Select Publications

Journal articles

Janbandhu V; Tallapragada V; Patrick R; Li Y; Abeygunawardena D; Humphreys DT; Martin EMMA; Ward AO; Contreras O; Farbehi N; Yao E; Du J; Dunwoodie SL; Bursac N; Harvey RP, 2021, 'Hif-1a suppresses ROS-induced proliferation of cardiac fibroblasts following myocardial infarction.', Cell Stem Cell, http://dx.doi.org/10.1016/j.stem.2021.10.009

Ogawa M; Geng FS; Humphreys DT; Kristianto E; Sheng DZ; Hui SP; Zhang Y; Sugimoto K; Nakayama M; Zheng D; Hesselson D; Hodson MP; Bogdanovic O; Kikuchi K, 2021, 'Krüppel-like factor 1 is a core cardiomyogenic trigger in zebrafish', Science, vol. 372, pp. 201 - 205, http://dx.doi.org/10.1126/science.abe2762

Santiago C; Huttner I; Chand R; Humphreys D; Young P; Ward A; Fatkin D, 2021, 'TTNtv Carriers do not Have Increased Susceptibility to Chemotherapy-Induced Cardiomyopathy', Heart, Lung and Circulation, vol. 30, pp. S97 - S97, http://dx.doi.org/10.1016/j.hlc.2021.06.018

Martin EMMA; Enriquez A; Sparrow DB; Humphreys DT; McInerney-Leo AM; Leo PJ; Duncan EL; Iyer KR; Greasby JA; Ip E; Giannoulatou E; Sheng D; Wohler E; Dimartino C; Amiel J; Capri Y; Lehalle D; Mory A; Wilnai Y; Lebenthal Y; Gharavi AG; Krzemień GG; Miklaszewska M; Steiner RD; Raggio C; Blank R; Baris Feldman H; Milo Rasouly H; Sobreira NLM; Jobling R; Gordon CT; Giampietro PF; Dunwoodie SL; Chapman G, 2020, 'Heterozygous loss of WBP11 function causes multiple congenital defects in humans and mice', Human Molecular Genetics, vol. 29, pp. 3662 - 3678, http://dx.doi.org/10.1093/hmg/ddaa258

Patrick R; Humphreys DT; Janbandhu V; Oshlack A; Ho JWK; Harvey RP; Lo KK, 2020, 'Sierra: Discovery of differential transcript usage from polyA-captured single-cell RNA-seq data', Genome Biology, vol. 21, pp. 167, http://dx.doi.org/10.1186/s13059-020-02071-7

Santiago C; Chand R; Humphreys D; Young P; Ward A; Huttner I; Fatkin D, 2020, '002 Titin Truncation Provides a Sensitised Template for Cardio-Depressant Effects of Alcohol', Heart, Lung and Circulation, vol. 29, pp. S37 - S38, http://dx.doi.org/10.1016/j.hlc.2020.09.009

Humphreys DT; Fossat N; Demuth M; Tam PPL; Ho JWK, 2019, 'Ularcirc: Visualization and enhanced analysis of circular RNAs via back and canonical forward splicing', Nucleic Acids Research, vol. 47, pp. e123, http://dx.doi.org/10.1093/nar/gkz718

Alankarage D; Ip E; Szot JO; Munro J; Blue GM; Harrison K; Cuny H; Enriquez A; Troup M; Humphreys DT; Wilson M; Harvey RP; Sholler GF; Graham RM; Ho JWK; Kirk EP; Pachter N; Chapman G; Winlaw DS; Giannoulatou E; Dunwoodie SL, 2019, 'Identification of clinically actionable variants from genome sequencing of families with congenital heart disease', Genetics in Medicine, vol. 21, pp. 1111 - 1120, http://dx.doi.org/10.1038/s41436-018-0296-x

Humphreys D; Fossat N; Tam P; Ho J, 2018, 'Ularcirc: Visualisation and enhanced analysis of circular RNAs via back and canonical forward splicing', , http://dx.doi.org/10.1101/318436

