herrmann D; Mélénec P; Anderson KI; Sansom OJ; Morton JP; Welch HC; Timpson P, 2018, 'Unmixing spectrally overlapping FRET biosensors in vivo using multispectral FLIM (Conference Presentation)', in Periasamy A; So PT; Xie XS; König K (eds.), Multiphoton Microscopy in the Biomedical Sciences XVIII, SPIE, pp. 23 - 23, presented at Multiphoton Microscopy in the Biomedical Sciences XVIII, 27 January 2018 - 01 February 2018, http://dx.doi.org/10.1117/12.2290152

Herrmann D; Cheng S; Driller K; Partanen J; Neubser A, 2009, 'Analysis of facial and palatal defects in Fgfr1 mutant mice', in MECHANISMS OF DEVELOPMENT, ELSEVIER SCIENCE BV, SCOTLAND, Edinburgh, pp. S166 - S166, presented at 16th Annual Conference of the International-Society-of-Development-Biologists, SCOTLAND, Edinburgh, 06 September 2009 - 10 September 2009, http://dx.doi.org/10.1016/j.mod.2009.06.384

Conference Abstracts

Tyma V; Liew Y-F; Tran A; Howell A; Ritchie S; Atlas AAPCM; Cox T; Pajic M; Herrmann D; Pereira B; Timpson P; Gordon K, 2024, 'Identifying and targeting FOLFIRINOX resistance mechanisms to improve outcomes in pancreatic cancer', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, MA, Boston, Vol. 84, presented at AACR Special Conference in Cancer Research: Advances in Pancreatic Cancer Research, MA, Boston, 15 September 2024 - 18 September 2024, http://dx.doi.org/10.1158/1538-7445.PANCREATIC24-A067

Golo M; Finkbeiner M; Piastra-Facon F; Heu C; Colakoglu F; Tay S; Herrmann D; Whan R; Timpson P; Kempe D; Biro M, 2024, '1354 The impact of the pancreatic tumour microenvironment on cytotoxic T lymphocyte migration and tumour eradication', BMJ, pp. a1517 - a1517, presented at Regular and Young Investigator Award Abstracts, http://dx.doi.org/10.1136/jitc-2024-sitc2024.1354

Murphy KJ; Reed DA; Chambers CR; Channon LM; Pajic M; Herrmann D; Timpson P, 2023, 'Anti-fibrotic FAK 'priming' to improve contemporary chemotherapy in pancreatic cancer', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, MA, Boston, Vol. 84, presented at AACR Special Conference - Pancreatic Cancer, MA, Boston, 27 September 2023 - 30 September 2023, http://dx.doi.org/10.1158/1538-7445.PANCA2023-B037

Pinho AV; Bulck MV; Chantrill L; Arshi M; Sklyarova T; Herrmann D; Vennin C; Gallego-Ortega D; Mawson A; Giry-Laterriere M; Magenau A; Baeyens L; Gill AJ; Phillips P; Timpson P; Biankin AV; Wu J; Rooman I, 2018, 'ROBO2 is a Stroma Suppressor Gene in the Pancreas Through Regulation of TGF-beta', in PANCREAS, LIPPINCOTT WILLIAMS & WILKINS, Vol. 47, pp. 1417 - 1417, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000449304600212&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Preprints

Bulloch S; Xu T; Herrman D; Timpson P; Phan TG; Lin Y-H; Banno M; Lim YJ; Lee WM, 2025, Defocused reflectance imaging for low numerical aperture, large field of view quantitative live cell imaging studies, http://dx.doi.org/10.1101/2025.03.24.645046

Chitty JL; Filipe EC; Lucas MC; Herrmann D; Cox TR; Timpson P, 2018, Recent advances in understanding the complexities of metastasis., http://dx.doi.org/10.12688/f1000research.15064.2

Sugiyama Y; Reed DA; Herrmann D; Lovicu FJ; Robinson ML; Timpson P; Masai I, Fibroblast Growth Factor-induced lens fiber cell elongation is driven by the stepwise activity of Rho and Rac, http://dx.doi.org/10.1101/2023.12.03.569812

Murphy KJ; Chambers CR; Reed DA; Channon LM; Mills NE; McKay SE; Lee V; Howell AE; Tran AM; Nobis M; Magenau A; Stoehr J; Pereira BA; Kuepper N; Ritchie S; Gordon K; Trpceski M; Tyma VM; Hafiz S; Johri V; Ang A; Barkauskas DS; Vennin C; Wang XQ; Naeini MM; Meyer B; Parker AL; Gummadi S; Chitti SV; Fajardo DC; Zaratzian A; Tayao M; Da Silva A; Initiative APG; Atlas APM; Cesare AJ; Mathivanan S; Stirzaker C; Latham SL; Croucher DR; Sharbeen G; Phillips PA; Goldstein LD; Lyons RJ; Nagrial A; Pavlakis N; Gill AJ; Biankin AV; Samra J; Caldon CE; Evans TRJ; Chantrill L; Horvath LG; Sansom OJ; Morton JP; Phan TG; Wang Y; Cock T-A; Kinkel SA; Bishop A; Devlin M; Lambert J; Cox TR; Pajic M; Burns CJ; Herrmann D; Timpson P, Pulsed priming with the FAK inhibitor narmafotinib enhances both gemcitabine/Abraxane and FOLFIRINOX chemotherapy response in pancreatic cancer, http://dx.doi.org/10.64898/2026.07.23.740234

Reed DA; Howell AE; Kuepper N; Tran AMH; Magenau A; Barkauskas DS; Nobis M; Chambers CR; Lee V; Channon LM; Zhu J; Ritchie S; Stoehr J; Wylie K; Chen J; Attwater D; Harvey K; Wu SZ; Saw K; Lyons RJ; Zaratzian A; Tayao M; Da Silva A; Gallego-Ortega D; Gill AJ; Cox TR; Pereira BA; Murphy KJ; Morton JP; Lim E; Swarbrick A; O’Toole S; Samuel MS; Caldon CE; Zanin-Zhorov A; Timpson P; Herrmann D, ROCK2 inhibition has a dual role in reducing ECM remodelling and cell growth, while impairing migration and invasion, http://dx.doi.org/10.1101/2025.07.21.666015

Cazet AS; Hui MN; Elsworth BL; Wu SZ; Roden D; Chan C-L; Skhinas JN; Collot R; Yang J; Harvey K; Johan MZ; Cooper C; Nair R; Herrmann D; McFarland A; Deng N-T; Ruiz-Borrego M; Rojo F; Trigo JM; Bezares S; Caballero R; Lim E; Timpson P; O’Toole S; Watkins DN; Cox TR; Samuel M; Martín M; Swarbrick A, Targeting stromal remodeling and cancer stem cell plasticity to overcome chemoresistance in triple negative breast cancer, http://dx.doi.org/10.1101/215954

Liu J; Lim YJ; Herrmann D; Timpson P; Phan TG; Liu H; Guo M; Lee WM, Using rotational integration of oblique interferometric scattering (RO-iSCAT) to track axial spatiotemporal responses of membrane protrusions, http://dx.doi.org/10.1101/2025.03.23.644841

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