Coleman JLJ; Mouat MA; Wu J; Jancovski N; Bassi JK; Chan AY; Humphreys DT; Mrad N; Yu ZY; Ngo T; Iismaa S; Dos Remedios CG; Feneley MP; Allen AM; Graham RM; Smith NJ, 2018, 'Orphan receptor GPR37L1 contributes to the sexual dimorphism of central cardiovascular control', Biology of Sex Differences, vol. 9, http://dx.doi.org/10.1186/s13293-018-0173-y

Szot JO; Cuny H; Blue GM; Humphreys DT; Ip E; Harrison K; Sholler GF; Giannoulatou E; Leo P; Duncan EL; Sparrow DB; Ho JWK; Graham RM; Pachter N; Chapman G; Winlaw DS; Dunwoodie SL, 2018, 'A Screening Approach to Identify Clinically Actionable Variants Causing Congenital Heart Disease in Exome Data', Circulation. Genomic and precision medicine, vol. 11, pp. e001978, http://dx.doi.org/10.1161/CIRCGEN.117.001978

Shi H; Enriquez A; Rapadas M; Martin EMMA; Wang R; Moreau J; Lim CK; Szot JO; Ip E; Hughes JN; Sugimoto K; Humphreys DT; McInerney-Leo AM; Leo PJ; Maghzal GJ; Halliday J; Smith J; Colley A; Mark PR; Collins F; Sillence DO; Winlaw DS; Ho JWK; Guillemin GJ; Brown MA; Kikuchi K; Thomas PQ; Stocker R; Giannoulatou E; Chapman G; Duncan EL; Sparrow DB; Dunwoodie SL, 2017, 'NAD deficiency, congenital malformations, and niacin supplementation', New England Journal of Medicine, vol. 377, pp. 544 - 552, http://dx.doi.org/10.1056/NEJMoa1616361

Muthiah K; Humphreys DT; Robson D; Dhital K; Spratt P; Jansz P; Macdonald PS; Hayward CS, 2017, 'Longitudinal structural, functional, and cellular myocardial alterations with chronic centrifugal continuous-flow left ventricular assist device support', Journal of Heart and Lung Transplantation, vol. 36, pp. 722 - 731, http://dx.doi.org/10.1016/j.healun.2016.05.017

Blue GM; Humphreys D; Szot J; Major J; Chapman G; Bosman A; Kirk EP; Sholler GF; Harvey RP; Dunwoodie SL; Winlaw DS, 2017, 'The promises and challenges of exome sequencing in familial, non-syndromic congenital heart disease', International Journal of Cardiology, vol. 230, pp. 155 - 163, http://dx.doi.org/10.1016/j.ijcard.2016.12.024

Cropley JE; Eaton SA; Aiken A; Young PE; Giannoulatou E; Ho JWK; Buckland ME; Keam SP; Hutvagner G; Humphreys DT; Langley KG; Henstridge DC; Martin DIK; Febbraio MA; Suter CM, 2016, 'Male-lineage transmission of an acquired metabolic phenotype induced by grand-paternal obesity', Molecular Metabolism, vol. 5, pp. 699 - 708, http://dx.doi.org/10.1016/j.molmet.2016.06.008

Soetanto R; Hynes CJ; Patel HR; Humphreys DT; Evers M; Duan G; Parker BJ; Archer SK; Clancy JL; Graham RM; Beilharz TH; Smith NJ; Preiss T, 2016, 'Role of miRNAs and alternative mRNA 3'-end cleavage and polyadenylation of their mRNA targets in cardiomyocyte hypertrophy', Biochimica et Biophysica Acta - Gene Regulatory Mechanisms, vol. 1859, pp. 744 - 756, http://dx.doi.org/10.1016/j.bbagrm.2016.03.010

Cropley J; Eaton S; Aiken A; Young P; Giannoulatou E; Ho JWK; Buckland M; Keam S; Hutvagner G; Humphreys D; Langley K; Henstridge D; Martin D; Febbraio M; Suter C, 2016, 'Grand paternal inheritance of an acquired metabolic trait induced by ancestral obesity is associated with sperm RNA', , http://dx.doi.org/10.1101/042101

Lie S; Morrison JL; Williams-Wyss O; Suter CM; Humphreys DT; Ozanne SE; Zhang S; Maclaughlin SM; Kleemann DO; Walker SK; Roberts CT; McMillen IC, 2016, 'Impact of maternal undernutrition around the time of conception on factors regulating hepatic lipid metabolism and microRNAs in singleton and twin fetuses', American Journal of Physiology - Endocrinology and Metabolism, vol. 310, pp. E148 - E159, http://dx.doi.org/10.1152/ajpendo.00600.2014

Lie S; Morrison JL; Williams-Wyss O; Suter CM; Humphreys DT; Ozanne SE; Zhang S; MacLaughlin SM; Kleemann DO; Walker SK; Roberts CT; McMillen IC, 2015, 'Impact of periconceptional and preimplantation undernutrition on factors regulating myogenesis and protein synthesis in muscle of singleton and twin fetal sheep', Physiological Reports, vol. 3, http://dx.doi.org/10.14814/phy2.12495

Djordjevic D; Deshpande V; Szczesnik T; Yang A; Humphreys DT; Giannoulatou E; Ho JWK, 2015, 'Decoding the complex genetic causes of heart diseases using systems biology', Biophysical Reviews, vol. 7, pp. 141 - 159, http://dx.doi.org/10.1007/s12551-014-0145-3

Deakin CT; Deakin JJ; Ginn SL; Young P; Humphreys D; Suter CM; Alexander IE; Hallwirth CV, 2014, 'Impact of next-generation sequencing error on analysis of barcoded plasmid libraries of known complexity and sequence', NUCLEIC ACIDS RESEARCH, vol. 42, http://dx.doi.org/10.1093/nar/gku607

Keam SP; Young PE; McCorkindale AL; Dang THY; Clancy JL; Humphreys DT; Preiss T; Hutvagner G; Martin DIK; Cropley JE; Suter CM, 2014, 'The human Piwi protein Hiwi2 associates with tRNA-derived piRNAs in somatic cells', Nucleic Acids Research, vol. 42, pp. 8984 - 8995, http://dx.doi.org/10.1093/nar/gku620

Lie S; Morrison JL; Williams-Wyss O; Zhang S; MacLaughlin SM; McMillen IC; Suter CM; Humphreys DT; Ozanne SE; Kleemann DO; Walker SK; Roberts CT, 2014, 'Impact of embryo number and maternal undernutrition around the time of conception on insulin signaling and gluconeogenic factors and microRNAs in the liver of fetal sheep', American Journal of Physiology - Endocrinology and Metabolism, vol. 306, http://dx.doi.org/10.1152/ajpendo.00456.2013

Lie S; Morrison JL; Williams-Wyss O; Suter CM; Humphreys DT; Ozanne SE; Zhang S; MacLaughlin SM; Kleemann DO; Walker SK; Roberts CT; McMillen IC, 2014, 'Impact of embryo number and maternal undernutrition around the time of conception on insulin signaling and gluconeogenic factors and microRNAs in the liver of fetal sheep', American Journal of Physiology - Endocrinology and Metabolism, vol. 306, http://dx.doi.org/10.1152/ajpendo.00553.2013

Lie S; Morrison JL; Williams-Wyss O; Suter CM; Humphreys DT; Ozanne SE; Zhang S; MacLaughlin SM; Kleemann DO; Walker SK; Roberts CT; Caroline McMillen I, 2014, 'Periconceptional undernutrition programs changes in insulin-signaling molecules and micrornas in skeletal muscle in singleton and twin fetal sheep', Biology of Reproduction, vol. 90, http://dx.doi.org/10.1095/biolreprod.113.109751

Muthiah K; Humphreys D; Robson D; Macdonald P; Dhital K; Jansz P; Hayward CS, 2014, 'Regression of Cellular Hypertrophy Leads to Functional Recovery Following Implantation with Centrifugal Continuous Flow Left Ventricular Assist Devices', The Journal of Heart and Lung Transplantation, vol. 33, pp. S236 - S236, http://dx.doi.org/10.1016/j.healun.2014.01.614

Giannoulatou E; Park S-H; Humphreys DT; Ho JWK, 2014, 'Verification and validation of bioinformatics software without a gold standard: a case study of BWA and Bowtie', BMC bioinformatics, vol. 15, pp. S15 - S15, http://dx.doi.org/10.1186/1471-2105-15-S16-S15

Liang B; Soka M; Christensen AH; Olesen MS; Larsen AP; Knop FK; Wang F; Nielsen JB; Andersen MN; Humphreys D; Mann SA; Huttner IG; Vandenberg JI; Svendsen JH; Haunsø S; Preiss T; Seebohm G; Olesen SP; Schmitt N; Fatkin D, 2013, 'Genetic variation in the two-pore domain potassium channel, TASK-1, may contribute to an atrial substrate for arrhythmogenesis.', J Mol Cell Cardiol, vol. 67, pp. 69 - 76, http://dx.doi.org/10.1016/j.yjmcc.2013.12.014

Olesen M; Liang B; Soka M; Larsen AP; Knop FK; Wang F; Nielsen JB; Andersen MN; Humphreys D; Mann SA; Vandenberg JI; Svendsen JH; Haunso S; Preiss T; Seebohm G; Olesen S-P; Schmitt N; Fatkin D, 2013, 'TASK-1 potassium channel mutations in atrial fibrillation', European Heart Journal, vol. 34, pp. 3411 - 3411, http://dx.doi.org/10.1093/eurheartj/eht309.3411

Humphreys DT; Suter CM, 2013, 'MiRspring: A compact standalone research tool for analyzing miRNA-seq data', Nucleic Acids Research, vol. 41, http://dx.doi.org/10.1093/nar/gkt485

Ohanian M; Humphreys DT; Anderson E; Preiss T; Fatkin D, 2013, 'A heterozygous variant in the human cardiac miR-133 gene, MIR133A2, alters miRNA duplex processing and strand abundance.', BMC genetics, vol. 14, http://dx.doi.org/10.1186/1471-2156-14-18

Li CCY; Eaton SA; Young PE; Lee M; Shuttleworth R; Humphreys DT; Grau GE; Combes V; Bebawy M; Gong J; Brammah S; Buckland ME; Suter CM, 2013, 'Glioma microvesicles carry selectively packaged coding and noncoding RNAs which alter gene expression in recipient cells', RNA Biology, vol. 10, pp. 1333 - 1344, http://dx.doi.org/10.4161/rna.25281

Samaraweera SE; O'Keefe LV; Van Eyk CL; Lawlor KT; Humphreys DT; Suter CM; Richards RI, 2013, 'Modeling and analysis of repeat RNA toxicity in drosophila', Methods in Molecular Biology, vol. 1017, pp. 173 - 192, http://dx.doi.org/10.1007/978-1-62703-438-8_13

Humphreys DT; Hynes CJ; Patel HR; Wei G; Cannon LE; Fatkin D; Suter CM; Clancy JL; Preiss T, 2012, 'Complexity of murine cardiomyocyte miRNA biogenesis, sequence variant expression and function', PLoS One, vol. 7, pp. e30933, http://dx.doi.org/10.1371/journal.pone.0030933

Humphreys DT; Preiss T; Hentze M, 2012, 'Insights into RNA Biology from an Atlas of Mammalian mRNA-Binding Proteins', Cell, vol. 149, pp. 1393 - 1406, http://dx.doi.org/10.1016/j.cell.2012.04.031

Squires JE; Patel HR; Nousch M; Sibbritt T; Humphreys DT; Parker BJ; Suter CM; Preiss T, 2012, 'Widespread occurrence of 5-methylcytosine in human coding and non-coding RNA', Nucleic Acids Research, vol. 40, pp. 5023 - 5033, http://dx.doi.org/10.1093/nar/gks144

Preiss T; Clancy JL; Wei G; Echner N; Humphreys D; Beilharz TH, 2011, 'mRNA isoform diversity can obscure detection of miRNA-mediated control of translation', RNA - a Publication of the RNA Society, vol. 17, pp. 1025 - 1031, http://dx.doi.org/10.1261/rna.2567611

Schonrock N; Humphreys D; Preiss T; Gotz J, 2011, 'Target Gene Repression Mediated by miRNAs miR-181c and miR-9 Both of Which Are Down-regulated by Amyloid-beta', Journal of Molecular Neuroscience, vol. 46, pp. 324 - 335, http://dx.doi.org/10.1007/s12031-011-9587-2

Larance M; Rowland AF; Hoehn KL; Humphreys D; Preiss T; Guilhaus M; James DE, 2010, 'Global phosphoproteomics identifies a major role for AKT and 14-3-3 in regulating EDC3', Molecular and Cellular Proteomics, vol. 9, pp. 682 - 694, http://dx.doi.org/10.1074/mcp.M900435-MCP200

Schonrock N; Yazi DK; Humphreys D; Staufenbiel M; Ittner LM; Preiss T; Gotz J, 2010, 'Neuronal microRNA deregulation in response to Alzheimer's disease amyloid-beta', PLoS One, vol. 5, pp. e11070, http://dx.doi.org/10.1371/journal.pone.0011070

Beilharz TH; Humphreys D; Clancy JL; Thermann R; Martin DI; Hentze MW; Preiss T, 2009, 'MicroRNA-mediated messenger RNA deadenylation contributes to translational repression in mammalian cells', PLoS One, vol. 4, http://dx.doi.org/10.1371/journal.pone.0006783

Clancy JL; Nousch M; Humphreys D; Westman B; Beilharz TH; Preiss T, 2007, 'Methods to analyze microRNA-mediated control of mRNA translation', Methods in Enzymology, vol. 431, pp. 83 - 112, http://dx.doi.org/10.1016/S0076-6879(07)31006-9

Lu DP; Read RL; Humphreys DT; Battah FM; Martin DIK; Rasko JEJ, 2005, 'PCR-based expression analysis and identification of microRNAs.', J RNAi Gene Silencing, vol. 1, pp. 44 - 49, https://www.ncbi.nlm.nih.gov/pubmed/19771204

Humphreys D; Westman B; Martin DI; Preiss T, 2005, 'MicroRNAs control translation initiation by inhibiting eukaryotic initiation factor 4E/cap and poly(A) tail function', Proceedings of the National Academy of Sciences of the United States of America, vol. 102, pp. 16961 - 16966, http://dx.doi.org/10.1073/pnas.0506482102

Hochgrebe TT; Humphreys D; Wilson MR; Easterbrook-Smith SB, 1999, 'A reexamination of the role of clusterin as a complement regulator', Experimental Cell Research, vol. 249, pp. 13 - 21, http://dx.doi.org/10.1006/excr.1999.4459

Humphreys DT; Carver JA; Easterbrook-Smith SB; Wilson MR, 1999, 'Clusterin has chaperone-like activity similar to that of small heat shock proteins', Journal of Biological Chemistry, vol. 274, pp. 6875 - 6881, http://dx.doi.org/10.1074/jbc.274.11.6875

Humphreys DT; Wilson MR, 1999, 'Modes of L929 cell death induced by TNF-α and other cytotoxic agents', Cytokine, vol. 11, pp. 773 - 782, http://dx.doi.org/10.1006/cyto.1998.0492

Humphreys D; Hochgrebe TT; Easterbrook-Smith SB; Tenniswood MP; Wilson MR, 1997, 'Effects of clusterin overexpression on TNFα- and TGFβ-mediated death of L929 cells', Biochemistry, vol. 36, pp. 15233 - 15243, http://dx.doi.org/10.1021/bi9703507


Back to profile page